Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.011 0.104 -9999.0 0.0 -0.46 13.0 13.0 IHH 0.043 0.062 0.22 24.0 -0.128 12.0 36.0 SHH Np/Cholesterol/GAS1 -0.016 0.07 -9999.0 0.0 -0.161 57.0 57.0 LRPAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.016 0.07 0.16 57.0 -9999.0 0.0 57.0 SMO/beta Arrestin2 0.025 0.09 0.273 2.0 -0.308 13.0 15.0 SMO 0.005 0.079 -9999.0 0.0 -0.316 14.0 14.0 AKT1 0.002 0.097 -9999.0 0.0 -0.411 10.0 10.0 ARRB2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.019 0.047 -9999.0 0.0 -0.298 7.0 7.0 ADRBK1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.005 0.078 -9999.0 0.0 -0.312 14.0 14.0 STIL -0.0 0.088 0.196 22.0 -0.258 12.0 34.0 DHH N/PTCH2 0.035 0.037 0.142 2.0 -0.207 7.0 9.0 DHH N/PTCH1 0.024 0.07 -9999.0 0.0 -0.222 19.0 19.0 PIK3CA 0.022 0.037 0.171 1.0 -0.298 4.0 5.0 DHH 0.022 0.045 0.171 2.0 -0.298 6.0 8.0 PTHLH 0.0 0.134 -9999.0 0.0 -0.592 13.0 13.0 determination of left/right symmetry 0.005 0.078 -9999.0 0.0 -0.312 14.0 14.0 PIK3R1 0.021 0.036 -9999.0 0.0 -0.298 4.0 4.0 skeletal system development 0.001 0.133 -9999.0 0.0 -0.587 13.0 13.0 IHH N/Hhip 0.025 0.095 0.155 25.0 -0.244 31.0 56.0 DHH N/Hhip 0.017 0.073 0.142 3.0 -0.207 31.0 34.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.005 0.078 -9999.0 0.0 -0.312 14.0 14.0 pancreas development 0.003 0.086 0.171 1.0 -0.298 25.0 26.0 HHAT 0.024 0.026 -9999.0 0.0 -0.298 2.0 2.0 PI3K 0.029 0.042 0.142 1.0 -0.231 7.0 8.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.004 0.093 -9999.0 0.0 -0.298 30.0 30.0 somite specification 0.005 0.078 -9999.0 0.0 -0.312 14.0 14.0 SHH Np/Cholesterol/PTCH1 -0.001 0.075 0.188 2.0 -0.267 12.0 14.0 SHH Np/Cholesterol/PTCH2 -0.003 0.063 0.179 3.0 -0.159 38.0 41.0 SHH Np/Cholesterol/Megalin -0.013 0.074 0.148 6.0 -0.16 57.0 63.0 SHH -0.034 0.069 0.26 3.0 -0.207 37.0 40.0 catabolic process 0.012 0.07 -9999.0 0.0 -0.252 20.0 20.0 SMO/Vitamin D3 -0.001 0.093 0.264 7.0 -0.288 15.0 22.0 SHH Np/Cholesterol/Hhip -0.013 0.078 0.164 4.0 -0.175 52.0 56.0 LRP2 0.001 0.09 0.171 3.0 -0.298 27.0 30.0 receptor-mediated endocytosis -0.016 0.095 0.251 1.0 -0.314 14.0 15.0 SHH Np/Cholesterol/BOC -0.006 0.061 0.174 1.0 -0.156 41.0 42.0 SHH Np/Cholesterol/CDO -0.003 0.061 0.164 4.0 -0.154 38.0 42.0 mesenchymal cell differentiation 0.014 0.077 0.174 52.0 -0.162 4.0 56.0 mol:Vitamin D3 0.01 0.094 0.218 23.0 -0.267 12.0 35.0 IHH N/PTCH2 0.04 0.06 0.155 24.0 -0.187 13.0 37.0 CDON 0.027 0.022 0.171 2.0 -0.298 1.0 3.0 IHH N/PTCH1 0.028 0.08 0.25 1.0 -0.254 20.0 21.0 Megalin/LRPAP1 0.019 0.068 -9999.0 0.0 -0.205 27.0 27.0 PTCH2 0.025 0.025 -9999.0 0.0 -0.298 2.0 2.0 SHH Np/Cholesterol -0.011 0.054 -9999.0 0.0 -0.152 38.0 38.0 PTCH1 0.012 0.07 -9999.0 0.0 -0.253 20.0 20.0 HHIP 0.003 0.087 0.171 1.0 -0.298 25.0 26.0