Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.004 0.154 -9999.0 0.0 -0.615 14.0 14.0 IHH -0.042 0.178 -9999.0 0.0 -0.537 37.0 37.0 SHH Np/Cholesterol/GAS1 -0.071 0.149 -9999.0 0.0 -0.282 103.0 103.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.071 0.148 0.28 103.0 -9999.0 0.0 103.0 SMO/beta Arrestin2 0.007 0.107 -9999.0 0.0 -0.407 10.0 10.0 SMO -0.0 0.112 -9999.0 0.0 -0.419 12.0 12.0 AKT1 0.013 0.089 -9999.0 0.0 -0.458 7.0 7.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.004 0.066 -9999.0 0.0 -0.446 7.0 7.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.0 0.11 -9999.0 0.0 -0.414 12.0 12.0 STIL -0.051 0.155 -9999.0 0.0 -0.439 22.0 22.0 DHH N/PTCH2 0.009 0.063 -9999.0 0.0 -0.33 11.0 11.0 DHH N/PTCH1 0.003 0.113 -9999.0 0.0 -0.423 10.0 10.0 PIK3CA 0.006 0.06 -9999.0 0.0 -0.475 5.0 5.0 DHH 0.0 0.08 -9999.0 0.0 -0.478 9.0 9.0 PTHLH -0.001 0.187 -9999.0 0.0 -0.785 14.0 14.0 determination of left/right symmetry 0.0 0.11 -9999.0 0.0 -0.414 12.0 12.0 PIK3R1 0.007 0.056 -9999.0 0.0 -0.446 5.0 5.0 skeletal system development -0.001 0.185 -9999.0 0.0 -0.775 14.0 14.0 IHH N/Hhip -0.044 0.151 -9999.0 0.0 -0.357 61.0 61.0 DHH N/Hhip -0.018 0.108 -9999.0 0.0 -0.318 38.0 38.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.0 0.11 -9999.0 0.0 -0.414 12.0 12.0 pancreas development -0.027 0.131 -9999.0 0.0 -0.45 29.0 29.0 HHAT 0.008 0.05 -9999.0 0.0 -0.446 4.0 4.0 PI3K 0.01 0.062 -9999.0 0.0 -0.351 9.0 9.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.036 0.143 -9999.0 0.0 -0.446 36.0 36.0 somite specification 0.0 0.11 -9999.0 0.0 -0.414 12.0 12.0 SHH Np/Cholesterol/PTCH1 -0.046 0.148 -9999.0 0.0 -0.428 19.0 19.0 SHH Np/Cholesterol/PTCH2 -0.046 0.128 -9999.0 0.0 -0.327 34.0 34.0 SHH Np/Cholesterol/Megalin -0.071 0.152 -9999.0 0.0 -0.289 100.0 100.0 SHH -0.068 0.163 -9999.0 0.0 -0.358 78.0 78.0 catabolic process 0.003 0.113 -9999.0 0.0 -0.479 6.0 6.0 SMO/Vitamin D3 -0.036 0.148 -9999.0 0.0 -0.437 18.0 18.0 SHH Np/Cholesterol/Hhip -0.066 0.149 -9999.0 0.0 -0.294 94.0 94.0 LRP2 -0.035 0.143 -9999.0 0.0 -0.459 34.0 34.0 receptor-mediated endocytosis -0.049 0.161 -9999.0 0.0 -0.431 28.0 28.0 SHH Np/Cholesterol/BOC -0.05 0.131 -9999.0 0.0 -0.337 33.0 33.0 SHH Np/Cholesterol/CDO -0.049 0.13 -9999.0 0.0 -0.272 81.0 81.0 mesenchymal cell differentiation 0.066 0.148 0.292 94.0 -9999.0 0.0 94.0 mol:Vitamin D3 -0.044 0.149 -9999.0 0.0 -0.429 19.0 19.0 IHH N/PTCH2 -0.015 0.113 -9999.0 0.0 -0.321 38.0 38.0 CDON 0.007 0.062 -9999.0 0.0 -0.555 4.0 4.0 IHH N/PTCH1 0.004 0.115 -9999.0 0.0 -0.484 6.0 6.0 Megalin/LRPAP1 -0.015 0.103 -9999.0 0.0 -0.319 34.0 34.0 PTCH2 0.011 0.035 -9999.0 0.0 -0.446 2.0 2.0 SHH Np/Cholesterol -0.053 0.125 -9999.0 0.0 -0.274 78.0 78.0 PTCH1 0.003 0.114 -9999.0 0.0 -0.481 6.0 6.0 HHIP -0.027 0.131 -9999.0 0.0 -0.451 29.0 29.0