Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.028 0.103 0.279 75.0 -9999.0 0.0 75.0 KIRREL -0.039 0.137 -9999.0 0.0 -0.414 62.0 62.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.028 0.103 -9999.0 0.0 -0.279 75.0 75.0 PLCG1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.011 0.076 -9999.0 0.0 -0.204 63.0 63.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.005 0.077 -9999.0 0.0 -0.21 62.0 62.0 FYN -0.013 0.072 -9999.0 0.0 -0.198 63.0 63.0 mol:Ca2+ -0.014 0.074 -9999.0 0.0 -0.202 63.0 63.0 mol:DAG -0.011 0.075 -9999.0 0.0 -0.203 63.0 63.0 NPHS2 -0.004 0.029 -9999.0 0.0 -0.332 3.0 3.0 mol:IP3 -0.011 0.075 -9999.0 0.0 -0.203 63.0 63.0 regulation of endocytosis -0.005 0.068 -9999.0 0.0 -0.181 60.0 60.0 Nephrin/NEPH1/podocin/Cholesterol -0.018 0.076 -9999.0 0.0 -0.21 63.0 63.0 establishment of cell polarity -0.028 0.103 -9999.0 0.0 -0.279 75.0 75.0 Nephrin/NEPH1/podocin/NCK1-2 -0.003 0.072 -9999.0 0.0 -0.334 4.0 4.0 Nephrin/NEPH1/beta Arrestin2 -0.005 0.069 -9999.0 0.0 -0.183 60.0 60.0 NPHS1 -0.005 0.055 -9999.0 0.0 -0.329 14.0 14.0 Nephrin/NEPH1/podocin -0.013 0.072 -9999.0 0.0 -0.199 63.0 63.0 TJP1 0.01 0.018 -9999.0 0.0 -0.41 1.0 1.0 NCK1 0.009 0.026 -9999.0 0.0 -0.41 2.0 2.0 NCK2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.011 0.076 -9999.0 0.0 -0.204 63.0 63.0 CD2AP 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.011 0.076 -9999.0 0.0 -0.204 63.0 63.0 GRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.026 0.096 -9999.0 0.0 -0.221 91.0 91.0 cytoskeleton organization -0.001 0.08 -9999.0 0.0 -0.214 62.0 62.0 Nephrin/NEPH1 -0.017 0.071 -9999.0 0.0 -0.189 75.0 75.0 Nephrin/NEPH1/ZO-1 -0.013 0.083 -9999.0 0.0 -0.224 63.0 63.0