Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
PPP2R1A	27 (11%)	221	0.075984	1	0.0518	1	0.024848	1	0.012874	1	0.1409	1	0.31271	1	0.0023337	0.782	0.0045621	1	0.0061321	1	0.037867	1	0.054918	1	0.0039842	1
PIK3CA	132 (53%)	116	0.8345	1	0.19816	1	0.3882	1	0.6765	1	0.36637	1	0.36468	1	0.71879	1	0.95551	1	0.32116	1	0.10946	1	0.29876	1	0.15716	1
CTNNB1	74 (30%)	174	5.6774e-07	0.000201	0.0011477	0.389	4.4265e-06	0.00156	0.0031504	1	1.289e-10	4.65e-08	0.11185	1	1.6187e-09	5.81e-07	6.5816e-13	2.41e-10	8.4083e-13	3.07e-10	0.18023	1	0.028219	1	0.0011443	0.389
PIK3R1	83 (33%)	165	0.066902	1	0.021768	1	0.0016351	0.549	3.3189e-05	0.0116	0.6489	1	0.87686	1	0.00012642	0.044	2.6691e-05	0.00937	0.010659	1	0.30987	1	0.018053	1	0.0007785	0.266
PRKAR1B	4 (2%)	244	NA	NA	NA	NA	0.9607	1	0.50869	1	0.88699	1	1	1	0.47172	1	0.84759	1	0.8255	1	1	1	0.79494	1	0.2084	1
PTEN	161 (65%)	87	0.0044164	1	0.00036209	0.125	1.686e-21	6.29e-19	1.7921e-12	6.52e-10	0.025685	1	0.18335	1	2.479e-21	9.22e-19	7.3804e-19	2.74e-16	1.2803e-16	4.72e-14	4.3185e-12	1.56e-09	1.9652e-09	7.04e-07	4.7825e-13	1.76e-10
KRAS	53 (21%)	195	0.203	1	0.0006492	0.223	0.0068542	1	0.12251	1	0.29674	1	0.85484	1	0.13803	1	0.049741	1	0.019182	1	0.79391	1	0.056833	1	0.85528	1
TP53	69 (28%)	179	3.7571e-05	0.0131	2.4479e-07	8.71e-05	1.0775e-30	4.05e-28	2.5331e-12	9.2e-10	2.0063e-05	0.00706	0.0014012	0.474	1.0731e-26	4.02e-24	8.1047e-23	3.03e-20	2.3297e-18	8.62e-16	1.1979e-13	4.41e-11	2.1294e-09	7.6e-07	8.5347e-10	3.07e-07
FBXW7	39 (16%)	209	0.225	1	0.69213	1	0.57648	1	0.075748	1	0.10644	1	0.10694	1	0.068317	1	0.17356	1	0.72402	1	0.11192	1	0.29957	1	0.039271	1
CTCF	44 (18%)	204	0.14875	1	0.42097	1	0.00034907	0.121	0.043279	1	0.045801	1	1	1	0.00084742	0.289	0.00044881	0.155	0.015378	1	0.0069917	1	0.010034	1	0.058189	1
ARID1A	83 (33%)	165	0.26564	1	0.010954	1	3.9254e-07	0.000139	0.22697	1	0.02713	1	1	1	0.021471	1	0.016406	1	0.037438	1	0.057676	1	0.028127	1	0.062188	1
SPOP	21 (8%)	227	0.34932	1	1	1	0.8605	1	0.35577	1	0.83433	1	0.41497	1	0.22942	1	0.92717	1	0.83958	1	0.36712	1	0.55001	1	0.68751	1
ARID5B	29 (12%)	219	0.96088	1	0.45933	1	0.031581	1	0.13611	1	0.16398	1	0.1818	1	0.15855	1	0.11053	1	0.21944	1	0.76208	1	0.3043	1	0.56522	1
FGFR2	31 (12%)	217	0.38513	1	0.29313	1	0.31688	1	0.91427	1	0.96987	1	0.82869	1	1	1	0.83618	1	0.48384	1	0.64819	1	0.58708	1	0.87943	1
NFE2L2	15 (6%)	233	0.090516	1	0.83347	1	0.020653	1	0.63063	1	0.2479	1	1	1	0.013996	1	0.045614	1	0.31401	1	0.72184	1	0.3043	1	0.56522	1
CCND1	14 (6%)	234	0.631	1	0.83347	1	0.084798	1	0.49484	1	0.51372	1	0.50942	1	0.4576	1	0.59109	1	0.074717	1	0.54248	1	0.4408	1	0.70859	1
CHD4	35 (14%)	213	0.098645	1	0.28356	1	0.43762	1	0.85174	1	0.96961	1	0.28657	1	0.36976	1	0.44249	1	0.60908	1	0.64819	1	0.41514	1	0.73299	1
FAM9A	14 (6%)	234	NA	NA	NA	NA	0.63034	1	0.26967	1	0.17795	1	0.022725	1	0.073304	1	0.14726	1	0.61245	1	0.15133	1	0.021979	1	0.13519	1
MORC4	20 (8%)	228	0.58319	1	0.17985	1	0.37121	1	0.27973	1	0.21229	1	0.033158	1	0.14418	1	0.17899	1	0.060551	1	0.23644	1	0.34811	1	1	1
CASP8	17 (7%)	231	0.38127	1	0.059544	1	0.040684	1	0.62611	1	0.15421	1	0.26865	1	0.62551	1	0.23918	1	0.3795	1	0.25731	1	0.36299	1	1	1
FOXA2	12 (5%)	236	NA	NA	NA	NA	0.8672	1	0.7954	1	0.071861	1	0.74395	1	0.81712	1	0.71175	1	0.39126	1	0.41141	1	0.6823	1	0.17885	1
ABI1	4 (2%)	244	NA	NA	NA	NA	0.69131	1	NA	NA	0.64001	1	0.63688	1	0.55069	1	0.69705	1	0.56466	1	0.6418	1	NA	NA	NA	NA
DNER	18 (7%)	230	0.1912	1	0.051469	1	0.00046066	0.158	0.59682	1	0.021717	1	0.58145	1	0.86386	1	1	1	0.56024	1	0.21675	1	0.6823	1	1	1
BCOR	30 (12%)	218	0.68711	1	0.4049	1	0.0014519	0.489	0.024617	1	0.51211	1	0.50027	1	0.032836	1	0.14333	1	0.78059	1	0.55758	1	0.92828	1	0.090227	1
BRS3	15 (6%)	233	0.53592	1	0.15102	1	0.21092	1	0.51936	1	0.3924	1	0.54035	1	0.081761	1	0.32874	1	0.23305	1	0.23557	1	0.55963	1	0.44093	1
SGK1	15 (6%)	233	0.38127	1	0.059544	1	0.33785	1	0.62525	1	0.22598	1	0.095402	1	0.3017	1	0.94393	1	0.29625	1	1	1	0.81127	1	0.70859	1
NRAS	9 (4%)	239	NA	NA	NA	NA	0.41539	1	NA	NA	0.31592	1	1	1	0.70561	1	0.64507	1	0.48075	1	0.75446	1	NA	NA	NA	NA
TIAL1	11 (4%)	237	0.38127	1	0.4049	1	0.16211	1	0.063416	1	0.56444	1	0.74395	1	0.044414	1	0.59329	1	0.79616	1	0.29776	1	0.3043	1	0.18707	1
SIN3A	21 (8%)	227	NA	NA	NA	NA	0.046281	1	0.59803	1	0.0060674	1	0.1293	1	0.021642	1	0.042079	1	0.022621	1	0.087565	1	0.51376	1	0.3581	1
SLC48A1	5 (2%)	243	NA	NA	NA	NA	0.58932	1	0.63905	1	0.80339	1	0.37153	1	0.6242	1	0.74705	1	0.069735	1	0.67368	1	0.79494	1	0.63412	1
RNF43	12 (5%)	236	0.13313	1	0.15102	1	0.2946	1	0.3775	1	0.29629	1	1	1	0.047778	1	0.011208	1	0.044511	1	0.21084	1	0.34554	1	1	1
ZFHX3	44 (18%)	204	0.37543	1	0.029136	1	0.068557	1	0.064832	1	0.31768	1	0.1793	1	0.92387	1	0.95944	1	0.12672	1	0.56849	1	0.57465	1	0.2583	1
RB1	20 (8%)	228	0.63931	1	1	1	0.17716	1	0.62611	1	0.12007	1	0.31271	1	0.47804	1	0.3825	1	0.13726	1	0.087249	1	1	1	1	1