Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	24.0	1110.0	46.0	-0.874	0.024	1000.0	-1000.0	-0.093	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	18.0	617.0	34.0	-0.283	0.014	1000.0	-1000.0	-0.074	-1000.0
IL23-mediated signaling events	14.0	873.0	60.0	-0.542	0.014	1000.0	-1000.0	-0.17	-1000.0
Signaling events mediated by the Hedgehog family	12.0	647.0	52.0	-0.223	0.143	1000.0	-1000.0	-0.093	-1000.0
IL4-mediated signaling events	12.0	1150.0	91.0	-0.762	0.677	1000.0	-1000.0	-0.19	-1000.0
IL6-mediated signaling events	11.0	838.0	75.0	-0.537	0.043	1000.0	-1000.0	-0.107	-1000.0
HIF-1-alpha transcription factor network	10.0	822.0	76.0	-0.594	0.023	1000.0	-1000.0	-0.184	-1000.0
Glypican 1 network	10.0	500.0	48.0	-0.383	0.026	1000.0	-1000.0	-0.064	-1000.0
BCR signaling pathway	10.0	1017.0	99.0	-0.429	0.014	1000.0	-1000.0	-0.125	-1000.0
amb2 Integrin signaling	9.0	751.0	82.0	-0.251	0.014	1000.0	-1000.0	-0.1	-1000.0
TCGA08_retinoblastoma	9.0	75.0	8.0	-0.19	0.067	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by PTP1B	8.0	676.0	76.0	-0.387	0.094	1000.0	-1000.0	-0.103	-1000.0
Reelin signaling pathway	8.0	448.0	56.0	-0.274	0.014	1000.0	-1000.0	-0.106	-1000.0
TCR signaling in naïve CD8+ T cells	8.0	773.0	93.0	-0.187	0.097	1000.0	-1000.0	-0.097	-1000.0
Wnt signaling	8.0	58.0	7.0	-0.214	0.014	1000.0	-1000.0	-0.035	-1000.0
EGFR-dependent Endothelin signaling events	8.0	174.0	21.0	-0.329	0.014	1000.0	-1000.0	-0.095	-1000.0
Ephrin A  reverse signaling	7.0	55.0	7.0	-0.062	-0.0	1000.0	-1000.0	-0.033	-1000.0
p75(NTR)-mediated signaling	7.0	930.0	125.0	-0.282	0.014	1000.0	-1000.0	-0.138	-1000.0
Glucocorticoid receptor regulatory network	7.0	834.0	114.0	-0.555	0.207	1000.0	-1000.0	-0.1	-1000.0
Syndecan-4-mediated signaling events	7.0	517.0	67.0	-0.278	0.056	1000.0	-1000.0	-0.121	-1000.0
IL12-mediated signaling events	6.0	607.0	87.0	-0.267	0.049	1000.0	-1000.0	-0.146	-1000.0
Visual signal transduction: Cones	6.0	247.0	38.0	-0.188	0.014	1000.0	-1000.0	-0.087	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	112.0	17.0	-0.129	0.014	1000.0	-1000.0	-0.081	-1000.0
Noncanonical Wnt signaling pathway	6.0	162.0	26.0	-0.214	0.014	1000.0	-1000.0	-0.1	-1000.0
Fc-epsilon receptor I signaling in mast cells	6.0	634.0	97.0	-0.193	0.031	1000.0	-1000.0	-0.116	-1000.0
Endothelins	6.0	588.0	96.0	-0.185	0.035	1000.0	-1000.0	-0.111	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	6.0	420.0	68.0	-0.299	0.082	1000.0	-1000.0	-0.146	-1000.0
Insulin Pathway	6.0	458.0	74.0	-0.383	0.023	1000.0	-1000.0	-0.124	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	541.0	88.0	-0.175	0.023	1000.0	-1000.0	-0.143	-1000.0
Visual signal transduction: Rods	6.0	316.0	52.0	-0.252	0.014	1000.0	-1000.0	-0.111	-1000.0
Syndecan-1-mediated signaling events	5.0	185.0	34.0	-0.171	0.014	1000.0	-1000.0	-0.077	-1000.0
Thromboxane A2 receptor signaling	5.0	552.0	105.0	-0.329	0.034	1000.0	-1000.0	-0.09	-1000.0
Arf6 signaling events	5.0	322.0	62.0	-0.33	0.014	1000.0	-1000.0	-0.078	-1000.0
BMP receptor signaling	5.0	456.0	81.0	-0.248	0.055	1000.0	-1000.0	-0.125	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	5.0	265.0	52.0	-0.228	0.041	1000.0	-1000.0	-0.092	-1000.0
Integrins in angiogenesis	5.0	501.0	84.0	-0.24	0.014	1000.0	-1000.0	-0.118	-1000.0
Effects of Botulinum toxin	5.0	142.0	26.0	-0.129	0.014	1000.0	-1000.0	-0.08	-1000.0
Calcium signaling in the CD4+ TCR pathway	5.0	177.0	31.0	-0.254	0.014	1000.0	-1000.0	-0.104	-1000.0
IL27-mediated signaling events	5.0	288.0	51.0	-0.23	0.073	1000.0	-1000.0	-0.104	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	5.0	613.0	120.0	-0.323	0.143	1000.0	-1000.0	-0.106	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.029	-1000.0	1000.0	-1000.0	-0.022	-1000.0
Coregulation of Androgen receptor activity	4.0	319.0	76.0	-0.307	0.052	1000.0	-1000.0	-0.061	-1000.0
ErbB4 signaling events	4.0	294.0	69.0	-0.209	0.155	1000.0	-1000.0	-0.108	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	260.0	54.0	-0.256	0.03	1000.0	-1000.0	-0.13	-1000.0
Syndecan-2-mediated signaling events	4.0	339.0	69.0	-0.193	0.029	1000.0	-1000.0	-0.076	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	24.0	5.0	-0.059	-0.003	1000.0	-1000.0	-0.05	-1000.0
mTOR signaling pathway	4.0	216.0	53.0	-0.387	0.031	1000.0	-1000.0	-0.086	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	182.0	37.0	-0.207	0.014	1000.0	-1000.0	-0.078	-1000.0
Signaling events regulated by Ret tyrosine kinase	4.0	390.0	82.0	-0.152	0.014	1000.0	-1000.0	-0.114	-1000.0
TCGA08_p53	4.0	33.0	7.0	-0.14	0.071	1000.0	-1000.0	-0.018	-1000.0
Nongenotropic Androgen signaling	4.0	228.0	52.0	-0.112	0.014	1000.0	-1000.0	-0.075	-1000.0
LPA receptor mediated events	4.0	410.0	102.0	-0.133	0.023	1000.0	-1000.0	-0.124	-1000.0
IGF1 pathway	4.0	246.0	57.0	-0.211	0.034	1000.0	-1000.0	-0.133	-1000.0
Plasma membrane estrogen receptor signaling	4.0	362.0	86.0	-0.21	0.025	1000.0	-1000.0	-0.101	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	70.0	17.0	-0.114	0.015	1000.0	-1000.0	-0.058	-1000.0
LPA4-mediated signaling events	3.0	41.0	12.0	-0.048	0.016	1000.0	-1000.0	-0.036	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	414.0	136.0	-0.188	0.13	1000.0	-1000.0	-0.09	-1000.0
Osteopontin-mediated events	3.0	130.0	38.0	-0.087	0.014	1000.0	-1000.0	-0.131	-1000.0
Cellular roles of Anthrax toxin	3.0	131.0	39.0	-0.067	0.015	1000.0	-1000.0	-0.037	-1000.0
IL1-mediated signaling events	3.0	194.0	62.0	-0.126	0.059	1000.0	-1000.0	-0.126	-1000.0
HIF-2-alpha transcription factor network	3.0	145.0	43.0	-0.073	0.035	1000.0	-1000.0	-0.114	-1000.0
Ephrin B reverse signaling	3.0	181.0	48.0	-0.099	0.046	1000.0	-1000.0	-0.084	-1000.0
FAS signaling pathway (CD95)	3.0	162.0	47.0	-0.239	0.059	1000.0	-1000.0	-0.057	-1000.0
Retinoic acid receptors-mediated signaling	3.0	195.0	58.0	-0.184	0.017	1000.0	-1000.0	-0.095	-1000.0
Syndecan-3-mediated signaling events	3.0	109.0	35.0	-0.115	0.014	1000.0	-1000.0	-0.082	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	175.0	44.0	-0.1	0.014	1000.0	-1000.0	-0.064	-1000.0
Rapid glucocorticoid signaling	3.0	77.0	20.0	-0.202	0.014	1000.0	-1000.0	-0.049	-1000.0
FOXM1 transcription factor network	3.0	182.0	51.0	-0.196	0.115	1000.0	-1000.0	-0.203	-1000.0
Regulation of Androgen receptor activity	3.0	224.0	70.0	-0.36	0.037	1000.0	-1000.0	-0.083	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	57.0	28.0	-0.046	0.014	1000.0	-1000.0	-0.069	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	168.0	61.0	-0.206	0.049	1000.0	-1000.0	-0.088	-1000.0
EPO signaling pathway	2.0	138.0	55.0	-0.111	0.016	1000.0	-1000.0	-0.124	-1000.0
PDGFR-alpha signaling pathway	2.0	123.0	44.0	-0.053	0.024	1000.0	-1000.0	-0.084	-1000.0
IFN-gamma pathway	2.0	137.0	68.0	-0.158	0.043	1000.0	-1000.0	-0.124	-1000.0
Ceramide signaling pathway	2.0	198.0	76.0	-0.329	0.096	1000.0	-1000.0	-0.088	-1000.0
S1P5 pathway	2.0	37.0	17.0	-0.042	0.039	1000.0	-1000.0	-0.068	-1000.0
S1P1 pathway	2.0	98.0	36.0	-0.067	0.014	1000.0	-1000.0	-0.07	-1000.0
IL2 signaling events mediated by PI3K	2.0	129.0	58.0	-0.132	0.052	1000.0	-1000.0	-0.108	-1000.0
Canonical Wnt signaling pathway	2.0	141.0	51.0	-0.206	0.067	1000.0	-1000.0	-0.078	-1000.0
EPHB forward signaling	2.0	223.0	85.0	-0.117	0.066	1000.0	-1000.0	-0.117	-1000.0
Regulation of p38-alpha and p38-beta	2.0	155.0	54.0	-0.341	0.014	1000.0	-1000.0	-0.076	-1000.0
Glypican 2 network	2.0	9.0	4.0	-0.018	0.005	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	290.0	125.0	-0.072	0.063	1000.0	-1000.0	-0.131	-1000.0
Class I PI3K signaling events	2.0	176.0	73.0	-0.341	0.021	1000.0	-1000.0	-0.094	-1000.0
Regulation of Telomerase	2.0	303.0	102.0	-0.331	0.046	1000.0	-1000.0	-0.128	-1000.0
S1P3 pathway	2.0	90.0	42.0	-0.041	0.016	1000.0	-1000.0	-0.071	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	68.0	33.0	-0.188	0.037	1000.0	-1000.0	-0.093	-1000.0
PDGFR-beta signaling pathway	2.0	222.0	97.0	-0.223	0.046	1000.0	-1000.0	-0.115	-1000.0
S1P4 pathway	2.0	62.0	25.0	-0.046	0.014	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	184.0	78.0	-0.112	0.039	1000.0	-1000.0	-0.086	-1000.0
p38 MAPK signaling pathway	2.0	91.0	44.0	-0.158	0.018	1000.0	-1000.0	-0.083	-1000.0
Aurora B signaling	2.0	152.0	67.0	-0.133	0.015	1000.0	-1000.0	-0.093	-1000.0
ErbB2/ErbB3 signaling events	1.0	83.0	65.0	-0.109	0.049	1000.0	-1000.0	-0.086	-1000.0
Caspase cascade in apoptosis	1.0	135.0	74.0	-0.07	0.024	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by HDAC Class II	1.0	85.0	75.0	-0.051	0.033	1000.0	-1000.0	-0.078	-1000.0
BARD1 signaling events	1.0	108.0	57.0	-0.036	0.043	1000.0	-1000.0	-0.096	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	-0.003	0.014	1000.0	-1000.0	-0.031	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	141.0	85.0	-0.072	0.033	1000.0	-1000.0	-0.102	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	75.0	65.0	-0.043	0.056	1000.0	-1000.0	-0.084	-1000.0
Aurora A signaling	1.0	71.0	60.0	-0.064	0.031	1000.0	-1000.0	-0.079	-1000.0
Arf6 downstream pathway	1.0	49.0	43.0	-0.029	0.027	1000.0	-1000.0	-0.046	-1000.0
PLK1 signaling events	1.0	94.0	85.0	-0.026	0.032	1000.0	-1000.0	-0.068	-1000.0
Nectin adhesion pathway	1.0	117.0	63.0	-0.051	0.041	1000.0	-1000.0	-0.088	-1000.0
Signaling events mediated by HDAC Class III	1.0	61.0	40.0	-0.078	0.021	1000.0	-1000.0	-0.063	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	125.0	83.0	-0.175	0.064	1000.0	-1000.0	-0.09	-1000.0
FoxO family signaling	1.0	118.0	64.0	-0.239	0.112	1000.0	-1000.0	-0.081	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	23.0	15.0	-0.009	0.028	1000.0	-1000.0	-0.035	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	57.0	36.0	-0.062	0.034	1000.0	-1000.0	-0.092	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	80.0	45.0	-0.089	0.046	1000.0	-1000.0	-0.125	-1000.0
TCGA08_rtk_signaling	1.0	30.0	26.0	-0.041	0.053	1000.0	-1000.0	-0.03	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	119.0	74.0	-0.329	0.086	1000.0	-1000.0	-0.121	-1000.0
IL2 signaling events mediated by STAT5	1.0	39.0	22.0	-0.065	0.03	1000.0	-1000.0	-0.066	-1000.0
Arf6 trafficking events	1.0	90.0	71.0	-0.205	0.046	1000.0	-1000.0	-0.091	-1000.0
VEGFR1 specific signals	1.0	58.0	56.0	-0.043	0.055	1000.0	-1000.0	-0.114	-1000.0
Signaling events mediated by PRL	1.0	45.0	34.0	-0.043	0.034	1000.0	-1000.0	-0.054	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	7.0	23.0	-0.02	0.051	1000.0	-1000.0	-0.095	-1000.0
Canonical NF-kappaB pathway	0.0	36.0	39.0	-0.067	0.084	1000.0	-1000.0	-0.111	-1000.0
Circadian rhythm pathway	0.0	13.0	22.0	-0.016	0.045	1000.0	-1000.0	-0.077	-1000.0
Aurora C signaling	0.0	6.0	7.0	-0.023	0.006	1000.0	-1000.0	-0.063	-1000.0
Insulin-mediated glucose transport	0.0	18.0	32.0	-0.022	0.04	1000.0	-1000.0	-0.087	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	17.0	68.0	-0.043	0.056	1000.0	-1000.0	-0.073	-1000.0
TRAIL signaling pathway	0.0	24.0	48.0	-0.019	0.053	1000.0	-1000.0	-0.089	-1000.0
ceramide signaling pathway	0.0	47.0	49.0	-0.066	0.035	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by HDAC Class I	0.0	89.0	104.0	-0.101	0.059	1000.0	-1000.0	-0.091	-1000.0
Atypical NF-kappaB pathway	0.0	14.0	31.0	-0.02	0.047	1000.0	-1000.0	-0.065	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	40.0	76.0	-0.03	0.064	1000.0	-1000.0	-0.104	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.004	0.033	1000.0	-1000.0	-0.078	-1000.0
E-cadherin signaling in keratinocytes	0.0	30.0	43.0	-0.014	0.047	1000.0	-1000.0	-0.093	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.0	0.014	1000.0	-1000.0	-0.056	-1000.0
Arf1 pathway	0.0	12.0	54.0	-0.018	0.029	1000.0	-1000.0	-0.058	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.014	1000.0	-1000.0	-0.082	-1000.0
Total	489	31612	7203	-23.0684721233	-994.134912098	131000	-131000	-11.8686888811	-131000