Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	20.0	929.0	46.0	-0.7	0.038	1000.0	-1000.0	-0.112	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	13.0	469.0	34.0	-0.114	0.033	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by the Hedgehog family	12.0	639.0	52.0	-0.126	0.043	1000.0	-1000.0	-0.032	-1000.0
EGFR-dependent Endothelin signaling events	12.0	257.0	21.0	-0.159	0.045	1000.0	-1000.0	-0.039	-1000.0
HIF-1-alpha transcription factor network	11.0	844.0	76.0	-0.367	0.041	1000.0	-1000.0	-0.1	-1000.0
IL4-mediated signaling events	11.0	1085.0	91.0	-0.707	0.625	1000.0	-1000.0	-0.128	-1000.0
IL23-mediated signaling events	11.0	704.0	60.0	-0.468	0.033	1000.0	-1000.0	-0.116	-1000.0
IL6-mediated signaling events	9.0	709.0	75.0	-0.437	0.044	1000.0	-1000.0	-0.056	-1000.0
Reelin signaling pathway	8.0	453.0	56.0	-0.101	0.081	1000.0	-1000.0	-0.035	-1000.0
TCR signaling in naïve CD8+ T cells	8.0	771.0	93.0	-0.084	0.045	1000.0	-1000.0	-0.044	-1000.0
Wnt signaling	8.0	62.0	7.0	-0.088	0.018	1000.0	-1000.0	-0.014	-1000.0
TCGA08_retinoblastoma	8.0	67.0	8.0	-0.069	0.036	1000.0	-1000.0	-0.002	-1000.0
BCR signaling pathway	8.0	825.0	99.0	-0.185	0.033	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by PTP1B	7.0	594.0	76.0	-0.191	0.047	1000.0	-1000.0	-0.033	-1000.0
p75(NTR)-mediated signaling	7.0	927.0	125.0	-0.109	0.083	1000.0	-1000.0	-0.049	-1000.0
amb2 Integrin signaling	7.0	650.0	82.0	-0.15	0.041	1000.0	-1000.0	-0.034	-1000.0
Endothelins	7.0	686.0	96.0	-0.158	0.045	1000.0	-1000.0	-0.045	-1000.0
IL12-mediated signaling events	6.0	554.0	87.0	-0.169	0.051	1000.0	-1000.0	-0.069	-1000.0
Ephrin A  reverse signaling	6.0	46.0	7.0	-0.01	0.027	1000.0	-1000.0	-0.006	-1000.0
Noncanonical Wnt signaling pathway	6.0	163.0	26.0	-0.088	0.032	1000.0	-1000.0	-0.036	-1000.0
Glypican 1 network	6.0	315.0	48.0	-0.187	0.054	1000.0	-1000.0	-0.032	-1000.0
Fc-epsilon receptor I signaling in mast cells	6.0	603.0	97.0	-0.097	0.054	1000.0	-1000.0	-0.046	-1000.0
Glucocorticoid receptor regulatory network	6.0	736.0	114.0	-0.425	0.156	1000.0	-1000.0	-0.052	-1000.0
TCGA08_p53	6.0	47.0	7.0	-0.056	0.047	1000.0	-1000.0	-0.013	-1000.0
Insulin Pathway	6.0	475.0	74.0	-0.188	0.063	1000.0	-1000.0	-0.031	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	540.0	88.0	-0.13	0.04	1000.0	-1000.0	-0.063	-1000.0
Syndecan-1-mediated signaling events	5.0	173.0	34.0	-0.073	0.032	1000.0	-1000.0	-0.036	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	92.0	17.0	-0.068	0.032	1000.0	-1000.0	-0.031	-1000.0
Thromboxane A2 receptor signaling	5.0	561.0	105.0	-0.159	0.041	1000.0	-1000.0	-0.042	-1000.0
Arf6 signaling events	5.0	324.0	62.0	-0.159	0.073	1000.0	-1000.0	-0.037	-1000.0
Integrins in angiogenesis	5.0	462.0	84.0	-0.091	0.063	1000.0	-1000.0	-0.036	-1000.0
Effects of Botulinum toxin	5.0	140.0	26.0	-0.042	0.031	1000.0	-1000.0	-0.002	-1000.0
Calcium signaling in the CD4+ TCR pathway	5.0	169.0	31.0	-0.145	0.032	1000.0	-1000.0	-0.038	-1000.0
LPA receptor mediated events	5.0	565.0	102.0	-0.111	0.034	1000.0	-1000.0	-0.083	-1000.0
Syndecan-4-mediated signaling events	5.0	363.0	67.0	-0.096	0.04	1000.0	-1000.0	-0.031	-1000.0
Visual signal transduction: Rods	5.0	291.0	52.0	-0.098	0.033	1000.0	-1000.0	-0.026	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.007	0.007	1000.0	-1000.0	-0.015	-1000.0
Coregulation of Androgen receptor activity	4.0	339.0	76.0	-0.256	0.079	1000.0	-1000.0	-0.024	-1000.0
Visual signal transduction: Cones	4.0	181.0	38.0	-0.048	0.043	1000.0	-1000.0	-0.014	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	261.0	54.0	-0.101	0.046	1000.0	-1000.0	-0.037	-1000.0
Syndecan-2-mediated signaling events	4.0	308.0	69.0	-0.062	0.051	1000.0	-1000.0	-0.044	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	23.0	5.0	-0.007	0.022	1000.0	-1000.0	0.011	-1000.0
BMP receptor signaling	4.0	396.0	81.0	-0.114	0.065	1000.0	-1000.0	-0.041	-1000.0
mTOR signaling pathway	4.0	254.0	53.0	-0.191	0.044	1000.0	-1000.0	-0.033	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	172.0	37.0	-0.089	0.056	1000.0	-1000.0	-0.026	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	232.0	52.0	-0.091	0.075	1000.0	-1000.0	-0.049	-1000.0
Nongenotropic Androgen signaling	4.0	248.0	52.0	-0.054	0.054	1000.0	-1000.0	-0.029	-1000.0
IL27-mediated signaling events	4.0	238.0	51.0	-0.097	0.062	1000.0	-1000.0	-0.039	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	329.0	68.0	-0.212	0.073	1000.0	-1000.0	-0.102	-1000.0
Plasma membrane estrogen receptor signaling	4.0	384.0	86.0	-0.08	0.064	1000.0	-1000.0	-0.051	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	539.0	120.0	-0.122	0.079	1000.0	-1000.0	-0.05	-1000.0
FOXM1 transcription factor network	4.0	213.0	51.0	-0.075	0.065	1000.0	-1000.0	-0.12	-1000.0
LPA4-mediated signaling events	3.0	41.0	12.0	-0.028	0.006	1000.0	-1000.0	-0.017	-1000.0
Osteopontin-mediated events	3.0	144.0	38.0	-0.06	0.034	1000.0	-1000.0	-0.04	-1000.0
Cellular roles of Anthrax toxin	3.0	141.0	39.0	-0.035	0.033	1000.0	-1000.0	-0.02	-1000.0
EPO signaling pathway	3.0	193.0	55.0	-0.041	0.035	1000.0	-1000.0	-0.039	-1000.0
Ceramide signaling pathway	3.0	294.0	76.0	-0.159	0.088	1000.0	-1000.0	-0.028	-1000.0
IL1-mediated signaling events	3.0	213.0	62.0	-0.027	0.078	1000.0	-1000.0	-0.036	-1000.0
ceramide signaling pathway	3.0	159.0	49.0	-0.009	0.047	1000.0	-1000.0	-0.032	-1000.0
HIF-2-alpha transcription factor network	3.0	143.0	43.0	-0.034	0.054	1000.0	-1000.0	-0.058	-1000.0
Ephrin B reverse signaling	3.0	166.0	48.0	-0.04	0.036	1000.0	-1000.0	-0.031	-1000.0
S1P1 pathway	3.0	127.0	36.0	-0.043	0.034	1000.0	-1000.0	-0.032	-1000.0
FAS signaling pathway (CD95)	3.0	143.0	47.0	-0.167	0.049	1000.0	-1000.0	-0.031	-1000.0
Retinoic acid receptors-mediated signaling	3.0	194.0	58.0	-0.082	0.065	1000.0	-1000.0	-0.033	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	143.0	44.0	-0.037	0.033	1000.0	-1000.0	-0.023	-1000.0
Canonical Wnt signaling pathway	3.0	175.0	51.0	-0.085	0.14	1000.0	-1000.0	-0.038	-1000.0
Regulation of p38-alpha and p38-beta	3.0	178.0	54.0	-0.132	0.067	1000.0	-1000.0	-0.048	-1000.0
IGF1 pathway	3.0	203.0	57.0	-0.079	0.057	1000.0	-1000.0	-0.036	-1000.0
Rapid glucocorticoid signaling	3.0	71.0	20.0	-0.083	0.032	1000.0	-1000.0	-0.004	-1000.0
Regulation of Androgen receptor activity	3.0	226.0	70.0	-0.297	0.037	1000.0	-1000.0	-0.051	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	67.0	17.0	-0.036	0.051	1000.0	-1000.0	-0.025	-1000.0
ErbB2/ErbB3 signaling events	2.0	130.0	65.0	-0.038	0.049	1000.0	-1000.0	-0.07	-1000.0
Caspase cascade in apoptosis	2.0	183.0	74.0	-0.062	0.066	1000.0	-1000.0	-0.041	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	397.0	136.0	-0.187	0.131	1000.0	-1000.0	-0.036	-1000.0
ErbB4 signaling events	2.0	203.0	69.0	-0.09	0.071	1000.0	-1000.0	-0.042	-1000.0
BARD1 signaling events	2.0	116.0	57.0	-0.045	0.065	1000.0	-1000.0	-0.035	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	207.0	85.0	-0.031	0.053	1000.0	-1000.0	-0.048	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	161.0	61.0	-0.085	0.083	1000.0	-1000.0	-0.048	-1000.0
PDGFR-alpha signaling pathway	2.0	120.0	44.0	-0.02	0.062	1000.0	-1000.0	-0.034	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	236.0	82.0	-0.023	0.033	1000.0	-1000.0	-0.053	-1000.0
FoxO family signaling	2.0	134.0	64.0	-0.199	0.066	1000.0	-1000.0	-0.054	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	91.0	36.0	-0.045	0.052	1000.0	-1000.0	-0.025	-1000.0
Syndecan-3-mediated signaling events	2.0	86.0	35.0	-0.042	0.083	1000.0	-1000.0	-0.024	-1000.0
IL2 signaling events mediated by PI3K	2.0	124.0	58.0	-0.044	0.066	1000.0	-1000.0	-0.044	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	131.0	45.0	-0.04	0.079	1000.0	-1000.0	-0.038	-1000.0
EPHB forward signaling	2.0	241.0	85.0	-0.056	0.095	1000.0	-1000.0	-0.056	-1000.0
Glypican 2 network	2.0	9.0	4.0	0.025	0.034	1000.0	-1000.0	0.011	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	286.0	125.0	-0.027	0.071	1000.0	-1000.0	-0.045	-1000.0
Class I PI3K signaling events	2.0	181.0	73.0	-0.132	0.059	1000.0	-1000.0	-0.042	-1000.0
Regulation of Telomerase	2.0	275.0	102.0	-0.162	0.076	1000.0	-1000.0	-0.054	-1000.0
PDGFR-beta signaling pathway	2.0	217.0	97.0	-0.134	0.073	1000.0	-1000.0	-0.039	-1000.0
Aurora B signaling	2.0	183.0	67.0	-0.131	0.062	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class II	1.0	78.0	75.0	-0.036	0.077	1000.0	-1000.0	-0.022	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	48.0	28.0	-0.0	0.055	1000.0	-1000.0	-0.014	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	94.0	65.0	0.0	0.076	1000.0	-1000.0	-0.042	-1000.0
Aurora C signaling	1.0	7.0	7.0	-0.0	0.038	1000.0	-1000.0	-0.009	-1000.0
PLK1 signaling events	1.0	159.0	85.0	-0.011	0.059	1000.0	-1000.0	-0.037	-1000.0
IFN-gamma pathway	1.0	129.0	68.0	-0.063	0.05	1000.0	-1000.0	-0.055	-1000.0
Nectin adhesion pathway	1.0	109.0	63.0	-0.005	0.076	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class III	1.0	75.0	40.0	-0.057	0.057	1000.0	-1000.0	-0.025	-1000.0
S1P5 pathway	1.0	33.0	17.0	-0.01	0.033	1000.0	-1000.0	-0.011	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	145.0	83.0	-0.072	0.065	1000.0	-1000.0	-0.029	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	15.0	15.0	-0.005	0.031	1000.0	-1000.0	-0.029	-1000.0
TCGA08_rtk_signaling	1.0	29.0	26.0	-0.047	0.072	1000.0	-1000.0	-0.012	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	131.0	74.0	-0.159	0.081	1000.0	-1000.0	-0.061	-1000.0
IL2 signaling events mediated by STAT5	1.0	40.0	22.0	-0.038	0.033	1000.0	-1000.0	-0.04	-1000.0
Arf6 trafficking events	1.0	99.0	71.0	-0.156	0.059	1000.0	-1000.0	-0.022	-1000.0
S1P3 pathway	1.0	83.0	42.0	-0.013	0.048	1000.0	-1000.0	-0.036	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	45.0	33.0	-0.073	0.076	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by PRL	1.0	35.0	34.0	-0.028	0.048	1000.0	-1000.0	-0.04	-1000.0
S1P4 pathway	1.0	47.0	25.0	-0.002	0.041	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	105.0	78.0	-0.06	0.055	1000.0	-1000.0	-0.061	-1000.0
p38 MAPK signaling pathway	1.0	85.0	44.0	-0.063	0.062	1000.0	-1000.0	-0.028	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	15.0	23.0	0.004	0.06	1000.0	-1000.0	-0.02	-1000.0
Canonical NF-kappaB pathway	0.0	29.0	39.0	-0.009	0.071	1000.0	-1000.0	-0.023	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.016	0.033	1000.0	-1000.0	-0.013	-1000.0
Circadian rhythm pathway	0.0	11.0	22.0	-0.01	0.063	1000.0	-1000.0	-0.042	-1000.0
Aurora A signaling	0.0	55.0	60.0	-0.008	0.066	1000.0	-1000.0	-0.012	-1000.0
Arf6 downstream pathway	0.0	41.0	43.0	-0.04	0.056	1000.0	-1000.0	-0.028	-1000.0
Insulin-mediated glucose transport	0.0	25.0	32.0	-0.0	0.054	1000.0	-1000.0	-0.03	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	46.0	68.0	-0.046	0.062	1000.0	-1000.0	-0.039	-1000.0
TRAIL signaling pathway	0.0	14.0	48.0	-0.0	0.077	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by HDAC Class I	0.0	98.0	104.0	-0.059	0.077	1000.0	-1000.0	-0.029	-1000.0
Atypical NF-kappaB pathway	0.0	16.0	31.0	0.0	0.042	1000.0	-1000.0	-0.015	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	56.0	76.0	-0.017	0.078	1000.0	-1000.0	-0.055	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.0	0.065	1000.0	-1000.0	-0.026	-1000.0
VEGFR1 specific signals	0.0	44.0	56.0	-0.016	0.081	1000.0	-1000.0	-0.041	-1000.0
E-cadherin signaling in keratinocytes	0.0	35.0	43.0	-0.028	0.062	1000.0	-1000.0	-0.029	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.032	0.063	1000.0	-1000.0	0.014	-1000.0
Arf1 pathway	0.0	9.0	54.0	-0.001	0.055	1000.0	-1000.0	-0.013	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.086	1000.0	-1000.0	0.0	-1000.0
Total	456	30242	7203	-12.3333927738	7.89816881436	131000	-131000	-4.85391586226	-131000