Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.014 0.108 0.218 69.0 -0.188 1.0 70.0 KIRREL 0.02 0.03 -9999.0 0.0 -0.313 2.0 2.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.014 0.108 0.188 1.0 -0.219 69.0 70.0 PLCG1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.016 0.098 0.226 1.0 -0.163 69.0 70.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.02 0.081 -9999.0 0.0 -0.184 63.0 63.0 FYN -0.026 0.083 0.243 15.0 -0.16 59.0 74.0 mol:Ca2+ 0.015 0.096 0.218 1.0 -0.161 68.0 69.0 mol:DAG 0.016 0.096 0.222 1.0 -0.162 68.0 69.0 NPHS2 -0.004 0.033 0.176 2.0 -0.05 53.0 55.0 mol:IP3 0.016 0.096 0.222 1.0 -0.162 68.0 69.0 regulation of endocytosis 0.002 0.081 -9999.0 0.0 -0.148 67.0 67.0 Nephrin/NEPH1/podocin/Cholesterol 0.005 0.09 0.207 1.0 -0.159 69.0 70.0 establishment of cell polarity -0.014 0.108 0.188 1.0 -0.218 69.0 70.0 Nephrin/NEPH1/podocin/NCK1-2 0.022 0.095 0.231 1.0 -0.151 66.0 67.0 Nephrin/NEPH1/beta Arrestin2 0.003 0.083 -9999.0 0.0 -0.15 67.0 67.0 NPHS1 0.005 0.045 0.188 9.0 -0.05 33.0 42.0 Nephrin/NEPH1/podocin 0.003 0.085 -9999.0 0.0 -0.157 69.0 69.0 TJP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.017 0.097 0.226 1.0 -0.162 68.0 69.0 CD2AP 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.018 0.097 0.226 1.0 -0.163 67.0 68.0 GRB2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.048 0.103 0.238 13.0 -0.192 83.0 96.0 cytoskeleton organization -0.032 0.078 0.2 1.0 -0.191 61.0 62.0 Nephrin/NEPH1 -0.003 0.075 0.13 8.0 -0.144 69.0 77.0 Nephrin/NEPH1/ZO-1 0.006 0.093 0.184 1.0 -0.171 67.0 68.0