Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Aurora B signaling	185.0	12405.0	67.0	-0.293	0.37	1000.0	-1000.0	-0.03	-1000.0
Aurora C signaling	118.0	827.0	7.0	-0.0	0.228	1000.0	-1000.0	-0.007	-1000.0
Endothelins	117.0	11313.0	96.0	-0.39	0.164	1000.0	-1000.0	-0.039	-1000.0
Signaling events regulated by Ret tyrosine kinase	111.0	9130.0	82.0	-0.146	0.038	1000.0	-1000.0	-0.032	-1000.0
Angiopoietin receptor Tie2-mediated signaling	103.0	9087.0	88.0	-0.304	0.114	1000.0	-1000.0	-0.05	-1000.0
p75(NTR)-mediated signaling	97.0	12175.0	125.0	-0.166	0.075	1000.0	-1000.0	-0.038	-1000.0
FOXM1 transcription factor network	88.0	4511.0	51.0	-0.284	0.28	1000.0	-1000.0	-0.057	-1000.0
PDGFR-alpha signaling pathway	85.0	3765.0	44.0	-0.276	0.036	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by the Hedgehog family	84.0	4401.0	52.0	-0.203	0.111	1000.0	-1000.0	-0.017	-1000.0
Integrins in angiogenesis	80.0	6728.0	84.0	-0.259	0.096	1000.0	-1000.0	-0.026	-1000.0
HIF-1-alpha transcription factor network	75.0	5769.0	76.0	-0.25	0.045	1000.0	-1000.0	-0.04	-1000.0
PLK1 signaling events	75.0	6409.0	85.0	-0.056	0.25	1000.0	-1000.0	-0.026	-1000.0
Reelin signaling pathway	74.0	4152.0	56.0	-0.117	0.045	1000.0	-1000.0	-0.019	-1000.0
Cellular roles of Anthrax toxin	65.0	2555.0	39.0	-0.092	0.053	1000.0	-1000.0	-0.016	-1000.0
Fc-epsilon receptor I signaling in mast cells	62.0	6104.0	97.0	-0.096	0.024	1000.0	-1000.0	-0.048	-1000.0
Effects of Botulinum toxin	61.0	1611.0	26.0	-0.104	0.114	1000.0	-1000.0	-0.007	-1000.0
S1P3 pathway	60.0	2557.0	42.0	-0.394	0.031	1000.0	-1000.0	-0.022	-1000.0
Nongenotropic Androgen signaling	59.0	3094.0	52.0	-0.231	0.136	1000.0	-1000.0	-0.023	-1000.0
Aurora A signaling	58.0	3493.0	60.0	-0.137	0.22	1000.0	-1000.0	-0.017	-1000.0
Wnt signaling	56.0	395.0	7.0	-0.066	0.035	1000.0	-1000.0	0.0	-1000.0
Noncanonical Wnt signaling pathway	51.0	1330.0	26.0	-0.123	0.035	1000.0	-1000.0	-0.019	-1000.0
IGF1 pathway	50.0	2873.0	57.0	-0.078	0.035	1000.0	-1000.0	-0.021	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	49.0	5920.0	120.0	-0.152	0.115	1000.0	-1000.0	-0.032	-1000.0
Ephrin B reverse signaling	48.0	2308.0	48.0	-0.092	0.028	1000.0	-1000.0	-0.028	-1000.0
TCGA08_p53	48.0	337.0	7.0	-0.033	0.019	1000.0	-1000.0	-0.007	-1000.0
Signaling mediated by p38-alpha and p38-beta	48.0	2118.0	44.0	-0.075	0.023	1000.0	-1000.0	-0.021	-1000.0
Glypican 1 network	46.0	2238.0	48.0	-0.168	0.102	1000.0	-1000.0	-0.022	-1000.0
TCGA08_retinoblastoma	45.0	364.0	8.0	-0.04	0.129	1000.0	-1000.0	-0.004	-1000.0
LPA4-mediated signaling events	44.0	531.0	12.0	-0.109	0.0	1000.0	-1000.0	-0.016	-1000.0
Thromboxane A2 receptor signaling	44.0	4636.0	105.0	-0.133	0.048	1000.0	-1000.0	-0.029	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	44.0	3011.0	68.0	-0.153	0.075	1000.0	-1000.0	-0.055	-1000.0
FOXA2 and FOXA3 transcription factor networks	42.0	1957.0	46.0	-0.191	0.183	1000.0	-1000.0	-0.061	-1000.0
Osteopontin-mediated events	41.0	1586.0	38.0	-0.087	0.096	1000.0	-1000.0	-0.023	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	40.0	1375.0	34.0	-0.017	0.029	1000.0	-1000.0	-0.021	-1000.0
BMP receptor signaling	40.0	3253.0	81.0	-0.23	0.043	1000.0	-1000.0	-0.022	-1000.0
Plasma membrane estrogen receptor signaling	40.0	3455.0	86.0	-0.192	0.081	1000.0	-1000.0	-0.031	-1000.0
Syndecan-1-mediated signaling events	39.0	1341.0	34.0	-0.048	0.158	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	39.0	3078.0	78.0	-0.136	0.056	1000.0	-1000.0	-0.034	-1000.0
amb2 Integrin signaling	38.0	3137.0	82.0	-0.104	0.128	1000.0	-1000.0	-0.021	-1000.0
Ephrin A  reverse signaling	34.0	241.0	7.0	-0.026	0.013	1000.0	-1000.0	-0.007	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	34.0	2971.0	85.0	-0.206	0.031	1000.0	-1000.0	-0.036	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	33.0	1823.0	54.0	-0.1	0.048	1000.0	-1000.0	-0.023	-1000.0
LPA receptor mediated events	33.0	3461.0	102.0	-0.134	0.128	1000.0	-1000.0	-0.058	-1000.0
IL4-mediated signaling events	32.0	2939.0	91.0	-0.302	0.092	1000.0	-1000.0	-0.083	-1000.0
S1P1 pathway	32.0	1164.0	36.0	-0.149	0.022	1000.0	-1000.0	-0.023	-1000.0
EPHB forward signaling	32.0	2768.0	85.0	-0.055	0.048	1000.0	-1000.0	-0.042	-1000.0
Ras signaling in the CD4+ TCR pathway	32.0	550.0	17.0	-0.09	0.023	1000.0	-1000.0	-0.018	-1000.0
Visual signal transduction: Rods	30.0	1564.0	52.0	-0.057	0.112	1000.0	-1000.0	-0.011	-1000.0
Arf6 signaling events	29.0	1827.0	62.0	-0.061	0.043	1000.0	-1000.0	-0.039	-1000.0
S1P4 pathway	29.0	735.0	25.0	-0.065	0.038	1000.0	-1000.0	-0.013	-1000.0
EGFR-dependent Endothelin signaling events	28.0	601.0	21.0	-0.083	0.047	1000.0	-1000.0	-0.028	-1000.0
Glucocorticoid receptor regulatory network	27.0	3169.0	114.0	-0.149	0.206	1000.0	-1000.0	-0.038	-1000.0
FAS signaling pathway (CD95)	27.0	1292.0	47.0	-0.048	0.038	1000.0	-1000.0	-0.024	-1000.0
S1P5 pathway	26.0	453.0	17.0	-0.065	0.036	1000.0	-1000.0	-0.004	-1000.0
HIF-2-alpha transcription factor network	26.0	1149.0	43.0	-0.165	0.076	1000.0	-1000.0	-0.022	-1000.0
Syndecan-4-mediated signaling events	26.0	1776.0	67.0	-0.204	0.128	1000.0	-1000.0	-0.026	-1000.0
Insulin Pathway	26.0	1935.0	74.0	-0.097	0.114	1000.0	-1000.0	-0.03	-1000.0
Coregulation of Androgen receptor activity	25.0	1915.0	76.0	-0.09	0.124	1000.0	-1000.0	-0.014	-1000.0
Presenilin action in Notch and Wnt signaling	25.0	1581.0	61.0	-0.087	0.083	1000.0	-1000.0	-0.026	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	25.0	1349.0	52.0	-0.055	0.047	1000.0	-1000.0	-0.019	-1000.0
Glypican 2 network	25.0	102.0	4.0	0.023	0.043	1000.0	-1000.0	0.021	-1000.0
TCGA08_rtk_signaling	25.0	663.0	26.0	-0.096	0.032	1000.0	-1000.0	-0.013	-1000.0
Visual signal transduction: Cones	24.0	943.0	38.0	-0.057	0.033	1000.0	-1000.0	-0.017	-1000.0
Syndecan-2-mediated signaling events	24.0	1701.0	69.0	-0.01	0.102	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by PTP1B	24.0	1851.0	76.0	-0.089	0.037	1000.0	-1000.0	-0.044	-1000.0
TCR signaling in naïve CD8+ T cells	24.0	2299.0	93.0	-0.014	0.052	1000.0	-1000.0	-0.033	-1000.0
Calcium signaling in the CD4+ TCR pathway	24.0	763.0	31.0	-0.088	0.042	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	24.0	3063.0	125.0	-0.054	0.044	1000.0	-1000.0	-0.026	-1000.0
Regulation of Androgen receptor activity	23.0	1628.0	70.0	-0.039	0.191	1000.0	-1000.0	-0.035	-1000.0
IL2 signaling events mediated by STAT5	22.0	490.0	22.0	-0.096	0.076	1000.0	-1000.0	-0.021	-1000.0
BCR signaling pathway	22.0	2206.0	99.0	-0.038	0.058	1000.0	-1000.0	-0.04	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	22.0	736.0	33.0	-0.122	0.125	1000.0	-1000.0	-0.029	-1000.0
Hedgehog signaling events mediated by Gli proteins	21.0	1386.0	65.0	-0.093	0.052	1000.0	-1000.0	-0.033	-1000.0
Canonical Wnt signaling pathway	21.0	1112.0	51.0	-0.048	0.083	1000.0	-1000.0	-0.026	-1000.0
EPO signaling pathway	20.0	1106.0	55.0	-0.042	0.039	1000.0	-1000.0	-0.014	-1000.0
Regulation of p38-alpha and p38-beta	20.0	1084.0	54.0	-0.133	0.053	1000.0	-1000.0	-0.038	-1000.0
IL6-mediated signaling events	20.0	1510.0	75.0	-0.086	0.089	1000.0	-1000.0	-0.03	-1000.0
mTOR signaling pathway	19.0	1024.0	53.0	-0.029	0.025	1000.0	-1000.0	-0.032	-1000.0
Class I PI3K signaling events mediated by Akt	19.0	1334.0	68.0	-0.082	0.206	1000.0	-1000.0	-0.022	-1000.0
IL1-mediated signaling events	19.0	1187.0	62.0	-0.026	0.068	1000.0	-1000.0	-0.029	-1000.0
BARD1 signaling events	18.0	1039.0	57.0	-0.045	0.132	1000.0	-1000.0	-0.038	-1000.0
Regulation of nuclear SMAD2/3 signaling	17.0	2335.0	136.0	-0.086	0.138	1000.0	-1000.0	-0.026	-1000.0
IL12-mediated signaling events	17.0	1539.0	87.0	-0.288	0.06	1000.0	-1000.0	-0.051	-1000.0
IFN-gamma pathway	17.0	1203.0	68.0	-0.179	0.073	1000.0	-1000.0	-0.04	-1000.0
Nectin adhesion pathway	17.0	1090.0	63.0	-0.038	0.054	1000.0	-1000.0	-0.036	-1000.0
Syndecan-3-mediated signaling events	17.0	601.0	35.0	-0.06	0.097	1000.0	-1000.0	-0.009	-1000.0
Rapid glucocorticoid signaling	17.0	351.0	20.0	-0.031	0.026	1000.0	-1000.0	-0.009	-1000.0
Retinoic acid receptors-mediated signaling	16.0	974.0	58.0	-0.017	0.05	1000.0	-1000.0	-0.03	-1000.0
IL2 signaling events mediated by PI3K	16.0	943.0	58.0	-0.033	0.117	1000.0	-1000.0	-0.023	-1000.0
Regulation of Telomerase	16.0	1633.0	102.0	-0.241	0.086	1000.0	-1000.0	-0.026	-1000.0
ErbB2/ErbB3 signaling events	15.0	982.0	65.0	-0.073	0.048	1000.0	-1000.0	-0.047	-1000.0
JNK signaling in the CD4+ TCR pathway	15.0	268.0	17.0	-0.045	0.056	1000.0	-1000.0	-0.022	-1000.0
Insulin-mediated glucose transport	15.0	511.0	32.0	-0.083	0.206	1000.0	-1000.0	-0.014	-1000.0
FoxO family signaling	15.0	973.0	64.0	-0.016	0.206	1000.0	-1000.0	-0.029	-1000.0
PDGFR-beta signaling pathway	15.0	1525.0	97.0	-0.021	0.049	1000.0	-1000.0	-0.034	-1000.0
Ceramide signaling pathway	14.0	1134.0	76.0	-0.048	0.06	1000.0	-1000.0	-0.023	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	14.0	1170.0	83.0	-0.022	0.206	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by PRL	14.0	483.0	34.0	-0.037	0.091	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling in keratinocytes	14.0	621.0	43.0	-0.008	0.038	1000.0	-1000.0	-0.011	-1000.0
Caspase cascade in apoptosis	13.0	972.0	74.0	-0.029	0.148	1000.0	-1000.0	-0.022	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	13.0	623.0	45.0	-0.005	0.057	1000.0	-1000.0	-0.03	-1000.0
IL23-mediated signaling events	13.0	832.0	60.0	-0.007	0.232	1000.0	-1000.0	-0.093	-1000.0
ErbB4 signaling events	12.0	853.0	69.0	-0.049	0.055	1000.0	-1000.0	-0.023	-1000.0
Sphingosine 1-phosphate (S1P) pathway	12.0	353.0	28.0	-0.065	0.041	1000.0	-1000.0	-0.014	-1000.0
ceramide signaling pathway	12.0	629.0	49.0	-0.01	0.054	1000.0	-1000.0	-0.023	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	11.0	417.0	37.0	-0.021	0.063	1000.0	-1000.0	-0.018	-1000.0
Signaling mediated by p38-gamma and p38-delta	11.0	173.0	15.0	-0.011	0.022	1000.0	-1000.0	-0.024	-1000.0
IL27-mediated signaling events	11.0	569.0	51.0	-0.032	0.039	1000.0	-1000.0	-0.032	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	840.0	74.0	-0.048	0.077	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling in the nascent adherens junction	11.0	852.0	76.0	-0.03	0.056	1000.0	-1000.0	-0.036	-1000.0
Class IB PI3K non-lipid kinase events	10.0	30.0	3.0	-0.022	0.022	1000.0	-1000.0	-0.019	-1000.0
Canonical NF-kappaB pathway	9.0	372.0	39.0	-0.008	0.053	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class III	8.0	346.0	40.0	-0.052	0.04	1000.0	-1000.0	-0.031	-1000.0
p38 MAPK signaling pathway	8.0	356.0	44.0	-0.003	0.064	1000.0	-1000.0	-0.012	-1000.0
Signaling events mediated by HDAC Class II	7.0	562.0	75.0	-0.033	0.044	1000.0	-1000.0	-0.019	-1000.0
Arf6 trafficking events	7.0	508.0	71.0	-0.155	0.041	1000.0	-1000.0	-0.031	-1000.0
Class I PI3K signaling events	6.0	500.0	73.0	-0.023	0.042	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by HDAC Class I	5.0	522.0	104.0	-0.035	0.057	1000.0	-1000.0	-0.035	-1000.0
Arf6 downstream pathway	4.0	185.0	43.0	-0.037	0.041	1000.0	-1000.0	-0.027	-1000.0
TRAIL signaling pathway	4.0	222.0	48.0	-0.01	0.049	1000.0	-1000.0	-0.026	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	174.0	36.0	-0.041	0.043	1000.0	-1000.0	-0.023	-1000.0
VEGFR1 specific signals	4.0	268.0	56.0	-0.041	0.047	1000.0	-1000.0	-0.026	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	3.0	78.0	23.0	0.002	0.045	1000.0	-1000.0	-0.013	-1000.0
PLK2 and PLK4 events	3.0	11.0	3.0	-0.011	0.025	1000.0	-1000.0	-0.015	-1000.0
Arf1 pathway	3.0	183.0	54.0	-0.006	0.041	1000.0	-1000.0	-0.01	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	10.0	5.0	0.022	0.033	1000.0	-1000.0	0.016	-1000.0
Atypical NF-kappaB pathway	2.0	86.0	31.0	-0.011	0.026	1000.0	-1000.0	-0.016	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	2.0	59.0	27.0	-0.013	0.054	1000.0	-1000.0	-0.026	-1000.0
E-cadherin signaling events	1.0	7.0	5.0	0.019	0.038	1000.0	-1000.0	0.018	-1000.0
Circadian rhythm pathway	0.0	19.0	22.0	-0.005	0.048	1000.0	-1000.0	-0.02	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	-0.0	0.059	1000.0	-1000.0	-0.0	-1000.0
Total	4123	247768	7203	-11.6765637425	10.3374094826	131000	-131000	-3.38495127801	-131000