Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.03 0.129 -9999.0 0.0 -0.49 10.0 10.0 IHH -0.028 0.143 -9999.0 0.0 -0.385 35.0 35.0 SHH Np/Cholesterol/GAS1 -0.01 0.083 -9999.0 0.0 -0.199 42.0 42.0 LRPAP1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.01 0.083 0.198 42.0 -9999.0 0.0 42.0 SMO/beta Arrestin2 -0.022 0.134 -9999.0 0.0 -0.411 15.0 15.0 SMO -0.033 0.13 -9999.0 0.0 -0.415 17.0 17.0 AKT1 -0.021 0.136 -9999.0 0.0 -0.463 17.0 17.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.005 0.09 -9999.0 0.0 -0.352 16.0 16.0 ADRBK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.031 0.129 -9999.0 0.0 -0.409 17.0 17.0 STIL -0.058 0.121 0.188 4.0 -0.317 28.0 32.0 DHH N/PTCH2 0.01 0.082 -9999.0 0.0 -0.207 33.0 33.0 DHH N/PTCH1 -0.009 0.109 -9999.0 0.0 -0.335 12.0 12.0 PIK3CA 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.019 0.054 -9999.0 0.0 -0.339 6.0 6.0 PTHLH -0.043 0.169 -9999.0 0.0 -0.639 13.0 13.0 determination of left/right symmetry -0.031 0.129 -9999.0 0.0 -0.409 17.0 17.0 PIK3R1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.043 0.167 -9999.0 0.0 -0.633 13.0 13.0 IHH N/Hhip -0.072 0.168 -9999.0 0.0 -0.31 83.0 83.0 DHH N/Hhip -0.041 0.134 -9999.0 0.0 -0.263 71.0 71.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.031 0.129 -9999.0 0.0 -0.409 17.0 17.0 pancreas development -0.071 0.17 -9999.0 0.0 -0.369 67.0 67.0 HHAT 0.024 0.034 -9999.0 0.0 -0.369 2.0 2.0 PI3K 0.036 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.002 0.093 -9999.0 0.0 -0.344 18.0 18.0 somite specification -0.031 0.129 -9999.0 0.0 -0.409 17.0 17.0 SHH Np/Cholesterol/PTCH1 -0.031 0.109 -9999.0 0.0 -0.311 19.0 19.0 SHH Np/Cholesterol/PTCH2 -0.017 0.083 -9999.0 0.0 -0.172 57.0 57.0 SHH Np/Cholesterol/Megalin -0.028 0.091 -9999.0 0.0 -0.176 69.0 69.0 SHH -0.018 0.087 -9999.0 0.0 -0.26 30.0 30.0 catabolic process -0.02 0.111 -9999.0 0.0 -0.374 11.0 11.0 SMO/Vitamin D3 -0.035 0.124 -9999.0 0.0 -0.375 17.0 17.0 SHH Np/Cholesterol/Hhip -0.049 0.123 -9999.0 0.0 -0.231 78.0 78.0 LRP2 -0.029 0.121 -9999.0 0.0 -0.289 48.0 48.0 receptor-mediated endocytosis -0.053 0.125 -9999.0 0.0 -0.357 22.0 22.0 SHH Np/Cholesterol/BOC -0.009 0.084 -9999.0 0.0 -0.202 41.0 41.0 SHH Np/Cholesterol/CDO -0.003 0.073 -9999.0 0.0 -0.192 34.0 34.0 mesenchymal cell differentiation 0.049 0.122 0.229 78.0 -9999.0 0.0 78.0 mol:Vitamin D3 -0.028 0.114 0.2 7.0 -0.317 18.0 25.0 IHH N/PTCH2 -0.023 0.114 -9999.0 0.0 -0.224 62.0 62.0 CDON 0.018 0.055 -9999.0 0.0 -0.318 7.0 7.0 IHH N/PTCH1 -0.014 0.115 -9999.0 0.0 -0.377 11.0 11.0 Megalin/LRPAP1 -0.003 0.09 -9999.0 0.0 -0.197 47.0 47.0 PTCH2 -0.004 0.095 -9999.0 0.0 -0.283 28.0 28.0 SHH Np/Cholesterol -0.008 0.067 -9999.0 0.0 -0.194 30.0 30.0 PTCH1 -0.02 0.111 -9999.0 0.0 -0.376 11.0 11.0 HHIP -0.071 0.17 -9999.0 0.0 -0.369 67.0 67.0