Correlation between copy number variation genes (focal events) and selected clinical features
Uterine Corpus Endometrioid Carcinoma (Primary solid tumor)
16 April 2014  |  analyses__2014_04_16
Maintainer Information
Citation Information
doi:10.7908/C1PR7TNZ
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2014): Correlation between copy number variation genes (focal events) and selected clinical features. Broad Institute of MIT and Harvard. doi:10.7908/C1PR7TNZ
Overview
Introduction

This pipeline computes the correlation between significant copy number variation (cnv focal) genes and selected clinical features.

Summary

Testing the association between copy number variation 99 focal events and 5 clinical features across 474 patients, 174 significant findings detected with Q value < 0.25.

  • amp_1p35.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_1p34.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_1q21.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_1q22 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_2p24.3 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_2q13 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • amp_3p25.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_3p14.1 cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • amp_3q26.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_3q26.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_4p16.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_5p15.33 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_5q35.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_6p24.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_6q25.1 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_8p11.21 cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • amp_8q24.21 cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • amp_8q24.21 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_9p24.2 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_9q34.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_11p11.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_11q13.2 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_11q14.1 cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • amp_12p12.1 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_12q13.11 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_12q13.2 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_13q34 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_14q24.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_15q26.3 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_16p11.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_17q11.2 cnv correlated to 'AGE',  'HISTOLOGICAL.TYPE', and 'COMPLETENESS.OF.RESECTION'.

  • amp_17q12 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_17q25.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_18p11.31 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_18q11.2 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_19p13.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_19p13.12 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_19q12 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • amp_20p13 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_20q11.21 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • amp_20q13.12 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_20q13.33 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_22q12.2 cnv correlated to 'HISTOLOGICAL.TYPE' and 'COMPLETENESS.OF.RESECTION'.

  • del_1p36.21 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_1p36.11 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_2q22.1 cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • del_2q37.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_3p14.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_3q13.31 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_4p16.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_4p15.31 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_4q22.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_4q34.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_5q11.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_6q26 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_7p22.3 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • del_7q11.22 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_7q31.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_7q36.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_8p23.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_8p21.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_9p23 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_9q21.2 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • del_9q34.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_10q23.31 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_11p15.5 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_11q14.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_11q25 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_12q23.1 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_12q24.33 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_13q11 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_13q14.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_14q13.1 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_15q15.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_15q23 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_16p13.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_16q21 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_16q23.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_17p13.3 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • del_17p11.2 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • del_17p11.2 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • del_17q11.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_17q21.31 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_18q21.2 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_18q23 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_19p13.3 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • del_19p12 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_19q13.43 cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • del_20p12.1 cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • del_22q11.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_22q13.31 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_xp21.1 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between significant copy number variation of 99 focal events and 5 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 174 significant findings detected.

Clinical
Features 		Time
to
Death 		AGE HISTOLOGICAL
TYPE 		RADIATIONS
RADIATION
REGIMENINDICATION 		COMPLETENESS
OF
RESECTION
nCNV (%) nWild-Type logrank test t-test Fisher's exact test Fisher's exact test Fisher's exact test
amp 2q13 100 (21%) 374 0.000524
(0.172) 		0.000285
(0.0967) 		1.32e-17
(6.08e-15) 		0.618
(1.00) 		0.103
(1.00)
amp 17q11 2 62 (13%) 412 0.0143
(1.00) 		0.000492
(0.162) 		3.35e-21
(1.58e-18) 		0.455
(1.00) 		0.00053
(0.173)
amp 19q12 96 (20%) 378 0.000399
(0.133) 		3.07e-09
(1.28e-06) 		2.02e-38
(9.97e-36) 		0.312
(1.00) 		0.0916
(1.00)
amp 20q11 21 121 (26%) 353 0.000241
(0.0834) 		5.93e-08
(2.38e-05) 		4.33e-24
(2.1e-21) 		0.0271
(1.00) 		0.0443
(1.00)
del 7p22 3 63 (13%) 411 0.000261
(0.089) 		6.34e-05
(0.0231) 		4.18e-15
(1.86e-12) 		0.294
(1.00) 		0.181
(1.00)
del 9q21 2 107 (23%) 367 0.00025
(0.086) 		5.32e-11
(2.28e-08) 		5.05e-21
(2.38e-18) 		0.33
(1.00) 		0.129
(1.00)
del 17p13 3 100 (21%) 374 0.000346
(0.116) 		0.000181
(0.0634) 		2.38e-21
(1.13e-18) 		0.134
(1.00) 		0.146
(1.00)
del 17p11 2 107 (23%) 367 0.000482
(0.16) 		9.56e-07
(0.000373) 		5.66e-27
(2.77e-24) 		0.144
(1.00) 		0.608
(1.00)
del 17p11 2 101 (21%) 373 0.000668
(0.216) 		2.81e-06
(0.00108) 		1.96e-20
(9.17e-18) 		0.265
(1.00) 		0.749
(1.00)
del 19p13 3 129 (27%) 345 2.42e-06
(0.000938) 		1.08e-11
(4.65e-09) 		7.83e-50
(3.88e-47) 		0.138
(1.00) 		0.0027
(0.79)
del xp21 1 72 (15%) 402 0.000229
(0.0798) 		0.000247
(0.0852) 		2.45e-16
(1.11e-13) 		0.256
(1.00) 		0.0773
(1.00)
amp 1p35 2 48 (10%) 426 0.127
(1.00) 		0.000424
(0.141) 		4.66e-13
(2.06e-10) 		1
(1.00) 		0.663
(1.00)
amp 1p34 2 61 (13%) 413 0.0216
(1.00) 		0.000169
(0.0595) 		1.07e-16
(4.86e-14) 		0.363
(1.00) 		0.0255
(1.00)
amp 1q21 3 210 (44%) 264 0.0376
(1.00) 		1.79e-05
(0.00672) 		0.000137
(0.0485) 		0.474
(1.00) 		0.782
(1.00)
amp 1q22 225 (47%) 249 0.00417
(1.00) 		4.57e-07
(0.00018) 		3.64e-07
(0.000144) 		0.31
(1.00) 		0.386
(1.00)
amp 3p25 1 67 (14%) 407 0.0376
(1.00) 		0.000231
(0.0803) 		3.06e-10
(1.3e-07) 		0.0809
(1.00) 		0.582
(1.00)
amp 3p14 1 52 (11%) 422 0.000655
(0.212) 		0.0117
(1.00) 		0.000166
(0.0586) 		0.0332
(1.00) 		0.195
(1.00)
amp 3q26 2 144 (30%) 330 0.00737
(1.00) 		8.51e-11
(3.63e-08) 		2.71e-27
(1.33e-24) 		0.078
(1.00) 		0.123
(1.00)
amp 3q26 2 136 (29%) 338 0.00725
(1.00) 		1.54e-08
(6.29e-06) 		7.21e-27
(3.52e-24) 		0.0918
(1.00) 		0.0891
(1.00)
amp 4p16 3 46 (10%) 428 0.12
(1.00) 		1.88e-05
(0.00703) 		2.41e-12
(1.05e-09) 		0.497
(1.00) 		0.185
(1.00)
amp 5q35 3 47 (10%) 427 0.0915
(1.00) 		0.000256
(0.0878) 		1.94e-09
(8.12e-07) 		0.173
(1.00) 		0.42
(1.00)
amp 6p24 2 97 (20%) 377 0.317
(1.00) 		3.98e-06
(0.00152) 		1.83e-18
(8.5e-16) 		0.102
(1.00) 		0.496
(1.00)
amp 8p11 21 143 (30%) 331 8.12e-05
(0.0294) 		0.39
(1.00) 		1.86e-07
(7.41e-05) 		0.0197
(1.00) 		0.00254
(0.754)
amp 8q24 21 178 (38%) 296 0.000356
(0.119) 		0.42
(1.00) 		3.19e-14
(1.42e-11) 		0.0156
(1.00) 		0.0932
(1.00)
amp 9q34 3 33 (7%) 441 0.00945
(1.00) 		0.00019
(0.0667) 		7.02e-07
(0.000275) 		0.842
(1.00) 		0.313
(1.00)
amp 11p11 2 44 (9%) 430 0.00643
(1.00) 		3.4e-05
(0.0126) 		7.19e-10
(3.03e-07) 		0.726
(1.00) 		0.266
(1.00)
amp 11q14 1 50 (11%) 424 6.93e-05
(0.0252) 		0.0093
(1.00) 		6.15e-10
(2.6e-07) 		0.187
(1.00) 		0.306
(1.00)
amp 13q34 51 (11%) 423 0.362
(1.00) 		7.74e-07
(0.000303) 		3.16e-15
(1.41e-12) 		1
(1.00) 		0.0182
(1.00)
amp 14q24 3 57 (12%) 417 0.000928
(0.294) 		0.000343
(0.116) 		1.17e-12
(5.13e-10) 		0.06
(1.00) 		0.329
(1.00)
amp 16p11 2 55 (12%) 419 0.00104
(0.326) 		0.000259
(0.0885) 		3.11e-13
(1.38e-10) 		0.638
(1.00) 		0.0567
(1.00)
amp 17q12 62 (13%) 412 0.00092
(0.293) 		4.55e-05
(0.0167) 		8.53e-20
(3.99e-17) 		1
(1.00) 		0.124
(1.00)
amp 17q25 1 87 (18%) 387 0.00386
(1.00) 		0.000111
(0.0396) 		1e-17
(4.62e-15) 		0.513
(1.00) 		0.139
(1.00)
amp 18p11 31 79 (17%) 395 0.0327
(1.00) 		9.92e-05
(0.0355) 		6.44e-22
(3.07e-19) 		0.0413
(1.00) 		0.0047
(1.00)
amp 19p13 2 77 (16%) 397 0.122
(1.00) 		2.12e-11
(9.1e-09) 		1.08e-20
(5.08e-18) 		0.214
(1.00) 		0.436
(1.00)
amp 19p13 12 81 (17%) 393 0.0123
(1.00) 		2.73e-11
(1.17e-08) 		1.27e-22
(6.07e-20) 		0.0147
(1.00) 		0.229
(1.00)
amp 20p13 99 (21%) 375 0.2
(1.00) 		1.46e-05
(0.0055) 		4.01e-13
(1.77e-10) 		0.08
(1.00) 		0.362
(1.00)
amp 20q13 12 126 (27%) 348 0.00322
(0.933) 		1.79e-08
(7.3e-06) 		3.84e-23
(1.84e-20) 		0.00578
(1.00) 		0.0271
(1.00)
amp 20q13 33 122 (26%) 352 0.0107
(1.00) 		9.07e-08
(3.63e-05) 		1.56e-18
(7.28e-16) 		0.00346
(0.991) 		0.0185
(1.00)
amp 22q12 2 53 (11%) 421 0.001
(0.317) 		0.0011
(0.344) 		1.78e-21
(8.48e-19) 		0.108
(1.00) 		0.000622
(0.202)
del 1p36 21 57 (12%) 417 0.51
(1.00) 		7.29e-05
(0.0265) 		3.6e-09
(1.49e-06) 		0.639
(1.00) 		0.544
(1.00)
del 1p36 11 69 (15%) 405 0.0376
(1.00) 		8.36e-06
(0.00316) 		3.14e-16
(1.42e-13) 		0.475
(1.00) 		0.0344
(1.00)
del 2q22 1 42 (9%) 432 3.43e-09
(1.42e-06) 		0.00336
(0.969) 		2.01e-08
(8.17e-06) 		0.00364
(1.00) 		0.00477
(1.00)
del 2q37 3 46 (10%) 428 0.0676
(1.00) 		0.000491
(0.162) 		0.000747
(0.241) 		0.173
(1.00) 		0.078
(1.00)
del 3p14 2 66 (14%) 408 0.185
(1.00) 		0.00011
(0.0391) 		9.28e-16
(4.18e-13) 		0.305
(1.00) 		0.634
(1.00)
del 4p16 3 75 (16%) 399 0.0045
(1.00) 		6.13e-05
(0.0224) 		4.97e-16
(2.25e-13) 		0.404
(1.00) 		0.748
(1.00)
del 4p15 31 77 (16%) 397 0.00501
(1.00) 		3.91e-05
(0.0145) 		2.22e-15
(9.97e-13) 		0.214
(1.00) 		0.279
(1.00)
del 4q22 1 86 (18%) 388 0.00368
(1.00) 		4.47e-06
(0.00171) 		3.46e-26
(1.68e-23) 		0.291
(1.00) 		0.0354
(1.00)
del 4q34 3 107 (23%) 367 0.0153
(1.00) 		4.56e-06
(0.00174) 		2e-27
(9.84e-25) 		0.33
(1.00) 		0.0656
(1.00)
del 5q11 2 92 (19%) 382 0.0147
(1.00) 		4.78e-05
(0.0176) 		4.09e-25
(1.98e-22) 		0.443
(1.00) 		0.407
(1.00)
del 7q11 22 37 (8%) 437 0.823
(1.00) 		2.39e-05
(0.0089) 		3.29e-08
(1.33e-05) 		0.448
(1.00) 		0.651
(1.00)
del 7q31 1 46 (10%) 428 0.0377
(1.00) 		5.99e-07
(0.000235) 		2.49e-18
(1.15e-15) 		1
(1.00) 		0.251
(1.00)
del 7q36 1 56 (12%) 418 0.00833
(1.00) 		1.02e-09
(4.3e-07) 		2.55e-21
(1.21e-18) 		0.754
(1.00) 		0.144
(1.00)
del 8p23 2 97 (20%) 377 0.00132
(0.407) 		0.000137
(0.0486) 		3.58e-31
(1.76e-28) 		0.259
(1.00) 		0.0195
(1.00)
del 8p21 2 94 (20%) 380 0.00588
(1.00) 		5.24e-06
(0.00199) 		3.91e-39
(1.93e-36) 		0.373
(1.00) 		0.0595
(1.00)
del 9q34 2 109 (23%) 365 0.00201
(0.605) 		1.14e-09
(4.77e-07) 		2.72e-19
(1.27e-16) 		0.149
(1.00) 		0.111
(1.00)
del 11p15 5 84 (18%) 390 0.0151
(1.00) 		1.43e-06
(0.000556) 		1.03e-18
(4.79e-16) 		0.0449
(1.00) 		0.0649
(1.00)
del 11q14 1 57 (12%) 417 0.00742
(1.00) 		3.88e-05
(0.0144) 		2.52e-15
(1.13e-12) 		0.213
(1.00) 		0.462
(1.00)
del 11q25 79 (17%) 395 0.00116
(0.362) 		0.000477
(0.158) 		5.29e-17
(2.42e-14) 		0.00929
(1.00) 		0.225
(1.00)
del 12q24 33 51 (11%) 423 0.0402
(1.00) 		8.23e-05
(0.0297) 		1.33e-15
(5.95e-13) 		0.0727
(1.00) 		0.0103
(1.00)
del 13q14 2 84 (18%) 390 0.00645
(1.00) 		0.000339
(0.115) 		2.02e-07
(8.01e-05) 		0.0449
(1.00) 		0.31
(1.00)
del 15q15 1 116 (24%) 358 0.00133
(0.409) 		4.51e-08
(1.82e-05) 		1.46e-23
(7.03e-21) 		0.0335
(1.00) 		0.0202
(1.00)
del 15q23 97 (20%) 377 0.0145
(1.00) 		1.6e-05
(0.00602) 		1.94e-23
(9.35e-21) 		0.102
(1.00) 		0.248
(1.00)
del 16p13 3 75 (16%) 399 0.0104
(1.00) 		5.36e-08
(2.15e-05) 		1.03e-21
(4.91e-19) 		0.265
(1.00) 		0.0921
(1.00)
del 16q21 130 (27%) 344 0.0148
(1.00) 		1.41e-08
(5.77e-06) 		4.39e-24
(2.12e-21) 		0.209
(1.00) 		0.102
(1.00)
del 16q23 1 139 (29%) 335 0.00419
(1.00) 		2.02e-07
(8.01e-05) 		9.37e-27
(4.56e-24) 		0.317
(1.00) 		0.00338
(0.97)
del 17q11 2 87 (18%) 387 0.0289
(1.00) 		3.94e-06
(0.00151) 		5.27e-12
(2.29e-09) 		0.149
(1.00) 		0.185
(1.00)
del 17q21 31 86 (18%) 388 0.00628
(1.00) 		8.9e-05
(0.032) 		4.78e-13
(2.1e-10) 		0.186
(1.00) 		0.291
(1.00)
del 19q13 43 54 (11%) 420 0.000297
(0.101) 		0.00137
(0.42) 		3.57e-17
(1.64e-14) 		0.75
(1.00) 		0.0498
(1.00)
del 20p12 1 30 (6%) 444 0.000206
(0.0718) 		0.188
(1.00) 		0.000554
(0.18) 		1
(1.00) 		0.117
(1.00)
del 22q11 1 72 (15%) 402 0.00461
(1.00) 		9.68e-05
(0.0347) 		6.26e-06
(0.00237) 		0.0158
(1.00) 		0.818
(1.00)
del 22q13 31 114 (24%) 360 0.00127
(0.392) 		3.05e-09
(1.27e-06) 		2.88e-23
(1.38e-20) 		0.0951
(1.00) 		0.658
(1.00)
amp 2p24 3 105 (22%) 369 0.00112
(0.351) 		0.0162
(1.00) 		8.83e-12
(3.81e-09) 		0.0145
(1.00) 		0.591
(1.00)
amp 5p15 33 74 (16%) 400 0.000787
(0.253) 		0.00114
(0.355) 		3.74e-18
(1.73e-15) 		0.326
(1.00) 		0.0683
(1.00)
amp 6q25 1 73 (15%) 401 0.447
(1.00) 		0.0121
(1.00) 		3.65e-06
(0.0014) 		0.325
(1.00) 		0.162
(1.00)
amp 8q24 21 187 (39%) 287 0.000923
(0.294) 		0.157
(1.00) 		9.68e-16
(4.36e-13) 		0.00669
(1.00) 		0.00322
(0.933)
amp 9p24 2 56 (12%) 418 0.0127
(1.00) 		0.00276
(0.802) 		1e-09
(4.23e-07) 		0.155
(1.00) 		0.172
(1.00)
amp 11q13 2 61 (13%) 413 0.0232
(1.00) 		0.00214
(0.641) 		1.54e-07
(6.16e-05) 		0.545
(1.00) 		0.0918
(1.00)
amp 12p12 1 76 (16%) 398 0.925
(1.00) 		0.227
(1.00) 		1.8e-08
(7.33e-06) 		0.492
(1.00) 		0.759
(1.00)
amp 12q13 11 75 (16%) 399 0.628
(1.00) 		0.76
(1.00) 		4.76e-09
(1.97e-06) 		0.163
(1.00) 		0.505
(1.00)
amp 12q13 2 85 (18%) 389 0.727
(1.00) 		0.152
(1.00) 		2.91e-08
(1.18e-05) 		0.0335
(1.00) 		0.18
(1.00)
amp 15q26 3 32 (7%) 442 0.0513
(1.00) 		0.0376
(1.00) 		3.98e-05
(0.0147) 		0.107
(1.00) 		0.0107
(1.00)
amp 18q11 2 60 (13%) 414 0.00698
(1.00) 		0.00154
(0.469) 		8.67e-17
(3.96e-14) 		0.444
(1.00) 		0.0138
(1.00)
del 3q13 31 27 (6%) 447 0.79
(1.00) 		0.00593
(1.00) 		2.05e-06
(0.000796) 		0.519
(1.00) 		0.591
(1.00)
del 6q26 40 (8%) 434 0.2
(1.00) 		0.0026
(0.767) 		1.11e-10
(4.7e-08) 		0.716
(1.00) 		0.97
(1.00)
del 9p23 61 (13%) 413 0.0697
(1.00) 		0.0021
(0.63) 		1.91e-12
(8.34e-10) 		0.224
(1.00) 		0.168
(1.00)
del 10q23 31 63 (13%) 411 0.0733
(1.00) 		0.00257
(0.762) 		4.99e-09
(2.06e-06) 		0.0165
(1.00) 		0.0961
(1.00)
del 12q23 1 40 (8%) 434 0.00507
(1.00) 		0.00488
(1.00) 		4.1e-12
(1.78e-09) 		0.273
(1.00) 		0.00804
(1.00)
del 13q11 79 (17%) 395 0.00606
(1.00) 		0.00122
(0.379) 		6.69e-13
(2.94e-10) 		0.0778
(1.00) 		0.105
(1.00)
del 14q13 1 59 (12%) 415 0.00485
(1.00) 		0.00447
(1.00) 		8.06e-11
(3.44e-08) 		0.646
(1.00) 		0.944
(1.00)
del 18q21 2 75 (16%) 399 0.371
(1.00) 		0.0018
(0.545) 		5.3e-12
(2.3e-09) 		0.025
(1.00) 		0.106
(1.00)
del 18q23 81 (17%) 393 0.00184
(0.555) 		0.00261
(0.767) 		1.55e-16
(7.06e-14) 		0.00273
(0.796) 		0.00718
(1.00)
del 19p12 44 (9%) 430 0.0035
(0.997) 		0.0421
(1.00) 		7.37e-09
(3.03e-06) 		0.159
(1.00) 		0.132
(1.00)
amp 1p22 3 83 (18%) 391 0.451
(1.00) 		0.00157
(0.477) 		0.00508
(1.00) 		0.691
(1.00) 		0.941
(1.00)
amp 1q44 197 (42%) 277 0.195
(1.00) 		0.00599
(1.00) 		0.25
(1.00) 		0.537
(1.00) 		0.547
(1.00)
amp 7q22 1 78 (16%) 396 0.000795
(0.255) 		0.0483
(1.00) 		0.0046
(1.00) 		0.1
(1.00) 		0.638
(1.00)
amp 10q22 2 129 (27%) 345 0.308
(1.00) 		0.469
(1.00) 		0.018
(1.00) 		0.569
(1.00) 		0.527
(1.00)
amp xp11 23 77 (16%) 397 0.343
(1.00) 		0.19
(1.00) 		0.00522
(1.00) 		0.0279
(1.00) 		0.43
(1.00)
amp xq28 77 (16%) 397 0.00239
(0.714) 		0.151
(1.00) 		0.00377
(1.00) 		0.891
(1.00) 		0.12
(1.00)
del 2p25 3 23 (5%) 451 0.03
(1.00) 		0.108
(1.00) 		0.00435
(1.00) 		0.102
(1.00) 		0.233
(1.00)
'amp_1p35.2' versus 'AGE'

P value = 0.000424 (t-test), Q value = 0.14

Table S1.  Gene #1: 'amp_1p35.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 1(1P35.2) MUTATED 48 68.6 (9.2)
AMP PEAK 1(1P35.2) WILD-TYPE 425 63.2 (11.4)

Figure S1.  Get High-res Image Gene #1: 'amp_1p35.2' versus Clinical Feature #2: 'AGE'

'amp_1p35.2' versus 'HISTOLOGICAL.TYPE'

P value = 4.66e-13 (Fisher's exact test), Q value = 2.1e-10

Table S2.  Gene #1: 'amp_1p35.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 1(1P35.2) MUTATED 14 5 29
AMP PEAK 1(1P35.2) WILD-TYPE 348 14 64

Figure S2.  Get High-res Image Gene #1: 'amp_1p35.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_1p34.2' versus 'AGE'

P value = 0.000169 (t-test), Q value = 0.059

Table S3.  Gene #2: 'amp_1p34.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 2(1P34.2) MUTATED 61 68.5 (10.0)
AMP PEAK 2(1P34.2) WILD-TYPE 412 63.0 (11.3)

Figure S3.  Get High-res Image Gene #2: 'amp_1p34.2' versus Clinical Feature #2: 'AGE'

'amp_1p34.2' versus 'HISTOLOGICAL.TYPE'

P value = 1.07e-16 (Fisher's exact test), Q value = 4.9e-14

Table S4.  Gene #2: 'amp_1p34.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 2(1P34.2) MUTATED 18 7 36
AMP PEAK 2(1P34.2) WILD-TYPE 344 12 57

Figure S4.  Get High-res Image Gene #2: 'amp_1p34.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_1q21.3' versus 'AGE'

P value = 1.79e-05 (t-test), Q value = 0.0067

Table S5.  Gene #4: 'amp_1q21.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 4(1Q21.3) MUTATED 210 66.2 (10.5)
AMP PEAK 4(1Q21.3) WILD-TYPE 263 61.8 (11.5)

Figure S5.  Get High-res Image Gene #4: 'amp_1q21.3' versus Clinical Feature #2: 'AGE'

'amp_1q21.3' versus 'HISTOLOGICAL.TYPE'

P value = 0.000137 (Fisher's exact test), Q value = 0.049

Table S6.  Gene #4: 'amp_1q21.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 4(1Q21.3) MUTATED 142 9 59
AMP PEAK 4(1Q21.3) WILD-TYPE 220 10 34

Figure S6.  Get High-res Image Gene #4: 'amp_1q21.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_1q22' versus 'AGE'

P value = 4.57e-07 (t-test), Q value = 0.00018

Table S7.  Gene #5: 'amp_1q22' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 5(1Q22) MUTATED 225 66.5 (10.5)
AMP PEAK 5(1Q22) WILD-TYPE 248 61.3 (11.4)

Figure S7.  Get High-res Image Gene #5: 'amp_1q22' versus Clinical Feature #2: 'AGE'

'amp_1q22' versus 'HISTOLOGICAL.TYPE'

P value = 3.64e-07 (Fisher's exact test), Q value = 0.00014

Table S8.  Gene #5: 'amp_1q22' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 5(1Q22) MUTATED 149 9 67
AMP PEAK 5(1Q22) WILD-TYPE 213 10 26

Figure S8.  Get High-res Image Gene #5: 'amp_1q22' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_2p24.3' versus 'HISTOLOGICAL.TYPE'

P value = 8.83e-12 (Fisher's exact test), Q value = 3.8e-09

Table S9.  Gene #7: 'amp_2p24.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 7(2P24.3) MUTATED 52 7 46
AMP PEAK 7(2P24.3) WILD-TYPE 310 12 47

Figure S9.  Get High-res Image Gene #7: 'amp_2p24.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_2q13' versus 'Time to Death'

P value = 0.000524 (logrank test), Q value = 0.17

Table S10.  Gene #8: 'amp_2q13' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
AMP PEAK 8(2Q13) MUTATED 99 22 0.0 - 149.6 (18.2)
AMP PEAK 8(2Q13) WILD-TYPE 373 37 0.1 - 191.8 (22.8)

Figure S10.  Get High-res Image Gene #8: 'amp_2q13' versus Clinical Feature #1: 'Time to Death'

'amp_2q13' versus 'AGE'

P value = 0.000285 (t-test), Q value = 0.097

Table S11.  Gene #8: 'amp_2q13' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 8(2Q13) MUTATED 99 67.0 (9.4)
AMP PEAK 8(2Q13) WILD-TYPE 374 62.9 (11.6)

Figure S11.  Get High-res Image Gene #8: 'amp_2q13' versus Clinical Feature #2: 'AGE'

'amp_2q13' versus 'HISTOLOGICAL.TYPE'

P value = 1.32e-17 (Fisher's exact test), Q value = 6.1e-15

Table S12.  Gene #8: 'amp_2q13' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 8(2Q13) MUTATED 43 5 52
AMP PEAK 8(2Q13) WILD-TYPE 319 14 41

Figure S12.  Get High-res Image Gene #8: 'amp_2q13' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_3p25.1' versus 'AGE'

P value = 0.000231 (t-test), Q value = 0.08

Table S13.  Gene #9: 'amp_3p25.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 9(3P25.1) MUTATED 67 68.5 (10.9)
AMP PEAK 9(3P25.1) WILD-TYPE 406 63.0 (11.1)

Figure S13.  Get High-res Image Gene #9: 'amp_3p25.1' versus Clinical Feature #2: 'AGE'

'amp_3p25.1' versus 'HISTOLOGICAL.TYPE'

P value = 3.06e-10 (Fisher's exact test), Q value = 1.3e-07

Table S14.  Gene #9: 'amp_3p25.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 9(3P25.1) MUTATED 31 1 35
AMP PEAK 9(3P25.1) WILD-TYPE 331 18 58

Figure S14.  Get High-res Image Gene #9: 'amp_3p25.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_3p14.1' versus 'Time to Death'

P value = 0.000655 (logrank test), Q value = 0.21

Table S15.  Gene #10: 'amp_3p14.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
AMP PEAK 10(3P14.1) MUTATED 51 14 0.1 - 191.8 (20.0)
AMP PEAK 10(3P14.1) WILD-TYPE 421 45 0.0 - 185.8 (21.7)

Figure S15.  Get High-res Image Gene #10: 'amp_3p14.1' versus Clinical Feature #1: 'Time to Death'

'amp_3p14.1' versus 'HISTOLOGICAL.TYPE'

P value = 0.000166 (Fisher's exact test), Q value = 0.059

Table S16.  Gene #10: 'amp_3p14.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 10(3P14.1) MUTATED 28 2 22
AMP PEAK 10(3P14.1) WILD-TYPE 334 17 71

Figure S16.  Get High-res Image Gene #10: 'amp_3p14.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_3q26.2' versus 'AGE'

P value = 8.51e-11 (t-test), Q value = 3.6e-08

Table S17.  Gene #11: 'amp_3q26.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 11(3Q26.2) MUTATED 144 68.5 (9.4)
AMP PEAK 11(3Q26.2) WILD-TYPE 329 61.7 (11.4)

Figure S17.  Get High-res Image Gene #11: 'amp_3q26.2' versus Clinical Feature #2: 'AGE'

'amp_3q26.2' versus 'HISTOLOGICAL.TYPE'

P value = 2.71e-27 (Fisher's exact test), Q value = 1.3e-24

Table S18.  Gene #11: 'amp_3q26.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 11(3Q26.2) MUTATED 64 8 72
AMP PEAK 11(3Q26.2) WILD-TYPE 298 11 21

Figure S18.  Get High-res Image Gene #11: 'amp_3q26.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_3q26.2' versus 'AGE'

P value = 1.54e-08 (t-test), Q value = 6.3e-06

Table S19.  Gene #12: 'amp_3q26.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 12(3Q26.2) MUTATED 136 68.0 (9.5)
AMP PEAK 12(3Q26.2) WILD-TYPE 337 62.0 (11.5)

Figure S19.  Get High-res Image Gene #12: 'amp_3q26.2' versus Clinical Feature #2: 'AGE'

'amp_3q26.2' versus 'HISTOLOGICAL.TYPE'

P value = 7.21e-27 (Fisher's exact test), Q value = 3.5e-24

Table S20.  Gene #12: 'amp_3q26.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 12(3Q26.2) MUTATED 59 7 70
AMP PEAK 12(3Q26.2) WILD-TYPE 303 12 23

Figure S20.  Get High-res Image Gene #12: 'amp_3q26.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_4p16.3' versus 'AGE'

P value = 1.88e-05 (t-test), Q value = 0.007

Table S21.  Gene #13: 'amp_4p16.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 13(4P16.3) MUTATED 46 69.8 (9.1)
AMP PEAK 13(4P16.3) WILD-TYPE 427 63.1 (11.3)

Figure S21.  Get High-res Image Gene #13: 'amp_4p16.3' versus Clinical Feature #2: 'AGE'

'amp_4p16.3' versus 'HISTOLOGICAL.TYPE'

P value = 2.41e-12 (Fisher's exact test), Q value = 1.1e-09

Table S22.  Gene #13: 'amp_4p16.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 13(4P16.3) MUTATED 15 1 30
AMP PEAK 13(4P16.3) WILD-TYPE 347 18 63

Figure S22.  Get High-res Image Gene #13: 'amp_4p16.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_5p15.33' versus 'HISTOLOGICAL.TYPE'

P value = 3.74e-18 (Fisher's exact test), Q value = 1.7e-15

Table S23.  Gene #14: 'amp_5p15.33' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 14(5P15.33) MUTATED 26 3 45
AMP PEAK 14(5P15.33) WILD-TYPE 336 16 48

Figure S23.  Get High-res Image Gene #14: 'amp_5p15.33' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_5q35.3' versus 'AGE'

P value = 0.000256 (t-test), Q value = 0.088

Table S24.  Gene #15: 'amp_5q35.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 15(5Q35.3) MUTATED 47 69.4 (10.5)
AMP PEAK 15(5Q35.3) WILD-TYPE 426 63.1 (11.2)

Figure S24.  Get High-res Image Gene #15: 'amp_5q35.3' versus Clinical Feature #2: 'AGE'

'amp_5q35.3' versus 'HISTOLOGICAL.TYPE'

P value = 1.94e-09 (Fisher's exact test), Q value = 8.1e-07

Table S25.  Gene #15: 'amp_5q35.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 15(5Q35.3) MUTATED 18 2 27
AMP PEAK 15(5Q35.3) WILD-TYPE 344 17 66

Figure S25.  Get High-res Image Gene #15: 'amp_5q35.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_6p24.2' versus 'AGE'

P value = 3.98e-06 (t-test), Q value = 0.0015

Table S26.  Gene #16: 'amp_6p24.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 16(6P24.2) MUTATED 97 68.3 (10.2)
AMP PEAK 16(6P24.2) WILD-TYPE 376 62.6 (11.2)

Figure S26.  Get High-res Image Gene #16: 'amp_6p24.2' versus Clinical Feature #2: 'AGE'

'amp_6p24.2' versus 'HISTOLOGICAL.TYPE'

P value = 1.83e-18 (Fisher's exact test), Q value = 8.5e-16

Table S27.  Gene #16: 'amp_6p24.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 16(6P24.2) MUTATED 40 5 52
AMP PEAK 16(6P24.2) WILD-TYPE 322 14 41

Figure S27.  Get High-res Image Gene #16: 'amp_6p24.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_6q25.1' versus 'HISTOLOGICAL.TYPE'

P value = 3.65e-06 (Fisher's exact test), Q value = 0.0014

Table S28.  Gene #17: 'amp_6q25.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 17(6Q25.1) MUTATED 40 2 31
AMP PEAK 17(6Q25.1) WILD-TYPE 322 17 62

Figure S28.  Get High-res Image Gene #17: 'amp_6q25.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_8p11.21' versus 'Time to Death'

P value = 8.12e-05 (logrank test), Q value = 0.029

Table S29.  Gene #19: 'amp_8p11.21' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
AMP PEAK 19(8P11.21) MUTATED 142 29 0.0 - 125.4 (18.1)
AMP PEAK 19(8P11.21) WILD-TYPE 330 30 0.1 - 191.8 (23.4)

Figure S29.  Get High-res Image Gene #19: 'amp_8p11.21' versus Clinical Feature #1: 'Time to Death'

'amp_8p11.21' versus 'HISTOLOGICAL.TYPE'

P value = 1.86e-07 (Fisher's exact test), Q value = 7.4e-05

Table S30.  Gene #19: 'amp_8p11.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 19(8P11.21) MUTATED 86 7 50
AMP PEAK 19(8P11.21) WILD-TYPE 276 12 43

Figure S30.  Get High-res Image Gene #19: 'amp_8p11.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_8q24.21' versus 'Time to Death'

P value = 0.000356 (logrank test), Q value = 0.12

Table S31.  Gene #20: 'amp_8q24.21' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
AMP PEAK 20(8Q24.21) MUTATED 177 33 0.0 - 191.8 (18.2)
AMP PEAK 20(8Q24.21) WILD-TYPE 295 26 0.1 - 185.8 (23.5)

Figure S31.  Get High-res Image Gene #20: 'amp_8q24.21' versus Clinical Feature #1: 'Time to Death'

'amp_8q24.21' versus 'HISTOLOGICAL.TYPE'

P value = 3.19e-14 (Fisher's exact test), Q value = 1.4e-11

Table S32.  Gene #20: 'amp_8q24.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 20(8Q24.21) MUTATED 102 9 67
AMP PEAK 20(8Q24.21) WILD-TYPE 260 10 26

Figure S32.  Get High-res Image Gene #20: 'amp_8q24.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_8q24.21' versus 'HISTOLOGICAL.TYPE'

P value = 9.68e-16 (Fisher's exact test), Q value = 4.4e-13

Table S33.  Gene #21: 'amp_8q24.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 21(8Q24.21) MUTATED 108 8 71
AMP PEAK 21(8Q24.21) WILD-TYPE 254 11 22

Figure S33.  Get High-res Image Gene #21: 'amp_8q24.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_9p24.2' versus 'HISTOLOGICAL.TYPE'

P value = 1e-09 (Fisher's exact test), Q value = 4.2e-07

Table S34.  Gene #22: 'amp_9p24.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 22(9P24.2) MUTATED 23 3 30
AMP PEAK 22(9P24.2) WILD-TYPE 339 16 63

Figure S34.  Get High-res Image Gene #22: 'amp_9p24.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_9q34.3' versus 'AGE'

P value = 0.00019 (t-test), Q value = 0.067

Table S35.  Gene #23: 'amp_9q34.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 23(9Q34.3) MUTATED 33 69.7 (8.4)
AMP PEAK 23(9Q34.3) WILD-TYPE 440 63.3 (11.3)

Figure S35.  Get High-res Image Gene #23: 'amp_9q34.3' versus Clinical Feature #2: 'AGE'

'amp_9q34.3' versus 'HISTOLOGICAL.TYPE'

P value = 7.02e-07 (Fisher's exact test), Q value = 0.00028

Table S36.  Gene #23: 'amp_9q34.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 23(9Q34.3) MUTATED 12 4 17
AMP PEAK 23(9Q34.3) WILD-TYPE 350 15 76

Figure S36.  Get High-res Image Gene #23: 'amp_9q34.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_11p11.2' versus 'AGE'

P value = 3.4e-05 (t-test), Q value = 0.013

Table S37.  Gene #25: 'amp_11p11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 25(11P11.2) MUTATED 44 70.0 (9.4)
AMP PEAK 25(11P11.2) WILD-TYPE 429 63.1 (11.3)

Figure S37.  Get High-res Image Gene #25: 'amp_11p11.2' versus Clinical Feature #2: 'AGE'

'amp_11p11.2' versus 'HISTOLOGICAL.TYPE'

P value = 7.19e-10 (Fisher's exact test), Q value = 3e-07

Table S38.  Gene #25: 'amp_11p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 25(11P11.2) MUTATED 15 4 25
AMP PEAK 25(11P11.2) WILD-TYPE 347 15 68

Figure S38.  Get High-res Image Gene #25: 'amp_11p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_11q13.2' versus 'HISTOLOGICAL.TYPE'

P value = 1.54e-07 (Fisher's exact test), Q value = 6.2e-05

Table S39.  Gene #26: 'amp_11q13.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 26(11Q13.2) MUTATED 29 3 29
AMP PEAK 26(11Q13.2) WILD-TYPE 333 16 64

Figure S39.  Get High-res Image Gene #26: 'amp_11q13.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_11q14.1' versus 'Time to Death'

P value = 6.93e-05 (logrank test), Q value = 0.025

Table S40.  Gene #27: 'amp_11q14.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
AMP PEAK 27(11Q14.1) MUTATED 50 14 0.0 - 102.3 (17.9)
AMP PEAK 27(11Q14.1) WILD-TYPE 422 45 0.1 - 191.8 (22.5)

Figure S40.  Get High-res Image Gene #27: 'amp_11q14.1' versus Clinical Feature #1: 'Time to Death'

'amp_11q14.1' versus 'HISTOLOGICAL.TYPE'

P value = 6.15e-10 (Fisher's exact test), Q value = 2.6e-07

Table S41.  Gene #27: 'amp_11q14.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 27(11Q14.1) MUTATED 20 1 29
AMP PEAK 27(11Q14.1) WILD-TYPE 342 18 64

Figure S41.  Get High-res Image Gene #27: 'amp_11q14.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_12p12.1' versus 'HISTOLOGICAL.TYPE'

P value = 1.8e-08 (Fisher's exact test), Q value = 7.3e-06

Table S42.  Gene #28: 'amp_12p12.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 28(12P12.1) MUTATED 38 3 35
AMP PEAK 28(12P12.1) WILD-TYPE 324 16 58

Figure S42.  Get High-res Image Gene #28: 'amp_12p12.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_12q13.11' versus 'HISTOLOGICAL.TYPE'

P value = 4.76e-09 (Fisher's exact test), Q value = 2e-06

Table S43.  Gene #29: 'amp_12q13.11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 29(12Q13.11) MUTATED 36 4 35
AMP PEAK 29(12Q13.11) WILD-TYPE 326 15 58

Figure S43.  Get High-res Image Gene #29: 'amp_12q13.11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_12q13.2' versus 'HISTOLOGICAL.TYPE'

P value = 2.91e-08 (Fisher's exact test), Q value = 1.2e-05

Table S44.  Gene #30: 'amp_12q13.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 30(12Q13.2) MUTATED 44 4 37
AMP PEAK 30(12Q13.2) WILD-TYPE 318 15 56

Figure S44.  Get High-res Image Gene #30: 'amp_12q13.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_13q34' versus 'AGE'

P value = 7.74e-07 (t-test), Q value = 3e-04

Table S45.  Gene #31: 'amp_13q34' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 31(13Q34) MUTATED 51 69.5 (7.6)
AMP PEAK 31(13Q34) WILD-TYPE 422 63.1 (11.4)

Figure S45.  Get High-res Image Gene #31: 'amp_13q34' versus Clinical Feature #2: 'AGE'

'amp_13q34' versus 'HISTOLOGICAL.TYPE'

P value = 3.16e-15 (Fisher's exact test), Q value = 1.4e-12

Table S46.  Gene #31: 'amp_13q34' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 31(13Q34) MUTATED 14 4 33
AMP PEAK 31(13Q34) WILD-TYPE 348 15 60

Figure S46.  Get High-res Image Gene #31: 'amp_13q34' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_14q24.3' versus 'AGE'

P value = 0.000343 (t-test), Q value = 0.12

Table S47.  Gene #32: 'amp_14q24.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 32(14Q24.3) MUTATED 57 68.2 (9.4)
AMP PEAK 32(14Q24.3) WILD-TYPE 416 63.1 (11.4)

Figure S47.  Get High-res Image Gene #32: 'amp_14q24.3' versus Clinical Feature #2: 'AGE'

'amp_14q24.3' versus 'HISTOLOGICAL.TYPE'

P value = 1.17e-12 (Fisher's exact test), Q value = 5.1e-10

Table S48.  Gene #32: 'amp_14q24.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 32(14Q24.3) MUTATED 20 4 33
AMP PEAK 32(14Q24.3) WILD-TYPE 342 15 60

Figure S48.  Get High-res Image Gene #32: 'amp_14q24.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_15q26.3' versus 'HISTOLOGICAL.TYPE'

P value = 3.98e-05 (Fisher's exact test), Q value = 0.015

Table S49.  Gene #33: 'amp_15q26.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 33(15Q26.3) MUTATED 15 0 17
AMP PEAK 33(15Q26.3) WILD-TYPE 347 19 76

Figure S49.  Get High-res Image Gene #33: 'amp_15q26.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_16p11.2' versus 'AGE'

P value = 0.000259 (t-test), Q value = 0.089

Table S50.  Gene #34: 'amp_16p11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 34(16P11.2) MUTATED 55 68.2 (8.9)
AMP PEAK 34(16P11.2) WILD-TYPE 418 63.2 (11.4)

Figure S50.  Get High-res Image Gene #34: 'amp_16p11.2' versus Clinical Feature #2: 'AGE'

'amp_16p11.2' versus 'HISTOLOGICAL.TYPE'

P value = 3.11e-13 (Fisher's exact test), Q value = 1.4e-10

Table S51.  Gene #34: 'amp_16p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 34(16P11.2) MUTATED 19 2 34
AMP PEAK 34(16P11.2) WILD-TYPE 343 17 59

Figure S51.  Get High-res Image Gene #34: 'amp_16p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_17q11.2' versus 'AGE'

P value = 0.000492 (t-test), Q value = 0.16

Table S52.  Gene #35: 'amp_17q11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 35(17Q11.2) MUTATED 62 67.7 (8.8)
AMP PEAK 35(17Q11.2) WILD-TYPE 411 63.2 (11.5)

Figure S52.  Get High-res Image Gene #35: 'amp_17q11.2' versus Clinical Feature #2: 'AGE'

'amp_17q11.2' versus 'HISTOLOGICAL.TYPE'

P value = 3.35e-21 (Fisher's exact test), Q value = 1.6e-18

Table S53.  Gene #35: 'amp_17q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 35(17Q11.2) MUTATED 15 6 41
AMP PEAK 35(17Q11.2) WILD-TYPE 347 13 52

Figure S53.  Get High-res Image Gene #35: 'amp_17q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_17q11.2' versus 'COMPLETENESS.OF.RESECTION'

P value = 0.00053 (Fisher's exact test), Q value = 0.17

Table S54.  Gene #35: 'amp_17q11.2' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

nPatients R0 R1 R2 RX
ALL 327 24 16 27
AMP PEAK 35(17Q11.2) MUTATED 33 7 6 6
AMP PEAK 35(17Q11.2) WILD-TYPE 294 17 10 21

Figure S54.  Get High-res Image Gene #35: 'amp_17q11.2' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

'amp_17q12' versus 'AGE'

P value = 4.55e-05 (t-test), Q value = 0.017

Table S55.  Gene #36: 'amp_17q12' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 36(17Q12) MUTATED 62 68.8 (9.6)
AMP PEAK 36(17Q12) WILD-TYPE 411 63.0 (11.3)

Figure S55.  Get High-res Image Gene #36: 'amp_17q12' versus Clinical Feature #2: 'AGE'

'amp_17q12' versus 'HISTOLOGICAL.TYPE'

P value = 8.53e-20 (Fisher's exact test), Q value = 4e-17

Table S56.  Gene #36: 'amp_17q12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 36(17Q12) MUTATED 17 3 42
AMP PEAK 36(17Q12) WILD-TYPE 345 16 51

Figure S56.  Get High-res Image Gene #36: 'amp_17q12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_17q25.1' versus 'AGE'

P value = 0.000111 (t-test), Q value = 0.04

Table S57.  Gene #37: 'amp_17q25.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 37(17Q25.1) MUTATED 87 67.6 (9.6)
AMP PEAK 37(17Q25.1) WILD-TYPE 386 62.9 (11.4)

Figure S57.  Get High-res Image Gene #37: 'amp_17q25.1' versus Clinical Feature #2: 'AGE'

'amp_17q25.1' versus 'HISTOLOGICAL.TYPE'

P value = 1e-17 (Fisher's exact test), Q value = 4.6e-15

Table S58.  Gene #37: 'amp_17q25.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 37(17Q25.1) MUTATED 33 9 45
AMP PEAK 37(17Q25.1) WILD-TYPE 329 10 48

Figure S58.  Get High-res Image Gene #37: 'amp_17q25.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_18p11.31' versus 'AGE'

P value = 9.92e-05 (t-test), Q value = 0.035

Table S59.  Gene #38: 'amp_18p11.31' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 38(18P11.31) MUTATED 79 67.7 (9.1)
AMP PEAK 38(18P11.31) WILD-TYPE 394 63.0 (11.5)

Figure S59.  Get High-res Image Gene #38: 'amp_18p11.31' versus Clinical Feature #2: 'AGE'

'amp_18p11.31' versus 'HISTOLOGICAL.TYPE'

P value = 6.44e-22 (Fisher's exact test), Q value = 3.1e-19

Table S60.  Gene #38: 'amp_18p11.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 38(18P11.31) MUTATED 25 5 49
AMP PEAK 38(18P11.31) WILD-TYPE 337 14 44

Figure S60.  Get High-res Image Gene #38: 'amp_18p11.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_18q11.2' versus 'HISTOLOGICAL.TYPE'

P value = 8.67e-17 (Fisher's exact test), Q value = 4e-14

Table S61.  Gene #39: 'amp_18q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 39(18Q11.2) MUTATED 18 4 38
AMP PEAK 39(18Q11.2) WILD-TYPE 344 15 55

Figure S61.  Get High-res Image Gene #39: 'amp_18q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_19p13.2' versus 'AGE'

P value = 2.12e-11 (t-test), Q value = 9.1e-09

Table S62.  Gene #40: 'amp_19p13.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 40(19P13.2) MUTATED 77 70.7 (8.6)
AMP PEAK 40(19P13.2) WILD-TYPE 396 62.4 (11.2)

Figure S62.  Get High-res Image Gene #40: 'amp_19p13.2' versus Clinical Feature #2: 'AGE'

'amp_19p13.2' versus 'HISTOLOGICAL.TYPE'

P value = 1.08e-20 (Fisher's exact test), Q value = 5.1e-18

Table S63.  Gene #40: 'amp_19p13.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 40(19P13.2) MUTATED 24 8 45
AMP PEAK 40(19P13.2) WILD-TYPE 338 11 48

Figure S63.  Get High-res Image Gene #40: 'amp_19p13.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_19p13.12' versus 'AGE'

P value = 2.73e-11 (t-test), Q value = 1.2e-08

Table S64.  Gene #41: 'amp_19p13.12' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 41(19P13.12) MUTATED 81 70.8 (9.2)
AMP PEAK 41(19P13.12) WILD-TYPE 392 62.3 (11.1)

Figure S64.  Get High-res Image Gene #41: 'amp_19p13.12' versus Clinical Feature #2: 'AGE'

'amp_19p13.12' versus 'HISTOLOGICAL.TYPE'

P value = 1.27e-22 (Fisher's exact test), Q value = 6.1e-20

Table S65.  Gene #41: 'amp_19p13.12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 41(19P13.12) MUTATED 25 7 49
AMP PEAK 41(19P13.12) WILD-TYPE 337 12 44

Figure S65.  Get High-res Image Gene #41: 'amp_19p13.12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_19q12' versus 'Time to Death'

P value = 0.000399 (logrank test), Q value = 0.13

Table S66.  Gene #42: 'amp_19q12' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
AMP PEAK 42(19Q12) MUTATED 96 21 0.0 - 125.4 (17.7)
AMP PEAK 42(19Q12) WILD-TYPE 376 38 0.1 - 191.8 (23.0)

Figure S66.  Get High-res Image Gene #42: 'amp_19q12' versus Clinical Feature #1: 'Time to Death'

'amp_19q12' versus 'AGE'

P value = 3.07e-09 (t-test), Q value = 1.3e-06

Table S67.  Gene #42: 'amp_19q12' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 42(19Q12) MUTATED 96 69.0 (8.7)
AMP PEAK 42(19Q12) WILD-TYPE 377 62.4 (11.5)

Figure S67.  Get High-res Image Gene #42: 'amp_19q12' versus Clinical Feature #2: 'AGE'

'amp_19q12' versus 'HISTOLOGICAL.TYPE'

P value = 2.02e-38 (Fisher's exact test), Q value = 1e-35

Table S68.  Gene #42: 'amp_19q12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 42(19Q12) MUTATED 22 10 64
AMP PEAK 42(19Q12) WILD-TYPE 340 9 29

Figure S68.  Get High-res Image Gene #42: 'amp_19q12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_20p13' versus 'AGE'

P value = 1.46e-05 (t-test), Q value = 0.0055

Table S69.  Gene #43: 'amp_20p13' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 43(20P13) MUTATED 99 68.2 (11.3)
AMP PEAK 43(20P13) WILD-TYPE 374 62.6 (11.0)

Figure S69.  Get High-res Image Gene #43: 'amp_20p13' versus Clinical Feature #2: 'AGE'

'amp_20p13' versus 'HISTOLOGICAL.TYPE'

P value = 4.01e-13 (Fisher's exact test), Q value = 1.8e-10

Table S70.  Gene #43: 'amp_20p13' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 43(20P13) MUTATED 47 5 47
AMP PEAK 43(20P13) WILD-TYPE 315 14 46

Figure S70.  Get High-res Image Gene #43: 'amp_20p13' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_20q11.21' versus 'Time to Death'

P value = 0.000241 (logrank test), Q value = 0.083

Table S71.  Gene #44: 'amp_20q11.21' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
AMP PEAK 44(20Q11.21) MUTATED 120 25 0.0 - 149.6 (17.7)
AMP PEAK 44(20Q11.21) WILD-TYPE 352 34 0.1 - 191.8 (23.1)

Figure S71.  Get High-res Image Gene #44: 'amp_20q11.21' versus Clinical Feature #1: 'Time to Death'

'amp_20q11.21' versus 'AGE'

P value = 5.93e-08 (t-test), Q value = 2.4e-05

Table S72.  Gene #44: 'amp_20q11.21' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 44(20Q11.21) MUTATED 121 68.2 (9.8)
AMP PEAK 44(20Q11.21) WILD-TYPE 352 62.2 (11.3)

Figure S72.  Get High-res Image Gene #44: 'amp_20q11.21' versus Clinical Feature #2: 'AGE'

'amp_20q11.21' versus 'HISTOLOGICAL.TYPE'

P value = 4.33e-24 (Fisher's exact test), Q value = 2.1e-21

Table S73.  Gene #44: 'amp_20q11.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 44(20Q11.21) MUTATED 51 6 64
AMP PEAK 44(20Q11.21) WILD-TYPE 311 13 29

Figure S73.  Get High-res Image Gene #44: 'amp_20q11.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_20q13.12' versus 'AGE'

P value = 1.79e-08 (t-test), Q value = 7.3e-06

Table S74.  Gene #45: 'amp_20q13.12' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 45(20Q13.12) MUTATED 126 68.4 (10.2)
AMP PEAK 45(20Q13.12) WILD-TYPE 347 62.1 (11.2)

Figure S74.  Get High-res Image Gene #45: 'amp_20q13.12' versus Clinical Feature #2: 'AGE'

'amp_20q13.12' versus 'HISTOLOGICAL.TYPE'

P value = 3.84e-23 (Fisher's exact test), Q value = 1.8e-20

Table S75.  Gene #45: 'amp_20q13.12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 45(20Q13.12) MUTATED 55 7 64
AMP PEAK 45(20Q13.12) WILD-TYPE 307 12 29

Figure S75.  Get High-res Image Gene #45: 'amp_20q13.12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_20q13.33' versus 'AGE'

P value = 9.07e-08 (t-test), Q value = 3.6e-05

Table S76.  Gene #46: 'amp_20q13.33' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
AMP PEAK 46(20Q13.33) MUTATED 122 68.3 (10.4)
AMP PEAK 46(20Q13.33) WILD-TYPE 351 62.2 (11.1)

Figure S76.  Get High-res Image Gene #46: 'amp_20q13.33' versus Clinical Feature #2: 'AGE'

'amp_20q13.33' versus 'HISTOLOGICAL.TYPE'

P value = 1.56e-18 (Fisher's exact test), Q value = 7.3e-16

Table S77.  Gene #46: 'amp_20q13.33' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 46(20Q13.33) MUTATED 57 6 59
AMP PEAK 46(20Q13.33) WILD-TYPE 305 13 34

Figure S77.  Get High-res Image Gene #46: 'amp_20q13.33' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_22q12.2' versus 'HISTOLOGICAL.TYPE'

P value = 1.78e-21 (Fisher's exact test), Q value = 8.5e-19

Table S78.  Gene #47: 'amp_22q12.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
AMP PEAK 47(22Q12.2) MUTATED 11 2 40
AMP PEAK 47(22Q12.2) WILD-TYPE 351 17 53

Figure S78.  Get High-res Image Gene #47: 'amp_22q12.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_22q12.2' versus 'COMPLETENESS.OF.RESECTION'

P value = 0.000622 (Fisher's exact test), Q value = 0.2

Table S79.  Gene #47: 'amp_22q12.2' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

nPatients R0 R1 R2 RX
ALL 327 24 16 27
AMP PEAK 47(22Q12.2) MUTATED 28 3 7 5
AMP PEAK 47(22Q12.2) WILD-TYPE 299 21 9 22

Figure S79.  Get High-res Image Gene #47: 'amp_22q12.2' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

'del_1p36.21' versus 'AGE'

P value = 7.29e-05 (t-test), Q value = 0.026

Table S80.  Gene #50: 'del_1p36.21' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 1(1P36.21) MUTATED 57 69.3 (10.5)
DEL PEAK 1(1P36.21) WILD-TYPE 416 63.0 (11.2)

Figure S80.  Get High-res Image Gene #50: 'del_1p36.21' versus Clinical Feature #2: 'AGE'

'del_1p36.21' versus 'HISTOLOGICAL.TYPE'

P value = 3.6e-09 (Fisher's exact test), Q value = 1.5e-06

Table S81.  Gene #50: 'del_1p36.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 1(1P36.21) MUTATED 24 4 29
DEL PEAK 1(1P36.21) WILD-TYPE 338 15 64

Figure S81.  Get High-res Image Gene #50: 'del_1p36.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_1p36.11' versus 'AGE'

P value = 8.36e-06 (t-test), Q value = 0.0032

Table S82.  Gene #51: 'del_1p36.11' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 2(1P36.11) MUTATED 69 69.0 (9.7)
DEL PEAK 2(1P36.11) WILD-TYPE 404 62.9 (11.3)

Figure S82.  Get High-res Image Gene #51: 'del_1p36.11' versus Clinical Feature #2: 'AGE'

'del_1p36.11' versus 'HISTOLOGICAL.TYPE'

P value = 3.14e-16 (Fisher's exact test), Q value = 1.4e-13

Table S83.  Gene #51: 'del_1p36.11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 2(1P36.11) MUTATED 24 4 41
DEL PEAK 2(1P36.11) WILD-TYPE 338 15 52

Figure S83.  Get High-res Image Gene #51: 'del_1p36.11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_2q22.1' versus 'Time to Death'

P value = 3.43e-09 (logrank test), Q value = 1.4e-06

Table S84.  Gene #53: 'del_2q22.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
DEL PEAK 4(2Q22.1) MUTATED 42 15 0.5 - 125.4 (10.9)
DEL PEAK 4(2Q22.1) WILD-TYPE 430 44 0.0 - 191.8 (23.3)

Figure S84.  Get High-res Image Gene #53: 'del_2q22.1' versus Clinical Feature #1: 'Time to Death'

'del_2q22.1' versus 'HISTOLOGICAL.TYPE'

P value = 2.01e-08 (Fisher's exact test), Q value = 8.2e-06

Table S85.  Gene #53: 'del_2q22.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 4(2Q22.1) MUTATED 16 2 24
DEL PEAK 4(2Q22.1) WILD-TYPE 346 17 69

Figure S85.  Get High-res Image Gene #53: 'del_2q22.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_2q37.3' versus 'AGE'

P value = 0.000491 (t-test), Q value = 0.16

Table S86.  Gene #54: 'del_2q37.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 5(2Q37.3) MUTATED 46 68.2 (8.4)
DEL PEAK 5(2Q37.3) WILD-TYPE 427 63.3 (11.4)

Figure S86.  Get High-res Image Gene #54: 'del_2q37.3' versus Clinical Feature #2: 'AGE'

'del_2q37.3' versus 'HISTOLOGICAL.TYPE'

P value = 0.000747 (Fisher's exact test), Q value = 0.24

Table S87.  Gene #54: 'del_2q37.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 5(2Q37.3) MUTATED 25 2 19
DEL PEAK 5(2Q37.3) WILD-TYPE 337 17 74

Figure S87.  Get High-res Image Gene #54: 'del_2q37.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_3p14.2' versus 'AGE'

P value = 0.00011 (t-test), Q value = 0.039

Table S88.  Gene #55: 'del_3p14.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 6(3P14.2) MUTATED 66 67.8 (8.4)
DEL PEAK 6(3P14.2) WILD-TYPE 407 63.1 (11.5)

Figure S88.  Get High-res Image Gene #55: 'del_3p14.2' versus Clinical Feature #2: 'AGE'

'del_3p14.2' versus 'HISTOLOGICAL.TYPE'

P value = 9.28e-16 (Fisher's exact test), Q value = 4.2e-13

Table S89.  Gene #55: 'del_3p14.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 6(3P14.2) MUTATED 22 6 38
DEL PEAK 6(3P14.2) WILD-TYPE 340 13 55

Figure S89.  Get High-res Image Gene #55: 'del_3p14.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_3q13.31' versus 'HISTOLOGICAL.TYPE'

P value = 2.05e-06 (Fisher's exact test), Q value = 8e-04

Table S90.  Gene #56: 'del_3q13.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 7(3Q13.31) MUTATED 9 2 16
DEL PEAK 7(3Q13.31) WILD-TYPE 353 17 77

Figure S90.  Get High-res Image Gene #56: 'del_3q13.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_4p16.3' versus 'AGE'

P value = 6.13e-05 (t-test), Q value = 0.022

Table S91.  Gene #57: 'del_4p16.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 8(4P16.3) MUTATED 75 68.0 (9.2)
DEL PEAK 8(4P16.3) WILD-TYPE 398 63.0 (11.4)

Figure S91.  Get High-res Image Gene #57: 'del_4p16.3' versus Clinical Feature #2: 'AGE'

'del_4p16.3' versus 'HISTOLOGICAL.TYPE'

P value = 4.97e-16 (Fisher's exact test), Q value = 2.2e-13

Table S92.  Gene #57: 'del_4p16.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 8(4P16.3) MUTATED 28 4 43
DEL PEAK 8(4P16.3) WILD-TYPE 334 15 50

Figure S92.  Get High-res Image Gene #57: 'del_4p16.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_4p15.31' versus 'AGE'

P value = 3.91e-05 (t-test), Q value = 0.014

Table S93.  Gene #58: 'del_4p15.31' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 9(4P15.31) MUTATED 77 68.1 (9.4)
DEL PEAK 9(4P15.31) WILD-TYPE 396 62.9 (11.4)

Figure S93.  Get High-res Image Gene #58: 'del_4p15.31' versus Clinical Feature #2: 'AGE'

'del_4p15.31' versus 'HISTOLOGICAL.TYPE'

P value = 2.22e-15 (Fisher's exact test), Q value = 1e-12

Table S94.  Gene #58: 'del_4p15.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 9(4P15.31) MUTATED 30 4 43
DEL PEAK 9(4P15.31) WILD-TYPE 332 15 50

Figure S94.  Get High-res Image Gene #58: 'del_4p15.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_4q22.1' versus 'AGE'

P value = 4.47e-06 (t-test), Q value = 0.0017

Table S95.  Gene #59: 'del_4q22.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 10(4Q22.1) MUTATED 86 68.2 (9.2)
DEL PEAK 10(4Q22.1) WILD-TYPE 387 62.8 (11.5)

Figure S95.  Get High-res Image Gene #59: 'del_4q22.1' versus Clinical Feature #2: 'AGE'

'del_4q22.1' versus 'HISTOLOGICAL.TYPE'

P value = 3.46e-26 (Fisher's exact test), Q value = 1.7e-23

Table S96.  Gene #59: 'del_4q22.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 10(4Q22.1) MUTATED 26 5 55
DEL PEAK 10(4Q22.1) WILD-TYPE 336 14 38

Figure S96.  Get High-res Image Gene #59: 'del_4q22.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_4q34.3' versus 'AGE'

P value = 4.56e-06 (t-test), Q value = 0.0017

Table S97.  Gene #60: 'del_4q34.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 11(4Q34.3) MUTATED 107 67.9 (10.1)
DEL PEAK 11(4Q34.3) WILD-TYPE 366 62.5 (11.3)

Figure S97.  Get High-res Image Gene #60: 'del_4q34.3' versus Clinical Feature #2: 'AGE'

'del_4q34.3' versus 'HISTOLOGICAL.TYPE'

P value = 2e-27 (Fisher's exact test), Q value = 9.8e-25

Table S98.  Gene #60: 'del_4q34.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 11(4Q34.3) MUTATED 38 7 62
DEL PEAK 11(4Q34.3) WILD-TYPE 324 12 31

Figure S98.  Get High-res Image Gene #60: 'del_4q34.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_5q11.2' versus 'AGE'

P value = 4.78e-05 (t-test), Q value = 0.018

Table S99.  Gene #61: 'del_5q11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 12(5Q11.2) MUTATED 92 67.8 (10.0)
DEL PEAK 12(5Q11.2) WILD-TYPE 381 62.8 (11.3)

Figure S99.  Get High-res Image Gene #61: 'del_5q11.2' versus Clinical Feature #2: 'AGE'

'del_5q11.2' versus 'HISTOLOGICAL.TYPE'

P value = 4.09e-25 (Fisher's exact test), Q value = 2e-22

Table S100.  Gene #61: 'del_5q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 12(5Q11.2) MUTATED 32 3 57
DEL PEAK 12(5Q11.2) WILD-TYPE 330 16 36

Figure S100.  Get High-res Image Gene #61: 'del_5q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_6q26' versus 'HISTOLOGICAL.TYPE'

P value = 1.11e-10 (Fisher's exact test), Q value = 4.7e-08

Table S101.  Gene #62: 'del_6q26' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 13(6Q26) MUTATED 12 3 25
DEL PEAK 13(6Q26) WILD-TYPE 350 16 68

Figure S101.  Get High-res Image Gene #62: 'del_6q26' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_7p22.3' versus 'Time to Death'

P value = 0.000261 (logrank test), Q value = 0.089

Table S102.  Gene #63: 'del_7p22.3' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
DEL PEAK 14(7P22.3) MUTATED 62 16 0.0 - 97.7 (19.7)
DEL PEAK 14(7P22.3) WILD-TYPE 410 43 0.1 - 191.8 (22.0)

Figure S102.  Get High-res Image Gene #63: 'del_7p22.3' versus Clinical Feature #1: 'Time to Death'

'del_7p22.3' versus 'AGE'

P value = 6.34e-05 (t-test), Q value = 0.023

Table S103.  Gene #63: 'del_7p22.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 14(7P22.3) MUTATED 62 68.9 (10.2)
DEL PEAK 14(7P22.3) WILD-TYPE 411 63.0 (11.2)

Figure S103.  Get High-res Image Gene #63: 'del_7p22.3' versus Clinical Feature #2: 'AGE'

'del_7p22.3' versus 'HISTOLOGICAL.TYPE'

P value = 4.18e-15 (Fisher's exact test), Q value = 1.9e-12

Table S104.  Gene #63: 'del_7p22.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 14(7P22.3) MUTATED 21 5 37
DEL PEAK 14(7P22.3) WILD-TYPE 341 14 56

Figure S104.  Get High-res Image Gene #63: 'del_7p22.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_7q11.22' versus 'AGE'

P value = 2.39e-05 (t-test), Q value = 0.0089

Table S105.  Gene #64: 'del_7q11.22' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 15(7Q11.22) MUTATED 37 71.1 (9.8)
DEL PEAK 15(7Q11.22) WILD-TYPE 436 63.1 (11.2)

Figure S105.  Get High-res Image Gene #64: 'del_7q11.22' versus Clinical Feature #2: 'AGE'

'del_7q11.22' versus 'HISTOLOGICAL.TYPE'

P value = 3.29e-08 (Fisher's exact test), Q value = 1.3e-05

Table S106.  Gene #64: 'del_7q11.22' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 15(7Q11.22) MUTATED 13 2 22
DEL PEAK 15(7Q11.22) WILD-TYPE 349 17 71

Figure S106.  Get High-res Image Gene #64: 'del_7q11.22' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_7q31.1' versus 'AGE'

P value = 5.99e-07 (t-test), Q value = 0.00024

Table S107.  Gene #65: 'del_7q31.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 16(7Q31.1) MUTATED 46 70.2 (7.9)
DEL PEAK 16(7Q31.1) WILD-TYPE 427 63.1 (11.4)

Figure S107.  Get High-res Image Gene #65: 'del_7q31.1' versus Clinical Feature #2: 'AGE'

'del_7q31.1' versus 'HISTOLOGICAL.TYPE'

P value = 2.49e-18 (Fisher's exact test), Q value = 1.2e-15

Table S108.  Gene #65: 'del_7q31.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 16(7Q31.1) MUTATED 9 3 34
DEL PEAK 16(7Q31.1) WILD-TYPE 353 16 59

Figure S108.  Get High-res Image Gene #65: 'del_7q31.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_7q36.1' versus 'AGE'

P value = 1.02e-09 (t-test), Q value = 4.3e-07

Table S109.  Gene #66: 'del_7q36.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 17(7Q36.1) MUTATED 56 71.4 (8.5)
DEL PEAK 17(7Q36.1) WILD-TYPE 417 62.7 (11.2)

Figure S109.  Get High-res Image Gene #66: 'del_7q36.1' versus Clinical Feature #2: 'AGE'

'del_7q36.1' versus 'HISTOLOGICAL.TYPE'

P value = 2.55e-21 (Fisher's exact test), Q value = 1.2e-18

Table S110.  Gene #66: 'del_7q36.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 17(7Q36.1) MUTATED 12 4 40
DEL PEAK 17(7Q36.1) WILD-TYPE 350 15 53

Figure S110.  Get High-res Image Gene #66: 'del_7q36.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_8p23.2' versus 'AGE'

P value = 0.000137 (t-test), Q value = 0.049

Table S111.  Gene #67: 'del_8p23.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 18(8P23.2) MUTATED 96 67.2 (9.4)
DEL PEAK 18(8P23.2) WILD-TYPE 377 62.9 (11.5)

Figure S111.  Get High-res Image Gene #67: 'del_8p23.2' versus Clinical Feature #2: 'AGE'

'del_8p23.2' versus 'HISTOLOGICAL.TYPE'

P value = 3.58e-31 (Fisher's exact test), Q value = 1.8e-28

Table S112.  Gene #67: 'del_8p23.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 18(8P23.2) MUTATED 30 4 63
DEL PEAK 18(8P23.2) WILD-TYPE 332 15 30

Figure S112.  Get High-res Image Gene #67: 'del_8p23.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_8p21.2' versus 'AGE'

P value = 5.24e-06 (t-test), Q value = 0.002

Table S113.  Gene #68: 'del_8p21.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 19(8P21.2) MUTATED 94 68.0 (9.2)
DEL PEAK 19(8P21.2) WILD-TYPE 379 62.7 (11.5)

Figure S113.  Get High-res Image Gene #68: 'del_8p21.2' versus Clinical Feature #2: 'AGE'

'del_8p21.2' versus 'HISTOLOGICAL.TYPE'

P value = 3.91e-39 (Fisher's exact test), Q value = 1.9e-36

Table S114.  Gene #68: 'del_8p21.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 19(8P21.2) MUTATED 22 5 67
DEL PEAK 19(8P21.2) WILD-TYPE 340 14 26

Figure S114.  Get High-res Image Gene #68: 'del_8p21.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_9p23' versus 'HISTOLOGICAL.TYPE'

P value = 1.91e-12 (Fisher's exact test), Q value = 8.3e-10

Table S115.  Gene #69: 'del_9p23' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 20(9P23) MUTATED 23 3 35
DEL PEAK 20(9P23) WILD-TYPE 339 16 58

Figure S115.  Get High-res Image Gene #69: 'del_9p23' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_9q21.2' versus 'Time to Death'

P value = 0.00025 (logrank test), Q value = 0.086

Table S116.  Gene #70: 'del_9q21.2' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
DEL PEAK 21(9Q21.2) MUTATED 106 23 0.1 - 125.4 (17.7)
DEL PEAK 21(9Q21.2) WILD-TYPE 366 36 0.0 - 191.8 (23.3)

Figure S116.  Get High-res Image Gene #70: 'del_9q21.2' versus Clinical Feature #1: 'Time to Death'

'del_9q21.2' versus 'AGE'

P value = 5.32e-11 (t-test), Q value = 2.3e-08

Table S117.  Gene #70: 'del_9q21.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 21(9Q21.2) MUTATED 107 69.4 (9.1)
DEL PEAK 21(9Q21.2) WILD-TYPE 366 62.1 (11.3)

Figure S117.  Get High-res Image Gene #70: 'del_9q21.2' versus Clinical Feature #2: 'AGE'

'del_9q21.2' versus 'HISTOLOGICAL.TYPE'

P value = 5.05e-21 (Fisher's exact test), Q value = 2.4e-18

Table S118.  Gene #70: 'del_9q21.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 21(9Q21.2) MUTATED 43 9 55
DEL PEAK 21(9Q21.2) WILD-TYPE 319 10 38

Figure S118.  Get High-res Image Gene #70: 'del_9q21.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_9q34.2' versus 'AGE'

P value = 1.14e-09 (t-test), Q value = 4.8e-07

Table S119.  Gene #71: 'del_9q34.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 22(9Q34.2) MUTATED 109 68.8 (8.7)
DEL PEAK 22(9Q34.2) WILD-TYPE 364 62.3 (11.5)

Figure S119.  Get High-res Image Gene #71: 'del_9q34.2' versus Clinical Feature #2: 'AGE'

'del_9q34.2' versus 'HISTOLOGICAL.TYPE'

P value = 2.72e-19 (Fisher's exact test), Q value = 1.3e-16

Table S120.  Gene #71: 'del_9q34.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 22(9Q34.2) MUTATED 46 9 54
DEL PEAK 22(9Q34.2) WILD-TYPE 316 10 39

Figure S120.  Get High-res Image Gene #71: 'del_9q34.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_10q23.31' versus 'HISTOLOGICAL.TYPE'

P value = 4.99e-09 (Fisher's exact test), Q value = 2.1e-06

Table S121.  Gene #72: 'del_10q23.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 23(10Q23.31) MUTATED 28 4 31
DEL PEAK 23(10Q23.31) WILD-TYPE 334 15 62

Figure S121.  Get High-res Image Gene #72: 'del_10q23.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_11p15.5' versus 'AGE'

P value = 1.43e-06 (t-test), Q value = 0.00056

Table S122.  Gene #73: 'del_11p15.5' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 24(11P15.5) MUTATED 84 68.5 (9.2)
DEL PEAK 24(11P15.5) WILD-TYPE 389 62.7 (11.4)

Figure S122.  Get High-res Image Gene #73: 'del_11p15.5' versus Clinical Feature #2: 'AGE'

'del_11p15.5' versus 'HISTOLOGICAL.TYPE'

P value = 1.03e-18 (Fisher's exact test), Q value = 4.8e-16

Table S123.  Gene #73: 'del_11p15.5' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 24(11P15.5) MUTATED 31 5 48
DEL PEAK 24(11P15.5) WILD-TYPE 331 14 45

Figure S123.  Get High-res Image Gene #73: 'del_11p15.5' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_11q14.1' versus 'AGE'

P value = 3.88e-05 (t-test), Q value = 0.014

Table S124.  Gene #74: 'del_11q14.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 25(11Q14.1) MUTATED 57 68.8 (9.0)
DEL PEAK 25(11Q14.1) WILD-TYPE 416 63.1 (11.4)

Figure S124.  Get High-res Image Gene #74: 'del_11q14.1' versus Clinical Feature #2: 'AGE'

'del_11q14.1' versus 'HISTOLOGICAL.TYPE'

P value = 2.52e-15 (Fisher's exact test), Q value = 1.1e-12

Table S125.  Gene #74: 'del_11q14.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 25(11Q14.1) MUTATED 17 6 34
DEL PEAK 25(11Q14.1) WILD-TYPE 345 13 59

Figure S125.  Get High-res Image Gene #74: 'del_11q14.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_11q25' versus 'AGE'

P value = 0.000477 (t-test), Q value = 0.16

Table S126.  Gene #75: 'del_11q25' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 26(11Q25) MUTATED 79 67.6 (10.3)
DEL PEAK 26(11Q25) WILD-TYPE 394 63.0 (11.3)

Figure S126.  Get High-res Image Gene #75: 'del_11q25' versus Clinical Feature #2: 'AGE'

'del_11q25' versus 'HISTOLOGICAL.TYPE'

P value = 5.29e-17 (Fisher's exact test), Q value = 2.4e-14

Table S127.  Gene #75: 'del_11q25' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 26(11Q25) MUTATED 29 6 44
DEL PEAK 26(11Q25) WILD-TYPE 333 13 49

Figure S127.  Get High-res Image Gene #75: 'del_11q25' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_12q23.1' versus 'HISTOLOGICAL.TYPE'

P value = 4.1e-12 (Fisher's exact test), Q value = 1.8e-09

Table S128.  Gene #76: 'del_12q23.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 27(12Q23.1) MUTATED 11 2 27
DEL PEAK 27(12Q23.1) WILD-TYPE 351 17 66

Figure S128.  Get High-res Image Gene #76: 'del_12q23.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_12q24.33' versus 'AGE'

P value = 8.23e-05 (t-test), Q value = 0.03

Table S129.  Gene #77: 'del_12q24.33' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 28(12Q24.33) MUTATED 51 68.9 (9.1)
DEL PEAK 28(12Q24.33) WILD-TYPE 422 63.1 (11.3)

Figure S129.  Get High-res Image Gene #77: 'del_12q24.33' versus Clinical Feature #2: 'AGE'

'del_12q24.33' versus 'HISTOLOGICAL.TYPE'

P value = 1.33e-15 (Fisher's exact test), Q value = 6e-13

Table S130.  Gene #77: 'del_12q24.33' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 28(12Q24.33) MUTATED 15 1 35
DEL PEAK 28(12Q24.33) WILD-TYPE 347 18 58

Figure S130.  Get High-res Image Gene #77: 'del_12q24.33' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_13q11' versus 'HISTOLOGICAL.TYPE'

P value = 6.69e-13 (Fisher's exact test), Q value = 2.9e-10

Table S131.  Gene #78: 'del_13q11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 29(13Q11) MUTATED 34 4 41
DEL PEAK 29(13Q11) WILD-TYPE 328 15 52

Figure S131.  Get High-res Image Gene #78: 'del_13q11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_13q14.2' versus 'AGE'

P value = 0.000339 (t-test), Q value = 0.11

Table S132.  Gene #79: 'del_13q14.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 30(13Q14.2) MUTATED 84 67.5 (9.9)
DEL PEAK 30(13Q14.2) WILD-TYPE 389 63.0 (11.4)

Figure S132.  Get High-res Image Gene #79: 'del_13q14.2' versus Clinical Feature #2: 'AGE'

'del_13q14.2' versus 'HISTOLOGICAL.TYPE'

P value = 2.02e-07 (Fisher's exact test), Q value = 8e-05

Table S133.  Gene #79: 'del_13q14.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 30(13Q14.2) MUTATED 44 5 35
DEL PEAK 30(13Q14.2) WILD-TYPE 318 14 58

Figure S133.  Get High-res Image Gene #79: 'del_13q14.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_14q13.1' versus 'HISTOLOGICAL.TYPE'

P value = 8.06e-11 (Fisher's exact test), Q value = 3.4e-08

Table S134.  Gene #80: 'del_14q13.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 31(14Q13.1) MUTATED 23 5 31
DEL PEAK 31(14Q13.1) WILD-TYPE 339 14 62

Figure S134.  Get High-res Image Gene #80: 'del_14q13.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_15q15.1' versus 'AGE'

P value = 4.51e-08 (t-test), Q value = 1.8e-05

Table S135.  Gene #81: 'del_15q15.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 32(15Q15.1) MUTATED 116 68.4 (9.8)
DEL PEAK 32(15Q15.1) WILD-TYPE 357 62.2 (11.3)

Figure S135.  Get High-res Image Gene #81: 'del_15q15.1' versus Clinical Feature #2: 'AGE'

'del_15q15.1' versus 'HISTOLOGICAL.TYPE'

P value = 1.46e-23 (Fisher's exact test), Q value = 7e-21

Table S136.  Gene #81: 'del_15q15.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 32(15Q15.1) MUTATED 47 8 61
DEL PEAK 32(15Q15.1) WILD-TYPE 315 11 32

Figure S136.  Get High-res Image Gene #81: 'del_15q15.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_15q23' versus 'AGE'

P value = 1.6e-05 (t-test), Q value = 0.006

Table S137.  Gene #82: 'del_15q23' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 33(15Q23) MUTATED 97 67.8 (9.7)
DEL PEAK 33(15Q23) WILD-TYPE 376 62.7 (11.4)

Figure S137.  Get High-res Image Gene #82: 'del_15q23' versus Clinical Feature #2: 'AGE'

'del_15q23' versus 'HISTOLOGICAL.TYPE'

P value = 1.94e-23 (Fisher's exact test), Q value = 9.3e-21

Table S138.  Gene #82: 'del_15q23' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 33(15Q23) MUTATED 35 6 56
DEL PEAK 33(15Q23) WILD-TYPE 327 13 37

Figure S138.  Get High-res Image Gene #82: 'del_15q23' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_16p13.3' versus 'AGE'

P value = 5.36e-08 (t-test), Q value = 2.2e-05

Table S139.  Gene #83: 'del_16p13.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 34(16P13.3) MUTATED 75 69.4 (8.7)
DEL PEAK 34(16P13.3) WILD-TYPE 398 62.7 (11.4)

Figure S139.  Get High-res Image Gene #83: 'del_16p13.3' versus Clinical Feature #2: 'AGE'

'del_16p13.3' versus 'HISTOLOGICAL.TYPE'

P value = 1.03e-21 (Fisher's exact test), Q value = 4.9e-19

Table S140.  Gene #83: 'del_16p13.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 34(16P13.3) MUTATED 23 4 48
DEL PEAK 34(16P13.3) WILD-TYPE 339 15 45

Figure S140.  Get High-res Image Gene #83: 'del_16p13.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_16q21' versus 'AGE'

P value = 1.41e-08 (t-test), Q value = 5.8e-06

Table S141.  Gene #84: 'del_16q21' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 35(16Q21) MUTATED 130 68.1 (9.4)
DEL PEAK 35(16Q21) WILD-TYPE 343 62.1 (11.5)

Figure S141.  Get High-res Image Gene #84: 'del_16q21' versus Clinical Feature #2: 'AGE'

'del_16q21' versus 'HISTOLOGICAL.TYPE'

P value = 4.39e-24 (Fisher's exact test), Q value = 2.1e-21

Table S142.  Gene #84: 'del_16q21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 35(16Q21) MUTATED 57 7 66
DEL PEAK 35(16Q21) WILD-TYPE 305 12 27

Figure S142.  Get High-res Image Gene #84: 'del_16q21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_16q23.1' versus 'AGE'

P value = 2.02e-07 (t-test), Q value = 8e-05

Table S143.  Gene #85: 'del_16q23.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 36(16Q23.1) MUTATED 139 67.6 (9.6)
DEL PEAK 36(16Q23.1) WILD-TYPE 334 62.1 (11.5)

Figure S143.  Get High-res Image Gene #85: 'del_16q23.1' versus Clinical Feature #2: 'AGE'

'del_16q23.1' versus 'HISTOLOGICAL.TYPE'

P value = 9.37e-27 (Fisher's exact test), Q value = 4.6e-24

Table S144.  Gene #85: 'del_16q23.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 36(16Q23.1) MUTATED 62 6 71
DEL PEAK 36(16Q23.1) WILD-TYPE 300 13 22

Figure S144.  Get High-res Image Gene #85: 'del_16q23.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_17p13.3' versus 'Time to Death'

P value = 0.000346 (logrank test), Q value = 0.12

Table S145.  Gene #86: 'del_17p13.3' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
DEL PEAK 37(17P13.3) MUTATED 99 21 0.0 - 125.4 (17.6)
DEL PEAK 37(17P13.3) WILD-TYPE 373 38 0.1 - 191.8 (23.3)

Figure S145.  Get High-res Image Gene #86: 'del_17p13.3' versus Clinical Feature #1: 'Time to Death'

'del_17p13.3' versus 'AGE'

P value = 0.000181 (t-test), Q value = 0.063

Table S146.  Gene #86: 'del_17p13.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 37(17P13.3) MUTATED 100 67.1 (9.3)
DEL PEAK 37(17P13.3) WILD-TYPE 373 62.9 (11.6)

Figure S146.  Get High-res Image Gene #86: 'del_17p13.3' versus Clinical Feature #2: 'AGE'

'del_17p13.3' versus 'HISTOLOGICAL.TYPE'

P value = 2.38e-21 (Fisher's exact test), Q value = 1.1e-18

Table S147.  Gene #86: 'del_17p13.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 37(17P13.3) MUTATED 38 9 53
DEL PEAK 37(17P13.3) WILD-TYPE 324 10 40

Figure S147.  Get High-res Image Gene #86: 'del_17p13.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_17p11.2' versus 'Time to Death'

P value = 0.000482 (logrank test), Q value = 0.16

Table S148.  Gene #87: 'del_17p11.2' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
DEL PEAK 38(17P11.2) MUTATED 106 22 0.0 - 125.4 (17.7)
DEL PEAK 38(17P11.2) WILD-TYPE 366 37 0.1 - 191.8 (23.1)

Figure S148.  Get High-res Image Gene #87: 'del_17p11.2' versus Clinical Feature #1: 'Time to Death'

'del_17p11.2' versus 'AGE'

P value = 9.56e-07 (t-test), Q value = 0.00037

Table S149.  Gene #87: 'del_17p11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 38(17P11.2) MUTATED 107 68.1 (9.6)
DEL PEAK 38(17P11.2) WILD-TYPE 366 62.5 (11.4)

Figure S149.  Get High-res Image Gene #87: 'del_17p11.2' versus Clinical Feature #2: 'AGE'

'del_17p11.2' versus 'HISTOLOGICAL.TYPE'

P value = 5.66e-27 (Fisher's exact test), Q value = 2.8e-24

Table S150.  Gene #87: 'del_17p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 38(17P11.2) MUTATED 38 8 61
DEL PEAK 38(17P11.2) WILD-TYPE 324 11 32

Figure S150.  Get High-res Image Gene #87: 'del_17p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_17p11.2' versus 'Time to Death'

P value = 0.000668 (logrank test), Q value = 0.22

Table S151.  Gene #88: 'del_17p11.2' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
DEL PEAK 39(17P11.2) MUTATED 100 20 0.0 - 125.4 (16.5)
DEL PEAK 39(17P11.2) WILD-TYPE 372 39 0.1 - 191.8 (23.4)

Figure S151.  Get High-res Image Gene #88: 'del_17p11.2' versus Clinical Feature #1: 'Time to Death'

'del_17p11.2' versus 'AGE'

P value = 2.81e-06 (t-test), Q value = 0.0011

Table S152.  Gene #88: 'del_17p11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 39(17P11.2) MUTATED 101 68.0 (9.5)
DEL PEAK 39(17P11.2) WILD-TYPE 372 62.6 (11.4)

Figure S152.  Get High-res Image Gene #88: 'del_17p11.2' versus Clinical Feature #2: 'AGE'

'del_17p11.2' versus 'HISTOLOGICAL.TYPE'

P value = 1.96e-20 (Fisher's exact test), Q value = 9.2e-18

Table S153.  Gene #88: 'del_17p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 39(17P11.2) MUTATED 40 7 54
DEL PEAK 39(17P11.2) WILD-TYPE 322 12 39

Figure S153.  Get High-res Image Gene #88: 'del_17p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_17q11.2' versus 'AGE'

P value = 3.94e-06 (t-test), Q value = 0.0015

Table S154.  Gene #89: 'del_17q11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 40(17Q11.2) MUTATED 87 68.4 (9.7)
DEL PEAK 40(17Q11.2) WILD-TYPE 386 62.7 (11.3)

Figure S154.  Get High-res Image Gene #89: 'del_17q11.2' versus Clinical Feature #2: 'AGE'

'del_17q11.2' versus 'HISTOLOGICAL.TYPE'

P value = 5.27e-12 (Fisher's exact test), Q value = 2.3e-09

Table S155.  Gene #89: 'del_17q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 40(17Q11.2) MUTATED 40 5 42
DEL PEAK 40(17Q11.2) WILD-TYPE 322 14 51

Figure S155.  Get High-res Image Gene #89: 'del_17q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_17q21.31' versus 'AGE'

P value = 8.9e-05 (t-test), Q value = 0.032

Table S156.  Gene #90: 'del_17q21.31' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 41(17Q21.31) MUTATED 86 67.8 (10.1)
DEL PEAK 41(17Q21.31) WILD-TYPE 387 62.9 (11.3)

Figure S156.  Get High-res Image Gene #90: 'del_17q21.31' versus Clinical Feature #2: 'AGE'

'del_17q21.31' versus 'HISTOLOGICAL.TYPE'

P value = 4.78e-13 (Fisher's exact test), Q value = 2.1e-10

Table S157.  Gene #90: 'del_17q21.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 41(17Q21.31) MUTATED 38 5 43
DEL PEAK 41(17Q21.31) WILD-TYPE 324 14 50

Figure S157.  Get High-res Image Gene #90: 'del_17q21.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_18q21.2' versus 'HISTOLOGICAL.TYPE'

P value = 5.3e-12 (Fisher's exact test), Q value = 2.3e-09

Table S158.  Gene #91: 'del_18q21.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 42(18Q21.2) MUTATED 32 5 38
DEL PEAK 42(18Q21.2) WILD-TYPE 330 14 55

Figure S158.  Get High-res Image Gene #91: 'del_18q21.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_18q23' versus 'HISTOLOGICAL.TYPE'

P value = 1.55e-16 (Fisher's exact test), Q value = 7.1e-14

Table S159.  Gene #92: 'del_18q23' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 43(18Q23) MUTATED 31 5 45
DEL PEAK 43(18Q23) WILD-TYPE 331 14 48

Figure S159.  Get High-res Image Gene #92: 'del_18q23' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_19p13.3' versus 'Time to Death'

P value = 2.42e-06 (logrank test), Q value = 0.00094

Table S160.  Gene #93: 'del_19p13.3' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
DEL PEAK 44(19P13.3) MUTATED 128 30 0.0 - 125.4 (18.5)
DEL PEAK 44(19P13.3) WILD-TYPE 344 29 0.1 - 191.8 (23.3)

Figure S160.  Get High-res Image Gene #93: 'del_19p13.3' versus Clinical Feature #1: 'Time to Death'

'del_19p13.3' versus 'AGE'

P value = 1.08e-11 (t-test), Q value = 4.6e-09

Table S161.  Gene #93: 'del_19p13.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 44(19P13.3) MUTATED 129 68.9 (8.8)
DEL PEAK 44(19P13.3) WILD-TYPE 344 61.8 (11.5)

Figure S161.  Get High-res Image Gene #93: 'del_19p13.3' versus Clinical Feature #2: 'AGE'

'del_19p13.3' versus 'HISTOLOGICAL.TYPE'

P value = 7.83e-50 (Fisher's exact test), Q value = 3.9e-47

Table S162.  Gene #93: 'del_19p13.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 44(19P13.3) MUTATED 38 8 83
DEL PEAK 44(19P13.3) WILD-TYPE 324 11 10

Figure S162.  Get High-res Image Gene #93: 'del_19p13.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_19p12' versus 'HISTOLOGICAL.TYPE'

P value = 7.37e-09 (Fisher's exact test), Q value = 3e-06

Table S163.  Gene #94: 'del_19p12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 45(19P12) MUTATED 16 5 23
DEL PEAK 45(19P12) WILD-TYPE 346 14 70

Figure S163.  Get High-res Image Gene #94: 'del_19p12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_19q13.43' versus 'Time to Death'

P value = 0.000297 (logrank test), Q value = 0.1

Table S164.  Gene #95: 'del_19q13.43' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
DEL PEAK 46(19Q13.43) MUTATED 53 15 0.0 - 125.4 (18.2)
DEL PEAK 46(19Q13.43) WILD-TYPE 419 44 0.1 - 191.8 (22.0)

Figure S164.  Get High-res Image Gene #95: 'del_19q13.43' versus Clinical Feature #1: 'Time to Death'

'del_19q13.43' versus 'HISTOLOGICAL.TYPE'

P value = 3.57e-17 (Fisher's exact test), Q value = 1.6e-14

Table S165.  Gene #95: 'del_19q13.43' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 46(19Q13.43) MUTATED 14 4 36
DEL PEAK 46(19Q13.43) WILD-TYPE 348 15 57

Figure S165.  Get High-res Image Gene #95: 'del_19q13.43' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_20p12.1' versus 'Time to Death'

P value = 0.000206 (logrank test), Q value = 0.072

Table S166.  Gene #96: 'del_20p12.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
DEL PEAK 47(20P12.1) MUTATED 30 11 0.1 - 149.6 (19.1)
DEL PEAK 47(20P12.1) WILD-TYPE 442 48 0.0 - 191.8 (22.0)

Figure S166.  Get High-res Image Gene #96: 'del_20p12.1' versus Clinical Feature #1: 'Time to Death'

'del_20p12.1' versus 'HISTOLOGICAL.TYPE'

P value = 0.000554 (Fisher's exact test), Q value = 0.18

Table S167.  Gene #96: 'del_20p12.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 47(20P12.1) MUTATED 14 2 14
DEL PEAK 47(20P12.1) WILD-TYPE 348 17 79

Figure S167.  Get High-res Image Gene #96: 'del_20p12.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_22q11.1' versus 'AGE'

P value = 9.68e-05 (t-test), Q value = 0.035

Table S168.  Gene #97: 'del_22q11.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 48(22Q11.1) MUTATED 72 67.8 (8.7)
DEL PEAK 48(22Q11.1) WILD-TYPE 401 63.0 (11.5)

Figure S168.  Get High-res Image Gene #97: 'del_22q11.1' versus Clinical Feature #2: 'AGE'

'del_22q11.1' versus 'HISTOLOGICAL.TYPE'

P value = 6.26e-06 (Fisher's exact test), Q value = 0.0024

Table S169.  Gene #97: 'del_22q11.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 48(22Q11.1) MUTATED 39 3 30
DEL PEAK 48(22Q11.1) WILD-TYPE 323 16 63

Figure S169.  Get High-res Image Gene #97: 'del_22q11.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_22q13.31' versus 'AGE'

P value = 3.05e-09 (t-test), Q value = 1.3e-06

Table S170.  Gene #98: 'del_22q13.31' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 49(22Q13.31) MUTATED 114 68.8 (9.4)
DEL PEAK 49(22Q13.31) WILD-TYPE 359 62.2 (11.3)

Figure S170.  Get High-res Image Gene #98: 'del_22q13.31' versus Clinical Feature #2: 'AGE'

'del_22q13.31' versus 'HISTOLOGICAL.TYPE'

P value = 2.88e-23 (Fisher's exact test), Q value = 1.4e-20

Table S171.  Gene #98: 'del_22q13.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 49(22Q13.31) MUTATED 46 8 60
DEL PEAK 49(22Q13.31) WILD-TYPE 316 11 33

Figure S171.  Get High-res Image Gene #98: 'del_22q13.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_xp21.1' versus 'Time to Death'

P value = 0.000229 (logrank test), Q value = 0.08

Table S172.  Gene #99: 'del_xp21.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 472 59 0.0 - 191.8 (21.5)
DEL PEAK 50(XP21.1) MUTATED 72 18 0.0 - 113.4 (16.9)
DEL PEAK 50(XP21.1) WILD-TYPE 400 41 0.1 - 191.8 (22.7)

Figure S172.  Get High-res Image Gene #99: 'del_xp21.1' versus Clinical Feature #1: 'Time to Death'

'del_xp21.1' versus 'AGE'

P value = 0.000247 (t-test), Q value = 0.085

Table S173.  Gene #99: 'del_xp21.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 473 63.8 (11.3)
DEL PEAK 50(XP21.1) MUTATED 72 67.8 (9.5)
DEL PEAK 50(XP21.1) WILD-TYPE 401 63.0 (11.4)

Figure S173.  Get High-res Image Gene #99: 'del_xp21.1' versus Clinical Feature #2: 'AGE'

'del_xp21.1' versus 'HISTOLOGICAL.TYPE'

P value = 2.45e-16 (Fisher's exact test), Q value = 1.1e-13

Table S174.  Gene #99: 'del_xp21.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 362 19 93
DEL PEAK 50(XP21.1) MUTATED 27 2 43
DEL PEAK 50(XP21.1) WILD-TYPE 335 17 50

Figure S174.  Get High-res Image Gene #99: 'del_xp21.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

Methods & Data
Input

  • Copy number data file = transformed.cor.cli.txt

  • Clinical data file = UCEC-TP.merged_data.txt

  • Number of patients = 474

  • Number of significantly focal cnvs = 99

  • Number of selected clinical features = 5

  • Exclude genes that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Student's t-test analysis

For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene mutations using 't.test' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)
[3] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[4] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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