Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	186.0	9504.0	51.0	-0.973	0.011	1000.0	-1000.0	-0.132	-1000.0
Aurora B signaling	167.0	11189.0	67.0	-0.525	0.011	1000.0	-1000.0	-0.038	-1000.0
Aurora C signaling	132.0	930.0	7.0	-0.289	0.01	1000.0	-1000.0	-0.017	-1000.0
HIF-1-alpha transcription factor network	124.0	9435.0	76.0	-0.489	0.017	1000.0	-1000.0	-0.064	-1000.0
Signaling events regulated by Ret tyrosine kinase	109.0	9015.0	82.0	-0.189	0.011	1000.0	-1000.0	-0.052	-1000.0
Angiopoietin receptor Tie2-mediated signaling	105.0	9267.0	88.0	-0.32	0.043	1000.0	-1000.0	-0.066	-1000.0
Endothelins	103.0	9944.0	96.0	-0.333	0.011	1000.0	-1000.0	-0.042	-1000.0
PDGFR-alpha signaling pathway	96.0	4251.0	44.0	-0.291	0.025	1000.0	-1000.0	-0.032	-1000.0
p75(NTR)-mediated signaling	88.0	11105.0	125.0	-0.2	0.03	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by the Hedgehog family	81.0	4216.0	52.0	-0.259	0.147	1000.0	-1000.0	-0.025	-1000.0
Integrins in angiogenesis	76.0	6428.0	84.0	-0.288	0.024	1000.0	-1000.0	-0.053	-1000.0
Cellular roles of Anthrax toxin	68.0	2658.0	39.0	-0.127	0.019	1000.0	-1000.0	-0.013	-1000.0
S1P3 pathway	68.0	2863.0	42.0	-0.414	0.016	1000.0	-1000.0	-0.019	-1000.0
Nongenotropic Androgen signaling	67.0	3496.0	52.0	-0.212	0.105	1000.0	-1000.0	-0.027	-1000.0
Fc-epsilon receptor I signaling in mast cells	62.0	6057.0	97.0	-0.123	0.028	1000.0	-1000.0	-0.045	-1000.0
Wnt signaling	59.0	418.0	7.0	-0.089	-0.003	1000.0	-1000.0	-0.01	-1000.0
PLK1 signaling events	57.0	4887.0	85.0	-0.298	0.044	1000.0	-1000.0	-0.027	-1000.0
Signaling mediated by p38-alpha and p38-beta	57.0	2516.0	44.0	-0.08	0.011	1000.0	-1000.0	-0.033	-1000.0
Effects of Botulinum toxin	54.0	1428.0	26.0	-0.112	0.018	1000.0	-1000.0	-0.036	-1000.0
Glypican 1 network	53.0	2570.0	48.0	-0.216	0.022	1000.0	-1000.0	-0.019	-1000.0
Reelin signaling pathway	53.0	2981.0	56.0	-0.156	0.03	1000.0	-1000.0	-0.041	-1000.0
IGF1 pathway	50.0	2878.0	57.0	-0.077	0.022	1000.0	-1000.0	-0.048	-1000.0
Aurora A signaling	48.0	2900.0	60.0	-0.254	0.022	1000.0	-1000.0	-0.019	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	48.0	5789.0	120.0	-0.188	0.138	1000.0	-1000.0	-0.041	-1000.0
LPA4-mediated signaling events	46.0	555.0	12.0	-0.122	0.015	1000.0	-1000.0	-0.01	-1000.0
Noncanonical Wnt signaling pathway	45.0	1174.0	26.0	-0.136	0.011	1000.0	-1000.0	-0.016	-1000.0
S1P5 pathway	45.0	781.0	17.0	-0.099	0.032	1000.0	-1000.0	-0.012	-1000.0
Syndecan-1-mediated signaling events	44.0	1505.0	34.0	-0.173	0.011	1000.0	-1000.0	-0.017	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	44.0	3016.0	68.0	-0.205	0.081	1000.0	-1000.0	-0.089	-1000.0
TCGA08_retinoblastoma	44.0	359.0	8.0	-0.134	0.024	1000.0	-1000.0	-0.009	-1000.0
S1P4 pathway	43.0	1079.0	25.0	-0.099	0.024	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	43.0	3417.0	78.0	-0.102	0.044	1000.0	-1000.0	-0.038	-1000.0
Thromboxane A2 receptor signaling	42.0	4446.0	105.0	-0.175	0.031	1000.0	-1000.0	-0.04	-1000.0
amb2 Integrin signaling	42.0	3456.0	82.0	-0.15	0.022	1000.0	-1000.0	-0.046	-1000.0
BMP receptor signaling	40.0	3290.0	81.0	-0.277	0.038	1000.0	-1000.0	-0.046	-1000.0
Plasma membrane estrogen receptor signaling	40.0	3468.0	86.0	-0.152	0.066	1000.0	-1000.0	-0.045	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	39.0	1351.0	34.0	-0.039	0.011	1000.0	-1000.0	-0.017	-1000.0
LPA receptor mediated events	39.0	3993.0	102.0	-0.142	0.029	1000.0	-1000.0	-0.042	-1000.0
Ephrin B reverse signaling	38.0	1837.0	48.0	-0.094	0.015	1000.0	-1000.0	-0.033	-1000.0
FOXA2 and FOXA3 transcription factor networks	37.0	1714.0	46.0	-0.22	0.015	1000.0	-1000.0	-0.066	-1000.0
S1P1 pathway	37.0	1335.0	36.0	-0.124	0.011	1000.0	-1000.0	-0.034	-1000.0
Ras signaling in the CD4+ TCR pathway	36.0	617.0	17.0	-0.075	0.016	1000.0	-1000.0	-0.017	-1000.0
Ephrin A  reverse signaling	35.0	250.0	7.0	-0.021	-0.0	1000.0	-1000.0	-0.01	-1000.0
Osteopontin-mediated events	34.0	1299.0	38.0	-0.116	0.014	1000.0	-1000.0	-0.052	-1000.0
IL4-mediated signaling events	31.0	2847.0	91.0	-0.522	0.265	1000.0	-1000.0	-0.132	-1000.0
TCGA08_p53	31.0	222.0	7.0	-0.089	0.047	1000.0	-1000.0	-0.008	-1000.0
FAS signaling pathway (CD95)	30.0	1443.0	47.0	-0.074	0.037	1000.0	-1000.0	-0.037	-1000.0
Glypican 2 network	29.0	117.0	4.0	-0.014	-0.001	1000.0	-1000.0	-0.007	-1000.0
EGFR-dependent Endothelin signaling events	29.0	612.0	21.0	-0.116	0.019	1000.0	-1000.0	-0.039	-1000.0
Arf6 signaling events	28.0	1745.0	62.0	-0.085	0.027	1000.0	-1000.0	-0.03	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	28.0	2424.0	85.0	-0.207	0.012	1000.0	-1000.0	-0.041	-1000.0
Syndecan-4-mediated signaling events	27.0	1815.0	67.0	-0.256	0.016	1000.0	-1000.0	-0.045	-1000.0
Visual signal transduction: Rods	27.0	1435.0	52.0	-0.11	0.011	1000.0	-1000.0	-0.044	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	26.0	1407.0	54.0	-0.142	0.022	1000.0	-1000.0	-0.058	-1000.0
Coregulation of Androgen receptor activity	25.0	1943.0	76.0	-0.131	0.022	1000.0	-1000.0	-0.026	-1000.0
BCR signaling pathway	24.0	2474.0	99.0	-0.06	0.047	1000.0	-1000.0	-0.048	-1000.0
Visual signal transduction: Cones	23.0	890.0	38.0	-0.081	0.011	1000.0	-1000.0	-0.032	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	23.0	1246.0	52.0	-0.079	0.023	1000.0	-1000.0	-0.024	-1000.0
Calcium signaling in the CD4+ TCR pathway	23.0	722.0	31.0	-0.116	0.015	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	23.0	2889.0	125.0	-0.065	0.029	1000.0	-1000.0	-0.059	-1000.0
TCGA08_rtk_signaling	22.0	590.0	26.0	-0.148	0.023	1000.0	-1000.0	-0.011	-1000.0
Regulation of Androgen receptor activity	22.0	1552.0	70.0	-0.218	0.023	1000.0	-1000.0	-0.039	-1000.0
Syndecan-2-mediated signaling events	21.0	1495.0	69.0	-0.103	0.028	1000.0	-1000.0	-0.015	-1000.0
Hedgehog signaling events mediated by Gli proteins	21.0	1419.0	65.0	-0.099	0.038	1000.0	-1000.0	-0.038	-1000.0
Glucocorticoid receptor regulatory network	21.0	2405.0	114.0	-0.24	0.045	1000.0	-1000.0	-0.045	-1000.0
EPHB forward signaling	21.0	1837.0	85.0	-0.034	0.03	1000.0	-1000.0	-0.047	-1000.0
IL6-mediated signaling events	21.0	1580.0	75.0	-0.116	0.061	1000.0	-1000.0	-0.043	-1000.0
IL2 signaling events mediated by STAT5	21.0	480.0	22.0	-0.105	0.056	1000.0	-1000.0	-0.032	-1000.0
Insulin Pathway	21.0	1625.0	74.0	-0.134	0.03	1000.0	-1000.0	-0.053	-1000.0
Presenilin action in Notch and Wnt signaling	20.0	1256.0	61.0	-0.116	0.03	1000.0	-1000.0	-0.037	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	19.0	648.0	33.0	-0.157	0.034	1000.0	-1000.0	-0.024	-1000.0
Regulation of nuclear SMAD2/3 signaling	18.0	2466.0	136.0	-0.155	0.053	1000.0	-1000.0	-0.035	-1000.0
Rapid glucocorticoid signaling	18.0	363.0	20.0	-0.051	0.011	1000.0	-1000.0	-0.008	-1000.0
Sphingosine 1-phosphate (S1P) pathway	17.0	478.0	28.0	-0.099	0.032	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by PTP1B	17.0	1345.0	76.0	-0.116	0.024	1000.0	-1000.0	-0.048	-1000.0
Nectin adhesion pathway	17.0	1084.0	63.0	-0.065	0.021	1000.0	-1000.0	-0.048	-1000.0
Retinoic acid receptors-mediated signaling	17.0	1006.0	58.0	-0.052	0.022	1000.0	-1000.0	-0.041	-1000.0
Canonical Wnt signaling pathway	17.0	868.0	51.0	-0.097	0.05	1000.0	-1000.0	-0.03	-1000.0
BARD1 signaling events	16.0	930.0	57.0	-0.127	0.028	1000.0	-1000.0	-0.039	-1000.0
Class I PI3K signaling events mediated by Akt	16.0	1116.0	68.0	-0.24	0.04	1000.0	-1000.0	-0.025	-1000.0
Regulation of p38-alpha and p38-beta	16.0	912.0	54.0	-0.175	0.044	1000.0	-1000.0	-0.038	-1000.0
Regulation of Telomerase	15.0	1582.0	102.0	-0.303	0.038	1000.0	-1000.0	-0.065	-1000.0
IL12-mediated signaling events	14.0	1293.0	87.0	-0.296	0.044	1000.0	-1000.0	-0.093	-1000.0
IL1-mediated signaling events	14.0	913.0	62.0	-0.039	0.041	1000.0	-1000.0	-0.049	-1000.0
Signaling mediated by p38-gamma and p38-delta	14.0	214.0	15.0	-0.017	0.021	1000.0	-1000.0	-0.012	-1000.0
TCR signaling in naïve CD8+ T cells	14.0	1348.0	93.0	-0.043	0.04	1000.0	-1000.0	-0.041	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	13.0	1146.0	83.0	-0.24	0.044	1000.0	-1000.0	-0.038	-1000.0
FoxO family signaling	13.0	838.0	64.0	-0.24	0.043	1000.0	-1000.0	-0.039	-1000.0
IL2 signaling events mediated by PI3K	13.0	757.0	58.0	-0.114	0.042	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by PRL	13.0	473.0	34.0	-0.127	0.018	1000.0	-1000.0	-0.02	-1000.0
Insulin-mediated glucose transport	12.0	400.0	32.0	-0.24	0.025	1000.0	-1000.0	-0.03	-1000.0
IFN-gamma pathway	12.0	865.0	68.0	-0.224	0.048	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by HDAC Class III	12.0	492.0	40.0	-0.077	0.016	1000.0	-1000.0	-0.022	-1000.0
Syndecan-3-mediated signaling events	12.0	441.0	35.0	-0.09	0.03	1000.0	-1000.0	-0.016	-1000.0
PDGFR-beta signaling pathway	12.0	1258.0	97.0	-0.021	0.039	1000.0	-1000.0	-0.046	-1000.0
ErbB2/ErbB3 signaling events	11.0	755.0	65.0	-0.117	0.022	1000.0	-1000.0	-0.037	-1000.0
ErbB4 signaling events	11.0	763.0	69.0	-0.074	0.031	1000.0	-1000.0	-0.065	-1000.0
mTOR signaling pathway	11.0	628.0	53.0	-0.026	0.018	1000.0	-1000.0	-0.033	-1000.0
HIF-2-alpha transcription factor network	11.0	514.0	43.0	-0.143	0.022	1000.0	-1000.0	-0.041	-1000.0
Class IB PI3K non-lipid kinase events	11.0	33.0	3.0	-0.003	0.003	1000.0	-1000.0	-0.007	-1000.0
JNK signaling in the CD4+ TCR pathway	10.0	180.0	17.0	-0.015	0.034	1000.0	-1000.0	-0.019	-1000.0
EPO signaling pathway	10.0	579.0	55.0	-0.026	0.035	1000.0	-1000.0	-0.05	-1000.0
Ceramide signaling pathway	10.0	782.0	76.0	-0.069	0.036	1000.0	-1000.0	-0.02	-1000.0
Caspase cascade in apoptosis	8.0	596.0	74.0	-0.032	0.035	1000.0	-1000.0	-0.018	-1000.0
IL27-mediated signaling events	8.0	434.0	51.0	-0.053	0.014	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class II	7.0	588.0	75.0	-0.053	0.029	1000.0	-1000.0	-0.026	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	7.0	269.0	37.0	-0.021	0.027	1000.0	-1000.0	-0.022	-1000.0
IL23-mediated signaling events	7.0	455.0	60.0	-0.048	0.042	1000.0	-1000.0	-0.117	-1000.0
p38 MAPK signaling pathway	7.0	321.0	44.0	-0.046	0.028	1000.0	-1000.0	-0.038	-1000.0
ceramide signaling pathway	6.0	339.0	49.0	-0.032	0.038	1000.0	-1000.0	-0.02	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	274.0	45.0	-0.032	0.056	1000.0	-1000.0	-0.049	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	403.0	74.0	-0.074	0.062	1000.0	-1000.0	-0.05	-1000.0
Canonical NF-kappaB pathway	4.0	170.0	39.0	-0.032	0.059	1000.0	-1000.0	-0.044	-1000.0
PLK2 and PLK4 events	4.0	12.0	3.0	0.008	0.015	1000.0	-1000.0	-0.008	-1000.0
Class I PI3K signaling events	4.0	314.0	73.0	-0.015	0.053	1000.0	-1000.0	-0.036	-1000.0
Arf6 trafficking events	4.0	344.0	71.0	-0.193	0.035	1000.0	-1000.0	-0.039	-1000.0
TRAIL signaling pathway	3.0	183.0	48.0	-0.001	0.038	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class I	3.0	380.0	104.0	-0.032	0.044	1000.0	-1000.0	-0.034	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	2.0	49.0	23.0	-0.004	0.036	1000.0	-1000.0	-0.022	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	11.0	5.0	0.009	0.015	1000.0	-1000.0	-0.01	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	98.0	36.0	-0.031	0.032	1000.0	-1000.0	-0.038	-1000.0
VEGFR1 specific signals	2.0	137.0	56.0	-0.063	0.052	1000.0	-1000.0	-0.023	-1000.0
Arf6 downstream pathway	1.0	50.0	43.0	-0.023	0.023	1000.0	-1000.0	-0.016	-1000.0
Atypical NF-kappaB pathway	1.0	36.0	31.0	0.0	0.04	1000.0	-1000.0	-0.019	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	97.0	76.0	-0.003	0.048	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling in keratinocytes	1.0	82.0	43.0	-0.034	0.036	1000.0	-1000.0	-0.034	-1000.0
E-cadherin signaling events	1.0	7.0	5.0	0.009	0.021	1000.0	-1000.0	-0.012	-1000.0
Circadian rhythm pathway	0.0	15.0	22.0	-0.011	0.04	1000.0	-1000.0	-0.026	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.028	1000.0	-1000.0	-0.031	-1000.0
Arf1 pathway	0.0	8.0	54.0	-0.0	0.028	1000.0	-1000.0	-0.019	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	-0.0	0.033	1000.0	-1000.0	-0.013	-1000.0
Total	4014	237281	7203	-17.3074503324	4.34775641723	131000	-131000	-4.72528982736	-131000