Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.005 0.062 -9999.0 0.0 -0.16 12.0 12.0 epithelial cell differentiation 0.035 0.063 -9999.0 0.0 -0.127 12.0 12.0 CYFIP2 0.024 0.011 -9999.0 0.0 0.0 18.0 18.0 ENAH -0.014 0.055 0.16 2.0 -9999.0 0.0 2.0 EGFR 0.025 0.009 -9999.0 0.0 0.0 12.0 12.0 EPHA2 0.026 0.008 -9999.0 0.0 0.0 9.0 9.0 MYO6 -0.008 0.062 0.201 2.0 -9999.0 0.0 2.0 CTNNB1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.038 -9999.0 0.0 -0.148 3.0 3.0 AQP5 -0.027 0.123 0.271 1.0 -0.368 10.0 11.0 CTNND1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.007 0.06 0.2 2.0 -9999.0 0.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.01 0.058 0.2 2.0 -9999.0 0.0 2.0 EGF 0.019 0.012 -9999.0 0.0 0.0 28.0 28.0 NCKAP1 0.028 0.003 -9999.0 0.0 0.0 1.0 1.0 AQP3 -0.009 0.085 0.271 1.0 -0.33 4.0 5.0 cortical microtubule organization 0.035 0.063 -9999.0 0.0 -0.127 12.0 12.0 GO:0000145 -0.011 0.053 0.185 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.04 0.066 -9999.0 0.0 -0.128 12.0 12.0 MLLT4 0.027 0.007 -9999.0 0.0 0.0 6.0 6.0 ARF6/GDP -0.032 0.037 -9999.0 0.0 -0.129 10.0 10.0 ARF6 0.028 0.006 -9999.0 0.0 0.0 4.0 4.0 Ephrin A1/EPHA2/NCK1/GIT1 0.064 0.026 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.009 0.059 0.223 1.0 -0.197 2.0 3.0 PVRL2 0.027 0.007 -9999.0 0.0 0.0 6.0 6.0 ZYX -0.007 0.061 0.201 2.0 -9999.0 0.0 2.0 ARF6/GTP 0.07 0.029 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.015 0.014 -9999.0 0.0 0.0 47.0 47.0 EGFR/EGFR/EGF/EGF -0.009 0.09 -9999.0 0.0 -0.148 27.0 27.0 RhoA/GDP 0.036 0.062 -9999.0 0.0 -0.124 12.0 12.0 actin cytoskeleton organization -0.015 0.057 0.185 2.0 -9999.0 0.0 2.0 IGF-1R heterotetramer 0.026 0.008 -9999.0 0.0 0.0 9.0 9.0 GIT1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.008 -9999.0 0.0 0.0 9.0 9.0 IGF1 0.022 0.012 -9999.0 0.0 0.0 23.0 23.0 DIAPH1 0.013 0.157 -9999.0 0.0 -0.538 5.0 5.0 Wnt receptor signaling pathway -0.035 0.063 0.127 12.0 -9999.0 0.0 12.0 RHOA 0.028 0.003 -9999.0 0.0 0.0 1.0 1.0 RhoA/GTP -0.033 0.036 -9999.0 0.0 -0.13 9.0 9.0 CTNNA1 0.028 0.005 -9999.0 0.0 0.0 3.0 3.0 VCL -0.015 0.058 0.187 2.0 -9999.0 0.0 2.0 EFNA1 0.026 0.008 -9999.0 0.0 0.0 9.0 9.0 LPP -0.021 0.066 0.22 1.0 -0.221 2.0 3.0 Ephrin A1/EPHA2 0.023 0.057 -9999.0 0.0 -0.127 10.0 10.0 SEC6/SEC8 -0.027 0.033 -9999.0 0.0 -0.129 7.0 7.0 MGAT3 -0.01 0.059 0.201 2.0 -9999.0 0.0 2.0 HGF/MET 0.022 0.068 -9999.0 0.0 -0.145 12.0 12.0 HGF 0.025 0.01 -9999.0 0.0 0.0 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.005 0.063 -9999.0 0.0 -0.161 12.0 12.0 actin cable formation -0.003 0.078 0.201 4.0 -0.284 2.0 6.0 KIAA1543 -0.014 0.057 0.187 2.0 -0.216 1.0 3.0 KIFC3 -0.011 0.064 0.201 2.0 -0.226 1.0 3.0 NCK1 0.028 0.004 -9999.0 0.0 0.0 2.0 2.0 EXOC3 0.025 0.009 -9999.0 0.0 0.0 12.0 12.0 ACTN1 -0.011 0.064 0.232 1.0 -0.226 2.0 3.0 NCK1/GIT1 0.042 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.035 0.063 -9999.0 0.0 -0.127 12.0 12.0 EXOC4 0.027 0.006 -9999.0 0.0 0.0 5.0 5.0 STX4 -0.01 0.061 0.201 2.0 -9999.0 0.0 2.0 PIP5K1C -0.007 0.061 0.201 2.0 -9999.0 0.0 2.0 LIMA1 0.028 0.006 -9999.0 0.0 0.0 4.0 4.0 ABI1 0.028 0.006 -9999.0 0.0 0.0 4.0 4.0 ROCK1 -0.01 0.064 0.179 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.019 0.086 0.228 1.0 -0.32 3.0 4.0 IGF-1R heterotetramer/IGF1 0.015 0.073 -9999.0 0.0 -0.136 17.0 17.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.036 0.025 -9999.0 0.0 -0.173 1.0 1.0 MET 0.026 0.008 -9999.0 0.0 0.0 10.0 10.0 PLEKHA7 -0.011 0.063 0.201 2.0 -0.226 1.0 3.0 mol:GTP 0.062 0.026 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.008 0.093 0.272 7.0 -9999.0 0.0 7.0 cortical actin cytoskeleton stabilization 0.005 0.062 -9999.0 0.0 -0.16 12.0 12.0 regulation of cell-cell adhesion -0.015 0.057 0.185 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.005 0.063 -9999.0 0.0 -0.161 12.0 12.0