Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.16 0.352 -9999.0 0.0 -0.885 12.0 12.0 IHH -0.207 0.355 -9999.0 0.0 -0.765 24.0 24.0 SHH Np/Cholesterol/GAS1 -0.117 0.237 -9999.0 0.0 -0.55 18.0 18.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.116 0.235 0.545 18.0 -9999.0 0.0 18.0 SMO/beta Arrestin2 -0.129 0.286 -9999.0 0.0 -0.668 13.0 13.0 SMO -0.143 0.302 -9999.0 0.0 -0.712 13.0 13.0 AKT1 -0.041 0.148 -9999.0 0.0 -0.738 1.0 1.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.004 0.118 -9999.0 0.0 -0.766 2.0 2.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.14 0.296 -9999.0 0.0 -0.697 13.0 13.0 STIL -0.141 0.287 -9999.0 0.0 -0.666 15.0 15.0 DHH N/PTCH2 -0.082 0.24 -9999.0 0.0 -0.701 10.0 10.0 DHH N/PTCH1 -0.161 0.278 -9999.0 0.0 -0.633 14.0 14.0 PIK3CA 0.005 0.084 -9999.0 0.0 -0.766 1.0 1.0 DHH -0.067 0.236 -9999.0 0.0 -0.753 9.0 9.0 PTHLH -0.203 0.44 -9999.0 0.0 -1.229 10.0 10.0 determination of left/right symmetry -0.14 0.296 -9999.0 0.0 -0.697 13.0 13.0 PIK3R1 0.005 0.084 -9999.0 0.0 -0.766 1.0 1.0 skeletal system development -0.199 0.43 -9999.0 0.0 -1.198 10.0 10.0 IHH N/Hhip -0.219 0.328 -9999.0 0.0 -0.606 33.0 33.0 DHH N/Hhip -0.148 0.293 -9999.0 0.0 -0.663 19.0 19.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.14 0.296 -9999.0 0.0 -0.697 13.0 13.0 pancreas development -0.114 0.277 -9999.0 0.0 -0.71 15.0 15.0 HHAT 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.012 0.114 -9999.0 0.0 -1.054 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.064 0.229 -9999.0 0.0 -0.727 9.0 9.0 somite specification -0.14 0.296 -9999.0 0.0 -0.697 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.158 0.302 -9999.0 0.0 -0.71 15.0 15.0 SHH Np/Cholesterol/PTCH2 -0.092 0.201 -9999.0 0.0 -0.49 16.0 16.0 SHH Np/Cholesterol/Megalin -0.129 0.225 -9999.0 0.0 -0.476 23.0 23.0 SHH -0.071 0.217 -9999.0 0.0 -0.559 14.0 14.0 catabolic process -0.131 0.269 -9999.0 0.0 -0.529 22.0 22.0 SMO/Vitamin D3 -0.161 0.321 -9999.0 0.0 -0.728 16.0 16.0 SHH Np/Cholesterol/Hhip -0.144 0.247 -9999.0 0.0 -0.512 24.0 24.0 LRP2 -0.089 0.248 -9999.0 0.0 -0.697 12.0 12.0 receptor-mediated endocytosis -0.223 0.292 -9999.0 0.0 -0.684 21.0 21.0 SHH Np/Cholesterol/BOC -0.083 0.183 -9999.0 0.0 -0.469 15.0 15.0 SHH Np/Cholesterol/CDO -0.082 0.171 -9999.0 0.0 -0.434 16.0 16.0 mesenchymal cell differentiation 0.143 0.244 0.507 24.0 -9999.0 0.0 24.0 mol:Vitamin D3 -0.157 0.305 -9999.0 0.0 -0.713 15.0 15.0 IHH N/PTCH2 -0.149 0.271 -9999.0 0.0 -0.565 23.0 23.0 CDON -0.003 0.11 -9999.0 0.0 -0.707 2.0 2.0 IHH N/PTCH1 -0.133 0.273 -9999.0 0.0 -0.536 22.0 22.0 Megalin/LRPAP1 -0.073 0.182 -9999.0 0.0 -0.519 12.0 12.0 PTCH2 -0.021 0.159 -9999.0 0.0 -0.736 4.0 4.0 SHH Np/Cholesterol -0.074 0.166 -9999.0 0.0 -0.447 14.0 14.0 PTCH1 -0.131 0.271 -9999.0 0.0 -0.531 22.0 22.0 HHIP -0.114 0.278 -9999.0 0.0 -0.711 15.0 15.0