Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.029 0.013 -9999.0 0.0 -0.202 1.0 1.0 epithelial cell differentiation 0.029 0.013 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.038 0.054 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.037 0.144 -9999.0 0.0 -0.446 37.0 37.0 EPHA2 -0.036 0.144 -9999.0 0.0 -0.454 35.0 35.0 MYO6 -0.009 0.109 -9999.0 0.0 -0.286 44.0 44.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.138 0.212 -9999.0 0.0 -0.385 141.0 141.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.023 0.052 -9999.0 0.0 -0.282 4.0 4.0 EGF -0.05 0.18 -9999.0 0.0 -0.556 37.0 37.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.037 0.063 -9999.0 0.0 -0.385 7.0 7.0 cortical microtubule organization 0.029 0.013 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.032 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.014 0.001 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.017 0.049 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.007 0.082 -9999.0 0.0 -0.322 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.029 0.045 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.012 0.076 -9999.0 0.0 -0.293 3.0 3.0 CDH1 0.012 0.025 -9999.0 0.0 -0.446 1.0 1.0 EGFR/EGFR/EGF/EGF -0.048 0.095 -9999.0 0.0 -0.388 3.0 3.0 RhoA/GDP -0.001 0.01 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.015 0.109 -9999.0 0.0 -0.455 1.0 1.0 IGF-1R heterotetramer 0.01 0.041 -9999.0 0.0 -0.518 2.0 2.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.042 -9999.0 0.0 -0.519 2.0 2.0 IGF1 -0.046 0.165 -9999.0 0.0 -0.494 39.0 39.0 DIAPH1 0.002 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.029 0.013 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.017 0.048 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.015 0.111 -9999.0 0.0 -0.467 1.0 1.0 EFNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.018 0.064 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.02 0.057 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.0 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.023 0.053 -9999.0 0.0 -0.286 4.0 4.0 HGF/MET -0.032 0.089 -9999.0 0.0 -0.342 18.0 18.0 HGF -0.021 0.129 -9999.0 0.0 -0.49 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.029 0.013 -9999.0 0.0 -0.203 1.0 1.0 actin cable formation 0.049 0.053 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.038 0.017 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.033 0.017 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.012 0.033 -9999.0 0.0 -0.592 1.0 1.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.032 0.025 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.019 0.025 -9999.0 0.0 -0.43 1.0 1.0 mol:GDP 0.029 0.013 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.034 0.06 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.051 0.025 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.027 0.076 -9999.0 0.0 -0.476 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.02 0.001 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.029 0.133 -9999.0 0.0 -0.446 31.0 31.0 PLEKHA7 0.033 0.017 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.006 0.081 -9999.0 0.0 -0.32 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.054 0.011 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.029 0.013 -9999.0 0.0 -0.202 1.0 1.0 regulation of cell-cell adhesion -0.015 0.109 -9999.0 0.0 -0.455 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.029 0.013 -9999.0 0.0 -0.203 1.0 1.0