E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.012 0.089 -9999.0 0.0 -0.256 38.0 38.0 KLHL20 0.013 0.045 0.169 1.0 -0.19 1.0 2.0 CYFIP2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.015 0.064 0.384 3.0 -9999.0 0.0 3.0 ENAH -0.011 0.087 -9999.0 0.0 -0.256 35.0 35.0 AP1M1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.019 -9999.0 0.0 -0.298 1.0 1.0 CTNNB1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.018 0.028 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.006 0.023 -9999.0 0.0 -0.134 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.047 -9999.0 0.0 -0.149 10.0 10.0 RAPGEF1 -0.01 0.081 0.233 3.0 -0.234 22.0 25.0 CTNND1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.004 0.094 -9999.0 0.0 -0.26 39.0 39.0 CRK -0.009 0.078 -9999.0 0.0 -0.247 29.0 29.0 E-cadherin/gamma catenin/alpha catenin 0.046 0.022 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin 0.03 0.044 0.142 3.0 -0.203 10.0 13.0 IQGAP1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.048 0.019 -9999.0 0.0 -0.156 1.0 1.0 DLG1 -0.011 0.087 -9999.0 0.0 -0.256 35.0 35.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.015 0.019 -9999.0 0.0 -0.214 1.0 1.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.051 0.027 -9999.0 0.0 -0.156 2.0 2.0 PI3K -0.019 0.024 -9999.0 0.0 -0.277 1.0 1.0 ARF6 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.035 0.015 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.024 0.032 0.171 1.0 -0.298 3.0 4.0 E-cadherin(dimer)/Ca2+ 0.053 0.026 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.007 0.029 0.122 1.0 -0.162 1.0 2.0 PIK3R1 0.021 0.036 -9999.0 0.0 -0.298 4.0 4.0 CDH1 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.018 0.069 0.346 5.0 -9999.0 0.0 5.0 actin cytoskeleton organization 0.014 0.041 0.183 5.0 -0.14 1.0 6.0 CDC42/GDP 0.022 0.078 0.327 10.0 -9999.0 0.0 10.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.016 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 0.018 0.058 0.171 3.0 -0.298 10.0 13.0 RAC1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.057 0.028 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.04 0.019 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.008 0.082 0.337 10.0 -9999.0 0.0 10.0 CDC42/GTP/IQGAP1 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.023 0.067 0.386 3.0 -9999.0 0.0 3.0 RAC1/GTP/IQGAP1 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.014 0.04 0.182 9.0 -0.091 1.0 10.0 NME1 0.032 0.026 0.171 11.0 -9999.0 0.0 11.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.01 0.087 -9999.0 0.0 -0.256 35.0 35.0 regulation of cell-cell adhesion 0.011 0.021 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.006 0.022 0.081 3.0 -9999.0 0.0 3.0 Rap1/GTP 0.022 0.038 0.233 2.0 -9999.0 0.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.05 -9999.0 0.0 -0.15 8.0 8.0 CCND1 0.016 0.046 0.206 9.0 -0.109 1.0 10.0 VAV2 0.003 0.093 -9999.0 0.0 -0.548 1.0 1.0 RAP1/GDP 0.027 0.051 0.256 4.0 -9999.0 0.0 4.0 adherens junction assembly -0.009 0.085 -9999.0 0.0 -0.25 35.0 35.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.042 0.044 -9999.0 0.0 -0.147 8.0 8.0 E-cadherin/beta catenin 0.011 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.013 0.089 -9999.0 0.0 -0.255 38.0 38.0 PIK3CA 0.022 0.037 0.171 1.0 -0.298 4.0 5.0 Rac1/GTP -0.0 0.049 -9999.0 0.0 -0.294 1.0 1.0 E-cadherin/beta catenin/alpha catenin 0.045 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.005 0.096 -9999.0 0.0 -0.264 39.0 39.0