Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.048 0.024 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.009 0.077 0.249 16.0 -9999.0 0.0 16.0 EGFR -0.011 0.101 -9999.0 0.0 -0.298 36.0 36.0 EPHA2 -0.003 0.096 0.171 2.0 -0.298 31.0 33.0 MYO6 0.012 0.061 0.206 17.0 -9999.0 0.0 17.0 CTNNB1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.052 0.015 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.13 0.188 -9999.0 0.0 -0.38 118.0 118.0 CTNND1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.001 0.052 0.196 19.0 -9999.0 0.0 19.0 regulation of calcium-dependent cell-cell adhesion -0.002 0.057 0.196 19.0 -9999.0 0.0 19.0 EGF 0.032 0.066 0.171 28.0 -0.298 8.0 36.0 NCKAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.002 0.068 0.359 1.0 -0.344 10.0 11.0 cortical microtubule organization 0.048 0.024 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.002 0.049 0.184 19.0 -9999.0 0.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.053 0.026 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.03 0.033 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.042 0.066 0.199 1.0 -0.16 26.0 27.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.007 0.032 0.171 4.0 -9999.0 0.0 4.0 PVRL2 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.007 0.031 0.175 8.0 -9999.0 0.0 8.0 ARF6/GTP 0.048 0.066 -9999.0 0.0 -0.152 26.0 26.0 CDH1 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF 0.021 0.068 -9999.0 0.0 -0.147 39.0 39.0 RhoA/GDP 0.049 0.024 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.011 0.051 0.171 18.0 -0.161 1.0 19.0 IGF-1R heterotetramer 0.026 0.02 0.171 1.0 -0.298 1.0 2.0 GIT1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.02 0.171 1.0 -0.298 1.0 2.0 IGF1 0.006 0.091 0.171 10.0 -0.298 25.0 35.0 DIAPH1 0.031 0.107 -9999.0 0.0 -0.475 10.0 10.0 Wnt receptor signaling pathway -0.048 0.024 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.03 0.032 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.011 0.051 0.172 18.0 -0.164 1.0 19.0 EFNA1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.014 0.05 0.214 9.0 -9999.0 0.0 9.0 Ephrin A1/EPHA2 0.027 0.055 -9999.0 0.0 -0.138 27.0 27.0 SEC6/SEC8 -0.02 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.002 0.057 0.197 19.0 -9999.0 0.0 19.0 HGF/MET 0.021 0.068 -9999.0 0.0 -0.168 31.0 31.0 HGF 0.014 0.069 0.171 7.0 -0.298 14.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.023 0.114 0.304 32.0 -0.225 5.0 37.0 KIAA1543 -0.004 0.045 0.177 17.0 -9999.0 0.0 17.0 KIFC3 -0.006 0.042 0.19 13.0 -9999.0 0.0 13.0 NCK1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.004 0.047 0.206 13.0 -9999.0 0.0 13.0 NCK1/GIT1 0.037 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.048 0.024 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.001 0.051 0.199 18.0 -9999.0 0.0 18.0 PIP5K1C -0.001 0.052 0.197 19.0 -9999.0 0.0 19.0 LIMA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.003 0.091 0.349 11.0 -9999.0 0.0 11.0 adherens junction assembly -0.009 0.096 0.273 9.0 -0.531 5.0 14.0 IGF-1R heterotetramer/IGF1 0.03 0.052 0.162 1.0 -0.138 21.0 22.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.003 0.09 -9999.0 0.0 -0.298 28.0 28.0 PLEKHA7 -0.003 0.048 0.189 17.0 -9999.0 0.0 17.0 mol:GTP 0.041 0.064 0.193 1.0 -0.16 26.0 27.0 establishment of epithelial cell apical/basal polarity 0.007 0.094 0.358 15.0 -9999.0 0.0 15.0 cortical actin cytoskeleton stabilization 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.011 0.051 0.171 18.0 -0.161 1.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0