Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.089 0.204 -9999.0 0.0 -0.548 10.0 10.0 IHH -0.108 0.221 -9999.0 0.0 -0.433 25.0 25.0 SHH Np/Cholesterol/GAS1 -0.029 0.121 -9999.0 0.0 -0.269 16.0 16.0 LRPAP1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.029 0.12 0.268 16.0 -9999.0 0.0 16.0 SMO/beta Arrestin2 -0.081 0.214 -9999.0 0.0 -0.406 22.0 22.0 SMO -0.096 0.215 -9999.0 0.0 -0.426 22.0 22.0 AKT1 -0.023 0.148 -9999.0 0.0 -1.041 1.0 1.0 ARRB2 0.029 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.021 0.073 -9999.0 0.0 -0.442 2.0 2.0 ADRBK1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.094 0.212 -9999.0 0.0 -0.42 22.0 22.0 STIL -0.068 0.18 0.265 2.0 -0.374 15.0 17.0 DHH N/PTCH2 0.016 0.114 -9999.0 0.0 -0.364 6.0 6.0 DHH N/PTCH1 -0.074 0.179 -9999.0 0.0 -0.448 10.0 10.0 PIK3CA 0.026 0.052 -9999.0 0.0 -0.442 1.0 1.0 DHH 0.005 0.106 -9999.0 0.0 -0.414 5.0 5.0 PTHLH -0.126 0.28 -9999.0 0.0 -0.785 9.0 9.0 determination of left/right symmetry -0.094 0.212 -9999.0 0.0 -0.42 22.0 22.0 PIK3R1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.125 0.276 -9999.0 0.0 -0.775 9.0 9.0 IHH N/Hhip -0.09 0.187 -9999.0 0.0 -0.33 29.0 29.0 DHH N/Hhip -0.022 0.149 -9999.0 0.0 -0.313 16.0 16.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.094 0.212 -9999.0 0.0 -0.42 22.0 22.0 pancreas development -0.035 0.153 -9999.0 0.0 -0.371 14.0 14.0 HHAT 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.042 0.045 -9999.0 0.0 -0.35 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.013 0.134 -9999.0 0.0 -0.395 9.0 9.0 somite specification -0.094 0.212 -9999.0 0.0 -0.42 22.0 22.0 SHH Np/Cholesterol/PTCH1 -0.085 0.172 -9999.0 0.0 -0.383 16.0 16.0 SHH Np/Cholesterol/PTCH2 -0.017 0.104 -9999.0 0.0 -0.26 11.0 11.0 SHH Np/Cholesterol/Megalin -0.039 0.122 -9999.0 0.0 -0.258 16.0 16.0 SHH -0.033 0.115 -9999.0 0.0 -0.299 13.0 13.0 catabolic process -0.079 0.18 -9999.0 0.0 -0.342 23.0 23.0 SMO/Vitamin D3 -0.091 0.207 -9999.0 0.0 -0.441 16.0 16.0 SHH Np/Cholesterol/Hhip -0.043 0.128 -9999.0 0.0 -0.28 16.0 16.0 LRP2 -0.026 0.139 -9999.0 0.0 -0.36 12.0 12.0 receptor-mediated endocytosis -0.105 0.208 -9999.0 0.0 -0.427 20.0 20.0 SHH Np/Cholesterol/BOC -0.009 0.091 -9999.0 0.0 -0.241 10.0 10.0 SHH Np/Cholesterol/CDO -0.014 0.095 -9999.0 0.0 -0.222 14.0 14.0 mesenchymal cell differentiation 0.043 0.127 0.278 16.0 -9999.0 0.0 16.0 mol:Vitamin D3 -0.075 0.184 -9999.0 0.0 -0.384 16.0 16.0 IHH N/PTCH2 -0.052 0.158 -9999.0 0.0 -0.302 22.0 22.0 CDON 0.022 0.063 -9999.0 0.0 -0.371 2.0 2.0 IHH N/PTCH1 -0.074 0.185 -9999.0 0.0 -0.346 23.0 23.0 Megalin/LRPAP1 0.003 0.106 -9999.0 0.0 -0.251 12.0 12.0 PTCH2 0.017 0.08 -9999.0 0.0 -0.395 3.0 3.0 SHH Np/Cholesterol -0.019 0.09 -9999.0 0.0 -0.226 13.0 13.0 PTCH1 -0.08 0.18 -9999.0 0.0 -0.343 23.0 23.0 HHIP -0.035 0.153 -9999.0 0.0 -0.371 14.0 14.0