Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.056 0.177 -9999.0 0.0 -0.594 37.0 37.0 IHH -0.129 0.2 -9999.0 0.0 -0.394 184.0 184.0 SHH Np/Cholesterol/GAS1 -0.148 0.13 -9999.0 0.0 -0.234 340.0 340.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.147 0.129 0.233 340.0 -9999.0 0.0 340.0 SMO/beta Arrestin2 -0.052 0.155 -9999.0 0.0 -0.417 27.0 27.0 SMO -0.061 0.163 -9999.0 0.0 -0.318 133.0 133.0 AKT1 -0.018 0.096 -9999.0 0.0 -0.52 5.0 5.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.003 0.077 -9999.0 0.0 -0.41 18.0 18.0 ADRBK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.06 0.161 -9999.0 0.0 -0.315 133.0 133.0 STIL -0.049 0.115 -9999.0 0.0 -0.344 32.0 32.0 DHH N/PTCH2 -0.023 0.105 -9999.0 0.0 -0.296 66.0 66.0 DHH N/PTCH1 -0.06 0.138 -9999.0 0.0 -0.353 52.0 52.0 PIK3CA 0.01 0.018 -9999.0 0.0 -0.41 1.0 1.0 DHH -0.023 0.113 -9999.0 0.0 -0.41 41.0 41.0 PTHLH -0.07 0.213 -9999.0 0.0 -0.649 37.0 37.0 determination of left/right symmetry -0.06 0.161 -9999.0 0.0 -0.315 133.0 133.0 PIK3R1 0.007 0.041 -9999.0 0.0 -0.41 5.0 5.0 skeletal system development -0.07 0.211 -9999.0 0.0 -0.643 37.0 37.0 IHH N/Hhip -0.08 0.132 -9999.0 0.0 -0.235 204.0 204.0 DHH N/Hhip -0.024 0.098 -9999.0 0.0 -0.263 74.0 74.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.06 0.161 -9999.0 0.0 -0.315 133.0 133.0 pancreas development -0.013 0.088 -9999.0 0.0 -0.343 35.0 35.0 HHAT 0.008 0.037 -9999.0 0.0 -0.41 4.0 4.0 PI3K 0.013 0.031 -9999.0 0.0 -0.28 6.0 6.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.259 0.202 -9999.0 0.0 -0.41 338.0 338.0 somite specification -0.06 0.161 -9999.0 0.0 -0.315 133.0 133.0 SHH Np/Cholesterol/PTCH1 -0.052 0.116 -9999.0 0.0 -0.363 26.0 26.0 SHH Np/Cholesterol/PTCH2 -0.017 0.08 -9999.0 0.0 -0.229 33.0 33.0 SHH Np/Cholesterol/Megalin -0.068 0.103 -9999.0 0.0 -0.176 232.0 232.0 SHH -0.015 0.082 -9999.0 0.0 -0.223 71.0 71.0 catabolic process -0.055 0.137 -9999.0 0.0 -0.358 37.0 37.0 SMO/Vitamin D3 -0.049 0.14 -9999.0 0.0 -0.402 27.0 27.0 SHH Np/Cholesterol/Hhip -0.018 0.075 -9999.0 0.0 -0.168 102.0 102.0 LRP2 -0.111 0.163 -9999.0 0.0 -0.33 188.0 188.0 receptor-mediated endocytosis -0.076 0.137 -9999.0 0.0 -0.326 76.0 76.0 SHH Np/Cholesterol/BOC -0.012 0.074 -9999.0 0.0 -0.174 86.0 86.0 SHH Np/Cholesterol/CDO -0.03 0.097 -9999.0 0.0 -0.24 63.0 63.0 mesenchymal cell differentiation 0.018 0.075 0.167 102.0 -9999.0 0.0 102.0 mol:Vitamin D3 -0.042 0.123 -9999.0 0.0 -0.365 26.0 26.0 IHH N/PTCH2 -0.079 0.139 -9999.0 0.0 -0.278 143.0 143.0 CDON -0.036 0.133 -9999.0 0.0 -0.41 59.0 59.0 IHH N/PTCH1 -0.035 0.15 -9999.0 0.0 -0.361 37.0 37.0 Megalin/LRPAP1 -0.068 0.112 -9999.0 0.0 -0.218 188.0 188.0 PTCH2 -0.012 0.096 -9999.0 0.0 -0.41 29.0 29.0 SHH Np/Cholesterol -0.012 0.061 -9999.0 0.0 -0.165 71.0 71.0 PTCH1 -0.055 0.138 -9999.0 0.0 -0.359 37.0 37.0 HHIP -0.013 0.089 -9999.0 0.0 -0.344 35.0 35.0