Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.019 0.066 -9999.0 0.0 -0.177 13.0 13.0 epithelial cell differentiation -0.025 0.069 -9999.0 0.0 -0.157 13.0 13.0 CYFIP2 -0.028 0.102 -9999.0 0.0 -0.268 15.0 15.0 ENAH -0.0 0.053 -9999.0 0.0 -0.163 2.0 2.0 EGFR -0.012 0.093 -9999.0 0.0 -0.356 7.0 7.0 EPHA2 0.01 0.023 -9999.0 0.0 -0.224 1.0 1.0 MYO6 -0.022 0.064 -9999.0 0.0 -0.145 13.0 13.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.002 0.06 -9999.0 0.0 -0.194 5.0 5.0 AQP5 -0.055 0.137 -9999.0 0.0 -0.435 10.0 10.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.022 0.063 -9999.0 0.0 -0.144 13.0 13.0 regulation of calcium-dependent cell-cell adhesion -0.036 0.077 -9999.0 0.0 -0.164 20.0 20.0 EGF -0.077 0.149 -9999.0 0.0 -0.321 27.0 27.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.028 0.101 -9999.0 0.0 -0.436 4.0 4.0 cortical microtubule organization -0.025 0.069 -9999.0 0.0 -0.157 13.0 13.0 GO:0000145 -0.022 0.059 -9999.0 0.0 -0.137 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.024 0.071 -9999.0 0.0 -0.158 13.0 13.0 MLLT4 0.009 0.036 -9999.0 0.0 -0.356 1.0 1.0 ARF6/GDP -0.031 0.045 -9999.0 0.0 -0.199 1.0 1.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.028 0.024 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.022 0.069 -9999.0 0.0 -0.217 4.0 4.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.022 0.064 -9999.0 0.0 -0.145 13.0 13.0 ARF6/GTP 0.031 0.022 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.094 0.141 -9999.0 0.0 -0.268 39.0 39.0 EGFR/EGFR/EGF/EGF -0.079 0.09 -9999.0 0.0 -0.182 36.0 36.0 RhoA/GDP -0.021 0.064 -9999.0 0.0 -0.144 13.0 13.0 actin cytoskeleton organization -0.018 0.062 -9999.0 0.0 -0.142 13.0 13.0 IGF-1R heterotetramer -0.004 0.074 -9999.0 0.0 -0.329 5.0 5.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.004 0.074 -9999.0 0.0 -0.329 5.0 5.0 IGF1 -0.042 0.115 -9999.0 0.0 -0.27 20.0 20.0 DIAPH1 -0.002 0.12 -9999.0 0.0 -0.526 5.0 5.0 Wnt receptor signaling pathway 0.025 0.069 0.157 13.0 -9999.0 0.0 13.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.031 0.045 -9999.0 0.0 -0.2 1.0 1.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.019 0.063 -9999.0 0.0 -0.145 13.0 13.0 EFNA1 0.006 0.04 -9999.0 0.0 -0.224 3.0 3.0 LPP -0.038 0.08 -9999.0 0.0 -0.161 23.0 23.0 Ephrin A1/EPHA2 -0.038 0.054 -9999.0 0.0 -0.146 15.0 15.0 SEC6/SEC8 -0.031 0.044 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.036 0.077 -9999.0 0.0 -0.166 20.0 20.0 HGF/MET -0.055 0.076 -9999.0 0.0 -0.24 9.0 9.0 HGF -0.02 0.092 -9999.0 0.0 -0.268 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.019 0.067 -9999.0 0.0 -0.178 13.0 13.0 actin cable formation -0.001 0.059 -9999.0 0.0 -0.208 2.0 2.0 KIAA1543 -0.034 0.079 -9999.0 0.0 -0.161 22.0 22.0 KIFC3 -0.026 0.072 -9999.0 0.0 -0.164 14.0 14.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.034 0.077 -9999.0 0.0 -0.164 18.0 18.0 NCK1/GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.025 0.069 -9999.0 0.0 -0.157 13.0 13.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.022 0.064 -9999.0 0.0 -0.145 13.0 13.0 PIP5K1C -0.022 0.064 -9999.0 0.0 -0.145 13.0 13.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.004 0.056 -9999.0 0.0 -0.177 1.0 1.0 adherens junction assembly -0.026 0.088 -9999.0 0.0 -0.285 5.0 5.0 IGF-1R heterotetramer/IGF1 -0.06 0.066 -9999.0 0.0 -0.16 23.0 23.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.016 0.025 -9999.0 0.0 -0.24 1.0 1.0 MET -0.007 0.076 -9999.0 0.0 -0.28 7.0 7.0 PLEKHA7 -0.031 0.074 -9999.0 0.0 -0.159 18.0 18.0 mol:GTP 0.026 0.024 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.006 0.058 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.019 0.066 -9999.0 0.0 -0.177 13.0 13.0 regulation of cell-cell adhesion -0.018 0.062 -9999.0 0.0 -0.142 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.019 0.067 -9999.0 0.0 -0.178 13.0 13.0