Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Lissencephaly gene (LIS1) in neuronal migration and development	62.0	3349.0	54.0	-0.26	0.038	1000.0	-1000.0	-0.04	-1000.0
FOXA2 and FOXA3 transcription factor networks	50.0	2324.0	46.0	-0.635	0.031	1000.0	-1000.0	-0.157	-1000.0
Aurora C signaling	38.0	272.0	7.0	-0.409	0.037	1000.0	-1000.0	-0.015	-1000.0
Signaling events regulated by Ret tyrosine kinase	38.0	3126.0	82.0	-0.104	0.028	1000.0	-1000.0	-0.048	-1000.0
Effects of Botulinum toxin	36.0	959.0	26.0	-0.122	0.027	1000.0	-1000.0	-0.005	-1000.0
IL4-mediated signaling events	35.0	3197.0	91.0	-0.704	0.563	1000.0	-1000.0	-0.167	-1000.0
Wnt signaling	34.0	239.0	7.0	-0.068	0.022	1000.0	-1000.0	-0.015	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	32.0	1113.0	34.0	-0.058	0.027	1000.0	-1000.0	-0.025	-1000.0
Reelin signaling pathway	32.0	1835.0	56.0	-0.099	0.057	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	32.0	2514.0	78.0	-0.205	0.06	1000.0	-1000.0	-0.046	-1000.0
p75(NTR)-mediated signaling	30.0	3843.0	125.0	-0.132	0.07	1000.0	-1000.0	-0.062	-1000.0
Fc-epsilon receptor I signaling in mast cells	29.0	2852.0	97.0	-0.097	0.034	1000.0	-1000.0	-0.058	-1000.0
Syndecan-1-mediated signaling events	27.0	932.0	34.0	-0.104	0.027	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by the Hedgehog family	27.0	1404.0	52.0	-0.072	0.049	1000.0	-1000.0	-0.039	-1000.0
Ephrin A  reverse signaling	26.0	182.0	7.0	-0.015	0.008	1000.0	-1000.0	-0.006	-1000.0
Canonical Wnt signaling pathway	26.0	1341.0	51.0	-0.26	0.108	1000.0	-1000.0	-0.046	-1000.0
Glypican 1 network	25.0	1229.0	48.0	-0.09	0.048	1000.0	-1000.0	-0.03	-1000.0
Syndecan-2-mediated signaling events	24.0	1698.0	69.0	-0.134	0.044	1000.0	-1000.0	-0.041	-1000.0
Noncanonical Wnt signaling pathway	23.0	602.0	26.0	-0.069	0.026	1000.0	-1000.0	-0.035	-1000.0
IL23-mediated signaling events	23.0	1417.0	60.0	-0.603	0.027	1000.0	-1000.0	-0.141	-1000.0
Presenilin action in Notch and Wnt signaling	22.0	1387.0	61.0	-0.26	0.07	1000.0	-1000.0	-0.045	-1000.0
BMP receptor signaling	21.0	1738.0	81.0	-0.202	0.048	1000.0	-1000.0	-0.044	-1000.0
Ephrin B reverse signaling	21.0	1027.0	48.0	-0.133	0.066	1000.0	-1000.0	-0.026	-1000.0
Aurora B signaling	21.0	1422.0	67.0	-0.297	0.071	1000.0	-1000.0	-0.03	-1000.0
EPHB forward signaling	20.0	1760.0	85.0	-0.134	0.1	1000.0	-1000.0	-0.058	-1000.0
BCR signaling pathway	20.0	2035.0	99.0	-0.26	0.034	1000.0	-1000.0	-0.049	-1000.0
amb2 Integrin signaling	18.0	1491.0	82.0	-0.128	0.04	1000.0	-1000.0	-0.036	-1000.0
Endothelins	18.0	1795.0	96.0	-0.207	0.027	1000.0	-1000.0	-0.068	-1000.0
Visual signal transduction: Cones	17.0	669.0	38.0	-0.037	0.046	1000.0	-1000.0	-0.014	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	17.0	890.0	52.0	-0.115	0.056	1000.0	-1000.0	-0.052	-1000.0
Glypican 2 network	16.0	66.0	4.0	0.004	0.018	1000.0	-1000.0	0.01	-1000.0
LPA receptor mediated events	16.0	1720.0	102.0	-0.116	0.037	1000.0	-1000.0	-0.051	-1000.0
HIF-1-alpha transcription factor network	15.0	1162.0	76.0	-0.229	0.037	1000.0	-1000.0	-0.127	-1000.0
PDGFR-alpha signaling pathway	15.0	682.0	44.0	-0.245	0.212	1000.0	-1000.0	-0.048	-1000.0
TCGA08_p53	15.0	111.0	7.0	-0.039	0.027	1000.0	-1000.0	-0.009	-1000.0
TCR signaling in naïve CD8+ T cells	15.0	1487.0	93.0	-0.098	0.049	1000.0	-1000.0	-0.043	-1000.0
TCGA08_retinoblastoma	15.0	126.0	8.0	-0.046	0.031	1000.0	-1000.0	-0.005	-1000.0
ErbB2/ErbB3 signaling events	14.0	941.0	65.0	-0.085	0.04	1000.0	-1000.0	-0.059	-1000.0
PLK2 and PLK4 events	14.0	43.0	3.0	-0.004	-1000.0	1000.0	-1000.0	-0.014	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	14.0	1705.0	120.0	-0.086	0.072	1000.0	-1000.0	-0.048	-1000.0
EGFR-dependent Endothelin signaling events	13.0	275.0	21.0	-0.028	0.04	1000.0	-1000.0	-0.037	-1000.0
Arf6 signaling events	12.0	786.0	62.0	-0.093	0.059	1000.0	-1000.0	-0.036	-1000.0
Glucocorticoid receptor regulatory network	12.0	1398.0	114.0	-0.257	0.151	1000.0	-1000.0	-0.059	-1000.0
Nongenotropic Androgen signaling	12.0	651.0	52.0	-0.03	0.043	1000.0	-1000.0	-0.037	-1000.0
Nectin adhesion pathway	11.0	732.0	63.0	-0.193	0.053	1000.0	-1000.0	-0.043	-1000.0
FAS signaling pathway (CD95)	11.0	531.0	47.0	-0.092	0.04	1000.0	-1000.0	-0.049	-1000.0
PDGFR-beta signaling pathway	11.0	1129.0	97.0	-0.06	0.071	1000.0	-1000.0	-0.046	-1000.0
Visual signal transduction: Rods	11.0	619.0	52.0	-0.038	0.036	1000.0	-1000.0	-0.029	-1000.0
ErbB4 signaling events	10.0	735.0	69.0	-0.103	0.045	1000.0	-1000.0	-0.042	-1000.0
IL1-mediated signaling events	10.0	681.0	62.0	-0.049	0.071	1000.0	-1000.0	-0.035	-1000.0
Integrins in angiogenesis	10.0	880.0	84.0	-0.13	0.062	1000.0	-1000.0	-0.038	-1000.0
Regulation of Androgen receptor activity	10.0	745.0	70.0	-0.186	0.034	1000.0	-1000.0	-0.05	-1000.0
LPA4-mediated signaling events	9.0	108.0	12.0	-0.055	0.007	1000.0	-1000.0	-0.022	-1000.0
Osteopontin-mediated events	9.0	362.0	38.0	-0.128	0.041	1000.0	-1000.0	-0.03	-1000.0
PLK1 signaling events	9.0	848.0	85.0	-0.025	0.046	1000.0	-1000.0	-0.035	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	9.0	344.0	37.0	-0.112	0.062	1000.0	-1000.0	-0.03	-1000.0
ceramide signaling pathway	9.0	446.0	49.0	-0.0	0.039	1000.0	-1000.0	-0.038	-1000.0
Syndecan-3-mediated signaling events	9.0	324.0	35.0	-0.128	0.07	1000.0	-1000.0	-0.03	-1000.0
IL27-mediated signaling events	9.0	497.0	51.0	-0.276	0.073	1000.0	-1000.0	-0.053	-1000.0
Syndecan-4-mediated signaling events	9.0	642.0	67.0	-0.127	0.031	1000.0	-1000.0	-0.041	-1000.0
FOXM1 transcription factor network	9.0	490.0	51.0	-0.086	0.03	1000.0	-1000.0	-0.176	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	753.0	85.0	-0.04	0.035	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by PTP1B	8.0	663.0	76.0	-0.076	0.035	1000.0	-1000.0	-0.033	-1000.0
Ceramide signaling pathway	8.0	659.0	76.0	-0.022	0.071	1000.0	-1000.0	-0.038	-1000.0
Calcium signaling in the CD4+ TCR pathway	8.0	262.0	31.0	-0.104	0.027	1000.0	-1000.0	-0.054	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	8.0	550.0	68.0	-0.192	0.029	1000.0	-1000.0	-0.095	-1000.0
Plasma membrane estrogen receptor signaling	8.0	720.0	86.0	-0.048	0.051	1000.0	-1000.0	-0.05	-1000.0
IL12-mediated signaling events	7.0	617.0	87.0	-0.059	0.048	1000.0	-1000.0	-0.085	-1000.0
Cellular roles of Anthrax toxin	7.0	277.0	39.0	-0.019	0.028	1000.0	-1000.0	-0.021	-1000.0
Class I PI3K signaling events mediated by Akt	7.0	476.0	68.0	-0.035	0.046	1000.0	-1000.0	-0.034	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	7.0	640.0	83.0	-0.26	0.053	1000.0	-1000.0	-0.033	-1000.0
S1P1 pathway	7.0	257.0	36.0	-0.03	0.027	1000.0	-1000.0	-0.043	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	7.0	519.0	74.0	-0.114	0.063	1000.0	-1000.0	-0.054	-1000.0
IGF1 pathway	7.0	454.0	57.0	-0.023	0.053	1000.0	-1000.0	-0.037	-1000.0
Caspase cascade in apoptosis	6.0	513.0	74.0	-0.044	0.063	1000.0	-1000.0	-0.046	-1000.0
Coregulation of Androgen receptor activity	6.0	466.0	76.0	-0.047	0.047	1000.0	-1000.0	-0.022	-1000.0
S1P5 pathway	6.0	112.0	17.0	-0.007	0.03	1000.0	-1000.0	-0.014	-1000.0
IL2 signaling events mediated by PI3K	6.0	401.0	58.0	-0.049	0.051	1000.0	-1000.0	-0.043	-1000.0
Class I PI3K signaling events	6.0	471.0	73.0	-0.043	0.049	1000.0	-1000.0	-0.04	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	110.0	17.0	-0.002	0.043	1000.0	-1000.0	-0.036	-1000.0
EPO signaling pathway	5.0	303.0	55.0	0.008	0.06	1000.0	-1000.0	-0.039	-1000.0
IFN-gamma pathway	5.0	370.0	68.0	-0.054	0.039	1000.0	-1000.0	-0.053	-1000.0
Retinoic acid receptors-mediated signaling	5.0	336.0	58.0	-0.124	0.05	1000.0	-1000.0	-0.053	-1000.0
Regulation of p38-alpha and p38-beta	5.0	301.0	54.0	-0.043	0.06	1000.0	-1000.0	-0.046	-1000.0
IL6-mediated signaling events	5.0	439.0	75.0	-0.186	0.044	1000.0	-1000.0	-0.074	-1000.0
Regulation of Telomerase	5.0	582.0	102.0	-0.104	0.062	1000.0	-1000.0	-0.056	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	5.0	196.0	33.0	-0.047	0.065	1000.0	-1000.0	-0.026	-1000.0
E-cadherin signaling in keratinocytes	5.0	232.0	43.0	-0.028	0.044	1000.0	-1000.0	-0.032	-1000.0
S1P4 pathway	5.0	145.0	25.0	-0.011	0.046	1000.0	-1000.0	-0.025	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	112.0	28.0	-0.007	0.047	1000.0	-1000.0	-0.022	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	84.0	17.0	-0.023	0.064	1000.0	-1000.0	-0.038	-1000.0
Thromboxane A2 receptor signaling	4.0	436.0	105.0	-0.03	0.045	1000.0	-1000.0	-0.053	-1000.0
Aurora A signaling	4.0	266.0	60.0	-0.034	0.053	1000.0	-1000.0	-0.018	-1000.0
mTOR signaling pathway	4.0	227.0	53.0	-0.034	0.039	1000.0	-1000.0	-0.036	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	73.0	15.0	-0.023	0.027	1000.0	-1000.0	-0.03	-1000.0
Signaling mediated by p38-alpha and p38-beta	4.0	216.0	44.0	-0.035	0.028	1000.0	-1000.0	-0.032	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	211.0	45.0	-0.0	0.068	1000.0	-1000.0	-0.049	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	309.0	76.0	-0.018	0.06	1000.0	-1000.0	-0.049	-1000.0
Insulin Pathway	4.0	332.0	74.0	-0.024	0.067	1000.0	-1000.0	-0.038	-1000.0
S1P3 pathway	4.0	199.0	42.0	-0.01	0.047	1000.0	-1000.0	-0.038	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	399.0	88.0	-0.068	0.07	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by PRL	4.0	142.0	34.0	-0.042	0.039	1000.0	-1000.0	-0.041	-1000.0
Class IB PI3K non-lipid kinase events	4.0	12.0	3.0	-0.023	0.023	1000.0	-1000.0	-0.011	-1000.0
p38 MAPK signaling pathway	4.0	187.0	44.0	-0.045	0.055	1000.0	-1000.0	-0.018	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	500.0	136.0	-0.091	0.073	1000.0	-1000.0	-0.051	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	203.0	65.0	-0.048	0.062	1000.0	-1000.0	-0.042	-1000.0
Insulin-mediated glucose transport	3.0	96.0	32.0	-0.048	0.051	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by HDAC Class III	3.0	157.0	40.0	-0.049	0.052	1000.0	-1000.0	-0.021	-1000.0
FoxO family signaling	3.0	242.0	64.0	-0.041	0.056	1000.0	-1000.0	-0.078	-1000.0
TCGA08_rtk_signaling	3.0	102.0	26.0	-0.041	0.074	1000.0	-1000.0	-0.017	-1000.0
IL2 signaling events mediated by STAT5	3.0	69.0	22.0	0.005	0.038	1000.0	-1000.0	-0.039	-1000.0
Arf6 trafficking events	3.0	237.0	71.0	-0.053	0.05	1000.0	-1000.0	-0.023	-1000.0
Canonical NF-kappaB pathway	2.0	103.0	39.0	-0.0	0.058	1000.0	-1000.0	-0.033	-1000.0
BARD1 signaling events	2.0	141.0	57.0	-0.057	0.065	1000.0	-1000.0	-0.038	-1000.0
VEGFR1 specific signals	2.0	123.0	56.0	-0.014	0.06	1000.0	-1000.0	-0.049	-1000.0
Rapid glucocorticoid signaling	2.0	55.0	20.0	-0.008	0.034	1000.0	-1000.0	-0.004	-1000.0
E-cadherin signaling events	2.0	14.0	5.0	0.02	0.043	1000.0	-1000.0	0.011	-1000.0
Signaling events mediated by HDAC Class II	1.0	115.0	75.0	-0.028	0.07	1000.0	-1000.0	-0.025	-1000.0
Circadian rhythm pathway	1.0	25.0	22.0	-0.005	0.057	1000.0	-1000.0	-0.043	-1000.0
Arf6 downstream pathway	1.0	85.0	43.0	-0.03	0.047	1000.0	-1000.0	-0.024	-1000.0
TRAIL signaling pathway	1.0	60.0	48.0	-0.0	0.057	1000.0	-1000.0	-0.03	-1000.0
HIF-2-alpha transcription factor network	1.0	67.0	43.0	-0.075	0.077	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by HDAC Class I	1.0	169.0	104.0	-0.051	0.065	1000.0	-1000.0	-0.029	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	39.0	36.0	-0.051	0.053	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	212.0	125.0	-0.0	0.068	1000.0	-1000.0	-0.051	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	20.0	23.0	0.009	0.046	1000.0	-1000.0	-0.031	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.024	0.039	1000.0	-1000.0	0.008	-1000.0
Atypical NF-kappaB pathway	0.0	25.0	31.0	0.0	0.036	1000.0	-1000.0	-0.018	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	14.0	27.0	-0.0	0.059	1000.0	-1000.0	-0.024	-1000.0
Arf1 pathway	0.0	52.0	54.0	-0.001	0.049	1000.0	-1000.0	-0.02	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.072	1000.0	-1000.0	0.0	-1000.0
Total	1487	87866	7203	-12.0059078385	-992.921354071	131000	-131000	-5.38780896435	-131000