rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(8)	238419	8	8	8	0	3	1	1	1	2	0	0.0857	0.00194	1.000
2	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(5), FMOD(8), KERA(1), LUM(5)	1194047	20	19	20	4	10	4	1	5	0	0	0.132	0.301	1.000
3	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCL5(1), CCR3(6), HLA-DRA(6), IL3(1)	999988	15	14	15	3	8	5	0	2	0	0	0.131	0.420	1.000
4	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(1), TGDS(3), UGDH(5), UXS1(3)	1268853	13	12	13	1	4	5	1	2	1	0	0.0486	0.631	1.000
5	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(2), FOSB(3), GRIA2(17), JUND(1), PPP1R1B(1)	1225092	24	20	24	5	6	9	1	6	2	0	0.126	0.655	1.000
6	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(4), TPI1(1)	539342	5	5	5	1	2	2	1	0	0	0	0.358	0.724	1.000
7	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4), IL8(1), SLPI(1)	563163	6	5	6	2	3	2	0	1	0	0	0.495	0.762	1.000
8	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(3), GSTZ1(3), HGD(3)	730546	9	8	9	3	4	2	0	3	0	0	0.492	0.765	1.000
9	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(2), IL12A(2), IL12B(1), IL18(1)	980615	8	8	8	2	0	3	1	4	0	0	0.559	0.770	1.000
10	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2)	375013	2	2	2	1	0	1	1	0	0	0	0.822	0.785	1.000
11	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(1), TGDS(3), UGDH(5), UGP2(3), UXS1(3)	1614572	16	14	16	2	6	5	1	3	1	0	0.0632	0.869	1.000
12	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(8), GLS2(6), GLUD1(3), GLUD2(10)	1489756	27	20	27	6	6	8	0	12	1	0	0.205	0.878	1.000
13	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(3), BAD(3), CASP9(2), GH1(1), GHR(6), NFKB1(7), NFKBIA(1), PDPK1(2), PIK3R1(8), PPP2CA(3), RELA(3), YWHAH(3)	3903135	42	29	42	7	8	15	3	9	7	0	0.0257	0.887	1.000
14	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(5), AASS(6), KARS(5)	1553133	16	12	16	2	4	6	1	5	0	0	0.117	0.888	1.000
15	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8)	1855447	24	19	23	5	3	7	0	10	4	0	0.212	0.889	1.000
16	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2), CASP3(2), CASP8(8), CFL1(1)	1273104	13	12	13	3	3	4	1	4	1	0	0.380	0.891	1.000
17	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(3), ACAT2(3), OXCT1(6)	1112143	12	11	12	4	1	8	0	2	1	0	0.608	0.893	1.000
18	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2), LIPT1(4)	502082	6	6	6	2	1	3	0	0	2	0	0.589	0.897	1.000
19	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(5), HLA-DRA(6)	781158	11	10	11	4	4	4	0	3	0	0	0.560	0.908	1.000
20	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(4)	692992	7	7	7	2	3	0	0	2	2	0	0.639	0.910	1.000
21	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(30), CDC25A(3), CDC25B(4), CDC25C(7), CHEK1(4), MYT1(14), WEE1(2), YWHAH(3)	4533076	67	43	65	13	20	15	3	18	9	2	0.0393	0.929	1.000
22	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(6), CD4(5), HLA-DRA(6), IL1B(2), IL4(1), IL5RA(4)	1755840	25	18	25	7	9	7	0	6	3	0	0.273	0.932	1.000
23	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(18), AKT1(3), ATM(30), BAX(1), CDKN1A(1), CPB2(6), CSNK1A1(3), CSNK1D(2), FHL2(2), HIC1(5), HIF1A(5), HSPA1A(1), IGFBP3(5), MAPK8(5), MDM2(3), NFKBIB(5), NQO1(2)	6542844	97	56	96	19	28	26	4	19	18	2	0.00339	0.933	1.000
24	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SRP19(7), SRP54(4), SRP68(2), SRP72(7), SRP9(1), SRPR(8)	2476389	31	24	31	5	11	10	1	7	2	0	0.0557	0.960	1.000
25	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(3), CDC25A(3), CDC25B(4), CDC25C(7), CSK(5), GRB2(4), PRKCA(3), PTPRA(7), SRC(2)	3030864	38	29	38	7	15	9	0	8	6	0	0.0314	0.965	1.000
26	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(3), GRB2(4), NTRK1(6), PIK3R1(8), PLCG1(16), PRKCA(3), SHC1(3), SOS1(6)	4392826	49	35	47	8	16	17	2	8	6	0	0.0116	0.967	1.000
27	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(4), ALDOB(3), ALDOC(3), TPI1(1)	1285594	11	11	11	3	3	3	1	4	0	0	0.410	0.967	1.000
28	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(30), CDC25A(3), CDC25B(4), CDC25C(7), CDK2(3), CHEK1(4), MYT1(14), RB1(6), WEE1(2), YWHAH(3)	5522460	76	45	73	13	20	20	4	20	10	2	0.0135	0.974	1.000
29	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(6), SQLE(4)	1047437	10	8	10	3	4	2	1	2	1	0	0.468	0.974	1.000
30	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(3), CD3E(2), CD4(5), CD58(1), CD8A(4), CSF3(1), IL3(1), IL8(1), KITLG(2)	2030518	22	20	22	6	4	8	2	6	2	0	0.282	0.974	1.000
31	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(4), NR3C1(5), PPARG(1), RXRA(3), TNF(1)	1901245	16	16	16	5	4	2	2	7	1	0	0.458	0.977	1.000
32	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(3), CCL2(1), CSF1(1), LDLR(7), LPL(4)	1749371	16	16	16	5	7	4	0	3	2	0	0.256	0.980	1.000
33	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(3), ACAT2(3), ACYP1(1), ACYP2(3), EHHADH(6), GCDH(5), HADHA(4), SDHB(4), SDS(2)	2563914	31	22	30	6	9	14	2	2	4	0	0.0327	0.981	1.000
34	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(1), GGT1(4), SHMT1(1), SHMT2(5)	1352041	11	11	11	8	4	0	0	2	5	0	0.919	0.985	1.000
35	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(5), CD8A(4), CSF1(1), CSF3(1), IL11(2), IL3(1), IL4(1), IL7(1), IL8(1)	1995040	17	15	17	4	5	5	1	5	1	0	0.262	0.986	1.000
36	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(3), CD3E(2), CD4(5)	1057796	10	10	10	4	1	5	1	3	0	0	0.685	0.988	1.000
37	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(9), AOC2(4), AOC3(4), CES1(8), ESD(1)	1981456	26	16	26	4	8	9	1	7	1	0	0.0444	0.990	1.000
38	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(2), FOS(1), FYN(8), JUN(3), MAPK14(1), THBS1(12)	2433210	29	22	29	7	8	10	1	7	3	0	0.154	0.990	1.000
39	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(5), PGLYRP2(2)	592724	7	6	7	3	3	3	0	1	0	0	0.670	0.991	1.000
40	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(3), SPCS1(1), SPCS3(2)	1010636	8	7	8	3	2	1	0	5	0	0	0.697	0.991	1.000
41	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(10), APOBEC1(3), APOBEC2(1), APOBEC3B(4), APOBEC3F(1), APOBEC3G(3), APOBEC4(1)	2406087	23	17	23	4	9	6	3	4	1	0	0.0934	0.992	1.000
42	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(1), FLT3(8), IGF1(4), IL11(2), IL1A(2), IL3(1), KITLG(2), TGFB1(3), TGFB2(6), TGFB3(5)	2718178	34	25	34	9	9	9	0	11	5	0	0.295	0.994	1.000
43	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(5), ERBB4(33), NRG2(6), NRG3(13), PRKCA(3), PSEN1(2)	2956158	62	44	60	17	18	18	6	15	5	0	0.140	0.994	1.000
44	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	APC(34), CREBBP(26), EP300(19), MAP2K1(5), MAP3K7(8), MAPK3(1), SKIL(2), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11)	7865498	125	69	120	29	32	36	5	22	28	2	0.0341	0.995	1.000
45	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(3), CCNH(2), CDC25A(3), CDC25B(4), CDC25C(7), MNAT1(2), SHH(4), XPO1(5)	2837526	30	17	30	5	10	9	1	7	3	0	0.0503	0.995	1.000
46	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(6), HADHA(4), SDS(2)	1591038	13	10	12	4	4	4	1	1	3	0	0.380	0.995	1.000
47	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(5), PLCG1(16), PRKCA(3), PTK2B(10)	2214210	34	26	32	8	19	6	1	4	4	0	0.123	0.996	1.000
48	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(4), ACADS(3), ACAT1(3), HADHA(4)	1776080	16	13	15	4	6	5	0	2	3	0	0.184	0.996	1.000
49	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(3), CAT(4), GH1(1), GHR(6), IGF1(4), IGF1R(15), PIK3R1(8), SHC1(3), SOD2(1)	3644761	45	32	45	11	8	17	2	11	7	0	0.114	0.997	1.000
50	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(7), NR0B2(2), NR1H3(4), NR1H4(4), RXRA(3)	1790084	23	20	23	7	13	2	0	5	3	0	0.264	0.997	1.000
51	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(4), CBS(5), CTH(2), MUT(3)	1603502	15	13	14	9	4	2	1	1	7	0	0.951	0.999	1.000
52	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(2), GBA(6), GBA3(1), GGT1(4), SHMT1(1), SHMT2(5)	1798976	19	17	19	9	8	2	1	3	5	0	0.682	0.999	1.000
53	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(3), CCL2(1), CCR5(3), CXCR4(1), FOS(1), GNAQ(3), JUN(3), MAPK14(1), MAPK8(5), PLCG1(16), PRKCA(3), PTK2B(10), SYT1(3)	4533592	54	38	52	10	22	16	2	10	4	0	0.00907	0.999	1.000
54	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(5), CD80(1), HLA-DRA(6), IL10(2), IL4(1)	1307987	15	13	15	5	6	4	0	4	1	0	0.485	0.999	1.000
55	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(8), ACO2(5), FH(2), IDH1(1), IDH2(1), MDH1(3), SDHB(4), SUCLA2(4)	2927140	28	20	27	7	14	6	0	5	3	0	0.161	0.999	1.000
56	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(6), GGPS1(1), SQLE(4)	1403200	11	8	11	4	4	3	1	2	1	0	0.585	1.000	1.000
57	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(3), B4GALT7(2), HS3ST1(2), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(3), XYLT1(8), XYLT2(7)	2111506	35	28	34	10	19	10	1	2	3	0	0.148	1.000	1.000
58	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(3), B4GALT7(2), HS3ST1(2), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(3), XYLT1(8), XYLT2(7)	2111506	35	28	34	10	19	10	1	2	3	0	0.148	1.000	1.000
59	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(9), PARK2(11), SNCA(1), SNCAIP(12), UBE2F(3), UBE2G2(1), UBE2L3(1), UBE2L6(1)	2110831	39	31	39	13	12	12	1	8	6	0	0.342	1.000	1.000
60	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(4), ARG1(2), GLS(8), GLUD1(3)	1810485	17	14	17	6	5	5	0	6	1	0	0.486	1.000	1.000
61	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(5), CPS1(18), GLS(8), GLUD1(3), GOT1(2)	2563580	38	31	38	10	11	9	2	14	2	0	0.247	1.000	1.000
62	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(1), IL1B(2), MST1(3), MST1R(10), TNF(1)	2150079	18	17	18	4	8	4	0	4	2	0	0.200	1.000	1.000
63	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(4), HADH(3), HADHA(4), HADHB(4), HSD17B4(4), MECR(4), PPT1(5), PPT2(3)	2782629	31	19	30	8	6	11	3	4	7	0	0.114	1.000	1.000
64	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(4), SNAP25(2), STX1A(2)	1071596	10	10	10	4	3	1	0	4	2	0	0.750	1.000	1.000
65	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(2), TAT(4)	864014	8	8	8	4	4	3	0	1	0	0	0.720	1.000	1.000
66	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(7), AKT1(3), ANXA1(2), CALM1(1), CALM2(3), GNAS(20), GNGT1(3), NFKB1(7), NOS3(5), NPPA(1), NR3C1(5), PIK3R1(8), RELA(3), SYT1(3)	5146022	71	50	70	15	25	19	0	17	10	0	0.0433	1.000	1.000
67	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(3), CREB1(3), GRB2(4), MAPK1(2), MAPK3(1), MAPK7(7), MEF2B(4), MEF2C(3), MEF2D(6), NTRK1(6), PIK3R1(8), PLCG1(16), RPS6KA1(6), SHC1(3)	5486126	72	43	69	15	25	24	4	10	9	0	0.00880	1.000	1.000
68	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(2), DFFA(4), DFFB(3), GZMB(2), HMGB2(2), TOP2A(3), TOP2B(8)	2937986	26	19	25	6	5	8	1	6	6	0	0.387	1.000	1.000
69	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), CAMP(2), DAG1(8), GNAQ(3), ITPKA(1), ITPKB(7)	1982156	23	19	23	8	10	4	0	7	2	0	0.434	1.000	1.000
70	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), ESCO1(4), ESCO2(4), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), SH3GLB1(1)	5433623	59	38	59	13	18	18	2	14	7	0	0.0444	1.000	1.000
71	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(7), PDXK(3), PDXP(1), PSAT1(3)	1587252	14	9	14	6	2	6	0	4	1	1	0.678	1.000	1.000
72	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAP3K14(3), MAPK14(1), MAPK8(5), NFKB1(7), RELA(3), TNFRSF13B(3), TNFRSF13C(2), TNFRSF17(1), TNFSF13B(3), TRAF2(2), TRAF3(3), TRAF6(5)	4763828	38	29	38	8	10	12	1	8	7	0	0.106	1.000	1.000
73	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(3), FOS(1), JUN(3), KEAP1(8), MAPK1(2), MAPK14(1), MAPK8(5), NFE2L2(1), PRKCA(3)	2896964	27	21	27	8	8	11	2	3	3	0	0.210	1.000	1.000
74	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(7), ELK1(3), FOS(1), GRB2(4), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(5), NGFR(4), PIK3R1(8), PLCG1(16), RAF1(7), SHC1(3), SOS1(6)	5551059	73	46	68	17	23	21	2	19	8	0	0.0447	1.000	1.000
75	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), MIOX(3), UGDH(5)	2792705	36	27	36	11	8	13	0	10	5	0	0.324	1.000	1.000
76	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(2), GOT1(2), GOT2(2), LDHA(3), LDHB(4), LDHC(1), MPST(2)	2244553	20	16	20	5	7	8	1	2	2	0	0.207	1.000	1.000
77	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(4), ACADS(3), ACADVL(1), ACSL1(2), ACSL3(6), ACSL4(2), CPT1A(7), CPT2(5), DCI(2), EHHADH(6), HADHA(4), SCP2(4), SLC25A20(2)	5524345	50	32	49	12	16	10	5	12	7	0	0.0748	1.000	1.000
78	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3)	4348062	55	35	54	14	11	17	0	18	9	0	0.137	1.000	1.000
79	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(7), FOS(1), GRB2(4), JAK2(10), JUN(3), MAP2K1(5), MAPK3(1), PIK3R1(8), PLCG1(16), PRKCA(3), RAF1(7), RASA1(11), SHC1(3), SOS1(6), STAT1(7), STAT3(6), STAT5A(4), STAT5B(6), THPO(4)	9128654	112	59	107	23	28	33	5	29	17	0	0.00745	1.000	1.000
80	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(7), CCNE1(3), CDC34(2), CDK2(3), CUL1(14), E2F1(2), RB1(6), SKP2(5), TFDP1(3)	2810669	45	32	43	14	11	21	2	9	2	0	0.189	1.000	1.000
81	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(2), IFNG(2), IL2RA(2), IL4(1), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), TGFBR3(4), TOB1(1), TOB2(4)	3477389	46	37	46	13	10	14	6	10	6	0	0.291	1.000	1.000
82	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(3), CDC34(2), CDK2(3), CUL1(14), E2F1(2), RB1(6), TFDP1(3)	2167672	33	24	31	10	11	13	2	5	2	0	0.209	1.000	1.000
83	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(5), AASDH(5), AASS(6), KARS(5)	2288651	21	17	21	7	5	10	1	5	0	0	0.461	1.000	1.000
84	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(4), ACAT1(3), ACAT2(3), EHHADH(6), HADHA(4), HADHB(4), SDS(2)	2746241	26	16	25	7	6	13	1	2	4	0	0.166	1.000	1.000
85	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(4), NR1I3(3), PTGS1(7), PTGS2(5)	1756774	23	18	23	8	8	8	1	3	3	0	0.410	1.000	1.000
86	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(5), GOT1(2), GOT2(2), TAT(4), TYR(6)	1545208	19	18	19	7	5	7	1	6	0	0	0.555	1.000	1.000
87	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(1), RB1(6), SP1(6), SP3(3)	2189978	16	14	15	5	2	9	0	3	2	0	0.445	1.000	1.000
88	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(3), MTMR1(4), MTMR2(3), MTMR6(5), PHPT1(2), THTPA(2), TPK1(4)	2111496	23	18	23	7	5	11	1	4	2	0	0.425	1.000	1.000
89	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(6), IFNAR1(5), IFNAR2(6), IFNB1(2), MAPK8(5), NFKB1(7), RELA(3), TNFRSF11A(3), TNFSF11(1), TRAF6(5)	3635783	44	33	44	12	13	15	1	10	5	0	0.164	1.000	1.000
90	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(3), CUL1(14), E2F1(2), RB1(6), RBX1(1), SKP2(5), TFDP1(3)	2826466	37	26	35	10	9	17	2	6	3	0	0.138	1.000	1.000
91	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(19), CPT1A(7), LEPR(13), PRKAA1(4), PRKAA2(5), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(3)	4760287	58	34	58	13	17	13	2	20	6	0	0.0959	1.000	1.000
92	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(26), EP300(19), ESR1(7), MAPK1(2), MAPK3(1), PELP1(5), SRC(2)	4802100	62	42	61	16	24	17	2	10	9	0	0.0609	1.000	1.000
93	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(3), APAF1(5), ATM(30), BAD(3), BAX(1), BCL2(2), BID(2), CASP3(2), CASP6(1), CASP7(2), CASP9(2), EIF2S1(2), PRKCA(3), PTK2(10), PXN(3), STAT1(7), TLN1(14)	8727169	92	52	90	20	29	25	9	16	11	2	0.0118	1.000	1.000
94	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(3), BCAR1(4), GRB2(4), ILK(3), ITGB1(6), MAPK1(2), MAPK3(1), PDPK1(2), PIK3R1(8), PTK2(10), SHC1(3), SOS1(6)	5328035	52	34	51	10	13	16	4	9	10	0	0.0267	1.000	1.000
95	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM2(3), CDKN1A(1), GNAQ(3), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKCA(3), SP1(6), SP3(3), SYT1(3)	6870159	94	57	92	25	37	29	1	15	12	0	0.0199	1.000	1.000
96	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(3), COASY(1), DPYD(12), DPYS(7), ENPP1(5), ENPP3(4), PANK1(4), PANK2(3), PANK3(1), PANK4(1), PPCS(2), UPB1(2)	4574881	45	31	43	13	8	11	3	16	7	0	0.229	1.000	1.000
97	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(4), ACOX3(8), FADS2(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5)	3331593	45	35	44	12	19	7	3	15	1	0	0.183	1.000	1.000
98	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(7), ELK1(3), FOS(1), GRB2(4), IGF1(4), IGF1R(15), IRS1(15), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(5), PIK3R1(8), PTPN11(5), RAF1(7), RASA1(11), SHC1(3), SOS1(6), SRF(1)	7419300	104	56	101	28	28	30	2	26	18	0	0.0661	1.000	1.000
99	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(3), ACAD9(5), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), ESCO1(4), ESCO2(4), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), SH3GLB1(1)	8198671	94	50	93	18	25	31	3	24	11	0	0.00300	1.000	1.000
100	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(2), CHST12(4), CHST13(2), PAPSS1(4), PAPSS2(4), SULT1A1(2), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(2)	3016658	31	23	31	9	16	8	1	5	1	0	0.217	1.000	1.000
101	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(21), C5(11), C6(10), C7(2), C8A(5), C9(6)	4139342	55	34	54	16	17	16	3	14	5	0	0.239	1.000	1.000
102	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(7), ELK1(3), FOS(1), GRB2(4), INSR(12), IRS1(15), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(5), PIK3R1(8), PTPN11(5), RAF1(7), RASA1(11), SHC1(3), SLC2A4(4), SOS1(6), SRF(1)	7639402	101	55	98	27	29	30	2	19	21	0	0.0444	1.000	1.000
103	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	DNAJC3(3), EIF2S1(2), EIF2S2(3), MAP3K14(3), NFKB1(7), NFKBIA(1), RELA(3)	2934948	22	15	22	6	6	8	0	6	2	0	0.374	1.000	1.000
104	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(3), CREM(3), FOS(1), JUN(3), MAPK3(1), OPRK1(6), POLR2A(15), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7)	4223145	54	38	52	16	18	21	2	9	4	0	0.0947	1.000	1.000
105	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(3), ACAT2(3), ACOT11(4), ACYP1(1), ACYP2(3), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), EHHADH(6), ESCO1(4), ESCO2(4), FN3K(2), GCDH(5), HADHA(4), ITGB1BP3(2), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), SH3GLB1(1), YOD1(2)	8520651	94	49	93	20	26	37	4	16	11	0	0.00388	1.000	1.000
106	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(20), GNA12(1), PRKACB(2), PRKACG(5), PRKAG1(3), PRKAR2A(2), PRKAR2B(7)	3309933	40	29	40	11	9	15	2	8	6	0	0.188	1.000	1.000
107	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	HLA-A(6), IL18(1), ITGB1(6), KLRC1(3), KLRC2(2), KLRC3(4), KLRD1(4), LAT(2), MAP2K1(5), MAPK3(1), PAK1(5), PIK3R1(8), PTK2B(10), PTPN6(3), SYK(6), VAV1(6)	5316019	72	53	70	20	17	24	1	19	11	0	0.138	1.000	1.000
108	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(4), GSS(3), IL8(1), NFKB1(7), NOX1(4), RELA(3), TNF(1), XDH(11)	3266058	35	25	35	10	7	14	2	9	3	0	0.212	1.000	1.000
109	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(4), ATM(30), BRCA1(14), CDKN1A(1), CHEK1(4), CHEK2(7), JUN(3), MAPK8(5), MDM2(3), MRE11A(2), NFKB1(7), NFKBIA(1), RAD50(9), RAD51(1), RBBP8(6), RELA(3), TP73(2)	9518657	102	59	101	21	23	26	6	30	15	2	0.0218	1.000	1.000
110	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(3), BCAT2(5), COASY(1), DPYD(12), DPYS(7), ENPP1(5), ENPP3(4), ILVBL(3), PANK1(4), PANK2(3), PANK3(1), PANK4(1), PPCDC(1), PPCS(2), UPB1(2), VNN1(1)	5682071	55	35	53	15	15	13	3	17	7	0	0.130	1.000	1.000
111	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(4), CRK(1), CXCR4(1), GNAI1(1), GNAQ(3), GNGT1(3), MAP2K1(5), MAPK1(2), MAPK3(1), NFKB1(7), PIK3C2G(7), PIK3R1(8), PLCG1(16), PRKCA(3), PTK2(10), PTK2B(10), PXN(3), RAF1(7), RELA(3)	8331611	95	52	91	19	30	23	4	21	17	0	0.00474	1.000	1.000
112	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(4), ALAS1(2), ALAS2(9), CPOX(2), FECH(6), HMBS(2), PPOX(2), UROD(1), UROS(3)	2493490	31	26	31	9	8	8	2	10	3	0	0.388	1.000	1.000
113	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(12), GABRA2(5), GABRA3(7), GABRA4(7), GABRA5(5), GABRA6(8), GPX1(1), PRKCE(8)	2583328	53	36	53	21	13	11	7	19	3	0	0.647	1.000	1.000
114	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(6), F13A1(10), F2(5), F2R(2), FGA(7), FGB(2), FGG(2), PLAT(4), PLAU(2), PLG(11), SERPINB2(6), SERPINE1(3)	4408870	60	40	59	19	19	12	5	18	6	0	0.237	1.000	1.000
115	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(3), GRB2(4), HBXIP(1), PTK2B(10), SHC1(3), SOS1(6), SRC(2)	2903718	29	21	29	9	9	8	0	9	3	0	0.418	1.000	1.000
116	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(6), ALPL(4), ALPP(7), ALPPL2(6), FPGS(1), GGH(3), SPR(2)	2134215	29	23	28	12	19	3	0	5	2	0	0.411	1.000	1.000
117	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), B3GNT1(3), FUT1(2), FUT9(5), GCNT2(1), ST8SIA1(4)	2004983	16	15	16	7	6	3	0	7	0	0	0.656	1.000	1.000
118	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(5), BAK1(3), BAX(1), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), DIABLO(1)	4414896	42	30	41	10	13	11	1	13	4	0	0.208	1.000	1.000
119	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(23), CR2(8), FCGR2B(3), HLA-DRA(6), ICAM1(1), ITGAL(11), ITGB2(5), PTPRC(15)	4996443	73	46	69	23	21	26	0	19	7	0	0.240	1.000	1.000
120	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(4), CYB5R3(1), GCK(4), GFPT1(3), GNE(5), GNPDA1(3), GNPDA2(2), HEXA(2), HEXB(2), HK1(11), HK2(8), HK3(5), PGM3(10), RENBP(2), UAP1(3)	5564768	65	43	65	17	21	21	3	16	4	0	0.0676	1.000	1.000
121	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(1), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(6), NDUFS2(2), NDUFV1(2)	2273199	22	19	22	7	5	7	1	7	2	0	0.546	1.000	1.000
122	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(4), PAPSS2(4), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(2)	2009771	21	17	21	7	10	7	0	3	1	0	0.526	1.000	1.000
123	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(7), CYP2A6(5), CYP2A7(5), NAT1(1), NAT2(4), XDH(11)	2622443	37	29	37	12	9	15	1	12	0	0	0.290	1.000	1.000
124	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(4), ALAS1(2), ALAS2(9), CPO(3), FECH(6), GATA1(3), HBB(1), HMBS(2), UROD(1), UROS(3)	2579949	34	28	34	10	9	7	3	12	3	0	0.424	1.000	1.000
125	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(4), AP2M1(5), ARF1(4), BAD(3), BTK(2), EEA1(9), GRASP(1), GSK3A(2), GSK3B(4), LYN(4), PDPK1(2), PFKL(4), PFKM(3), PFKP(8), PLCG1(16), PRKCE(8), RAB5A(2), RPS6KB1(4), VAV2(11)	8194563	99	48	97	26	35	30	6	18	9	1	0.0276	1.000	1.000
126	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AGPAT6(3), AGPS(1), CHPT1(3), ENPP2(5), ENPP6(5), PAFAH1B1(5), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(1), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLD1(13), PLD2(13), PPAP2A(1), PPAP2C(4)	7613397	97	45	97	18	31	33	4	19	10	0	0.000826	1.000	1.000
127	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(5), ARHGAP5(11), ARHGDIB(1), CASP1(2), CASP10(5), CASP3(2), CASP8(8), CASP9(2), GZMB(2), JUN(3), PRF1(1)	4235643	42	33	41	13	9	9	4	13	6	1	0.468	1.000	1.000
128	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), ENO1(2), GPI(5), HK1(11), PFKL(4), PGK1(4), PKLR(5), TPI1(1)	3037998	35	28	35	12	11	11	2	10	1	0	0.330	1.000	1.000
129	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(3), EIF2B5(6), EIF2S1(2), EIF2S2(3), EIF4E(2), EIF4EBP1(2), GSK3B(4), IGF1(4), IGF1R(15), INPPL1(14), PDPK1(2), PIK3R1(8), PPP2CA(3), RPS6(1), RPS6KB1(4)	5464798	73	44	71	19	22	20	2	15	14	0	0.157	1.000	1.000
130	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(1), JUN(3), MAP2K1(5), MAPK1(2), MAPK3(1), MYC(3), NFKB1(7), NFKBIA(1), PLCB1(13), PRKCA(3), RAF1(7), RELA(3), TNF(1)	5102124	52	36	49	16	16	13	1	18	4	0	0.252	1.000	1.000
131	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(13), HSD17B1(4), HSD17B2(2), HSD17B3(1), HSD17B4(4), HSD17B7(2), HSD3B1(1), HSD3B2(3)	2662456	33	29	33	12	6	10	2	11	4	0	0.413	1.000	1.000
132	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(6), NDUFA1(1), SDHA(6), SDHB(4), SDHC(1), UQCRC1(2)	2174679	22	18	22	9	9	6	2	3	2	0	0.556	1.000	1.000
133	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(3), FDPS(6), HMGCR(6), LSS(4), MVD(2), MVK(8), NQO1(2), NQO2(3), SC5DL(4), SQLE(4)	3613235	42	26	40	13	13	10	1	12	6	0	0.328	1.000	1.000
134	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(3), BCL2(2), BCR(9), CRKL(1), FOS(1), GRB2(4), JAK2(10), JUN(3), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK3(1), MAPK8(5), MYC(3), PIK3R1(8), RAF1(7), SOS1(6), STAT1(7), STAT5A(4), STAT5B(6)	8504524	101	56	97	27	25	32	2	23	19	0	0.0556	1.000	1.000
135	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(10), EIF2AK4(7), EIF2B5(6), EIF2S1(2), EIF2S2(3), EIF5(5), GSK3B(4), PPP1CA(2)	3790495	39	30	39	11	8	13	1	13	4	0	0.317	1.000	1.000
136	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(3), CDC25B(4), CDKN1A(1), CHEK1(4), NEK1(2), WEE1(2)	2266134	16	14	16	6	5	6	0	4	1	0	0.711	1.000	1.000
137	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(3), NFKB1(7), NFKBIA(1), PLCB1(13), PRKCA(3), RELA(3)	2704713	30	23	29	10	9	7	0	9	5	0	0.483	1.000	1.000
138	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(2), BFAR(2), BRAF(9), CAMP(2), CREB1(3), CREB3(4), CREB5(4), MAPK1(2), RAF1(7), SNX13(6), SRC(2), TERF2IP(4)	3679905	47	33	45	14	15	12	0	13	7	0	0.321	1.000	1.000
139	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(3), ACAT2(3), BDH1(4), HMGCS1(1), HMGCS2(3), OXCT1(6), OXCT2(1)	2364535	21	18	21	9	5	8	1	6	1	0	0.721	1.000	1.000
140	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD3E(2), CD80(1), CD86(2), CTLA4(3), GRB2(4), HLA-DRA(6), ICOS(1), ITK(5), LCK(3), PIK3R1(8), PTPN11(5)	3488891	40	35	40	12	11	13	2	9	5	0	0.311	1.000	1.000
141	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(19), ACACB(22), FASN(14), MCAT(2), OXSM(3)	5146327	60	36	59	17	17	15	2	17	9	0	0.156	1.000	1.000
142	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(1), EPOR(2), GRIN1(4), HIF1A(5), JAK2(10), NFKB1(7), NFKBIA(1), RELA(3), SOD2(1)	4148563	35	23	35	11	6	12	1	8	8	0	0.421	1.000	1.000
143	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(18), ABCB11(8), ABCB4(17), ABCC1(9), ABCC3(8)	4713923	60	40	60	19	16	19	3	12	10	0	0.196	1.000	1.000
144	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA2(1), PSMA3(2), PSMA4(4), PSMA6(4), PSMA7(4), PSMB1(2), PSMB10(1), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(1), PSMB8(3), PSMB9(1)	2874614	33	22	32	11	12	11	2	5	3	0	0.361	1.000	1.000
145	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(3), ALOX15(3), ALOX15B(3), ALOX5(6), ALOX5AP(3), DPEP1(1), GGT1(4), LTA4H(4), PLA2G2A(1), PLA2G6(5), PTGDS(1), PTGIS(5), PTGS1(7), PTGS2(5), TBXAS1(2)	4926750	53	38	53	15	20	12	4	10	7	0	0.106	1.000	1.000
146	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(6), DHCR7(3), FDPS(6), HMGCR(6), HMGCS1(1), LSS(4), MVD(2), MVK(8), NSDHL(3), SC4MOL(4), SC5DL(4), SQLE(4)	4313277	51	31	49	16	14	11	2	16	8	0	0.396	1.000	1.000
147	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(5), CDO1(1), CTH(2), GOT1(2), GOT2(2), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), MPST(2), SDS(2), SULT1B1(3), SULT1C2(1), SULT1C4(2), SULT4A1(1)	4110623	39	27	39	12	15	14	1	6	3	0	0.214	1.000	1.000
148	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(3), BAD(3), CASP9(2), CDC42(1), ELK1(3), MAP2K1(5), MAPK3(1), NFKB1(7), PIK3R1(8), RAF1(7), RALBP1(5), RALGDS(10), RELA(3)	5404530	58	38	55	17	19	19	2	10	8	0	0.148	1.000	1.000
149	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(7), ELK1(3), EPOR(2), FOS(1), GRB2(4), JAK2(10), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(5), PLCG1(16), PTPN6(3), RAF1(7), SHC1(3), SOS1(6), STAT5A(4), STAT5B(6)	7054795	86	46	82	23	25	29	2	23	7	0	0.0911	1.000	1.000
150	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(13), AP2A1(4), AP2M1(5), BIN1(2), CALM1(1), CALM2(3), DNM1(5), EPN1(1), PICALM(2), PPP3CA(5), PPP3CB(6), PPP3CC(3), SYNJ1(7), SYNJ2(9), SYT1(3)	7108672	69	46	68	19	21	15	3	21	9	0	0.118	1.000	1.000
151	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(5), BAD(3), BAK1(3), BAX(1), BCL10(1), BCL2(2), BCL2L11(1), BID(2), CASP8AP2(7), CASP9(2), CES1(8)	3588047	35	20	35	12	13	12	1	7	2	0	0.398	1.000	1.000
152	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA2(1), PSMA3(2), PSMA4(4), PSMA6(4), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(1), PSMC2(5), PSMC3(6), PSMD1(2), PSMD11(2), PSMD12(2), PSMD13(2), PSMD2(12), PSMD6(1)	5259356	60	33	59	15	21	20	2	13	4	0	0.102	1.000	1.000
153	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG5(1), ATG7(4), BECN1(6), GABARAPL1(4), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNG(2), PIK3C3(10), PIK3R4(10), PRKAA1(4), PRKAA2(5), ULK1(11), ULK2(5)	6919459	88	47	86	25	18	22	8	29	11	0	0.176	1.000	1.000
154	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(3), B3GAT2(2), B3GAT3(3), B4GALT7(2), CHPF(2), CHST11(2), CHST12(4), CHST13(2), CHST14(2), CHST3(3), CHST7(7), CHSY1(4), DSE(5), UST(7), XYLT1(8), XYLT2(7)	4526816	63	39	63	18	33	19	1	8	2	0	0.0633	1.000	1.000
155	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(3), APC(34), AXIN1(8), CCND1(1), CD14(2), CTNNB1(16), DVL1(4), FZD1(7), GJA1(9), GNAI1(1), GSK3B(4), IRAK1(5), LBP(1), LEF1(5), LY96(1), MYD88(1), NFKB1(7), PDPK1(2), PIK3R1(8), PPP2CA(3), RELA(3), TIRAP(1), TLR4(18), TOLLIP(2), WNT1(5)	9336845	151	84	144	38	33	38	6	39	32	3	0.0234	1.000	1.000
156	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(1), DAB1(8), FYN(8), LRP8(3), RELN(37), VLDLR(5)	4608160	64	38	64	22	17	26	2	12	7	0	0.224	1.000	1.000
157	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(9), ACY1(2), ADC(1), AGMAT(1), ALDH18A1(6), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AMD1(3), AOC2(4), AOC3(4), ARG1(2), ASL(5), ASS1(7), CPS1(18), GATM(3), MAOA(1), MAOB(3), NAGS(1), ODC1(3), OTC(2), SAT1(1), SMS(3), SRM(1)	9671378	108	49	108	26	30	38	5	27	8	0	0.0116	1.000	1.000
158	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(4), EPX(6), LPO(7), MPO(6), MTHFR(6), PRDX6(1), SHMT1(1), SHMT2(5), TPO(15)	3800101	54	40	54	17	21	10	3	12	8	0	0.315	1.000	1.000
159	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(6), DCXR(1), GUSB(8), RPE(4), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(2), UGT2B4(3)	5742609	52	31	52	15	15	19	1	11	6	0	0.139	1.000	1.000
160	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(7), MBTPS1(8), MBTPS2(3), SCAP(9), SREBF1(8), SREBF2(5)	3866039	41	28	41	13	16	14	1	8	2	0	0.193	1.000	1.000
161	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(3), ENO3(4), FARS2(6), GOT1(2), GOT2(2), PAH(4), TAT(4), YARS(3)	2730565	30	23	30	10	11	10	0	7	2	0	0.413	1.000	1.000
162	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(11), KHK(2), LCT(15), MPI(3), PGM1(2), PYGL(6), PYGM(9), TPI1(1), TREH(3)	4393626	52	38	52	17	23	17	1	6	5	0	0.228	1.000	1.000
163	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(5), CSF1(1), CSF3(1), HLA-DRA(6), IFNA1(1), IFNB1(2), IFNG(2), IL10(2), IL11(2), IL12A(2), IL12B(1), IL13(1), IL1A(2), IL3(1), IL4(1), IL7(1), IL8(1), LTA(3), PDGFA(2), TGFB1(3), TGFB2(6), TGFB3(5), TNF(1)	4366098	52	38	52	18	15	16	2	15	4	0	0.411	1.000	1.000
164	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(3), CREB1(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K6(1), MAP3K1(9), MAPK1(2), MAPK14(1), MAPK3(1), NFKB1(7), PIK3R1(8), RB1(6), RELA(3), SP1(6)	5650593	64	43	60	18	12	25	2	12	13	0	0.145	1.000	1.000
165	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(3), PIK3R1(8), PLCB1(13), PLCG1(16), PRKCA(3), VAV1(6)	3497174	49	35	46	15	17	15	1	7	9	0	0.289	1.000	1.000
166	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(4), ACO1(8), ACO2(5), ACSS1(9), ACSS2(6), FH(2), IDH1(1), IDH2(1), MDH1(3), SUCLA2(4)	4373260	43	29	42	14	19	8	3	7	6	0	0.241	1.000	1.000
167	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(3), BAX(1), BCL2(2), CASP8(8), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK1(2), MAPK3(1), MAPK8(5), NFKB1(7), NSMAF(7), RAF1(7), RELA(3), RIPK1(1), SMPD1(5), TNFRSF1A(3), TRADD(2), TRAF2(2)	6723990	80	47	76	25	30	19	2	15	14	0	0.192	1.000	1.000
168	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(26), EP300(19), LPL(4), NCOA1(12), NCOA2(21), PPARG(1), RXRA(3)	6067007	86	45	85	28	25	28	4	18	11	0	0.233	1.000	1.000
169	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(3), CCND1(1), CCNE1(3), CDK2(3), CDK6(4), CDKN1A(1), E2F1(2), MAPK1(2), MAPK3(1), NFKB1(7), NFKBIA(1), PAK1(5), PIK3R1(8), RAF1(7), RB1(6), RELA(3), TFDP1(3)	5919420	60	38	58	17	13	22	2	14	9	0	0.200	1.000	1.000
170	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(26), DAXX(9), PAX3(7), PML(7), RARA(2), RB1(6), SIRT1(4), SP100(10), TNF(1), TNFRSF1A(3), TNFRSF1B(1)	5957742	76	51	75	24	28	22	2	14	10	0	0.169	1.000	1.000
171	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(5), ATM(30), BAX(1), BCL2(2), CCND1(1), CCNE1(3), CDK2(3), CDKN1A(1), E2F1(2), MDM2(3), PCNA(2), RB1(6), TIMP3(3)	5688841	62	38	60	17	16	19	3	16	6	2	0.219	1.000	1.000
172	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1L(1), BNIP1(4), GOSR1(2), GOSR2(1), SEC22B(1), SNAP25(2), SNAP29(1), STX10(3), STX11(5), STX12(1), STX16(5), STX17(1), STX18(1), STX19(3), STX2(2), STX3(2), STX4(1), STX5(1), STX6(5), STX7(2), STX8(3), TSNARE1(6), USE1(4), VAMP4(1), VAMP5(1), VAMP7(4), VTI1A(1), VTI1B(3), YKT6(1)	5487041	68	37	68	19	27	19	2	13	7	0	0.143	1.000	1.000
173	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(3), BAD(3), GRB2(4), IGF1R(15), IRS1(15), MAP2K1(5), MAPK1(2), MAPK3(1), PIK3R1(8), RAF1(7), SHC1(3), SOS1(6), YWHAH(3)	5513018	75	44	73	23	22	26	1	15	11	0	0.199	1.000	1.000
174	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(3), ABP1(9), AOC2(4), AOC3(4), CES1(8), CES7(7), DDHD1(9), ESCO1(4), ESCO2(4), LIPA(1), MYST3(20), MYST4(15), NAT6(2), PLA1A(2), PNPLA3(1), PRDX6(1), SH3GLB1(1)	8314382	95	47	94	26	27	30	3	26	9	0	0.0858	1.000	1.000
175	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(9), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), AOC2(4), AOC3(4), DDC(5), EPX(6), GOT1(2), GOT2(2), HPD(1), LPO(7), MAOA(1), MAOB(3), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(1), TAT(4), TPO(15)	7199899	93	52	93	28	31	24	4	28	6	0	0.132	1.000	1.000
176	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(5), IFNB1(2), JAK1(6), PTPRU(16), REG1A(3), STAT1(7), STAT2(4), TYK2(4)	4095015	47	32	47	15	17	15	2	10	3	0	0.262	1.000	1.000
177	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(3), EIF4A1(3), EIF4A2(4), EIF4E(2), EIF4EBP1(2), EIF4G1(19), EIF4G2(5), EIF4G3(7), GHR(6), IRS1(15), MAPK1(2), MAPK14(1), MAPK3(1), MKNK1(3), PABPC1(2), PDPK1(2), PIK3R1(8), PRKCA(3), RPS6KB1(4)	8256109	92	52	92	23	25	30	4	17	16	0	0.0643	1.000	1.000
178	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(5), IFNAR2(6), IFNB1(2), JAK1(6), STAT1(7), STAT2(4), TYK2(4)	3549994	35	23	35	12	10	11	2	9	3	0	0.388	1.000	1.000
179	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(5), CYSLTR2(1), GPR109B(3), GPR161(3), GPR171(2), GPR18(2), GPR39(6), GPR45(9), GPR65(1), GPR68(2), GPR75(4), GPR81(3)	3234234	41	32	41	16	20	8	3	8	2	0	0.379	1.000	1.000
180	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(13), CALM1(1), CALM2(3), CAPN2(3), CAPNS1(2), CAPNS2(2), EP300(19), HDAC1(3), HDAC2(2), MEF2D(6), NFATC1(11), NFATC2(14), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKCA(3), SYT1(3)	8008371	99	48	98	28	41	24	0	19	15	0	0.0517	1.000	1.000
181	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(4), COPS5(2), CREB1(3), EDN1(2), EP300(19), HIF1A(5), JUN(3), LDHA(3), NOS3(5), P4HB(2)	5565792	49	32	48	15	16	13	3	10	7	0	0.236	1.000	1.000
182	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLRMT(10)	4398776	46	28	45	14	19	16	0	9	2	0	0.193	1.000	1.000
183	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(2), IFNGR1(5), JAK1(6), JAK2(10), PLA2G2A(1), PTPRU(16), REG1A(3), STAT1(7)	3765039	51	31	51	17	14	18	3	11	5	0	0.351	1.000	1.000
184	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(2), CALM1(1), CALM2(3), ELK1(3), FCER1A(2), FOS(1), GRB2(4), JUN(3), LYN(4), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK1(2), MAPK3(1), MAPK8(5), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), PAK2(6), PIK3R1(8), PLA2G4A(4), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), RAF1(7), SHC1(3), SOS1(6), SYK(6), SYT1(3), VAV1(6)	13182950	172	77	166	40	60	49	4	32	27	0	0.00109	1.000	1.000
185	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(30), ATR(12), CDC25C(7), CHEK1(4), CHEK2(7), YWHAH(3)	4991874	63	43	62	14	17	13	3	18	10	2	0.231	1.000	1.000
186	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1R(3), C1S(5), C2(2), C3(21), C5(11), C6(10), C7(2), C8A(5), C8B(11), C9(6), MASP1(3)	6841557	80	45	77	24	25	19	4	21	10	1	0.308	1.000	1.000
187	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM2(3), CAMK1(2), CAMK1G(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), HDAC5(6), MEF2B(4), MEF2C(3), MEF2D(6), PPARA(3), PPP3CA(5), PPP3CB(6), PPP3CC(3), SLC2A4(4), SYT1(3), YWHAH(3)	6619327	73	48	72	23	25	18	3	16	11	0	0.213	1.000	1.000
188	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(4), HK1(11), HK2(8), HK3(5), IMPA1(3), PGM1(2), PGM3(10), TGDS(3)	3361435	46	33	46	17	14	17	2	10	3	0	0.353	1.000	1.000
189	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(7), METTL6(2), PCYT1A(6), PCYT1B(5), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), WBSCR22(4)	4619591	47	31	47	16	14	16	1	10	6	0	0.339	1.000	1.000
190	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(9), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), AOC2(4), AOC3(4), ASPA(1), CNDP1(1), DDC(5), HAL(1), HARS(5), HDC(7), HNMT(2), MAOA(1), MAOB(3), PRPS1(2), PRPS2(2)	8019771	93	46	93	29	30	25	4	25	9	0	0.196	1.000	1.000
191	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), IFNG(2), IKBKB(7), IL4(1), JUN(3), MAP3K1(9), MAP3K5(4), MAP4K5(3), MAPK14(1), MAPK8(5), NFKB1(7), NFKBIA(1), RELA(3), TNFRSF9(6), TRAF2(2)	6356161	55	33	52	16	21	9	3	10	12	0	0.268	1.000	1.000
192	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(5), BIRC2(3), BIRC3(3), CASP10(5), CASP3(2), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), GZMB(2), PRF1(1), SCAP(9), SREBF1(8), SREBF2(5)	5939073	62	42	61	18	20	14	3	19	6	0	0.278	1.000	1.000
193	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	APC(34), ASAH1(2), CAMP(2), CASP3(2), CERK(5), CREB1(3), CREB3(4), CREB5(4), CXCL2(2), DAG1(8), EPHB2(8), FOS(1), GNAQ(3), ITPKA(1), ITPKB(7), JUN(3), MAP2K4(7), MAPK1(2), MAPK10(5), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4)	9111327	127	66	124	33	37	33	3	26	26	2	0.0269	1.000	1.000
194	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(7), ELK1(3), FOS(1), GRB2(4), IL2RA(2), IL2RB(2), IL2RG(5), JAK1(6), JAK3(9), JUN(3), LCK(3), MAP2K1(5), MAPK3(1), MAPK8(5), RAF1(7), SHC1(3), SOS1(6), STAT5A(4), STAT5B(6), SYK(6)	7641287	88	47	84	26	22	30	1	28	7	0	0.177	1.000	1.000
195	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(8), IL13(1), IL4(1), JUNB(1), MAF(3), MAP2K3(7), MAPK14(1), NFATC1(11), NFATC2(14), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7)	3958058	69	46	69	29	31	20	2	11	5	0	0.277	1.000	1.000
196	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	189	ACTB(7), ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), AKT1(3), AKT2(6), AKT3(6), ARHGAP5(11), BAD(3), BCAR1(4), BCL2(2), BIRC2(3), BIRC3(3), BRAF(9), CAPN2(3), CAV1(4), CAV2(2), CAV3(2), CCND1(1), CCND2(3), CCND3(2), CDC42(1), CHAD(2), COL11A1(18), COL11A2(7), COL1A1(6), COL1A2(23), COL2A1(13), COL3A1(7), COL4A1(18), COL4A2(10), COL4A4(10), COL4A6(6), COL5A1(21), COL5A2(11), COL5A3(10), COL6A1(7), COL6A2(15), COL6A3(36), COL6A6(27), COMP(2), CRK(1), CRKL(1), CTNNB1(16), DIAPH1(7), DOCK1(15), EGF(8), EGFR(11), ELK1(3), ERBB2(12), FARP2(3), FLNA(16), FLNB(11), FLNC(22), FLT1(13), FN1(23), FYN(8), GRB2(4), GRLF1(15), GSK3B(4), HGF(13), IBSP(2), IGF1(4), IGF1R(15), ILK(3), ITGA1(7), ITGA10(5), ITGA11(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGAV(5), ITGB1(6), ITGB3(3), ITGB4(12), ITGB5(5), ITGB6(3), ITGB7(4), ITGB8(8), JUN(3), KDR(8), LAMA1(36), LAMA2(23), LAMA3(17), LAMA4(14), LAMA5(23), LAMB1(11), LAMB2(16), LAMB3(14), LAMB4(13), LAMC1(11), LAMC2(7), LAMC3(13), MAP2K1(5), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(4), MET(7), MYL2(6), MYL7(1), MYL9(2), MYLK(15), MYLK2(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PARVA(1), PARVB(4), PARVG(3), PDGFA(2), PDGFB(5), PDGFC(5), PDGFD(5), PDGFRA(11), PDGFRB(10), PDPK1(2), PGF(1), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PIP5K1C(8), PPP1CA(2), PPP1CB(1), PPP1CC(4), PPP1R12A(2), PRKCA(3), PRKCG(13), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(7), RAP1A(2), RAP1B(5), RAPGEF1(9), RELN(37), ROCK1(9), ROCK2(7), SHC1(3), SHC2(2), SHC3(8), SHC4(1), SOS1(6), SOS2(11), SPP1(3), SRC(2), THBS1(12), THBS2(7), THBS3(6), THBS4(10), TLN1(14), TLN2(21), TNC(17), TNN(17), TNR(18), TNXB(38), VASP(2), VAV1(6), VAV2(11), VAV3(10), VCL(1), VEGFC(8), VTN(4), VWF(19), ZYX(5)	120704830	1504	188	1477	621	534	406	55	349	157	3	0.660	1.000	1.000
197	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY7(13), ADCY8(21), ADCY9(8), ADORA2A(1), ADORA2B(1), ADRA1A(12), ADRA1B(4), ADRA1D(2), ADRB1(7), ADRB2(7), AGTR1(1), ATP2A1(4), ATP2A2(5), ATP2A3(5), ATP2B1(10), ATP2B2(16), ATP2B3(18), ATP2B4(2), AVPR1A(8), AVPR1B(2), BDKRB1(1), BDKRB2(3), BST1(2), CACNA1A(16), CACNA1B(22), CACNA1C(27), CACNA1D(21), CACNA1E(30), CACNA1F(9), CACNA1G(15), CACNA1H(16), CACNA1I(16), CACNA1S(11), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), CCKAR(4), CCKBR(6), CD38(3), CHRM1(2), CHRM2(13), CHRM3(9), CHRM5(1), CHRNA7(2), CYSLTR1(5), CYSLTR2(1), DRD1(3), EDNRA(3), EGFR(11), ERBB2(12), ERBB3(29), ERBB4(33), F2R(2), GNA11(5), GNA14(3), GNA15(3), GNAL(2), GNAQ(3), GNAS(20), GRIN1(4), GRIN2A(11), GRIN2C(4), GRIN2D(4), GRM1(26), GRM5(23), GRPR(7), HRH1(4), HRH2(8), HTR2A(5), HTR2B(4), HTR2C(5), HTR4(4), HTR5A(7), HTR6(2), HTR7(8), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), LHCGR(10), LTB4R2(2), MYLK(15), MYLK2(2), NOS1(22), NOS3(5), NTSR1(5), OXTR(5), P2RX2(6), P2RX3(4), P2RX4(5), P2RX5(4), P2RX7(1), PDE1A(6), PDE1B(3), PDE1C(5), PDGFRA(11), PDGFRB(10), PHKA1(7), PHKA2(9), PHKB(1), PHKG1(2), PHKG2(7), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCD3(8), PLCD4(2), PLCE1(11), PLCG1(16), PLCG2(11), PLCZ1(3), PPID(3), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), PTAFR(5), PTGER3(3), PTGFR(3), PTK2B(10), RYR1(43), RYR2(61), RYR3(47), SLC25A4(2), SLC25A5(2), SLC25A6(5), SLC8A1(12), SLC8A2(9), SLC8A3(8), SPHK1(4), SPHK2(2), TACR1(3), TACR2(1), TACR3(11), TBXA2R(8), TNNC1(3), TRHR(4), TRPC1(5), VDAC1(2), VDAC2(2), VDAC3(2)	87935726	1320	182	1289	517	535	343	54	279	108	1	0.123	1.000	1.000
198	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(4), ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), ADRA1A(12), ADRA1B(4), ADRA2A(5), ADRA2B(4), ADRA2C(4), ADRB1(7), ADRB2(7), AGTR1(1), AGTR2(2), AVPR1A(8), AVPR1B(2), AVPR2(4), BDKRB1(1), BDKRB2(3), BRS3(3), C3AR1(5), C5AR1(5), CALCR(6), CALCRL(5), CCKAR(4), CCKBR(6), CGA(1), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), CNR1(7), CRHR1(10), CRHR2(3), CTSG(3), CYSLTR1(5), CYSLTR2(1), DRD1(3), DRD2(7), DRD3(7), DRD4(2), DRD5(10), EDNRA(3), F2(5), F2R(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(4), FSHB(1), GABBR1(8), GABBR2(8), GABRA1(12), GABRA2(5), GABRA3(7), GABRA4(7), GABRA5(5), GABRA6(8), GABRB1(5), GABRB2(2), GABRB3(7), GABRE(5), GABRG1(2), GABRG2(9), GABRG3(5), GABRP(4), GABRQ(9), GABRR1(6), GABRR2(4), GALR1(5), GALR2(9), GALR3(1), GH1(1), GH2(3), GHR(6), GHRHR(4), GHSR(8), GIPR(3), GLP1R(1), GLP2R(8), GLRA1(4), GLRA2(3), GLRA3(4), GLRB(8), GNRHR(4), GPR156(3), GPR35(3), GPR50(7), GPR63(1), GPR83(4), GRIA1(17), GRIA2(17), GRIA3(6), GRIA4(7), GRID1(16), GRID2(14), GRIK1(8), GRIK2(11), GRIK3(12), GRIK4(9), GRIK5(10), GRIN1(4), GRIN2A(11), GRIN2B(18), GRIN2C(4), GRIN2D(4), GRIN3A(14), GRIN3B(2), GRM1(26), GRM2(19), GRM3(12), GRM4(6), GRM5(23), GRM6(8), GRM7(15), GRM8(15), GRPR(7), GZMA(1), HCRTR1(3), HCRTR2(3), HRH1(4), HRH2(8), HRH3(3), HRH4(3), HTR1A(10), HTR1B(8), HTR1D(3), HTR1E(5), HTR1F(5), HTR2A(5), HTR2B(4), HTR2C(5), HTR4(4), HTR5A(7), HTR6(2), HTR7(8), LEPR(13), LHCGR(10), LTB4R(1), LTB4R2(2), MAS1(1), MC2R(2), MC3R(3), MC4R(5), MC5R(5), MCHR1(5), MCHR2(4), MLNR(2), MTNR1A(4), MTNR1B(6), NMBR(3), NMUR1(3), NMUR2(3), NPBWR1(10), NPBWR2(6), NPFFR1(1), NPFFR2(8), NPY1R(3), NPY2R(3), NPY5R(3), NR3C1(5), NTSR1(5), NTSR2(3), OPRD1(1), OPRK1(6), OPRL1(6), OPRM1(3), OXTR(5), P2RX2(6), P2RX3(4), P2RX4(5), P2RX5(4), P2RX7(1), P2RY1(3), P2RY10(10), P2RY13(2), P2RY14(4), P2RY2(5), P2RY4(2), P2RY6(6), P2RY8(5), PARD3(9), PPYR1(6), PRL(1), PRLHR(4), PRLR(2), PRSS1(2), PRSS3(3), PTAFR(5), PTGDR(6), PTGER2(4), PTGER3(3), PTGER4(4), PTGFR(3), PTH2R(5), RXFP1(6), RXFP2(6), SCTR(2), SSTR1(9), SSTR2(3), SSTR3(5), SSTR4(11), SSTR5(4), TAAR1(2), TAAR2(3), TAAR5(5), TAAR6(6), TAAR9(1), TACR1(3), TACR2(1), TACR3(11), TBXA2R(8), THRA(4), THRB(7), TRHR(4), TRPV1(6), TSHB(2), TSHR(8), UTS2R(1), VIPR1(2), VIPR2(3)	71890428	1209	175	1189	461	459	312	54	311	72	1	0.0273	1.000	1.000
199	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	200	ABI2(3), ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), APC(34), APC2(12), ARAF(8), ARHGEF1(9), ARHGEF12(8), ARHGEF4(5), ARHGEF6(12), ARHGEF7(7), ARPC1A(3), ARPC2(1), ARPC4(2), BAIAP2(4), BCAR1(4), BDKRB1(1), BDKRB2(3), BRAF(9), CD14(2), CDC42(1), CFL1(1), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), CRK(1), CRKL(1), CSK(5), CYFIP1(11), CYFIP2(13), DIAPH1(7), DIAPH2(6), DIAPH3(9), DOCK1(15), EGF(8), EGFR(11), EZR(3), F2(5), F2R(2), FGD1(10), FGD3(10), FGF1(2), FGF10(5), FGF11(1), FGF12(5), FGF13(7), FGF14(6), FGF17(4), FGF18(2), FGF2(2), FGF20(3), FGF21(2), FGF22(1), FGF23(1), FGF3(1), FGF5(1), FGF6(5), FGF7(2), FGF8(1), FGF9(6), FGFR1(11), FGFR2(8), FGFR3(3), FGFR4(6), FN1(23), GIT1(3), GNA12(1), GNA13(3), GNG12(1), GRLF1(15), GSN(9), IQGAP1(11), IQGAP2(8), IQGAP3(12), ITGA1(7), ITGA10(5), ITGA11(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGAD(9), ITGAE(6), ITGAL(11), ITGAM(6), ITGAV(5), ITGAX(8), ITGB1(6), ITGB2(5), ITGB3(3), ITGB4(12), ITGB5(5), ITGB6(3), ITGB7(4), ITGB8(8), LIMK1(3), LIMK2(1), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MOS(9), MSN(9), MYH10(24), MYH14(12), MYH9(23), MYL2(6), MYL7(1), MYL9(2), MYLK(15), MYLK2(2), NCKAP1(8), NCKAP1L(10), NRAS(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PDGFA(2), PDGFB(5), PDGFRA(11), PDGFRB(10), PFN2(2), PFN3(2), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1B(1), PIP5K1C(8), PPP1CA(2), PPP1CB(1), PPP1CC(4), PPP1R12A(2), PPP1R12B(12), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(7), RDX(4), ROCK1(9), ROCK2(7), RRAS(1), RRAS2(3), SCIN(5), SLC9A1(8), SOS1(6), SOS2(11), SSH1(7), SSH2(17), SSH3(6), TIAM1(28), TIAM2(20), TMSL3(1), VAV1(6), VAV2(11), VAV3(10), VCL(1), WAS(1), WASF1(3), WASF2(6), WASL(1)	89602926	1143	170	1124	446	421	298	40	250	130	4	0.463	1.000	1.000
200	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(7), CHAD(2), COL11A1(18), COL11A2(7), COL17A1(6), COL1A1(6), COL1A2(23), COL2A1(13), COL3A1(7), COL4A1(18), COL4A2(10), COL4A4(10), COL4A6(6), COL5A1(21), COL5A2(11), COL5A3(10), COL6A1(7), COL6A2(15), COL6A3(36), COL6A6(27), COMP(2), DES(1), DSC1(1), DSC2(9), DSC3(2), DSG1(4), DSG2(3), DSG3(9), DSG4(7), FN1(23), GJA1(9), GJA10(3), GJA3(1), GJA4(2), GJA5(3), GJA8(3), GJA9(3), GJB3(3), GJB4(2), GJB5(1), GJB6(5), GJB7(1), GJC1(1), GJC2(2), GJD2(3), GJD4(5), IBSP(2), INA(5), ITGA6(4), ITGB4(12), KRT1(4), KRT10(6), KRT12(3), KRT13(8), KRT14(2), KRT15(1), KRT16(7), KRT17(4), KRT18(2), KRT19(1), KRT2(8), KRT20(4), KRT23(8), KRT24(3), KRT25(6), KRT27(6), KRT28(8), KRT3(8), KRT31(5), KRT32(4), KRT33A(7), KRT33B(4), KRT34(5), KRT35(5), KRT36(5), KRT37(3), KRT38(3), KRT39(7), KRT4(4), KRT40(1), KRT5(2), KRT6A(10), KRT6B(3), KRT6C(8), KRT7(2), KRT71(2), KRT72(5), KRT73(10), KRT74(2), KRT75(2), KRT76(3), KRT77(2), KRT78(2), KRT79(3), KRT8(5), KRT81(3), KRT82(2), KRT83(3), KRT84(4), KRT85(2), KRT86(2), KRT9(1), LAMA1(36), LAMA2(23), LAMA3(17), LAMA4(14), LAMA5(23), LAMB1(11), LAMB2(16), LAMB3(14), LAMB4(13), LAMC1(11), LAMC2(7), LAMC3(13), LMNA(3), LMNB1(1), LMNB2(4), NES(5), PRPH(3), RELN(37), SPP1(3), THBS1(12), THBS2(7), THBS3(6), THBS4(10), TNC(17), TNN(17), TNR(18), TNXB(38), VIM(8), VTN(4), VWF(19)	81726449	1021	167	1012	479	359	276	41	255	89	1	0.995	1.000	1.000
201	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(6), CD36(2), CD44(4), CHAD(2), COL11A1(18), COL11A2(7), COL1A1(6), COL1A2(23), COL2A1(13), COL3A1(7), COL4A1(18), COL4A2(10), COL4A4(10), COL4A6(6), COL5A1(21), COL5A2(11), COL5A3(10), COL6A1(7), COL6A2(15), COL6A3(36), COL6A6(27), DAG1(8), FN1(23), FNDC1(13), FNDC3A(6), FNDC4(2), FNDC5(1), GP5(5), GP6(3), GP9(1), HMMR(7), HSPG2(22), IBSP(2), ITGA1(7), ITGA10(5), ITGA11(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGAV(5), ITGB1(6), ITGB3(3), ITGB4(12), ITGB5(5), ITGB6(3), ITGB7(4), ITGB8(8), LAMA1(36), LAMA2(23), LAMA3(17), LAMA4(14), LAMA5(23), LAMB1(11), LAMB2(16), LAMB3(14), LAMB4(13), LAMC1(11), LAMC2(7), LAMC3(13), RELN(37), SDC1(1), SDC2(2), SDC3(4), SDC4(3), SPP1(3), SV2A(10), SV2B(2), SV2C(6), THBS1(12), THBS2(7), THBS3(6), THBS4(10), TNC(17), TNN(17), TNR(18), TNXB(38), VTN(4), VWF(19)	73529504	886	163	876	406	315	221	33	226	90	1	0.978	1.000	1.000
202	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ADRA1A(12), ADRA1B(4), ADRA1D(2), ADRB1(7), ADRB2(7), ANXA6(2), ARRB1(3), ATP1A4(12), ATP1B1(1), ATP1B2(2), ATP1B3(3), ATP2A2(5), ATP2A3(5), ATP2B1(10), ATP2B2(16), ATP2B3(18), CACNA1A(16), CACNA1B(22), CACNA1C(27), CACNA1D(21), CACNA1E(30), CACNA1S(11), CACNB1(1), CACNB3(2), CALM1(1), CALM2(3), CALR(3), CAMK1(2), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), CASQ1(6), CASQ2(2), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), GJA1(9), GJA4(2), GJA5(3), GJB3(3), GJB4(2), GJB5(1), GJB6(5), GNA11(5), GNAI2(2), GNAI3(6), GNAQ(3), GNAZ(11), GNB2(4), GNB4(3), GNG12(1), GNG13(2), GNG7(3), GNGT1(3), GRK6(2), ITPR1(21), ITPR2(20), ITPR3(30), KCNB1(8), KCNJ3(9), KCNJ5(3), MIB1(4), NME7(1), PKIA(1), PKIG(2), PLCB3(8), PRKACA(3), PRKACB(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCQ(7), PRKD1(16), RGS1(2), RGS10(3), RGS11(1), RGS14(2), RGS16(3), RGS17(2), RGS18(4), RGS19(2), RGS2(2), RGS20(4), RGS3(13), RGS4(3), RGS5(3), RGS6(14), RGS7(2), RGS9(8), RYR1(43), RYR2(61), RYR3(47), SLC8A1(12), SLC8A3(8), USP5(4), YWHAB(1), YWHAH(3), YWHAQ(2)	61531238	908	162	897	370	361	231	40	192	83	1	0.369	1.000	1.000
203	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	243	ACVR1B(12), ACVR1C(3), AKT1(3), AKT2(6), AKT3(6), ARRB1(3), ATF2(1), BDNF(5), BRAF(9), CACNA1A(16), CACNA1B(22), CACNA1C(27), CACNA1D(21), CACNA1E(30), CACNA1F(9), CACNA1G(15), CACNA1H(16), CACNA1I(16), CACNA1S(11), CACNA2D1(7), CACNA2D2(6), CACNA2D3(13), CACNA2D4(8), CACNB1(1), CACNB2(12), CACNB3(2), CACNB4(4), CACNG1(1), CACNG2(1), CACNG3(5), CACNG4(3), CACNG5(7), CACNG6(1), CACNG7(8), CACNG8(1), CASP3(2), CD14(2), CDC25B(4), CDC42(1), CRK(1), CRKL(1), DAXX(9), DDIT3(3), DUSP1(2), DUSP10(6), DUSP14(2), DUSP16(8), DUSP2(2), DUSP3(1), DUSP5(7), DUSP6(3), DUSP8(1), DUSP9(3), ECSIT(1), EGF(8), EGFR(11), ELK1(3), ELK4(1), FAS(3), FASLG(2), FGF1(2), FGF10(5), FGF11(1), FGF12(5), FGF13(7), FGF14(6), FGF17(4), FGF18(2), FGF2(2), FGF20(3), FGF21(2), FGF22(1), FGF23(1), FGF3(1), FGF5(1), FGF6(5), FGF7(2), FGF8(1), FGF9(6), FGFR1(11), FGFR2(8), FGFR3(3), FGFR4(6), FLNA(16), FLNB(11), FLNC(22), FOS(1), GNA12(1), GNG12(1), GRB2(4), IKBKB(7), IL1A(2), IL1B(2), IL1R1(4), IL1R2(5), JUN(3), JUND(1), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K5(1), MAP2K6(1), MAP3K1(9), MAP3K10(8), MAP3K12(9), MAP3K13(7), MAP3K14(3), MAP3K2(3), MAP3K3(4), MAP3K4(15), MAP3K5(4), MAP3K6(5), MAP3K7(8), MAP4K1(3), MAP4K2(4), MAP4K3(3), MAP4K4(8), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(7), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), MAPKAPK2(1), MAPKAPK3(4), MAPKAPK5(1), MAPT(4), MAX(3), MEF2C(3), MKNK1(3), MKNK2(1), MOS(9), MYC(3), NF1(15), NFATC2(14), NFATC4(12), NFKB1(7), NFKB2(2), NLK(6), NR4A1(4), NRAS(2), NTF3(3), NTRK1(6), NTRK2(9), PAK1(5), PAK2(6), PDGFA(2), PDGFB(5), PDGFRA(11), PDGFRB(10), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PPM1A(3), PPM1B(8), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PPP5C(6), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), PTPN5(1), PTPN7(3), PTPRR(7), RAC2(2), RAC3(3), RAF1(7), RAP1A(2), RAP1B(5), RAPGEF2(10), RASA1(11), RASA2(4), RASGRF1(7), RASGRF2(12), RASGRP1(5), RASGRP2(6), RASGRP3(4), RASGRP4(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KA4(1), RPS6KA5(2), RRAS(1), RRAS2(3), SOS1(6), SOS2(11), SRF(1), STK3(4), STK4(3), STMN1(2), TAOK1(10), TAOK2(15), TAOK3(9), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), TNF(1), TNFRSF1A(3), TRAF2(2), TRAF6(5), ZAK(7)	92408588	1190	162	1166	420	456	326	48	222	137	1	0.00338	1.000	1.000
204	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(4), ABLIM1(9), ABLIM2(3), ABLIM3(4), ARHGEF12(8), CDC42(1), CDK5(2), CFL1(1), CXCR4(1), DCC(22), DPYSL2(1), DPYSL5(6), EFNA1(2), EFNA2(1), EFNA4(1), EFNA5(2), EFNB1(2), EFNB2(3), EFNB3(3), EPHA1(10), EPHA2(9), EPHA3(15), EPHA4(14), EPHA5(22), EPHA6(22), EPHA7(4), EPHA8(11), EPHB1(18), EPHB2(8), EPHB3(11), EPHB4(8), EPHB6(8), FES(6), FYN(8), GNAI1(1), GNAI2(2), GNAI3(6), GSK3B(4), ITGB1(6), L1CAM(12), LIMK1(3), LIMK2(1), LRRC4C(2), MAPK1(2), MAPK3(1), MET(7), NCK1(6), NCK2(3), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NGEF(6), NRAS(2), NRP1(13), NTN1(6), NTN4(2), NTNG1(14), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PLXNA1(24), PLXNA2(17), PLXNA3(11), PLXNB1(10), PLXNB2(11), PLXNB3(11), PLXNC1(14), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PTK2(10), RAC2(2), RAC3(3), RASA1(11), RGS3(13), RHOD(1), RND1(1), ROBO1(21), ROBO2(21), ROBO3(6), ROCK1(9), ROCK2(7), SEMA3A(14), SEMA3B(4), SEMA3C(6), SEMA3D(10), SEMA3E(9), SEMA3F(10), SEMA3G(5), SEMA4A(5), SEMA4B(5), SEMA4C(4), SEMA4D(11), SEMA4F(6), SEMA4G(1), SEMA5A(20), SEMA5B(13), SEMA6A(13), SEMA6B(3), SEMA6C(6), SEMA6D(15), SEMA7A(8), SLIT1(5), SLIT2(23), SLIT3(11), SRGAP1(11), SRGAP2(5), SRGAP3(7), UNC5A(8), UNC5B(6), UNC5C(12), UNC5D(12)	64275491	920	159	912	361	306	228	57	228	98	3	0.532	1.000	1.000
205	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(7), ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), AKT1(3), AKT2(6), AKT3(6), AMOTL1(5), ASH1L(28), CASK(2), CDC42(1), CGN(7), CLDN1(2), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(4), CLDN18(2), CLDN19(3), CLDN20(3), CLDN22(2), CLDN23(2), CLDN3(1), CLDN4(5), CLDN5(2), CLDN6(4), CLDN8(1), CLDN9(3), CSDA(4), CSNK2A1(7), CSNK2A2(4), CSNK2B(1), CTNNA1(11), CTNNA2(16), CTNNA3(9), CTNNB1(16), CTTN(5), EPB41(7), EPB41L1(5), EPB41L2(8), EPB41L3(19), EXOC3(3), EXOC4(7), F11R(2), GNAI1(1), GNAI2(2), GNAI3(6), HCLS1(3), IGSF5(2), INADL(9), JAM2(2), JAM3(4), LLGL1(8), LLGL2(5), MAGI1(14), MAGI2(23), MAGI3(4), MLLT4(18), MPDZ(18), MPP5(1), MYH1(17), MYH10(24), MYH11(18), MYH13(20), MYH14(12), MYH15(10), MYH2(23), MYH3(23), MYH4(16), MYH6(24), MYH7(15), MYH7B(15), MYH8(13), MYH9(23), MYL2(6), MYL7(1), MYL9(2), NRAS(2), OCLN(4), PARD3(9), PARD6A(1), PARD6B(3), PARD6G(3), PPM1J(2), PPP2CA(3), PPP2CB(2), PPP2R1A(9), PPP2R1B(4), PPP2R2A(5), PPP2R2B(5), PPP2R2C(5), PPP2R3A(7), PPP2R3B(6), PPP2R4(3), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCI(4), PRKCQ(7), RAB13(2), RAB3B(3), RRAS(1), RRAS2(3), SPTAN1(18), SRC(2), SYMPK(5), TJAP1(2), TJP1(11), TJP2(8), TJP3(6), VAPA(1), YES1(2), ZAK(7)	63136515	844	157	833	293	300	225	32	209	77	1	0.0568	1.000	1.000
206	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	128	ALCAM(6), CADM1(11), CADM3(5), CD2(2), CD22(3), CD226(2), CD274(1), CD276(6), CD34(3), CD4(5), CD40(1), CD40LG(4), CD58(1), CD6(5), CD80(1), CD86(2), CD8A(4), CD8B(2), CD99(1), CDH15(4), CDH2(11), CDH3(8), CDH4(17), CDH5(5), CLDN1(2), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(4), CLDN18(2), CLDN19(3), CLDN20(3), CLDN22(2), CLDN23(2), CLDN3(1), CLDN4(5), CLDN5(2), CLDN6(4), CLDN8(1), CLDN9(3), CNTN1(15), CNTN2(7), CNTNAP1(15), CNTNAP2(29), CTLA4(3), ESAM(5), F11R(2), GLG1(13), HLA-A(6), HLA-C(3), HLA-DMA(1), HLA-DMB(3), HLA-DOA(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(6), HLA-E(3), HLA-F(7), HLA-G(3), ICAM1(1), ICAM2(2), ICAM3(1), ICOS(1), ITGA4(9), ITGA6(4), ITGA8(5), ITGA9(7), ITGAL(11), ITGAM(6), ITGAV(5), ITGB1(6), ITGB2(5), ITGB7(4), ITGB8(8), JAM2(2), JAM3(4), L1CAM(12), MAG(9), MPZ(2), MPZL1(1), NCAM1(4), NCAM2(16), NEGR1(6), NEO1(10), NFASC(15), NLGN1(13), NLGN2(8), NLGN3(10), NRCAM(8), NRXN1(27), NRXN2(20), NRXN3(21), OCLN(4), PDCD1(2), PDCD1LG2(1), PTPRC(15), PTPRF(15), PTPRM(25), PVR(2), PVRL1(1), PVRL2(4), PVRL3(4), SDC1(1), SDC2(2), SDC3(4), SDC4(3), SELE(4), SELL(4), SELP(6), SELPLG(6), SIGLEC1(9), SPN(3), VCAM1(8), VCAN(35)	47628970	703	154	690	280	241	209	20	174	59	0	0.276	1.000	1.000
207	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(5), ACVR1B(12), ACVR2A(6), ACVR2B(3), AMHR2(2), BMP2(2), BMP7(5), BMPR1A(3), BMPR1B(4), BMPR2(11), CCL1(2), CCL11(1), CCL15(2), CCL16(1), CCL18(2), CCL19(1), CCL2(1), CCL20(1), CCL22(1), CCL23(1), CCL24(1), CCL25(1), CCL27(1), CCL5(1), CCL7(1), CCL8(2), CCR1(2), CCR2(5), CCR3(6), CCR5(3), CCR6(1), CCR7(2), CCR8(1), CCR9(3), CD27(2), CD40(1), CD40LG(4), CD70(1), CLCF1(2), CNTF(3), CNTFR(2), CSF1(1), CSF1R(7), CSF2RA(8), CSF2RB(7), CSF3(1), CSF3R(6), CX3CL1(6), CX3CR1(3), CXCL10(1), CXCL16(3), CXCL2(2), CXCL9(2), CXCR4(1), CXCR6(2), EDA(1), EDA2R(3), EDAR(5), EGF(8), EGFR(11), EPOR(2), FAS(3), FASLG(2), FLT1(13), FLT3(8), FLT4(17), GDF5(7), GH1(1), GH2(3), GHR(6), HGF(13), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR1(5), IFNAR2(6), IFNB1(2), IFNG(2), IFNGR1(5), IFNGR2(1), IFNK(1), IFNW1(2), IL10(2), IL10RA(4), IL10RB(2), IL11(2), IL11RA(2), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL13(1), IL13RA1(3), IL15RA(3), IL17B(3), IL17RA(6), IL17RB(1), IL18(1), IL18R1(2), IL18RAP(2), IL1A(2), IL1B(2), IL1R1(4), IL1R2(5), IL1RAP(5), IL20(1), IL20RA(6), IL21(2), IL21R(9), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(5), IL25(1), IL26(4), IL28A(2), IL28B(3), IL28RA(1), IL2RA(2), IL2RB(2), IL2RG(5), IL3(1), IL3RA(5), IL4(1), IL4R(1), IL5RA(4), IL6R(1), IL6ST(4), IL7(1), IL7R(5), IL8(1), IL9R(3), INHBA(7), INHBB(8), INHBC(3), INHBE(1), KDR(8), KIT(12), KITLG(2), LEPR(13), LIF(1), LIFR(10), LTA(3), LTBR(1), MET(7), NGFR(4), OSM(2), OSMR(4), PDGFB(5), PDGFC(5), PDGFRA(11), PDGFRB(10), PF4V1(1), PLEKHO2(1), PRL(1), PRLR(2), RELT(2), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(3), TNFRSF11A(3), TNFRSF11B(2), TNFRSF13B(3), TNFRSF13C(2), TNFRSF17(1), TNFRSF19(7), TNFRSF1A(3), TNFRSF1B(1), TNFRSF21(5), TNFRSF25(4), TNFRSF4(2), TNFRSF8(2), TNFRSF9(6), TNFSF10(3), TNFSF11(1), TNFSF13B(3), TNFSF14(2), TNFSF15(2), TNFSF18(2), TNFSF4(1), TNFSF8(3), TPO(15), TSLP(3), VEGFC(8), XCL1(1), XCR1(3)	58113564	703	148	687	284	219	205	33	171	73	2	0.492	1.000	1.000
208	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(2), ACTA2(6), ACTN2(22), ACTN3(2), ACTN4(6), DES(1), DMD(48), FAM48A(7), MYBPC1(5), MYBPC2(7), MYBPC3(4), MYH3(23), MYH6(24), MYH7(15), MYH8(13), MYL1(1), MYL2(6), MYL3(2), MYL9(2), MYOM1(6), NEB(48), TMOD1(2), TNNI1(1), TNNI2(4), TNNT1(3), TNNT2(2), TPM1(4), TPM3(3), TPM4(3), TTN(401), VIM(8)	44816195	681	148	669	221	178	188	40	232	38	5	0.0626	1.000	1.000
209	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	141	APC(34), APC2(12), AXIN1(8), AXIN2(4), BTRC(4), CACYBP(2), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CCND1(1), CCND2(3), CCND3(2), CER1(2), CHD8(15), CREBBP(26), CSNK1A1(3), CSNK1A1L(2), CSNK1E(7), CSNK2A1(7), CSNK2A2(4), CSNK2B(1), CTBP1(3), CTBP2(5), CTNNB1(16), CTNNBIP1(1), CUL1(14), CXXC4(2), DAAM1(9), DAAM2(12), DKK1(7), DKK2(4), DKK4(1), DVL1(4), DVL2(3), DVL3(8), EP300(19), FBXW11(10), FZD1(7), FZD10(14), FZD2(7), FZD3(5), FZD4(4), FZD5(3), FZD6(5), FZD7(4), FZD8(6), FZD9(2), GSK3B(4), JUN(3), LEF1(5), LRP5(12), LRP6(6), MAP3K7(8), MAPK10(5), MAPK8(5), MAPK9(4), MMP7(2), MYC(3), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NKD1(5), NKD2(1), NLK(6), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PORCN(3), PPARD(7), PPP2CA(3), PPP2CB(2), PPP2R1A(9), PPP2R1B(4), PPP2R2A(5), PPP2R2B(5), PPP2R2C(5), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRICKLE1(13), PRICKLE2(16), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), PSEN1(2), RAC2(2), RAC3(3), RBX1(1), ROCK1(9), ROCK2(7), RUVBL1(7), SENP2(2), SFRP1(4), SFRP2(4), SFRP4(3), SFRP5(1), SIAH1(1), SMAD2(8), SMAD3(3), SOX17(5), TBL1X(5), TBL1XR1(2), TBL1Y(1), TCF7(3), TCF7L1(3), TCF7L2(8), VANGL1(2), VANGL2(4), WIF1(2), WNT1(5), WNT10A(4), WNT10B(1), WNT11(2), WNT16(5), WNT2(4), WNT2B(7), WNT3(5), WNT3A(4), WNT4(1), WNT5A(4), WNT5B(3), WNT6(2), WNT7A(3), WNT7B(6), WNT8A(1), WNT8B(1), WNT9A(3), WNT9B(3)	52088797	752	147	735	237	287	199	26	139	96	5	0.000255	1.000	1.000
210	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(2), ACTA2(6), ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ARRB1(3), ATF2(1), ATF5(2), ATP2A2(5), ATP2A3(5), CACNB3(2), CALCA(1), CALM1(1), CALM2(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CNN1(2), CNN2(1), CORIN(13), CREB3(4), CRHR1(10), DGKZ(4), ETS2(3), FOS(1), GABPA(2), GABPB2(2), GJA1(9), GNAQ(3), GNB2(4), GNB4(3), GNG12(1), GNG13(2), GNG7(3), GNGT1(3), GRK6(2), GUCA2A(1), GUCY1A3(14), IGFBP1(5), IGFBP2(2), IGFBP3(5), IGFBP4(1), IGFBP6(1), IL1B(2), ITPR1(21), ITPR2(20), ITPR3(30), JUN(3), MIB1(4), MYL2(6), MYLK2(2), NFKB1(7), NOS1(22), NOS3(5), OXT(1), OXTR(5), PDE4B(4), PDE4D(1), PKIA(1), PKIG(2), PLCB3(8), PLCD1(4), PLCG1(16), PLCG2(11), PRKACA(3), PRKACB(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PRKCD(7), PRKCE(8), PRKCH(6), PRKCQ(7), PRKD1(16), RAMP3(3), RGS1(2), RGS10(3), RGS11(1), RGS14(2), RGS16(3), RGS17(2), RGS18(4), RGS19(2), RGS2(2), RGS20(4), RGS3(13), RGS4(3), RGS5(3), RGS6(14), RGS7(2), RGS9(8), RLN1(1), RYR1(43), RYR2(61), RYR3(47), SLC8A1(12), SP1(6), TNXB(38), USP5(4), YWHAB(1), YWHAH(3), YWHAQ(2)	56801553	776	147	767	315	302	188	32	182	71	1	0.451	1.000	1.000
211	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	160	ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), ADRA1A(12), ADRA1B(4), ADRA1D(2), ADRA2A(5), ADRA2C(4), ADRB1(7), ADRB2(7), AGTR1(1), AGTR2(2), AVPR1A(8), AVPR1B(2), AVPR2(4), BDKRB1(1), BDKRB2(3), BRS3(3), C3AR1(5), CCBP2(2), CCKAR(4), CCKBR(6), CCR1(2), CCR10(2), CCR2(5), CCR3(6), CCR5(3), CCR6(1), CCR7(2), CCR8(1), CCR9(3), CCRL1(5), CHML(3), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), CMKLR1(2), CNR1(7), CX3CR1(3), CXCR4(1), DRD1(3), DRD2(7), DRD3(7), DRD4(2), DRD5(10), EDNRA(3), F2R(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(4), GALR1(5), GALR2(9), GALR3(1), GALT(1), GHSR(8), GNB2L1(4), GPR17(1), GPR173(3), GPR174(3), GPR27(5), GPR3(4), GPR35(3), GPR37(9), GPR37L1(4), GPR4(2), GPR50(7), GPR6(9), GPR63(1), GPR77(1), GPR83(4), GPR85(2), GPR87(4), GRPR(7), HCRTR1(3), HCRTR2(3), HRH1(4), HRH2(8), HRH3(3), HTR1A(10), HTR1B(8), HTR1D(3), HTR1E(5), HTR1F(5), HTR2A(5), HTR2B(4), HTR2C(5), HTR4(4), HTR5A(7), HTR6(2), HTR7(8), LHCGR(10), LTB4R(1), MAS1(1), MC3R(3), MC4R(5), MC5R(5), MLNR(2), MTNR1A(4), MTNR1B(6), NMBR(3), NMUR1(3), NMUR2(3), NPY1R(3), NPY2R(3), NPY5R(3), NTSR1(5), NTSR2(3), OPN1SW(1), OPN3(4), OPRD1(1), OPRK1(6), OPRL1(6), OPRM1(3), OR10A5(5), OR11A1(5), OR12D3(1), OR1C1(2), OR1F1(3), OR1Q1(5), OR2H1(2), OR5V1(6), OR7C1(2), OR8B8(5), OXTR(5), P2RY1(3), P2RY10(10), P2RY12(6), P2RY13(2), P2RY14(4), P2RY2(5), P2RY6(6), PPYR1(6), PTAFR(5), PTGDR(6), PTGER2(4), PTGER4(4), PTGFR(3), RGR(1), RHO(6), RRH(2), SSTR1(9), SSTR2(3), SSTR3(5), SSTR4(11), SUCNR1(4), TBXA2R(8), TRHR(4)	39086266	634	144	626	251	242	175	25	150	42	0	0.0624	1.000	1.000
212	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(6), ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ADK(2), ADSL(3), ADSS(4), ADSSL1(7), AK1(1), AK5(3), AK7(3), ALLC(5), AMPD1(8), AMPD2(7), AMPD3(13), APRT(2), ATIC(6), CANT1(3), DGUOK(2), ENPP1(5), ENPP3(4), ENTPD1(5), ENTPD3(4), ENTPD4(7), ENTPD6(2), ENTPD8(6), GART(8), GDA(2), GMPR(1), GMPR2(2), GMPS(4), GUCY1A2(8), GUCY1A3(14), GUCY1B3(7), GUCY2C(7), GUCY2D(12), GUCY2F(13), GUK1(3), IMPDH1(5), IMPDH2(3), NME6(2), NME7(1), NPR1(9), NPR2(7), NT5C(1), NT5C1A(4), NT5C1B(5), NT5C2(7), NT5C3(1), NUDT2(3), NUDT5(1), NUDT9(1), PAICS(1), PAPSS1(4), PAPSS2(4), PDE10A(7), PDE11A(6), PDE1A(6), PDE1C(5), PDE2A(8), PDE3B(13), PDE4A(7), PDE4B(4), PDE4C(4), PDE4D(1), PDE5A(6), PDE6G(1), PDE7A(4), PDE7B(2), PDE8A(8), PDE8B(4), PDE9A(4), PFAS(5), PKLR(5), PKM2(5), PNPT1(4), POLA1(5), POLA2(3), POLD1(10), POLD2(1), POLD3(3), POLE(17), POLE2(3), POLE3(1), POLR1A(12), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLR3A(15), POLR3B(7), POLR3G(2), POLR3K(1), PPAT(3), PRIM1(2), PRIM2(6), PRPS1(2), PRPS1L1(2), PRPS2(2), PRUNE(3), RFC5(1), RRM1(5), RRM2(3), RRM2B(4), XDH(11)	53568441	621	139	615	241	214	180	24	153	50	0	0.455	1.000	1.000
213	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ADRB1(7), CSNK1D(2), DRD1(3), DRD2(7), EGF(8), EGFR(11), GJA1(9), GJD2(3), GNA11(5), GNAI1(1), GNAI2(2), GNAI3(6), GNAQ(3), GNAS(20), GRB2(4), GRM1(26), GRM5(23), GUCY1A2(8), GUCY1A3(14), GUCY1B3(7), GUCY2C(7), GUCY2D(12), GUCY2F(13), HTR2A(5), HTR2B(4), HTR2C(5), ITPR1(21), ITPR2(20), ITPR3(30), MAP2K1(5), MAP2K2(2), MAP2K5(1), MAP3K2(3), MAPK1(2), MAPK3(1), MAPK7(7), NPR1(9), NPR2(7), NRAS(2), PDGFA(2), PDGFB(5), PDGFC(5), PDGFD(5), PDGFRA(11), PDGFRB(10), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKG1(8), PRKG2(10), PRKX(4), RAF1(7), SOS1(6), SOS2(11), SRC(2), TJP1(11), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(5), TUBA3D(4), TUBA3E(9), TUBA4A(1), TUBA8(4), TUBAL3(4), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB3(12), TUBB4(4), TUBB4Q(4), TUBB6(7), TUBB8(3)	43212447	653	137	640	255	237	177	26	166	46	1	0.403	1.000	1.000
214	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(3), AKT2(6), AKT3(6), CBL(2), CBLB(3), CBLC(2), CCND1(1), CCND2(3), CCND3(2), CISH(1), CLCF1(2), CNTF(3), CNTFR(2), CREBBP(26), CSF2RA(8), CSF2RB(7), CSF3(1), CSF3R(6), EP300(19), EPOR(2), GH1(1), GH2(3), GHR(6), GRB2(4), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR1(5), IFNAR2(6), IFNB1(2), IFNG(2), IFNGR1(5), IFNGR2(1), IFNK(1), IFNW1(2), IL10(2), IL10RA(4), IL10RB(2), IL11(2), IL11RA(2), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL13(1), IL13RA1(3), IL13RA2(6), IL15RA(3), IL20(1), IL20RA(6), IL21(2), IL21R(9), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(5), IL26(4), IL28A(2), IL28B(3), IL28RA(1), IL2RA(2), IL2RB(2), IL2RG(5), IL3(1), IL3RA(5), IL4(1), IL4R(1), IL5RA(4), IL6R(1), IL6ST(4), IL7(1), IL7R(5), IL9R(3), IRF9(3), JAK1(6), JAK2(10), JAK3(9), LEPR(13), LIF(1), LIFR(10), MYC(3), OSM(2), OSMR(4), PIAS1(6), PIAS2(7), PIAS3(2), PIAS4(5), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PIM1(2), PRL(1), PRLR(2), PTPN11(5), PTPN6(3), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SOCS5(7), SOCS7(3), SOS1(6), SOS2(11), SPRED1(10), SPRED2(6), SPRY1(2), SPRY3(6), SPRY4(4), STAM(5), STAM2(4), STAT1(7), STAT2(4), STAT3(6), STAT4(3), STAT5A(4), STAT5B(6), STAT6(1), TPO(15), TSLP(3), TYK2(4)	46956110	558	134	545	195	170	161	28	143	56	0	0.109	1.000	1.000
215	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(8), BRAF(9), C7orf16(3), CACNA1A(16), CRHR1(10), GNA11(5), GNA12(1), GNA13(3), GNAI1(1), GNAI2(2), GNAI3(6), GNAQ(3), GNAS(20), GNAZ(11), GRIA1(17), GRIA2(17), GRIA3(6), GRID2(14), GRM1(26), GRM5(23), GUCY1A2(8), GUCY1A3(14), GUCY1B3(7), GUCY2C(7), GUCY2D(12), GUCY2F(13), IGF1(4), IGF1R(15), ITPR1(21), ITPR2(20), ITPR3(30), LYN(4), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), NOS1(22), NOS3(5), NPR1(9), NPR2(7), NRAS(2), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PPP2CA(3), PPP2CB(2), PPP2R1A(9), PPP2R1B(4), PPP2R2A(5), PPP2R2B(5), PPP2R2C(5), PRKCA(3), PRKCG(13), PRKG1(8), PRKG2(10), RAF1(7), RYR1(43)	35990158	591	134	579	189	226	144	25	154	41	1	0.0107	1.000	1.000
216	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	72	ACTB(7), ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), ACVR1B(12), ACVR1C(3), BAIAP2(4), CDC42(1), CREBBP(26), CSNK2A1(7), CSNK2A2(4), CSNK2B(1), CTNNA1(11), CTNNA2(16), CTNNA3(9), CTNNB1(16), CTNND1(13), EGFR(11), EP300(19), ERBB2(12), FARP2(3), FER(9), FGFR1(11), FYN(8), IGF1R(15), INSR(12), IQGAP1(11), LEF1(5), LMO7(11), MAP3K7(8), MAPK1(2), MAPK3(1), MET(7), MLLT4(18), NLK(6), PARD3(9), PTPN1(2), PTPN6(3), PTPRB(17), PTPRF(15), PTPRJ(21), PTPRM(25), PVRL1(1), PVRL2(4), PVRL3(4), PVRL4(6), RAC2(2), RAC3(3), SMAD2(8), SMAD3(3), SNAI1(3), SNAI2(8), SORBS1(7), SRC(2), SSX2IP(6), TCF7(3), TCF7L1(3), TCF7L2(8), TGFBR1(5), TGFBR2(11), TJP1(11), VCL(1), WAS(1), WASF1(3), WASF2(6), WASF3(6), WASL(1), YES1(2)	38280099	545	133	530	183	172	167	19	110	77	0	0.0333	1.000	1.000
217	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(4), ANAPC1(8), ANAPC10(1), ANAPC11(1), ANAPC2(4), ANAPC5(2), ANAPC7(3), ATM(30), ATR(12), BUB1(10), BUB1B(7), BUB3(2), CCNA1(7), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(16), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(2), CCNH(2), CDC14A(7), CDC14B(2), CDC16(4), CDC20(4), CDC23(4), CDC25A(3), CDC25B(4), CDC25C(7), CDC26(1), CDC27(2), CDC6(5), CDC7(3), CDK2(3), CDK6(4), CDKN1A(1), CDKN2A(6), CDKN2D(3), CHEK1(4), CHEK2(7), CREBBP(26), CUL1(14), DBF4(6), E2F1(2), E2F2(3), E2F3(2), EP300(19), ESPL1(15), FZR1(3), GSK3B(4), HDAC1(3), HDAC2(2), MAD1L1(8), MAD2L1(1), MCM2(11), MCM3(3), MCM4(8), MCM5(5), MCM6(2), MCM7(5), MDM2(3), ORC1L(8), ORC2L(2), ORC3L(5), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PKMYT1(3), PLK1(6), PRKDC(32), PTTG1(1), PTTG2(3), RB1(6), RBL1(7), RBL2(4), RBX1(1), SKP2(5), SMAD2(8), SMAD3(3), SMC1A(5), SMC1B(8), TFDP1(3), TGFB1(3), TGFB2(6), TGFB3(5), WEE1(2), YWHAB(1), YWHAE(1), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(2)	44011961	489	131	481	168	149	140	19	119	60	2	0.241	1.000	1.000
218	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(19), ACACB(22), AKT1(3), AKT2(6), AKT3(6), ARAF(8), BAD(3), BRAF(9), CALM1(1), CALM2(3), CALML3(1), CBL(2), CBLB(3), CBLC(2), CRK(1), CRKL(1), EIF4EBP1(2), ELK1(3), EXOC7(7), FASN(14), FBP1(2), FBP2(4), FLOT1(2), FLOT2(3), FOXO1(3), G6PC2(1), GCK(4), GRB2(4), GSK3B(4), GYS1(3), GYS2(4), IKBKB(7), INPP5D(1), INSR(12), IRS1(15), IRS2(4), IRS4(16), LIPE(6), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(4), MKNK1(3), MKNK2(1), NRAS(2), PCK1(6), PCK2(7), PDE3A(11), PDE3B(13), PDPK1(2), PFKL(4), PFKM(3), PFKP(8), PHKA1(7), PHKA2(9), PHKB(1), PHKG1(2), PHKG2(7), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PKLR(5), PKM2(5), PPARGC1A(9), PPP1CA(2), PPP1CB(1), PPP1CC(4), PPP1R3A(21), PPP1R3B(6), PPP1R3C(3), PPP1R3D(2), PRKAA1(4), PRKAA2(5), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKACB(2), PRKACG(5), PRKAG1(3), PRKAG2(3), PRKAG3(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCI(4), PRKX(4), PTPN1(2), PTPRF(15), PYGB(8), PYGL(6), PYGM(9), RAF1(7), RAPGEF1(9), RHEB(1), RPS6(1), RPS6KB1(4), RPS6KB2(3), SH2B2(2), SHC1(3), SHC2(2), SHC3(8), SHC4(1), SLC2A4(4), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SORBS1(7), SOS1(6), SOS2(11), SREBF1(8), TRIP10(7), TSC1(3), TSC2(7)	51557428	635	131	625	240	244	169	19	131	72	0	0.165	1.000	1.000
219	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(4), ABL2(6), AKT1(3), AKT2(6), AKT3(6), ARAF(8), BAD(3), BRAF(9), BTC(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CBL(2), CBLB(3), CBLC(2), CDKN1A(1), CRK(1), CRKL(1), EGF(8), EGFR(11), EIF4EBP1(2), ELK1(3), ERBB2(12), ERBB3(29), ERBB4(33), EREG(3), GAB1(2), GRB2(4), GSK3B(4), HBEGF(2), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K4(7), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(4), MYC(3), NCK1(6), NCK2(3), NRAS(2), NRG1(11), NRG2(6), NRG3(13), NRG4(1), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG1(16), PLCG2(11), PRKCA(3), PRKCG(13), PTK2(10), RAF1(7), RPS6KB1(4), RPS6KB2(3), SHC1(3), SHC2(2), SHC3(8), SHC4(1), SOS1(6), SOS2(11), SRC(2), STAT5A(4), STAT5B(6), TGFA(2)	32662443	464	128	443	151	164	124	21	105	50	0	0.0366	1.000	1.000
220	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), AKAP1(2), AKAP10(3), AKAP11(9), AKAP12(9), AKAP3(8), AKAP4(10), AKAP5(2), AKAP6(18), AKAP7(2), AKAP8(9), AKAP9(28), ARHGEF1(9), CALM1(1), CALM2(3), CHMP1B(1), GNA11(5), GNA12(1), GNA13(3), GNA14(3), GNA15(3), GNAI2(2), GNAI3(6), GNAL(2), GNAQ(3), GNAZ(11), GNB2(4), GNG12(1), GNG13(2), GNG7(3), GNGT1(3), GNGT2(2), ITPR1(21), KCNJ3(9), NRAS(2), PDE1A(6), PDE1B(3), PDE1C(5), PDE4A(7), PDE4B(4), PDE4C(4), PDE4D(1), PDE7A(4), PDE7B(2), PDE8A(8), PDE8B(4), PLCB3(8), PPP3CA(5), PPP3CC(3), PRKACA(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCI(4), PRKCQ(7), PRKD1(16), PRKD3(4), RRAS(1), SLC9A1(8), USP5(4)	38075867	471	125	463	182	148	143	21	107	51	1	0.301	1.000	1.000
221	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(6), ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADK(2), ADSL(3), ADSS(4), AK1(1), AK5(3), ALLC(5), AMPD1(8), AMPD2(7), AMPD3(13), APRT(2), ATIC(6), ATP1B1(1), ATP5A1(2), ATP5B(3), ATP5C1(3), ATP5F1(1), ATP5G2(1), ATP5J(1), ATP5J2(1), CANT1(3), DGUOK(2), ENPP1(5), ENPP3(4), ENTPD1(5), GART(8), GDA(2), GMPS(4), GUCY1A2(8), GUCY1A3(14), GUCY1B3(7), GUCY2C(7), GUCY2D(12), GUCY2F(13), GUK1(3), IMPDH1(5), IMPDH2(3), NPR1(9), NPR2(7), NT5C(1), NUDT2(3), PAICS(1), PAPSS1(4), PAPSS2(4), PDE1A(6), PDE4A(7), PDE4B(4), PDE4C(4), PDE4D(1), PDE5A(6), PDE6B(8), PDE6C(3), PDE6G(1), PDE7B(2), PDE8A(8), PDE9A(4), PFAS(5), PKLR(5), PKM2(5), POLB(2), POLD1(10), POLD2(1), POLE(17), POLG(5), POLL(2), POLQ(22), POLR1B(4), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLRMT(10), PPAT(3), PRPS1(2), PRPS1L1(2), PRPS2(2), PRUNE(3), RRM1(5), RRM2(3)	42009235	494	124	489	193	159	149	21	127	38	0	0.503	1.000	1.000
222	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(4), ATM(30), BUB1(10), BUB1B(7), BUB3(2), CCNA1(7), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(16), CCND2(3), CCND3(2), CCNE1(3), CCNE2(2), CCNH(2), CDAN1(7), CDC14A(7), CDC14B(2), CDC20(4), CDC25A(3), CDC25B(4), CDC25C(7), CDC6(5), CDC7(3), CDK2(3), CDKN1A(1), CDKN2A(6), CHEK1(4), CHEK2(7), DTX4(6), E2F1(2), E2F2(3), E2F3(2), E2F4(1), E2F5(1), E2F6(2), EP300(19), ESPL1(15), GSK3B(4), HDAC1(3), HDAC2(2), HDAC3(4), HDAC4(13), HDAC5(6), HDAC6(6), HDAC8(3), MAD1L1(8), MAD2L1(1), MCM2(11), MCM3(3), MCM4(8), MCM5(5), MCM6(2), MCM7(5), MDM2(3), MPEG1(6), ORC1L(8), ORC2L(2), ORC3L(5), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PLK1(6), PRKDC(32), PTPRA(7), PTTG1(1), PTTG2(3), RB1(6), RBL1(7), SKP2(5), TBC1D8(7), TFDP1(3), TGFB1(3), WEE1(2)	34922706	406	122	400	139	122	117	20	98	47	2	0.190	1.000	1.000
223	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), ARHGAP5(11), BCAR1(4), CD99(1), CDC42(1), CDH5(5), CLDN1(2), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(4), CLDN18(2), CLDN19(3), CLDN20(3), CLDN22(2), CLDN23(2), CLDN3(1), CLDN4(5), CLDN5(2), CLDN6(4), CLDN8(1), CLDN9(3), CTNNA1(11), CTNNA2(16), CTNNA3(9), CTNNB1(16), CTNND1(13), CXCR4(1), CYBB(6), ESAM(5), EZR(3), F11R(2), GNAI1(1), GNAI2(2), GNAI3(6), GRLF1(15), ICAM1(1), ITGA4(9), ITGAL(11), ITGAM(6), ITGB1(6), ITGB2(5), ITK(5), JAM2(2), JAM3(4), MAPK11(1), MAPK13(1), MAPK14(1), MLLT4(18), MMP2(3), MMP9(13), MSN(9), MYL2(6), MYL7(1), MYL9(2), NCF1(3), NCF2(2), NOX1(4), NOX3(3), OCLN(4), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG1(16), PLCG2(11), PRKCA(3), PRKCG(13), PTK2(10), PTK2B(10), PTPN11(5), PXN(3), RAC2(2), RAP1A(2), RAP1B(5), RAPGEF3(2), RAPGEF4(7), RASSF5(2), RHOH(2), ROCK1(9), ROCK2(7), SIPA1(1), THY1(1), TXK(2), VASP(2), VAV1(6), VAV2(11), VAV3(10), VCAM1(8), VCL(1)	39884275	539	122	529	213	197	141	22	105	72	2	0.489	1.000	1.000
224	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(16), ADCY8(21), ARAF(8), BRAF(9), CACNA1C(27), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), CREBBP(26), EP300(19), GNAQ(3), GRIA1(17), GRIA2(17), GRIN1(4), GRIN2A(11), GRIN2B(18), GRIN2C(4), GRIN2D(4), GRM1(26), GRM5(23), ITPR1(21), ITPR2(20), ITPR3(30), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), NRAS(2), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PPP1CA(2), PPP1CB(1), PPP1CC(4), PPP1R12A(2), PPP1R1A(1), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), RAF1(7), RAP1A(2), RAP1B(5), RAPGEF3(2), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3)	32039107	483	121	472	181	176	135	11	105	55	1	0.168	1.000	1.000
225	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(6), BCAR1(4), CAPN1(2), CAPN10(3), CAPN11(2), CAPN2(3), CAPN3(9), CAPN5(3), CAPN6(5), CAPN7(5), CAPN9(2), CAPNS1(2), CAV1(4), CAV2(2), CAV3(2), CDC42(1), CRK(1), CSK(5), DOCK1(15), FYN(8), GIT2(1), GRB2(4), ILK(3), ITGA10(5), ITGA11(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGAD(9), ITGAE(6), ITGAL(11), ITGAM(6), ITGAV(5), ITGAX(8), ITGB1(6), ITGB2(5), ITGB3(3), ITGB4(12), ITGB5(5), ITGB6(3), ITGB7(4), ITGB8(8), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K6(1), MAPK10(5), MAPK4(6), MAPK6(1), MAPK7(7), MYLK2(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PDPK1(2), PIK3R2(8), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAP1B(5), RAPGEF1(9), RHO(6), ROCK1(9), ROCK2(7), SDCCAG8(3), SHC1(3), SHC3(8), SORBS1(7), SOS1(6), SRC(2), TLN1(14), TNS1(22), VASP(2), VAV2(11), VAV3(10), VCL(1), ZYX(5)	43935585	473	121	466	197	165	120	24	107	56	1	0.759	1.000	1.000
226	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(16), BDKRB1(1), BDKRB2(3), C1QA(1), C1QC(2), C1R(3), C1S(5), C2(2), C3(21), C3AR1(5), C4BPA(1), C4BPB(2), C5(11), C5AR1(5), C6(10), C7(2), C8A(5), C8B(11), C9(6), CD46(2), CD55(2), CFB(5), CFH(12), CFI(9), CPB2(6), CR1(23), CR2(8), F10(6), F11(3), F12(2), F13A1(10), F13B(13), F2(5), F2R(2), F3(1), F5(13), F7(9), F8(15), F9(6), FGA(7), FGB(2), FGG(2), KLKB1(7), KNG1(8), MASP1(3), MASP2(4), MBL2(1), PLAT(4), PLAU(2), PLAUR(3), PLG(11), PROC(2), PROS1(8), SERPINA1(3), SERPINA5(5), SERPINC1(4), SERPIND1(3), SERPINE1(3), SERPINF2(5), SERPING1(5), TFPI(3), THBD(1), VWF(19)	29731419	379	120	372	123	111	104	20	102	41	1	0.0839	1.000	1.000
227	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), CACNA1C(27), CACNA1D(21), CACNA1F(9), CACNA1S(11), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CDC42(1), CGA(1), EGFR(11), ELK1(3), FSHB(1), GNA11(5), GNAQ(3), GNAS(20), GNRH1(1), GNRH2(2), GNRHR(4), GRB2(4), HBEGF(2), ITPR1(21), ITPR2(20), ITPR3(30), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K1(9), MAP3K2(3), MAP3K3(4), MAP3K4(15), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(7), MAPK8(5), MAPK9(4), MMP2(3), NRAS(2), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLD1(13), PLD2(13), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCD(7), PRKX(4), PTK2B(10), RAF1(7), SOS1(6), SOS2(11), SRC(2)	41355188	552	120	543	211	213	144	22	116	56	1	0.271	1.000	1.000
228	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(5), ACVR1B(12), ACVRL1(3), AKT1(3), AURKB(4), BMPR1A(3), BMPR2(11), BUB1(10), CDIPT(1), CDKL1(2), CDKL2(3), CDS1(4), CDS2(2), CLK1(3), CLK2(8), CLK4(2), COL4A3BP(3), CSNK2A1(7), CSNK2A2(4), CSNK2B(1), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKZ(4), IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(5), INPPL1(14), ITPKA(1), ITPKB(7), MAP3K10(8), MOS(9), NEK1(2), NEK3(1), OCRL(8), PAK4(6), PIK3C2A(8), PIK3C2B(15), PIK3C2G(7), PIK3CB(7), PIK3CG(15), PIM2(2), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCG1(16), PLCG2(11), PLK3(4), PRKACA(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCQ(7), PRKD1(16), PRKG1(8), RAF1(7), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KA4(1), RPS6KB1(4), STK11(2), TGFBR1(5), VRK1(1)	36289666	451	120	436	154	141	130	20	104	53	3	0.153	1.000	1.000
229	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM1(1), CALM2(3), CALML3(1), CDIPT(1), CDS1(4), CDS2(2), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKI(9), DGKZ(4), FN3K(2), IMPA1(3), IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(5), INPP5B(7), INPP5D(1), INPP5E(6), INPPL1(14), ITGB1BP3(2), ITPK1(4), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), OCRL(8), PI4KA(11), PI4KB(3), PIK3C2A(8), PIK3C2B(15), PIK3C2G(7), PIK3C3(10), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1B(1), PIP5K1C(8), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCD3(8), PLCD4(2), PLCE1(11), PLCG1(16), PLCG2(11), PLCZ1(3), PRKCA(3), PRKCG(13), PTPMT1(1), SYNJ1(7), SYNJ2(9)	39867984	450	117	438	155	170	126	15	94	43	2	0.0498	1.000	1.000
230	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	123	ARAF(8), BID(2), BRAF(9), CASP3(2), CD244(2), CD247(3), FAS(3), FASLG(2), FCGR3A(3), FCGR3B(3), FYN(8), GRB2(4), GZMB(2), HCST(1), HLA-A(6), HLA-C(3), HLA-E(3), HLA-G(3), ICAM1(1), ICAM2(2), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR1(5), IFNAR2(6), IFNB1(2), IFNG(2), IFNGR1(5), IFNGR2(1), ITGAL(11), ITGB2(5), KIR2DL1(5), KIR2DL3(2), KIR2DL4(3), KIR3DL1(5), KIR3DL2(1), KLRC1(3), KLRC2(2), KLRC3(4), KLRD1(4), LAT(2), LCK(3), LCP2(5), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MICA(1), MICB(2), NCR1(3), NCR2(4), NCR3(1), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NRAS(2), PAK1(5), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG1(16), PLCG2(11), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRF1(1), PRKCA(3), PRKCG(13), PTK2B(10), PTPN11(5), PTPN6(3), RAC2(2), RAC3(3), RAF1(7), SH2D1A(1), SH2D1B(1), SH3BP2(3), SHC1(3), SHC2(2), SHC3(8), SHC4(1), SOS1(6), SOS2(11), SYK(6), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(3), TNFSF10(3), ULBP1(2), ULBP3(1), VAV1(6), VAV2(11), VAV3(10), ZAP70(10)	36108946	492	117	480	159	158	138	15	119	62	0	0.0138	1.000	1.000
231	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	97	ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ASIP(1), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CREB1(3), CREB3(4), CREB3L1(3), CREB3L2(3), CREB3L3(3), CREB3L4(1), CREBBP(26), CTNNB1(16), DCT(8), DVL1(4), DVL2(3), DVL3(8), EDN1(2), EP300(19), FZD1(7), FZD10(14), FZD2(7), FZD3(5), FZD4(4), FZD5(3), FZD6(5), FZD7(4), FZD8(6), FZD9(2), GNAI1(1), GNAI2(2), GNAI3(6), GNAQ(3), GNAS(20), GSK3B(4), KIT(12), KITLG(2), LEF1(5), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MITF(8), NRAS(2), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), POMC(6), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), RAF1(7), TCF7(3), TCF7L1(3), TCF7L2(8), TYR(6), TYRP1(3), WNT1(5), WNT10A(4), WNT10B(1), WNT11(2), WNT16(5), WNT2(4), WNT2B(7), WNT3(5), WNT3A(4), WNT4(1), WNT5A(4), WNT5B(3), WNT6(2), WNT7A(3), WNT7B(6), WNT8A(1), WNT8B(1), WNT9A(3), WNT9B(3)	35190529	518	117	509	206	205	144	16	105	47	1	0.202	1.000	1.000
232	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(3), AKT2(6), AKT3(6), BAD(3), CDC42(1), CDK2(3), CDKN2A(6), CREB1(3), CREB3(4), CREB5(4), EBP(1), ERBB4(33), F2RL2(2), GAB1(2), GRB2(4), GSK3A(2), GSK3B(4), IGF1(4), IGFBP1(5), INPPL1(14), IRS1(15), IRS2(4), IRS4(16), MET(7), MYC(3), NOLC1(6), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PARD3(9), PARD6A(1), PDK1(2), PIK3CD(10), PPP1R13B(6), PREX1(13), PTK2(10), PTPN1(2), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), SHC1(3), SLC2A4(4), SOS1(6), SOS2(11), TSC1(3), TSC2(7), YWHAB(1), YWHAE(1), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(2)	24387691	312	117	307	101	110	84	15	59	44	0	0.0464	1.000	1.000
233	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(4), ACTN1(6), ACTR2(2), ACTR3(2), AKT1(3), AKT2(6), AKT3(6), ANGPTL2(3), ARHGEF6(12), ARHGEF7(7), BCAR1(4), BRAF(9), CAV1(4), CDC42(1), CDKN2A(6), CRK(1), CSE1L(2), DOCK1(15), EPHB2(8), FYN(8), GRB2(4), GRB7(7), GRLF1(15), ILK(3), ITGA1(7), ITGA10(5), ITGA11(7), ITGA2(5), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGB3BP(1), MAP2K4(7), MAP3K11(7), MAPK1(2), MAPK10(5), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), MYLK(15), MYLK2(2), P4HB(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PIK3CB(7), PKLR(5), PLCG1(16), PLCG2(11), PTK2(10), RAF1(7), RHO(6), ROCK1(9), ROCK2(7), SHC1(3), SOS1(6), SOS2(11), SRC(2), TERF2IP(4), TLN1(14), TLN2(21), VASP(2), WAS(1), ZYX(5)	38933566	450	117	444	161	162	116	18	95	58	1	0.239	1.000	1.000
234	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(1), ALG1(5), ALG10(6), ALG10B(3), ALG12(3), ALG13(7), ALG14(1), ALG3(2), ALG6(2), ALG8(1), ALG9(1), B3GNT1(3), B3GNT2(2), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT4(4), B4GALT5(5), B4GALT7(2), C1GALT1(3), C1GALT1C1(4), CHPF(2), CHST1(13), CHST11(2), CHST12(4), CHST13(2), CHST14(2), CHST2(10), CHST3(3), CHST4(4), CHST6(6), CHST7(7), CHSY1(4), DPAGT1(1), EXT1(16), EXT2(5), EXTL1(4), EXTL2(2), EXTL3(10), FUT11(3), FUT8(3), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(1), GALNT13(7), GALNT14(6), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(7), GALNT6(2), GALNT8(5), GALNT9(2), GALNTL1(7), GALNTL2(7), GALNTL4(7), GALNTL5(3), GANAB(4), GCNT3(2), GCNT4(2), HS2ST1(2), HS3ST1(2), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(3), HS3ST5(6), HS6ST1(2), HS6ST2(4), HS6ST3(6), MAN1A1(2), MAN1A2(3), MAN1B1(5), MAN1C1(2), MAN2A1(3), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(2), MGAT5(8), MGAT5B(4), NDST1(10), NDST2(6), NDST3(10), NDST4(13), OGT(2), RPN1(2), RPN2(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(1), ST3GAL4(4), ST6GALNAC1(2), STT3B(3), UST(7), XYLT1(8), XYLT2(7)	35680064	412	115	406	171	155	113	17	89	37	1	0.721	1.000	1.000
235	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	86	ACVR1(5), ACVR1B(12), ACVR1C(3), ACVR2A(6), ACVR2B(3), ACVRL1(3), AMHR2(2), BMP2(2), BMP4(4), BMP5(9), BMP6(6), BMP7(5), BMP8A(1), BMP8B(2), BMPR1A(3), BMPR1B(4), BMPR2(11), CHRD(6), COMP(2), CREBBP(26), CUL1(14), DCN(5), E2F4(1), E2F5(1), EP300(19), FST(2), GDF5(7), GDF6(11), GDF7(2), ID3(1), IFNG(2), INHBA(7), INHBB(8), INHBC(3), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(15), MAPK1(2), MAPK3(1), MYC(3), PITX2(4), PPP2CA(3), PPP2CB(2), PPP2R1A(9), PPP2R1B(4), PPP2R2A(5), PPP2R2B(5), PPP2R2C(5), RBL1(7), RBL2(4), RBX1(1), ROCK1(9), ROCK2(7), RPS6KB1(4), RPS6KB2(3), SMAD1(2), SMAD2(8), SMAD3(3), SMAD5(2), SMAD6(5), SMAD7(3), SMAD9(8), SMURF1(3), SMURF2(3), SP1(6), TFDP1(3), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), THBS1(12), THBS2(7), THBS3(6), THBS4(10), TNF(1), ZFYVE16(7), ZFYVE9(5)	31911395	419	115	411	172	147	116	22	73	58	3	0.615	1.000	1.000
236	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(28), ASH2L(4), C17orf79(1), CARM1(2), CTCFL(7), DOT1L(8), EHMT1(10), EHMT2(6), EZH1(4), EZH2(5), FBXO11(9), HCFC1(15), HSF4(4), JMJD4(1), JMJD6(2), KDM6A(9), MEN1(6), MLL(22), MLL2(45), MLL3(53), MLL4(26), MLL5(15), NSD1(16), OGT(2), PAXIP1(4), PPP1CA(2), PPP1CB(1), PPP1CC(4), PRDM2(22), PRDM9(15), PRMT1(2), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), RBBP5(1), SATB1(11), SETD1A(9), SETD2(11), SETD7(1), SETDB1(13), SETDB2(6), SMYD3(3), STK38(4), SUV39H1(5), SUV39H2(2), SUV420H1(9), SUV420H2(3), SUZ12(3), WHSC1(12), WHSC1L1(9)	38964491	463	113	458	158	144	128	13	96	74	8	0.268	1.000	1.000
237	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(3), AKT2(6), AKT3(6), BCL10(1), CARD11(15), CBL(2), CBLB(3), CBLC(2), CD247(3), CD3E(2), CD4(5), CD40LG(4), CD8A(4), CD8B(2), CDC42(1), CTLA4(3), FOS(1), FYN(8), GRAP2(4), GRB2(4), ICOS(1), IFNG(2), IKBKB(7), IL10(2), IL4(1), ITK(5), JUN(3), LAT(2), LCK(3), LCP2(5), MALT1(4), MAP3K14(3), NCK1(6), NCK2(3), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NRAS(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PDCD1(2), PDK1(2), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKCQ(7), PTPN6(3), PTPRC(15), RASGRP1(5), SOS1(6), SOS2(11), TEC(4), TNF(1), VAV1(6), VAV2(11), VAV3(10), ZAP70(10)	32307493	411	111	403	145	142	115	16	90	48	0	0.163	1.000	1.000
238	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(13), ABCA10(14), ABCA12(25), ABCA13(37), ABCA2(13), ABCA3(14), ABCA4(13), ABCA5(12), ABCA6(7), ABCA7(6), ABCA8(10), ABCA9(12), ABCB1(18), ABCB10(11), ABCB11(8), ABCB4(17), ABCB5(9), ABCB6(4), ABCB7(2), ABCB8(4), ABCB9(3), ABCC1(9), ABCC10(5), ABCC11(14), ABCC12(14), ABCC2(11), ABCC3(8), ABCC4(11), ABCC5(8), ABCC6(9), ABCC8(13), ABCC9(30), ABCD1(6), ABCD2(2), ABCD3(4), ABCD4(6), ABCG1(7), ABCG2(3), ABCG4(4), ABCG8(5), CFTR(8), TAP1(2), TAP2(10)	38721408	441	110	434	167	130	143	16	105	46	1	0.219	1.000	1.000
239	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(13), AMY2A(3), ASCC3(24), ATP13A2(10), DDX18(8), DDX19A(4), DDX23(7), DDX4(4), DDX41(7), DDX47(2), DDX50(6), DDX51(2), DDX52(1), DDX54(13), DDX55(3), DDX56(4), DHX58(7), ENPP1(5), ENPP3(4), ENTPD7(9), EP400(25), ERCC2(5), ERCC3(7), G6PC2(1), GAA(2), GANC(7), GBA(6), GBA3(1), GBE1(3), GCK(4), GPI(5), GUSB(8), GYS1(3), GYS2(4), HK1(11), HK2(8), HK3(5), IFIH1(5), LYZL1(4), MGAM(9), MOV10L1(3), NUDT5(1), PGM1(2), PGM3(10), PYGB(8), PYGL(6), PYGM(9), RAD54B(3), RAD54L(4), RUVBL2(2), SETX(12), SI(19), SKIV2L2(7), SMARCA2(16), SMARCA5(3), TREH(3), UGDH(5), UGP2(3), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(8), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3), UXS1(3)	40226518	426	109	426	155	132	135	14	104	41	0	0.278	1.000	1.000
240	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(3), AKT2(6), AKT3(6), CASP8(8), CCL5(1), CD14(2), CD40(1), CD80(1), CD86(2), CXCL10(1), CXCL9(2), FOS(1), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR1(5), IFNAR2(6), IFNB1(2), IKBKB(7), IKBKE(8), IL12A(2), IL12B(1), IL1B(2), IL8(1), IRAK1(5), IRAK4(2), IRF5(3), IRF7(1), JUN(3), LBP(1), LY96(1), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K7(8), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(5), MAPK9(4), MYD88(1), NFKB1(7), NFKB2(2), NFKBIA(1), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), RELA(3), RIPK1(1), SPP1(3), STAT1(7), TBK1(5), TICAM1(9), TIRAP(1), TLR1(5), TLR2(1), TLR3(5), TLR4(18), TLR5(8), TLR6(1), TLR7(5), TLR8(10), TLR9(13), TNF(1), TOLLIP(2), TRAF3(3), TRAF6(5)	28463223	335	108	322	124	103	85	17	89	41	0	0.392	1.000	1.000
241	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(4), ALG6(2), CCKBR(6), CCR2(5), CCR3(6), CCR5(3), CELSR1(23), CELSR2(17), CELSR3(30), CHRM2(13), CHRM3(9), CIDEB(2), DRD4(2), EDNRA(3), EMR2(9), EMR3(4), F2R(2), GHRHR(4), GNRHR(4), GPR116(11), GPR132(2), GPR133(9), GPR135(7), GPR143(4), GPR17(1), GPR18(2), GPR55(7), GPR56(4), GPR61(6), GPR77(1), GPR84(1), GRM1(26), GRPR(7), HRH4(3), LGR6(10), LPHN2(17), LPHN3(14), LTB4R2(2), NTSR1(5), OR2M4(5), OR8G2(5), P2RY13(2), PTGFR(3), SMO(10), SSTR2(3), TAAR5(5), TSHR(8), VN1R1(2)	21352906	330	107	327	121	111	92	16	89	22	0	0.134	1.000	1.000
242	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(34), AXIN1(8), CCND1(1), CCND2(3), CCND3(2), CSNK1E(7), CTNNB1(16), DVL1(4), DVL2(3), DVL3(8), FBXW2(3), FZD1(7), FZD10(14), FZD2(7), FZD3(5), FZD5(3), FZD6(5), FZD7(4), FZD8(6), FZD9(2), GSK3B(4), JUN(3), LDLR(7), MAPK10(5), MAPK9(4), MYC(3), PAFAH1B1(5), PLAU(2), PPP2R5C(6), PPP2R5E(4), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCI(4), PRKCQ(7), PRKD1(16), SFRP4(3), TCF7(3), WNT1(5), WNT10A(4), WNT10B(1), WNT11(2), WNT16(5), WNT2(4), WNT2B(7), WNT3(5), WNT4(1), WNT5A(4), WNT5B(3), WNT6(2), WNT7A(3), WNT7B(6)	19523144	307	107	300	106	109	68	15	63	48	4	0.0746	1.000	1.000
243	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(7), BAD(3), BCL2(2), CABIN1(13), CALM1(1), CALM2(3), CAMK2B(2), CAMK4(6), CD3E(2), CDKN1A(1), CNR1(7), CREBBP(26), CSNK2A1(7), CSNK2B(1), CTLA4(3), EGR2(6), EGR3(5), EP300(19), FCER1A(2), FCGR3A(3), FOS(1), GATA3(8), GATA4(4), GRLF1(15), GSK3A(2), GSK3B(4), ICOS(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(2), IL13(1), IL1B(2), IL2RA(2), IL3(1), IL4(1), IL8(1), ITK(5), JUNB(1), KPNA5(4), MAPK14(1), MAPK8(5), MAPK9(4), MEF2B(4), MEF2D(6), MYF5(3), NCK2(3), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NFKB2(2), NFKBIB(5), NPPB(2), NUP214(15), OPRD1(1), P2RX7(1), PAK1(5), PIN1(1), PPP3CB(6), PPP3CC(3), PTPRC(15), RELA(3), RPL13A(2), SLA(2), SP1(6), SP3(3), TGFB1(3), TNF(1), TRAF2(2), TRPV6(6), VAV1(6), VAV2(11), VAV3(10), XPO5(3)	29656458	369	105	365	142	123	114	12	78	42	0	0.330	1.000	1.000
244	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(6), CD14(2), CD19(3), CD1A(6), CD1B(5), CD1C(5), CD1D(7), CD1E(7), CD2(2), CD22(3), CD33(7), CD34(3), CD36(2), CD37(2), CD38(3), CD3E(2), CD4(5), CD44(4), CD5(4), CD55(2), CD7(3), CD8A(4), CD8B(2), CD9(1), CR1(23), CR2(8), CSF1(1), CSF1R(7), CSF2RA(8), CSF3(1), CSF3R(6), DNTT(2), EPOR(2), FCER2(1), FLT3(8), GP5(5), GP9(1), GYPA(3), HLA-DRA(6), IL11(2), IL11RA(2), IL1A(2), IL1B(2), IL1R1(4), IL1R2(5), IL2RA(2), IL3(1), IL3RA(5), IL4(1), IL4R(1), IL5RA(4), IL6R(1), IL7(1), IL7R(5), IL9R(3), ITGA1(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGAM(6), ITGB3(3), KIT(12), KITLG(2), MME(5), MS4A1(1), TFRC(1), THPO(4), TNF(1), TPO(15)	26757339	306	105	296	121	91	77	17	84	37	0	0.577	1.000	1.000
245	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(30), CCNA1(7), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(2), CCNH(2), CDC25A(3), CDK2(3), CDKN1A(1), CDKN2A(6), CDKN2D(3), CREB3(4), CREB3L1(3), CREB3L3(3), CREB3L4(1), E2F1(2), E2F2(3), E2F3(2), E2F4(1), E2F5(1), E2F6(2), MCM2(11), MCM3(3), MCM4(8), MCM5(5), MCM6(2), MCM7(5), MDM2(3), MNAT1(2), MYC(3), MYT1(14), NACA(2), ORC1L(8), ORC2L(2), ORC3L(5), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(3), POLE(17), POLE2(3), PRIM1(2), RB1(6), RBL1(7), RPA1(1), RPA2(1), RPA3(2), TFDP1(3), TFDP2(3), TNXB(38), WEE1(2)	25052377	261	103	256	94	95	72	13	52	27	2	0.209	1.000	1.000
246	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(2), BMP4(4), BMP5(9), BMP6(6), BMP7(5), BMP8A(1), BMP8B(2), BTRC(4), CSNK1A1(3), CSNK1A1L(2), CSNK1D(2), CSNK1E(7), CSNK1G1(2), CSNK1G2(4), CSNK1G3(5), DHH(2), FBXW11(10), GLI1(7), GLI2(11), GLI3(33), GSK3B(4), HHIP(7), IHH(4), LRP2(50), PRKACA(3), PRKACB(2), PRKACG(5), PRKX(4), PTCH1(15), PTCH2(6), RAB23(1), SHH(4), SMO(10), STK36(10), SUFU(5), WNT1(5), WNT10A(4), WNT10B(1), WNT11(2), WNT16(5), WNT2(4), WNT2B(7), WNT3(5), WNT3A(4), WNT4(1), WNT5A(4), WNT5B(3), WNT6(2), WNT7A(3), WNT7B(6), WNT8A(1), WNT8B(1), WNT9A(3), WNT9B(3), ZIC2(2)	19822309	317	103	313	99	124	79	13	72	29	0	0.0125	1.000	1.000
247	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(9), CPEB1(3), EGFR(11), ERBB2(12), ERBB4(33), ETS1(5), ETS2(3), ETV6(3), ETV7(4), FMN2(23), GRB2(4), MAP2K1(5), MAPK1(2), MAPK3(1), NOTCH1(19), NOTCH2(19), NOTCH3(16), NOTCH4(11), PIWIL1(5), PIWIL2(5), PIWIL3(2), PIWIL4(4), RAF1(7), SOS1(6), SOS2(11), SPIRE1(4), SPIRE2(2)	16951050	229	100	216	89	83	57	10	60	19	0	0.559	1.000	1.000
248	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(22), ACSL1(2), ACSL3(6), ACSL4(2), ACSL5(5), ACSL6(5), ADIPOQ(3), ADIPOR1(4), ADIPOR2(4), AGRP(1), AKT1(3), AKT2(6), AKT3(6), CAMKK1(5), CAMKK2(1), CD36(2), CPT1A(7), CPT1B(3), CPT1C(6), CPT2(5), G6PC2(1), IKBKB(7), IRS1(15), IRS2(4), IRS4(16), JAK1(6), JAK2(10), JAK3(9), LEPR(13), MAPK10(5), MAPK8(5), MAPK9(4), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NPY(1), PCK1(6), PCK2(7), POMC(6), PPARA(3), PPARGC1A(9), PRKAA1(4), PRKAA2(5), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(3), PRKAG3(2), PRKCQ(7), PTPN11(5), RELA(3), RXRA(3), RXRB(1), RXRG(5), SLC2A1(6), SLC2A4(4), SOCS3(3), STAT3(6), STK11(2), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF2(2), TYK2(4)	27172795	319	100	317	121	116	74	9	81	39	0	0.394	1.000	1.000
249	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(3), CDC40(5), CLK2(8), CLK3(8), CLK4(2), COL2A1(13), CPSF1(13), CPSF2(3), CPSF3(3), CPSF4(1), CSTF1(7), CSTF2(5), CSTF2T(4), CSTF3(5), DDIT3(3), DDX1(5), DDX20(4), DHX15(7), DHX16(4), DHX38(9), DHX8(10), DHX9(3), DICER1(8), DNAJC8(4), GIPC1(2), LOC440563(7), NCBP1(5), NONO(2), NUDT21(1), NXF1(5), PABPN1(2), PAPOLA(3), PHF5A(1), POLR2A(15), PPM1G(4), PRPF18(1), PRPF3(5), PRPF4(3), PRPF4B(10), PRPF8(13), PSKH1(4), PTBP1(5), PTBP2(1), RBM17(1), RBM5(4), RNGTT(3), RNMT(4), SF3A1(2), SF3A2(2), SF3A3(3), SF3B1(6), SF3B2(8), SF3B4(3), SF4(3), SFRS12(4), SFRS14(7), SFRS16(5), SFRS4(4), SFRS5(5), SFRS6(6), SFRS7(2), SFRS8(11), SFRS9(1), SNRPA(7), SNRPA1(2), SNRPB(1), SNRPB2(1), SNRPD1(2), SNRPD2(3), SNRPD3(2), SNRPE(1), SNRPN(5), SPOP(2), SRPK1(3), SRPK2(7), SRRM1(6), SUPT5H(7), U2AF1(3), U2AF2(3), XRN2(13)	34754765	378	98	376	119	140	111	19	72	36	0	0.113	1.000	1.000
250	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(3), AKT2(6), AKT3(6), BAD(3), CASP9(2), CDC42(1), KDR(8), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(4), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NOS3(5), NRAS(2), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCG1(16), PLCG2(11), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKCA(3), PRKCG(13), PTGS2(5), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(7), SH2D2A(5), SHC2(2), SPHK1(4), SPHK2(2), SRC(2)	22701643	297	97	289	86	112	74	11	68	32	0	0.00443	1.000	1.000
251	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(2), AKT1(3), BDKRB2(3), CALM1(1), CALM2(3), CAV1(4), CHRM1(2), CHRNA1(4), FLT1(13), FLT4(17), KDR(8), NOS3(5), PDE2A(8), PDE3A(11), PDE3B(13), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKG1(8), PRKG2(10), RYR2(61), SLC7A1(4), SYT1(3), TNNI1(1)	13296629	206	96	206	79	64	59	7	63	13	0	0.375	1.000	1.000
252	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(2), ACTR3(2), AKT1(3), AKT2(6), AKT3(6), ANGPTL2(3), ARHGAP1(1), ARHGAP4(4), ARHGEF11(12), BTK(2), CDC42(1), CFL1(1), GDI1(2), GDI2(3), INPPL1(14), ITPR1(21), ITPR2(20), ITPR3(30), LIMK1(3), MYLK(15), MYLK2(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PDK1(2), PIK3CD(10), PIK3CG(15), PIK3R1(8), PITX2(4), PPP1R13B(6), RACGAP1(5), RHO(6), ROCK1(9), ROCK2(7), SAG(2), WASF1(3), WASL(1)	22063068	264	96	257	88	104	68	12	49	29	2	0.105	1.000	1.000
253	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), AK3(5), CAD(12), CANT1(3), CTPS(2), CTPS2(3), DCTD(1), DHODH(2), DPYD(12), DPYS(7), DUT(1), ENTPD1(5), ENTPD3(4), ENTPD4(7), ENTPD6(2), ENTPD8(6), NME6(2), NME7(1), NT5C(1), NT5C1A(4), NT5C1B(5), NT5C2(7), NT5C3(1), NUDT2(3), PNPT1(4), POLA1(5), POLA2(3), POLD1(10), POLD2(1), POLD3(3), POLE(17), POLE2(3), POLE3(1), POLR1A(12), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLR3A(15), POLR3B(7), POLR3G(2), POLR3K(1), PRIM1(2), PRIM2(6), RFC5(1), RRM1(5), RRM2(3), RRM2B(4), TK1(1), TK2(2), TXNRD1(5), TXNRD2(2), TYMS(1), UCK1(5), UCK2(1), UMPS(3), UPB1(2), UPP2(4), UPRT(3)	26600100	271	95	267	97	98	72	13	60	28	0	0.219	1.000	1.000
254	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(5), ATM(30), ATR(12), BAI1(8), BAX(1), BID(2), CASP3(2), CASP8(8), CASP9(2), CCNB1(3), CCNB2(1), CCNB3(16), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(2), CD82(3), CDK2(3), CDK6(4), CDKN1A(1), CDKN2A(6), CHEK1(4), CHEK2(7), DDB2(1), EI24(1), FAS(3), GTSE1(3), IGF1(4), IGFBP3(5), LRDD(6), MDM2(3), MDM4(4), PERP(3), PPM1D(7), RCHY1(1), RFWD2(5), RPRM(3), RRM2(3), RRM2B(4), SERPINB5(2), SERPINE1(3), SESN1(1), SESN2(2), SESN3(4), SIAH1(1), STEAP3(6), THBS1(12), TNFRSF10B(2), TP73(2), TSC2(7), ZMAT3(4)	20865295	231	95	229	79	71	67	7	55	29	2	0.262	1.000	1.000
255	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	78	AIFM1(2), AKT1(3), AKT2(6), AKT3(6), APAF1(5), ATM(30), BAD(3), BAX(1), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CAPN1(2), CAPN2(3), CASP10(5), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), CSF2RB(7), DFFA(4), DFFB(3), FAS(3), FASLG(2), IKBKB(7), IL1A(2), IL1B(2), IL1R1(4), IL1RAP(5), IL3(1), IL3RA(5), IRAK1(5), IRAK2(8), IRAK3(4), IRAK4(2), MAP3K14(3), MYD88(1), NFKB1(7), NFKB2(2), NFKBIA(1), NTRK1(6), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKACA(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RELA(3), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(3), TNFRSF1A(3), TNFSF10(3), TRADD(2), TRAF2(2)	26372946	298	95	290	93	105	71	9	67	44	2	0.0662	1.000	1.000
256	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(4), ACTB(7), ARHGEF2(10), CD14(2), CDC42(1), CLDN1(2), CTNNB1(16), CTTN(5), EZR(3), FYN(8), HCLS1(3), ITGB1(6), KRT18(2), LY96(1), NCK1(6), NCK2(3), NCL(6), OCLN(4), PRKCA(3), ROCK1(9), ROCK2(7), TLR4(18), TLR5(8), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(5), TUBA3D(4), TUBA3E(9), TUBA4A(1), TUBA8(4), TUBAL3(4), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB3(12), TUBB4(4), TUBB4Q(4), TUBB6(7), TUBB8(3), WAS(1), WASL(1), YWHAQ(2), YWHAZ(2)	16560495	210	95	203	70	69	64	6	54	16	1	0.0926	1.000	1.000
257	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(4), ACTB(7), ARHGEF2(10), CD14(2), CDC42(1), CLDN1(2), CTNNB1(16), CTTN(5), EZR(3), FYN(8), HCLS1(3), ITGB1(6), KRT18(2), LY96(1), NCK1(6), NCK2(3), NCL(6), OCLN(4), PRKCA(3), ROCK1(9), ROCK2(7), TLR4(18), TLR5(8), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(5), TUBA3D(4), TUBA3E(9), TUBA4A(1), TUBA8(4), TUBAL3(4), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB3(12), TUBB4(4), TUBB4Q(4), TUBB6(7), TUBB8(3), WAS(1), WASL(1), YWHAQ(2), YWHAZ(2)	16560495	210	95	203	70	69	64	6	54	16	1	0.0926	1.000	1.000
258	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(1), BRAF(9), CREB1(3), DAXX(9), ELK1(3), FOS(1), GRB2(4), IKBKB(7), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K5(1), MAP2K6(1), MAP3K1(9), MAP3K10(8), MAP3K11(7), MAP3K12(9), MAP3K13(7), MAP3K14(3), MAP3K2(3), MAP3K3(4), MAP3K4(15), MAP3K5(4), MAP3K6(5), MAP3K7(8), MAP3K9(3), MAP4K1(3), MAP4K2(4), MAP4K3(3), MAP4K4(8), MAP4K5(3), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(6), MAPK6(1), MAPK7(7), MAPK8(5), MAPK9(4), MAPKAPK2(1), MAPKAPK3(4), MAPKAPK5(1), MAX(3), MEF2B(4), MEF2C(3), MEF2D(6), MKNK1(3), MKNK2(1), MYC(3), NFKB1(7), NFKBIA(1), PAK1(5), PAK2(6), RAF1(7), RELA(3), RIPK1(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KA4(1), RPS6KA5(2), RPS6KB1(4), RPS6KB2(3), SHC1(3), SP1(6), STAT1(7), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TRADD(2), TRAF2(2)	30931102	328	95	320	125	112	87	16	60	53	0	0.498	1.000	1.000
259	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(2), ADAM17(5), ATP6AP1(5), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), CASP3(2), CCL5(1), CDC42(1), CSK(5), EGFR(11), F11R(2), GIT1(3), HBEGF(2), IGSF5(2), IKBKB(7), IL8(1), JAM2(2), JAM3(4), JUN(3), LYN(4), MAP2K4(7), MAP3K14(3), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK8(5), MAPK9(4), MET(7), NFKB1(7), NFKB2(2), NFKBIA(1), NOD1(8), PAK1(5), PLCG1(16), PLCG2(11), PTPN11(5), PTPRZ1(19), RELA(3), SRC(2), TCIRG1(6), TJP1(11)	23054693	253	94	248	97	74	73	8	67	31	0	0.523	1.000	1.000
260	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(9), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), AOC2(4), AOC3(4), AOX1(7), CARM1(2), COMT(4), DBH(5), DCT(8), DDC(5), ESCO1(4), ESCO2(4), FAH(3), GOT1(2), GOT2(2), GSTZ1(3), HEMK1(1), HGD(3), HPD(1), LCMT1(1), LCMT2(7), MAOA(1), MAOB(3), METTL6(2), MIF(1), MYST3(20), MYST4(15), NAT6(2), PNMT(8), PNPLA3(1), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), SH3GLB1(1), TAT(4), TH(2), TPO(15), TYR(6), TYRP1(3), WBSCR22(4)	19503124	229	92	227	69	76	64	6	61	21	1	0.0226	1.000	1.000
261	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(6), AKT3(6), ANKRD6(3), APC(34), AXIN1(8), AXIN2(4), CER1(2), CSNK1A1(3), CTNNB1(16), DACT1(8), DKK1(7), DKK2(4), DKK3(2), DKK4(1), DVL1(4), FSTL1(2), GSK3A(2), GSK3B(4), LRP1(25), MVP(5), NKD1(5), NKD2(1), PIN1(1), PSEN1(2), PTPRA(7), SENP2(2), SFRP1(4), TSHB(2), WIF1(2)	13210667	175	92	169	60	56	45	3	41	27	3	0.378	1.000	1.000
262	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(3), ADCY4(5), ADCY6(10), ADCY8(21), CACNA1A(16), CACNA1B(22), GNAS(20), GNAT3(4), GNG13(2), GRM4(6), ITPR3(30), KCNB1(8), PDE1A(6), PLCB2(4), PRKACA(3), PRKACB(2), PRKACG(5), PRKX(4), SCNN1A(1), SCNN1B(7), SCNN1G(3), TAS1R1(6), TAS1R2(5), TAS1R3(7), TAS2R1(3), TAS2R13(3), TAS2R14(1), TAS2R16(5), TAS2R3(2), TAS2R38(5), TAS2R39(1), TAS2R4(4), TAS2R40(3), TAS2R41(1), TAS2R43(3), TAS2R5(3), TAS2R50(1), TAS2R60(3), TAS2R7(3), TAS2R8(1), TAS2R9(1), TRPM5(4)	18620215	247	91	244	97	93	72	10	57	15	0	0.390	1.000	1.000
263	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(3), AKT2(6), AKT3(6), BAD(3), BCL2(2), BCR(9), BLNK(3), BTK(2), CD19(3), CD22(3), CD81(3), CR2(8), CSK(5), DAG1(8), FLOT1(2), FLOT2(3), GRB2(4), GSK3A(2), GSK3B(4), INPP5D(1), ITPR1(21), ITPR2(20), ITPR3(30), LYN(4), MAP4K1(3), MAPK1(2), MAPK3(1), NFATC1(11), NFATC2(14), NR0B2(2), PDK1(2), PIK3CD(10), PIK3R1(8), PLCG2(11), PPP1R13B(6), PPP3CA(5), PPP3CB(6), PPP3CC(3), PTPRC(15), RAF1(7), SHC1(3), SOS1(6), SOS2(11), SYK(6), VAV1(6)	23590738	293	91	287	100	111	71	7	70	33	1	0.117	1.000	1.000
264	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(2), AGT(3), AKT1(3), CALM1(1), CALM2(3), CALR(3), CAMK1(2), CAMK1G(3), CAMK4(6), CREBBP(26), CSNK1A1(3), EDN1(2), ELSPBP1(1), F2(5), FGF2(2), FKBP1A(2), GATA4(4), GSK3B(4), HAND1(2), HAND2(1), IGF1(4), LIF(1), MAP2K1(5), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(5), MEF2C(3), MYH2(23), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NKX2-5(3), NPPA(1), PIK3R1(8), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RAF1(7), RPS6KB1(4), SYT1(3)	15905471	226	90	223	76	84	59	8	45	30	0	0.0669	1.000	1.000
265	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(6), AKT3(6), ASAH1(2), BRAF(9), DAG1(8), DRD2(7), EGFR(11), EPHB2(8), GRB2(4), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), KCNJ3(9), KCNJ5(3), MAPK1(2), PI3(1), PIK3CB(7), PITX2(4), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), RAF1(7), RGS20(4), SHC1(3), SOS1(6), SOS2(11), SRC(2), STAT3(6), TERF2IP(4)	19212115	246	90	241	96	97	64	7	61	16	1	0.498	1.000	1.000
266	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(3), AKT2(6), AKT3(6), BCR(9), BTK(2), CD19(3), CDKN2A(6), DAPP1(1), FLOT1(2), FLOT2(3), GAB1(2), ITPR1(21), ITPR2(20), ITPR3(30), LYN(4), NR0B2(2), PDK1(2), PHF11(4), PITX2(4), PLCG2(11), PPP1R13B(6), PREX1(13), PTPRC(15), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), SAG(2), SYK(6), TEC(4), VAV1(6)	17162294	214	89	211	84	82	51	5	52	23	1	0.582	1.000	1.000
267	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(3), APC(34), AR(11), ASAH1(2), BRAF(9), CAMP(2), CCL15(2), CCL16(1), DAG1(8), EGFR(11), GNA11(5), GNA15(3), GNAI1(1), GNAQ(3), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), KCNJ3(9), KCNJ5(3), MAPK1(2), MAPK10(5), MAPK14(1), PHKA2(9), PIK3CD(10), PIK3R1(8), PITX2(4), PTX3(2), RAF1(7), SRC(2)	16790187	236	89	227	82	88	55	11	50	29	3	0.164	1.000	1.000
268	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(9), AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AGPAT6(3), CDIPT(1), CDS1(4), CDS2(2), CHAT(4), CHKA(1), CHKB(2), CHPT1(3), CRLS1(1), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKI(9), DGKZ(4), ESCO1(4), ESCO2(4), ETNK1(1), ETNK2(1), GNPAT(1), GPAM(7), GPD1(6), GPD1L(3), GPD2(6), LCAT(4), MYST3(20), MYST4(15), NAT6(2), PCYT1A(6), PCYT1B(5), PEMT(1), PISD(5), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLD1(13), PLD2(13), PNPLA3(1), PPAP2A(1), PPAP2C(4), PTDSS1(3), PTDSS2(2), SH3GLB1(1)	21395653	243	88	242	87	82	76	9	55	20	1	0.163	1.000	1.000
269	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(3), AKT2(6), AKT3(6), BCL10(1), BLNK(3), BTK(2), CARD11(15), CD19(3), CD22(3), CD72(1), CD79A(6), CD79B(1), CD81(3), CR2(8), FCGR2B(3), FOS(1), GSK3B(4), IFITM1(3), IKBKB(7), INPP5D(1), JUN(3), LILRB3(3), LYN(4), MALT1(4), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NRAS(2), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG2(11), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PTPN6(3), RAC2(2), RAC3(3), RASGRP3(4), SYK(6), VAV1(6), VAV2(11), VAV3(10)	23571755	293	88	289	103	109	81	7	62	34	0	0.113	1.000	1.000
270	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(7), AKT1(3), APC(34), ASAH1(2), CAMP(2), CAV3(2), DAG1(8), DLG4(3), EPHB2(8), GNAI1(1), GNAQ(3), ITPR1(21), ITPR2(20), ITPR3(30), KCNJ3(9), KCNJ5(3), MAPK1(2), PITX2(4), PTX3(2), RHO(6), RYR1(43)	15057186	213	88	208	79	87	45	7	45	26	3	0.259	1.000	1.000
271	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	71	AKT1(3), AKT2(6), AKT3(6), BTK(2), FCER1A(2), FYN(8), GRB2(4), IL13(1), IL3(1), IL4(1), INPP5D(1), LAT(2), LCP2(5), LYN(4), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(5), MAPK9(4), MS4A2(1), NRAS(2), PDK1(2), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCG1(16), PLCG2(11), PRKCA(3), PRKCD(7), PRKCE(8), RAC2(2), RAC3(3), RAF1(7), SOS1(6), SOS2(11), SYK(6), TNF(1), VAV1(6), VAV2(11), VAV3(10)	22554606	289	87	282	90	99	81	8	68	33	0	0.0479	1.000	1.000
272	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	64	AGTR1(1), AGTR2(2), ATP8A1(7), AVPR1A(8), AVPR1B(2), AVPR2(4), BDKRB1(1), BDKRB2(3), BRS3(3), C3AR1(5), CCKAR(4), CCKBR(6), CCR1(2), CCR10(2), CCR2(5), CCR3(6), CCR5(3), CCR6(1), CCR7(2), CCR8(1), CX3CR1(3), CXCR4(1), CXCR6(2), EDNRA(3), FPR1(4), GALR1(5), GALR2(9), GALR3(1), GALT(1), GHSR(8), GNB2L1(4), GNRHR(4), GPR77(1), GRPR(7), LHCGR(10), MC2R(2), MC3R(3), MC4R(5), MC5R(5), NMBR(3), NPY1R(3), NPY2R(3), NPY5R(3), NTSR1(5), NTSR2(3), OPRD1(1), OPRK1(6), OPRL1(6), OPRM1(3), OXTR(5), PPYR1(6), SSTR1(9), SSTR2(3), SSTR3(5), SSTR4(11), TACR1(3), TACR2(1), TACR3(11), TRHR(4), TSHR(8)	16399395	248	87	243	100	99	77	8	47	17	0	0.156	1.000	1.000
273	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	47	AKT1(3), AKT2(6), AKT3(6), BRD4(9), CAP1(3), CBL(2), CDC42(1), CDKN2A(6), F2RL2(2), FLOT1(2), FLOT2(3), GRB2(4), GSK3A(2), GSK3B(4), IGFBP1(5), INPPL1(14), IRS1(15), IRS2(4), IRS4(16), LNPEP(8), MAPK1(2), MAPK3(1), PARD3(9), PARD6A(1), PDK1(2), PIK3CD(10), PIK3R1(8), PPYR1(6), PTPN1(2), RAF1(7), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), SERPINB6(3), SHC1(3), SLC2A4(4), SORBS1(7), SOS1(6), SOS2(11), YWHAB(1), YWHAE(1), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(2)	18523139	228	87	224	78	94	58	3	40	33	0	0.179	1.000	1.000
274	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(2), ACTN1(6), ACTN2(22), ACTN3(2), BCAR1(4), BCR(9), CAPN1(2), CAPNS1(2), CAPNS2(2), CAV1(4), CRKL(1), CSK(5), FYN(8), GRB2(4), ITGA1(7), ITGB1(6), JUN(3), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MAPK8(5), PPP1R12B(12), PTK2(10), PXN(3), RAF1(7), RAP1A(2), ROCK1(9), SHC1(3), SOS1(6), SRC(2), TLN1(14), VCL(1), ZYX(5)	15422014	178	86	173	68	63	45	9	47	13	1	0.451	1.000	1.000
275	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(4), APOA1(5), CD36(2), CITED2(3), CPT1B(3), CREBBP(26), DUSP1(2), DUT(1), EHHADH(6), EP300(19), HSD17B4(4), HSPA1A(1), JUN(3), LPL(4), MAPK1(2), MAPK3(1), ME1(1), MYC(3), NCOA1(12), NCOR1(24), NCOR2(21), NFKBIA(1), NR0B2(2), NR1H3(4), NR2F1(3), NRIP1(11), PDGFA(2), PIK3R1(8), PPARA(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PTGS2(5), RB1(6), RELA(3), RXRA(3), SP1(6), SRA1(2), STAT5A(4), STAT5B(6), TNF(1)	20001670	242	86	240	81	68	74	8	58	33	1	0.105	1.000	1.000
276	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(5), APC(34), ATF2(1), AXIN1(8), BMP10(4), BMP2(2), BMP4(4), BMP5(9), BMP7(5), BMPR1A(3), BMPR2(11), CHRD(6), CTNNB1(16), DVL1(4), FZD1(7), GATA4(4), GSK3B(4), MAP3K7(8), MEF2C(3), MYL2(6), NKX2-5(3), NPPA(1), NPPB(2), RFC1(5), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), TGFBR3(4), WNT1(5)	11912653	194	85	188	66	51	47	9	42	40	5	0.402	1.000	1.000
277	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(2), IMPA1(3), IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(5), INPP5B(7), INPP5E(6), INPPL1(14), IPMK(1), ISYNA1(2), ITGB1BP3(2), ITPK1(4), ITPKA(1), ITPKB(7), MINPP1(4), MIOX(3), OCRL(8), PI4KA(11), PI4KB(3), PIK3C3(10), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1B(1), PIP5K1C(8), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCD3(8), PLCD4(2), PLCE1(11), PLCG1(16), PLCG2(11), PLCZ1(3), PTPMT1(1), SYNJ1(7), SYNJ2(9)	23369459	259	85	250	86	102	76	4	54	23	0	0.0601	1.000	1.000
278	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(7), AR(11), ESR1(7), ESR2(8), HNF4A(8), NR0B1(2), NR1D1(4), NR1D2(5), NR1H2(6), NR1H3(4), NR1I2(6), NR1I3(3), NR2C2(2), NR2E1(2), NR2F1(3), NR2F2(3), NR2F6(3), NR3C1(5), NR4A1(4), NR4A2(9), NR5A1(5), NR5A2(1), PGR(12), PPARA(3), PPARD(7), PPARG(1), RARA(2), RARB(6), ROR1(6), RORA(5), RORC(4), RXRA(3), RXRB(1), RXRG(5), THRA(4), THRB(7), VDR(3)	13747936	177	85	175	78	71	38	13	43	12	0	0.772	1.000	1.000
279	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(5), CAD(12), CANT1(3), CTPS(2), CTPS2(3), DCTD(1), DHODH(2), DPYD(12), DPYS(7), DUT(1), ENTPD1(5), NT5C(1), NUDT2(3), POLB(2), POLD1(10), POLD2(1), POLE(17), POLG(5), POLL(2), POLQ(22), POLR1B(4), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLRMT(10), RRM1(5), RRM2(3), TK1(1), TK2(2), TXNRD1(5), TYMS(1), UCK1(5), UCK2(1), UMPS(3), UNG(1), UPB1(2)	18781247	191	85	188	74	58	53	11	49	20	0	0.514	1.000	1.000
280	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAK1(3), BAX(1), BFAR(2), BTK(2), CAD(12), CASP10(5), CASP3(2), CASP8(8), CASP8AP2(7), CD7(3), CSNK1A1(3), DAXX(9), DEDD(2), DEDD2(1), DFFA(4), DIABLO(1), EGFR(11), EPHB2(8), FAF1(8), FAIM2(1), IL1A(2), IL8(1), MAP2K4(7), MAP3K1(9), MAP3K5(4), MAPK1(2), MAPK10(5), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), MET(7), NFAT5(9), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), NR0B2(2), PFN2(2), PTPN13(16), RALBP1(5), RIPK1(1), ROCK1(9), SMPD1(5), TPX2(6), TRAF2(2), TUFM(3)	23374031	238	85	235	95	79	65	7	55	31	1	0.585	1.000	1.000
281	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(2), CSK(5), CTLA4(3), DAG1(8), EPHB2(8), GRAP2(4), GRB2(4), ITK(5), ITPKA(1), ITPKB(7), LAT(2), LCK(3), LCP2(5), MAPK1(2), NCK1(6), NFAT5(9), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PLCG1(16), PTPRC(15), RAF1(7), RASGRP1(5), RASGRP2(6), RASGRP3(4), RASGRP4(3), SOS1(6), SOS2(11), VAV1(6), ZAP70(10)	17762791	220	85	215	77	75	59	9	55	22	0	0.313	1.000	1.000
282	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), AGK(5), AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AGPAT6(3), AKR1A1(1), AKR1B1(6), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), CEL(7), DAK(5), DGAT1(1), DGAT2(1), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKI(9), DGKZ(4), GK(3), GK2(3), GLB1(2), GPAM(7), LCT(15), LIPA(1), LIPC(2), LIPF(2), LIPG(2), LPL(4), MGLL(1), PNLIP(4), PNLIPRP1(3), PNLIPRP2(5), PNPLA3(1), PPAP2A(1), PPAP2C(4)	19253651	199	83	198	84	57	69	5	47	20	1	0.567	1.000	1.000
283	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	APAF1(5), ARHGDIB(1), BAG4(1), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CASP2(3), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), CRADD(1), DAXX(9), DFFA(4), DFFB(3), GSN(9), LMNA(3), LMNB1(1), LMNB2(4), MAP3K1(9), MAP3K14(3), MAP3K5(4), MAPK8(5), MDM2(3), NFKB1(7), NFKBIA(1), NUMA1(17), PAK2(6), PRKCD(7), PRKDC(32), PSEN1(2), PSEN2(2), PTK2(10), RASA1(11), RB1(6), RELA(3), RIPK1(1), SPTAN1(18), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF1(3), TRAF2(2)	22473626	228	82	223	79	70	66	12	46	34	0	0.264	1.000	1.000
284	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(6), ALPL(4), ALPP(7), ALPPL2(6), ASCC3(24), ATP13A2(10), DDX18(8), DDX19A(4), DDX23(7), DDX4(4), DDX41(7), DDX47(2), DDX50(6), DDX51(2), DDX52(1), DDX54(13), DDX55(3), DDX56(4), DHX58(7), ENTPD7(9), EP400(25), ERCC2(5), ERCC3(7), FPGS(1), GGH(3), IFIH1(5), MOV10L1(3), NUDT5(1), QDPR(1), RAD54B(3), RAD54L(4), RUVBL2(2), SETX(12), SKIV2L2(7), SMARCA2(16), SMARCA5(3), SPR(2)	20604849	234	82	233	90	92	62	8	51	21	0	0.482	1.000	1.000
285	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(34), AXIN1(8), CREBBP(26), CTNNB1(16), DVL1(4), EP300(19), FZD1(7), GSK3B(4), HDAC1(3), LDB1(4), LEF1(5), PITX2(4), TRRAP(37), WNT1(5)	10862484	176	82	168	52	64	39	5	32	33	3	0.0571	1.000	1.000
286	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM1(1), CALM2(3), CD3E(2), ELK1(3), FOS(1), FYN(8), GRB2(4), JUN(3), LAT(2), LCK(3), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK3(1), MAPK8(5), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NFKB1(7), NFKBIA(1), PIK3R1(8), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKCA(3), PTPN7(3), RAF1(7), RASA1(11), RELA(3), SHC1(3), SOS1(6), SYT1(3), VAV1(6), ZAP70(10)	14970604	199	81	192	49	68	56	4	38	33	0	0.00195	1.000	1.000
287	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(34), AXIN1(8), BTRC(4), CCND1(1), CREBBP(26), CSNK1A1(3), CSNK1D(2), CSNK2A1(7), CTBP1(3), CTNNB1(16), DVL1(4), FZD1(7), GSK3B(4), HDAC1(3), MAP3K7(8), MYC(3), NLK(6), PPARD(7), PPP2CA(3), TLE1(5), WIF1(2), WNT1(5)	9597024	161	81	153	44	50	38	8	27	35	3	0.0360	1.000	1.000
288	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(5), AASS(6), ACAT1(3), ACAT2(3), AKR1B10(2), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), BBOX1(3), DLST(4), DOT1L(8), EHHADH(6), EHMT1(10), EHMT2(6), GCDH(5), HADH(3), HADHA(4), HSD17B4(4), HSD3B7(4), NSD1(16), OGDH(7), OGDHL(10), PIPOX(3), PLOD1(7), PLOD2(6), PLOD3(8), RDH11(1), RDH12(1), RDH13(3), SETD1A(9), SETD7(1), SETDB1(13), SHMT1(1), SHMT2(5), SPCS1(1), SPCS3(2), SUV39H1(5), SUV39H2(2), TMLHE(5)	19021800	210	80	207	68	71	62	7	43	27	0	0.0829	1.000	1.000
289	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(2), ACADM(4), ACOX1(4), ACOX2(6), ACOX3(8), ACSL1(2), ACSL3(6), ACSL4(2), ACSL5(5), ACSL6(5), ADIPOQ(3), ANGPTL4(2), APOA1(5), APOA5(5), AQP7(2), CD36(2), CPT1A(7), CPT1B(3), CPT1C(6), CPT2(5), CYP27A1(4), CYP4A11(2), CYP4A22(2), CYP7A1(4), CYP8B1(5), EHHADH(6), FABP2(1), FABP3(1), FABP5(1), FABP6(3), FABP7(1), FADS2(4), GK(3), GK2(3), HMGCS2(3), ILK(3), LPL(4), ME1(1), MMP1(3), NR1H3(4), OLR1(2), PCK1(6), PCK2(7), PDPK1(2), PLTP(2), PPARA(3), PPARD(7), PPARG(1), RXRA(3), RXRB(1), RXRG(5), SCD(1), SCP2(4), SLC27A1(3), SLC27A2(4), SLC27A4(6), SLC27A5(4), SLC27A6(7), SORBS1(7), UBC(5), UCP1(1)	21504904	223	80	220	81	85	44	16	59	19	0	0.322	1.000	1.000
290	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(7), ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(3), CDC42(1), CFL1(1), FLNA(16), FLNC(22), FSCN1(5), FSCN3(11), GDI1(2), GDI2(3), LIMK1(3), MYH2(23), MYLK(15), MYLK2(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PFN2(2), RHO(6), ROCK1(9), ROCK2(7), VASP(2), WASF1(3), WASL(1)	15700591	184	80	183	66	75	49	6	37	16	1	0.173	1.000	1.000
291	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(12), GABBR1(8), GPRC5B(8), GPRC5C(3), GPRC5D(2), GRM1(26), GRM2(19), GRM3(12), GRM4(6), GRM5(23), GRM7(15), GRM8(15)	6883262	149	79	141	55	67	26	7	39	10	0	0.225	1.000	1.000
292	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(18), COL4A2(10), COL4A3(8), COL4A4(10), COL4A5(9), COL4A6(6), F10(6), F11(3), F12(2), F2(5), F2R(2), F5(13), F8(15), F9(6), FGA(7), FGB(2), FGG(2), KLKB1(7), PROC(2), PROS1(8), SERPINC1(4), SERPING1(5)	14598158	150	79	150	56	40	45	7	48	10	0	0.298	1.000	1.000
293	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(4), ABO(1), B3GALNT1(2), B3GALT1(3), B3GALT2(6), B3GALT4(4), B3GALT5(1), B3GNT1(3), B3GNT2(2), B3GNT3(5), B3GNT4(4), B3GNT5(3), B4GALNT1(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT4(4), B4GALT6(2), FUT1(2), FUT3(1), FUT4(1), FUT5(2), FUT6(2), FUT7(2), FUT9(5), GBGT1(1), GCNT2(1), PIGA(2), PIGB(5), PIGC(3), PIGG(8), PIGK(3), PIGL(2), PIGM(5), PIGN(5), PIGO(4), PIGP(1), PIGQ(2), PIGS(3), PIGT(2), PIGU(1), PIGV(4), PIGX(2), PIGZ(2), ST3GAL1(4), ST3GAL2(4), ST3GAL3(1), ST3GAL4(4), ST3GAL5(2), ST3GAL6(3), ST6GALNAC3(5), ST6GALNAC5(1), ST6GALNAC6(2), ST8SIA1(4), ST8SIA5(4), UGCG(3)	15889413	164	78	161	76	67	40	4	39	13	1	0.871	1.000	1.000
294	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(5), APH1A(1), CREBBP(26), CTBP1(3), CTBP2(5), DLL1(10), DLL3(5), DLL4(3), DTX1(11), DTX2(4), DTX3(1), DTX3L(1), DTX4(6), DVL1(4), DVL2(3), DVL3(8), EP300(19), HDAC1(3), HDAC2(2), JAG1(10), JAG2(4), MAML1(5), MAML2(6), MAML3(8), NCOR2(21), NCSTN(4), NOTCH1(19), NOTCH2(19), NOTCH3(16), NOTCH4(11), NUMB(2), NUMBL(3), PSEN1(2), PSEN2(2), PSENEN(2), PTCRA(1), RBPJ(5), RBPJL(2), RFNG(2), SNW1(3)	22550659	267	78	263	123	104	65	14	52	32	0	0.802	1.000	1.000
295	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(2), DAXX(9), EGF(8), EGFR(11), ETS1(5), ETS2(3), FOS(1), HOXA7(2), IKBKB(7), JUN(3), MAP2K1(5), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K1(9), MAP3K14(3), MAP3K5(4), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(5), NFKB1(7), NFKBIA(1), PPP2CA(3), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCQ(7), RAF1(7), RELA(3), RIPK1(1), SP1(6), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2)	15879375	176	78	170	68	62	47	5	35	27	0	0.381	1.000	1.000
296	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(3), ASAH1(2), BRAF(9), CAMP(2), CREB1(3), CREB3(4), CREB5(4), CREBBP(26), CRKL(1), DAG1(8), EGR1(4), EGR2(6), EGR3(5), EGR4(4), ELK1(3), FRS2(3), GNAQ(3), JUN(3), MAP1B(12), MAP2K4(7), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), NTRK1(6), OPN1LW(6), PIK3C2G(7), PIK3CD(10), PIK3R1(8), PTPN11(5), RPS6KA3(3), SHC1(3), SRC(2), TERF2IP(4), TH(2)	15847083	200	78	198	75	72	58	3	39	28	0	0.226	1.000	1.000
297	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(13), AMY2A(3), ENPP1(5), ENPP3(4), GAA(2), GANAB(4), GBA3(1), GBE1(3), GCK(4), GPI(5), GUSB(8), GYS1(3), GYS2(4), HK1(11), HK2(8), HK3(5), MGAM(9), PGM1(2), PGM3(10), PYGB(8), PYGL(6), PYGM(9), RNPC3(1), SI(19), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(2), UGT2B4(3), UXS1(3)	18327464	183	78	183	68	53	57	4	47	22	0	0.381	1.000	1.000
298	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(2), CRK(1), CRKL(1), DOCK1(15), ELK1(3), FOS(1), GAB1(2), GRB2(4), HGF(13), ITGA1(7), ITGB1(6), JUN(3), MAP2K1(5), MAP2K2(2), MAP4K1(3), MAPK1(2), MAPK3(1), MAPK8(5), MET(7), PAK1(5), PIK3R1(8), PTK2(10), PTK2B(10), PTPN11(5), PXN(3), RAF1(7), RAP1A(2), RAP1B(5), RASA1(11), SOS1(6), SRC(2), STAT3(6)	13527236	163	77	156	54	45	41	9	43	25	0	0.233	1.000	1.000
299	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(3), AKT2(6), AKT3(6), BAD(3), BCR(9), BLNK(3), BTK(2), CD19(3), CSK(5), DAG1(8), EPHB2(8), GRB2(4), ITPKA(1), ITPKB(7), LYN(4), MAP2K1(5), MAP2K2(2), MAPK1(2), NFAT5(9), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PI3(1), PIK3CD(10), PIK3R1(8), PLCG2(11), PPP1R13B(6), RAF1(7), SERPINA4(2), SHC1(3), SOS1(6), SOS2(11), SYK(6), VAV1(6)	16569310	191	77	188	72	67	50	4	49	21	0	0.440	1.000	1.000
300	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(3), DAG1(8), DGKA(4), ETFA(1), GCA(2), ITGA9(7), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), MAP2K1(5), MAPK1(2), MAPK3(1), NR1I3(3), PAK1(5), PDE3A(11), PDE3B(13), PI3(1), PIK3C2G(7), PIK3CD(10), PIK3R1(8), PLDN(1), PSME1(2), RIPK3(4), SGCB(3), VASP(2)	15267121	189	77	186	63	69	49	8	42	20	1	0.101	1.000	1.000
301	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(5), BAD(3), BAX(1), BCL2(2), BCL2L2(1), BOK(1), CASP1(2), CASP10(5), CASP2(3), CASP3(2), CASP4(4), CASP6(1), CASP7(2), CASP8(8), CASP9(2), CD40(1), CD40LG(4), CRADD(1), DAXX(9), DFFA(4), DFFB(3), FAS(3), FASLG(2), IKBKE(8), LTA(3), MCL1(1), NFKB1(7), NFKBIA(1), NGFR(4), NR3C1(5), NTRK1(6), PTPN13(16), RIPK1(1), SFRS2IP(12), TFG(1), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF1(3), TRAF2(2), TRAF3(3), TRAF6(5)	14249159	154	76	151	57	39	37	13	44	21	0	0.508	1.000	1.000
302	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AKR1A1(1), AKR1B1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), CEL(7), DGAT1(1), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKZ(4), GK(3), GLB1(2), LCT(15), LIPC(2), LIPF(2), LIPG(2), LPL(4), PNLIP(4), PNLIPRP1(3), PNLIPRP2(5), PPAP2A(1), PPAP2C(4)	15816961	168	76	167	80	49	55	4	42	17	1	0.860	1.000	1.000
303	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(3), AKT2(6), AKT3(6), BRAF(9), CAB39(1), EIF4B(4), EIF4EBP1(2), HIF1A(5), IGF1(4), MAPK1(2), MAPK3(1), PDPK1(2), PGF(1), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PRKAA1(4), PRKAA2(5), RHEB(1), RICTOR(13), RPS6(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), RPS6KB2(3), STK11(2), TSC1(3), TSC2(7), ULK1(11), ULK2(5), VEGFC(8)	16228568	189	76	185	64	85	44	7	37	16	0	0.167	1.000	1.000
304	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(9), ACSS2(6), ACYP1(1), ACYP2(3), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), AKR1A1(1), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), ALDOB(3), ALDOC(3), BPGM(3), DLAT(3), DLD(3), ENO1(2), ENO2(3), ENO3(4), FBP1(2), FBP2(4), G6PC2(1), GALM(3), GAPDH(1), GAPDHS(3), GCK(4), GPI(5), HK1(11), HK2(8), HK3(5), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), PDHA1(1), PDHA2(4), PDHB(3), PFKL(4), PFKM(3), PFKP(8), PGAM2(4), PGAM4(2), PGK1(4), PGK2(2), PGM1(2), PGM3(10), PKLR(5), PKM2(5), TPI1(1)	19096741	226	75	225	88	65	72	9	59	21	0	0.406	1.000	1.000
305	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	71	CALR(3), CANX(1), CD4(5), CD74(1), CD8A(4), CD8B(2), CIITA(13), CREB1(3), CTSL1(2), CTSS(1), HLA-A(6), HLA-C(3), HLA-DMA(1), HLA-DMB(3), HLA-DOA(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(6), HLA-E(3), HLA-F(7), HLA-G(3), HSP90AA1(7), HSP90AB1(4), IFI30(2), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), KIR2DL1(5), KIR2DL3(2), KIR2DL4(3), KIR2DS4(2), KIR3DL1(5), KIR3DL2(1), KLRC1(3), KLRC2(2), KLRC3(4), KLRD1(4), LGMN(4), LTA(3), NFYC(1), PDIA3(2), PSME1(2), PSME2(1), RFX5(6), RFXANK(3), TAP1(2), TAP2(10), TAPBP(3)	14918339	179	75	174	56	34	61	16	50	18	0	0.0954	1.000	1.000
306	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	64	APAF1(5), BAD(3), BAK1(3), BAX(1), BCL2(2), BCL2L11(1), BID(2), BIRC2(3), BIRC3(3), BIRC5(1), CASP1(2), CASP10(5), CASP2(3), CASP3(2), CASP4(4), CASP6(1), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), FAS(3), FASLG(2), GZMB(2), HELLS(5), IKBKB(7), IRF1(4), IRF4(3), IRF5(3), IRF6(3), IRF7(1), JUN(3), LTA(3), MAP2K4(7), MAP3K1(9), MAPK10(5), MDM2(3), MYC(3), NFKB1(7), NFKBIA(1), NFKBIB(5), PLEKHG5(6), PRF1(1), RELA(3), RIPK1(1), TNF(1), TNFRSF10B(2), TNFRSF1A(3), TNFRSF1B(1), TNFRSF21(5), TNFRSF25(4), TNFSF10(3), TP73(2), TRADD(2), TRAF1(3), TRAF2(2), TRAF3(3)	18277620	181	74	177	61	56	47	9	41	28	0	0.195	1.000	1.000
307	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(14), CARM1(2), CCND1(1), CREBBP(26), EP300(19), ERCC3(7), ESR1(7), GRIP1(12), GTF2A1(2), GTF2E1(4), GTF2F1(5), HDAC1(3), HDAC2(2), HDAC3(4), HDAC4(13), HDAC5(6), HDAC6(6), MEF2C(3), NCOR2(21), NR0B1(2), NRIP1(11), PELP1(5), POLR2A(15), SRA1(2), TBP(2)	15055680	194	74	190	59	70	59	7	36	22	0	0.0201	1.000	1.000
308	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(9), AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AGPS(1), CDIPT(1), CDS1(4), CDS2(2), CHAT(4), CHKA(1), CHKB(2), CLC(1), CPT1B(3), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKZ(4), ETNK1(1), GNPAT(1), GPD1(6), GPD2(6), LCAT(4), PAFAH1B1(5), PAFAH2(1), PCYT1A(6), PCYT1B(5), PEMT(1), PISD(5), PLA2G2A(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCB2(4), PLCG1(16), PLCG2(11), PPAP2A(1), PPAP2C(4)	16351742	174	74	171	71	60	54	6	41	12	1	0.548	1.000	1.000
309	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(11), ATP4A(11), ATP4B(1), ATP5A1(2), ATP5B(3), ATP5C1(3), ATP5F1(1), ATP5G2(1), ATP5J(1), ATP5J2(1), ATP5L(2), ATP6AP1(5), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), COX10(1), COX15(5), COX4I1(3), COX4I2(1), COX6B1(2), COX7A2(1), COX7C(1), COX8C(1), LHPP(3), NDUFA1(1), NDUFA10(1), NDUFA13(3), NDUFA3(1), NDUFA6(1), NDUFA8(5), NDUFA9(2), NDUFAB1(2), NDUFB2(1), NDUFB3(2), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFB8(1), NDUFB9(1), NDUFC2(2), NDUFS1(6), NDUFS2(2), NDUFS3(1), NDUFS4(1), NDUFS5(2), NDUFS6(3), NDUFS7(3), NDUFS8(2), NDUFV1(2), PPA1(2), PPA2(3), SDHA(6), SDHB(4), SDHC(1), TCIRG1(6), UQCRB(1), UQCRC1(2), UQCRC2(3), UQCRFS1(1), UQCRQ(1)	18281319	200	74	197	87	68	63	8	47	14	0	0.806	1.000	1.000
310	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(12), ADRA1B(4), ADRA1D(2), ADRA2A(5), ADRA2C(4), ADRB1(7), ADRB2(7), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), DRD1(3), DRD2(7), DRD3(7), DRD4(2), DRD5(10), HRH1(4), HRH2(8), HTR1A(10), HTR1B(8), HTR1D(3), HTR1E(5), HTR1F(5), HTR2A(5), HTR2B(4), HTR2C(5), HTR4(4), HTR5A(7), HTR6(2), HTR7(8)	8415536	175	74	172	67	65	42	11	45	12	0	0.209	1.000	1.000
311	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(3), ATF2(1), CDC42(1), DLD(3), DUSP10(6), DUSP8(1), GAB1(2), GCK(4), IL1R1(4), JUN(3), MAP2K4(7), MAP2K5(1), MAP3K1(9), MAP3K10(8), MAP3K11(7), MAP3K12(9), MAP3K13(7), MAP3K2(3), MAP3K3(4), MAP3K4(15), MAP3K5(4), MAP3K7(8), MAP3K9(3), MAPK10(5), MAPK7(7), MAPK8(5), MAPK9(4), MYEF2(9), NFATC3(4), NR2C2(2), PAPPA(19), SHC1(3), TRAF6(5), ZAK(7)	16021854	183	74	180	68	53	55	12	34	29	0	0.441	1.000	1.000
312	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(30), ATR(12), BRCA1(14), CCNB1(3), CDC25A(3), CDC25B(4), CDC25C(7), CDC34(2), CDKN1A(1), CDKN2D(3), CHEK1(4), CHEK2(7), EP300(19), MDM2(3), MYT1(14), PRKDC(32), RPS6KA1(6), WEE1(2), YWHAH(3), YWHAQ(2)	13515884	171	73	168	49	53	47	6	43	20	2	0.104	1.000	1.000
313	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(16), CALM1(1), CALM2(3), CREB1(3), ELK1(3), FOS(1), GNAI1(1), GNAQ(3), GNAS(20), GNGT1(3), JUN(3), MAP2K1(5), MAPK3(1), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), RAF1(7), RPS6KA3(3), SYT1(3)	11459617	172	73	167	56	71	49	2	32	18	0	0.0707	1.000	1.000
314	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(30), BMPR1B(4), CCND2(3), DMC1(4), EGR1(4), ESR2(8), GJA4(2), INHA(3), LHCGR(10), MLH1(3), MSH5(3), NCOR1(24), NR5A1(5), NRIP1(11), PGR(12), PRLR(2), PTGER2(4), SMPD1(5), VDR(3), ZP2(7)	11015317	147	73	145	46	43	49	5	31	16	3	0.0943	1.000	1.000
315	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(6), AKT3(6), ARHGEF11(12), BCL2(2), CDC42(1), DLG4(3), GNA13(3), LPA(14), MAP2K4(7), MAP3K1(9), MAP3K5(4), MAPK8(5), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PDK1(2), PHKA2(9), PI3(1), PIK3CB(7), PLD1(13), PLD2(13), PLD3(4), PTK2(10), RDX(4), ROCK1(9), ROCK2(7), SERPINA4(2), SRF(1), TBXA2R(8)	16107373	189	73	184	58	74	55	9	25	25	1	0.0593	1.000	1.000
316	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(4), EEF1B2(3), EEF1D(2), EEF1G(4), EEF2(4), EEF2K(7), EIF1AX(2), EIF1AY(1), EIF2AK1(3), EIF2AK2(5), EIF2AK3(10), EIF2B1(3), EIF2B2(3), EIF2B3(5), EIF2B4(6), EIF2B5(6), EIF2S1(2), EIF2S2(3), EIF4A1(3), EIF4A2(4), EIF4E(2), EIF4EBP1(2), EIF4EBP2(1), EIF4G1(19), EIF4G3(7), EIF5(5), EIF5A(3), EIF5B(9), ETF1(4), GSPT2(1), KIAA0664(8), PABPC1(2), PABPC3(8), PAIP1(2), SLC35A4(4)	14309794	157	73	155	50	51	50	7	35	14	0	0.119	1.000	1.000
317	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(9), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), AOC2(4), AOC3(4), AOX1(7), COMT(4), DBH(5), DCT(8), DDC(5), FAH(3), GOT1(2), GOT2(2), GSTZ1(3), HGD(3), HPD(1), MAOA(1), MAOB(3), PNMT(8), TAT(4), TH(2), TPO(15), TYR(6)	10394738	142	73	140	44	49	40	3	40	9	1	0.0607	1.000	1.000
318	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(3), BTK(2), CALM1(1), CALM2(3), CD79A(6), CD79B(1), ELK1(3), FOS(1), GRB2(4), JUN(3), LYN(4), MAP2K1(5), MAP3K1(9), MAPK14(1), MAPK3(1), MAPK8(5), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKCA(3), RAF1(7), SHC1(3), SOS1(6), SYK(6), SYT1(3), VAV1(6)	12552425	157	72	151	41	64	43	3	31	16	0	0.00685	1.000	1.000
319	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(4), CALCR(6), CALCRL(5), CD97(1), CRHR1(10), CRHR2(3), ELTD1(14), EMR1(14), EMR2(9), GHRHR(4), GIPR(3), GLP1R(1), GLP2R(8), GPR64(10), LPHN1(13), LPHN2(17), LPHN3(14), SCTR(2), VIPR1(2), VIPR2(3)	8739085	143	72	140	42	36	40	6	46	15	0	0.0470	1.000	1.000
320	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(4), ADC(1), ALDH4A1(4), ALDH5A1(5), CAD(12), CPS1(18), EARS2(3), EPRS(7), GAD1(6), GAD2(7), GCLC(1), GCLM(2), GFPT1(3), GFPT2(4), GLS(8), GLS2(6), GLUD1(3), GLUD2(10), GLUL(5), GMPS(4), GNPNAT1(2), GOT1(2), GOT2(2), GPT(1), GPT2(2), GSR(4), GSS(3), NADSYN1(4), PPAT(3), QARS(3)	12964519	139	72	138	59	43	44	5	38	9	0	0.763	1.000	1.000
321	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(9), AGXT(1), AGXT2(7), AKR1B10(2), ALAS1(2), ALAS2(9), AMT(3), AOC2(4), AOC3(4), BHMT(4), CBS(5), CHDH(4), CHKA(1), CHKB(2), CTH(2), DAO(8), DLD(3), DMGDH(7), GARS(1), GATM(3), GCAT(2), GLDC(7), GNMT(2), HSD3B7(4), MAOA(1), MAOB(3), PEMT(1), PHGDH(1), PIPOX(3), PISD(5), PSAT1(3), PSPH(2), RDH11(1), RDH12(1), RDH13(3), SARDH(10), SARS(4), SARS2(6), SDS(2), SHMT1(1), SHMT2(5), TARS(6), TARS2(5)	13993365	159	72	158	58	56	39	12	35	17	0	0.330	1.000	1.000
322	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), AKR1C1(1), AKR1C3(2), AKR1C4(5), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), CYP1A1(4), CYP1A2(4), CYP1B1(2), CYP2B6(6), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2E1(4), CYP2F1(5), CYP2S1(7), CYP3A4(2), CYP3A43(4), CYP3A7(4), DHDH(5), EPHX1(4), GSTA1(2), GSTA2(1), GSTA4(2), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(2), GSTM5(1), GSTO2(3), GSTZ1(3), MGST1(2), MGST3(2), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(8), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3)	18767768	188	72	187	56	51	61	2	54	20	0	0.0507	1.000	1.000
323	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(7), AKT1(3), AKT2(6), AKT3(6), DAG1(8), GNAQ(3), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PDK1(2), PHKA2(9), PIK3CB(7), PITX2(4), PLD1(13), PLD2(13), PLD3(4), VN1R1(2)	14718492	190	72	189	61	79	48	10	39	13	1	0.0655	1.000	1.000
324	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(3), CASP3(2), CASP8(8), CRADD(1), DFFA(4), DFFB(3), JUN(3), LMNA(3), LMNB1(1), LMNB2(4), MADD(15), MAP2K4(7), MAP3K1(9), MAP3K7(8), MAPK8(5), PAK1(5), PAK2(6), PRKDC(32), RB1(6), RIPK1(1), SPTAN1(18), TNF(1), TNFRSF1A(3), TRADD(2), TRAF2(2)	12732697	154	72	151	51	46	46	8	30	24	0	0.227	1.000	1.000
325	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(2), CALM1(1), CALM2(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CDK5(2), F2(5), FYN(8), GNA11(5), GNAI1(1), GNGT1(3), GRB2(4), JAK2(10), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(5), MAPT(4), MYLK(15), PLCG1(16), PRKCA(3), PTK2B(10), RAF1(7), SHC1(3), SOS1(6), STAT1(7), STAT3(6), STAT5A(4), SYT1(3)	13661694	159	71	155	53	57	46	6	38	12	0	0.184	1.000	1.000
326	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CALM2(3), CAMK1(2), CAMK1G(3), ELK1(3), FPR1(4), GNA15(3), GNGT1(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K6(1), MAP3K1(9), MAPK1(2), MAPK14(1), MAPK3(1), NCF1(3), NCF2(2), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NFKB1(7), NFKBIA(1), PAK1(5), PIK3C2G(7), PLCB1(13), PPP3CA(5), PPP3CB(6), PPP3CC(3), RAF1(7), RELA(3), SYT1(3)	12542950	156	71	151	56	53	43	4	35	21	0	0.271	1.000	1.000
327	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(5), AANAT(1), ABP1(9), ACAT1(3), ACAT2(3), ACMSD(4), AFMID(1), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AOC2(4), AOC3(4), AOX1(7), ASMT(3), CARM1(2), CAT(4), CYP1A1(4), CYP1A2(4), CYP1B1(2), DDC(5), EHHADH(6), GCDH(5), HADH(3), HADHA(4), HEMK1(1), HSD17B4(4), INMT(2), KMO(1), KYNU(8), LCMT1(1), LCMT2(7), LNX1(4), MAOA(1), MAOB(3), METTL6(2), NFX1(2), OGDH(7), OGDHL(10), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), TDO2(5), TPH1(3), TPH2(5), WARS(3), WARS2(7), WBSCR22(4)	19876306	207	71	202	70	59	67	10	43	27	1	0.121	1.000	1.000
328	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(6), F11(3), F12(2), F13B(13), F2(5), F5(13), F7(9), F8(15), F9(6), FGA(7), FGB(2), FGG(2), LPA(14), PLAT(4), PLAU(2), PLG(11), SERPINB2(6), SERPINE1(3), SERPINF2(5), VWF(19)	11587373	147	70	145	41	44	40	8	44	11	0	0.0354	1.000	1.000
329	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ACYP2(3), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), AKR1A1(1), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), ALDOB(3), ALDOC(3), BPGM(3), DLAT(3), DLD(3), ENO1(2), ENO2(3), ENO3(4), FBP1(2), FBP2(4), GAPDH(1), GCK(4), GPI(5), HK1(11), HK2(8), HK3(5), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(4), PDHB(3), PFKM(3), PFKP(8), PGK1(4), PGM1(2), PGM3(10), PKLR(5), PKM2(5), TPI1(1)	16043828	193	70	192	78	54	58	7	55	19	0	0.608	1.000	1.000
330	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ACYP2(3), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), AKR1A1(1), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), ALDOB(3), ALDOC(3), BPGM(3), DLAT(3), DLD(3), ENO1(2), ENO2(3), ENO3(4), FBP1(2), FBP2(4), GAPDH(1), GCK(4), GPI(5), HK1(11), HK2(8), HK3(5), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(4), PDHB(3), PFKM(3), PFKP(8), PGK1(4), PGM1(2), PGM3(10), PKLR(5), PKM2(5), TPI1(1)	16043828	193	70	192	78	54	58	7	55	19	0	0.608	1.000	1.000
331	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(9), ACAT1(3), ACAT2(3), ACMSD(4), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AOC2(4), AOC3(4), AOX1(7), ASMT(3), CAT(4), CYP19A1(9), CYP1A1(4), CYP1A2(4), CYP2A13(7), CYP2A6(5), CYP2A7(5), CYP2B6(6), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2D6(4), CYP2E1(4), CYP2F1(5), CYP2J2(4), CYP3A4(2), CYP3A7(4), CYP4B1(7), CYP4F8(2), CYP51A1(6), DDC(5), EHHADH(6), GCDH(5), HADHA(4), KMO(1), KYNU(8), MAOA(1), MAOB(3), SDS(2), TDO2(5), TPH1(3), WARS(3), WARS2(7)	18080179	220	70	215	66	65	68	6	55	25	1	0.0475	1.000	1.000
332	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(9), AGMAT(1), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH4A1(4), ALDH9A1(3), AMD1(3), AOC2(4), AOC3(4), ARG1(2), ASL(5), CKB(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(18), DAO(8), GATM(3), GLUD1(3), GOT1(2), GOT2(2), MAOA(1), MAOB(3), NOS1(22), NOS3(5), ODC1(3), OTC(2), P4HA1(3), P4HA2(8), P4HA3(4), P4HB(2), PYCR1(3), RARS(4), SMS(3)	14491519	178	69	177	54	64	54	8	38	14	0	0.0376	1.000	1.000
333	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(5), CDC7(3), CDK2(3), CDT1(3), DIAPH2(6), GMNN(1), MCM10(7), MCM2(11), MCM3(3), MCM4(8), MCM5(5), MCM6(2), MCM7(5), NACA(2), ORC1L(8), ORC2L(2), ORC3L(5), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(3), POLD1(10), POLD2(1), POLD3(3), POLE(17), POLE2(3), PRIM1(2), RFC1(5), RFC2(1), RFC3(2), RFC4(1), RFC5(1), RPA1(1), RPA2(1), RPA3(2), RPA4(5), RPS27A(1), UBA52(1), UBC(5)	16668244	153	69	152	53	58	38	9	27	21	0	0.239	1.000	1.000
334	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(7), EGF(8), EGFR(11), ELK1(3), FOS(1), GRB2(4), JAK1(6), JUN(3), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK3(1), MAPK8(5), PIK3R1(8), PLCG1(16), PRKCA(3), RAF1(7), RASA1(11), SHC1(3), SOS1(6), SRF(1), STAT1(7), STAT3(6), STAT5A(4)	11595883	142	69	135	42	43	41	4	30	24	0	0.0909	1.000	1.000
335	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(7), ELK1(3), FOS(1), GRB2(4), JAK1(6), JUN(3), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK3(1), MAPK8(5), PDGFA(2), PDGFRA(11), PIK3R1(8), PLCG1(16), PRKCA(3), RAF1(7), RASA1(11), SHC1(3), SOS1(6), SRF(1), STAT1(7), STAT3(6), STAT5A(4)	10750559	136	69	129	36	39	43	4	27	23	0	0.0242	1.000	1.000
336	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(5), APC(34), AXIN1(8), BTRC(4), CTNNB1(16), DLL1(10), DVL1(4), FZD1(7), GSK3B(4), NOTCH1(19), PSEN1(2), WNT1(5)	6976055	118	69	113	42	39	21	6	23	26	3	0.387	1.000	1.000
337	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(2), ACTN1(6), ACTN2(22), ACTN3(2), CAPN1(2), CAPNS1(2), CAPNS2(2), ITGA1(7), ITGB1(6), ITGB3(3), PTK2(10), PXN(3), SPTAN1(18), SRC(2), TLN1(14)	9349683	101	69	98	51	41	23	8	22	7	0	0.922	1.000	1.000
338	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(5), CASP3(2), CASP6(1), CASP7(2), CASP8(8), DAXX(9), DFFA(4), DFFB(3), FAF1(8), JUN(3), LMNA(3), LMNB1(1), LMNB2(4), MAP2K4(7), MAP3K1(9), MAP3K7(8), MAPK8(5), PAK1(5), PAK2(6), PRKDC(32), PTPN13(16), RB1(6), RIPK2(1), SPTAN1(18)	13388742	167	68	163	51	40	55	9	35	28	0	0.133	1.000	1.000
339	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(9), AGXT(1), AGXT2(7), ALAS1(2), ALAS2(9), AMT(3), AOC2(4), AOC3(4), BHMT(4), CBS(5), CHDH(4), CHKA(1), CHKB(2), CPT1B(3), CTH(2), DAO(8), DLD(3), DMGDH(7), GARS(1), GATM(3), GCAT(2), GLDC(7), MAOA(1), MAOB(3), PEMT(1), PISD(5), PLCB2(4), PLCG1(16), PLCG2(11), PSPH(2), SARDH(10), SARS(4), SHMT1(1), SHMT2(5), TARS(6)	13766858	160	68	157	58	50	40	10	41	19	0	0.414	1.000	1.000
340	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(9), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), AOC2(4), AOC3(4), DDC(5), EPX(6), ESCO1(4), ESCO2(4), GOT1(2), GOT2(2), HPD(1), LPO(7), MAOA(1), MAOB(3), MIF(1), MPO(6), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(4), TPO(15)	11214464	137	68	137	36	45	37	4	40	11	0	0.0249	1.000	1.000
341	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(9), AADAC(3), ABAT(4), ACADS(3), ACAT1(3), ACAT2(3), ACSM1(4), AKR1B10(2), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH5A1(5), ALDH9A1(3), BDH1(4), DDHD1(9), EHHADH(6), GAD1(6), GAD2(7), HADH(3), HADHA(4), HMGCS1(1), HMGCS2(3), HSD17B4(4), HSD3B7(4), ILVBL(3), L2HGDH(1), OXCT1(6), OXCT2(1), PDHA1(1), PDHA2(4), PDHB(3), PLA1A(2), PRDX6(1), RDH11(1), RDH12(1), RDH13(3)	13313100	142	68	139	60	47	37	2	39	17	0	0.753	1.000	1.000
342	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(5), AZIN1(1), CLDN5(2), CLOCK(3), CRY1(3), CRY2(4), DAZAP2(7), DNAJA1(3), EIF4G2(5), ETV6(3), G0S2(2), GFRA1(8), GSTM3(2), HERPUD1(1), HSPA8(4), KLF9(2), MYF6(3), NCKAP1(8), NCOA4(4), NR1D2(5), PER1(5), PER2(9), PPP1R3C(3), PPP2CB(2), PSMA4(4), PURA(1), SF3A3(3), SUMO3(1), TOB1(1), TUBB3(12), UCP3(2), UGP2(3), VAPA(1), ZFR(8)	11973853	130	67	129	45	41	38	4	37	10	0	0.314	1.000	1.000
343	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(10), ABAT(4), ACY3(1), ADSL(3), ADSS(4), ADSSL1(7), AGXT(1), AGXT2(7), ASL(5), ASNS(3), ASPA(1), ASRGL1(2), ASS1(7), CAD(12), CRAT(1), DARS(2), DARS2(1), DDO(4), DLAT(3), DLD(3), GAD1(6), GAD2(7), GOT1(2), GOT2(2), GPT(1), GPT2(2), NARS(4), PC(7), PDHA1(1), PDHA2(4), PDHB(3)	12399584	124	67	122	58	48	39	1	29	7	0	0.857	1.000	1.000
344	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(19), ACACB(22), ACAT1(3), ACAT2(3), ACOT12(5), ACSS1(9), ACSS2(6), ACYP1(1), ACYP2(3), AKR1B1(6), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), DLAT(3), DLD(3), GLO1(1), GRHPR(2), HAGH(2), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), LDHD(3), MDH1(3), ME1(1), ME2(4), ME3(4), PC(7), PCK1(6), PCK2(7), PDHA1(1), PDHA2(4), PDHB(3), PKLR(5), PKM2(5)	15350589	181	67	179	62	55	56	6	41	23	0	0.212	1.000	1.000
345	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(10), CARS(4), CARS2(5), DARS(2), DARS2(1), EARS2(3), EPRS(7), FARS2(6), FARSA(1), FARSB(1), GARS(1), HARS(5), HARS2(2), IARS(9), IARS2(7), KARS(5), LARS(4), LARS2(7), MARS(4), MARS2(1), MTFMT(1), NARS(4), QARS(3), RARS(4), RARS2(3), SARS(4), SARS2(6), TARS(6), TARS2(5), VARS(10), VARS2(9), WARS(3), WARS2(7), YARS(3), YARS2(3)	17826650	160	67	159	57	55	49	7	38	11	0	0.435	1.000	1.000
346	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(3), ALOX15(3), ALOX5(6), CBR1(1), CBR3(3), CYP4F2(8), CYP4F3(7), EPX(6), GGT1(4), LPO(7), LTA4H(4), MPO(6), PLA2G2A(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(1), PTGDS(1), PTGES2(3), PTGIS(5), PTGS1(7), PTGS2(5), TBXAS1(2), TPO(15)	9135694	126	67	124	38	42	25	8	36	15	0	0.110	1.000	1.000
347	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(28), B3GALT4(4), CDR1(4), DGKI(9), IL6ST(4), PIGK(3), RPL10(6), RPL12(1), RPL13A(2), RPL14(1), RPL18(1), RPL19(2), RPL24(1), RPL26(1), RPL28(1), RPL3(2), RPL31(1), RPL34(2), RPL36(1), RPL38(1), RPL3L(2), RPL5(1), RPL6(1), RPL7(1), RPL7A(2), RPL8(2), RPL9(3), RPLP0(3), RPLP1(1), RPLP2(1), RPS10(1), RPS11(1), RPS13(2), RPS14(2), RPS23(1), RPS24(1), RPS27(1), RPS27A(1), RPS3(1), RPS3A(2), RPS4Y1(1), RPS5(3), RPS6(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), RPS6KB2(3), RPS9(1), RPSA(6), SLC36A2(7), TBC1D10C(2), TSPAN9(1), UBA52(1), UBC(5)	16735247	157	67	157	70	42	55	7	38	14	1	0.913	1.000	1.000
348	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(4), ACADL(2), ACADM(4), ACADS(3), ACADSB(5), ACADVL(1), ACAT1(3), ACAT2(3), ACOX1(4), ACOX3(8), ACSL1(2), ACSL3(6), ACSL4(2), ACSL5(5), ACSL6(5), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), CPT1A(7), CPT1B(3), CPT1C(6), CPT2(5), CYP4A11(2), CYP4A22(2), DCI(2), EHHADH(6), GCDH(5), HADH(3), HADHA(4), HADHB(4), HSD17B4(4), PECI(1)	16084841	166	66	163	52	44	49	6	44	23	0	0.0808	1.000	1.000
349	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(4), ARG1(2), ASL(5), ASS1(7), CKB(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(18), DAO(8), EPRS(7), GATM(3), GLUD1(3), GLUD2(10), GOT1(2), GOT2(2), LAP3(1), NOS1(22), NOS3(5), OTC(2), P4HA1(3), P4HA2(8), P4HA3(4), PYCR1(3), PYCRL(1), RARS(4), RARS2(3)	11767967	138	66	137	43	53	38	8	32	7	0	0.0850	1.000	1.000
350	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(5), INPPL1(14), ITPKA(1), ITPKB(7), MIOX(3), OCRL(8), PIK3C2A(8), PIK3C2B(15), PIK3C2G(7), PIK3CB(7), PIK3CG(15), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCG1(16), PLCG2(11)	13988552	166	66	159	57	59	50	7	37	13	0	0.278	1.000	1.000
351	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(1), EIF1(1), EIF2B1(3), EIF2B2(3), EIF2B3(5), EIF2B4(6), EIF2B5(6), EIF2S1(2), EIF2S2(3), ELAVL1(7), FLT1(13), FLT4(17), HIF1A(5), KDR(8), NOS3(5), PIK3R1(8), PLCG1(16), PRKCA(3), PTK2(10), PXN(3), SHC1(3)	10423240	128	66	125	34	45	34	7	27	15	0	0.0238	1.000	1.000
352	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(2), ARHGAP1(1), ARHGAP4(4), ARHGAP5(11), ARHGAP6(6), ARHGEF1(9), ARHGEF11(12), ARHGEF5(4), ARPC1A(3), ARPC2(1), ARPC4(2), BAIAP2(4), CFL1(1), DIAPH1(7), GSN(9), LIMK1(3), MYL2(6), MYLK(15), OPHN1(6), PIP5K1A(3), PIP5K1B(1), PPP1R12B(12), ROCK1(9), SRC(2), TLN1(14), VCL(1)	14894981	150	65	148	56	49	45	8	30	16	2	0.508	1.000	1.000
353	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(9), BLNK(3), ELK1(3), FOS(1), GRB2(4), JUN(3), LYN(4), MAP2K1(5), MAP3K1(9), MAPK1(2), MAPK3(1), MAPK8IP3(10), PAPPA(19), RPS6KA1(6), RPS6KA3(3), SHC1(3), SOS1(6), SYK(6), VAV1(6), VAV2(11), VAV3(10)	10510062	125	65	121	53	40	36	3	32	14	0	0.678	1.000	1.000
354	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(16), CD3E(2), CD4(5), CREBBP(26), CSK(5), GNAS(20), GNGT1(3), HLA-DRA(6), LCK(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PTPRC(15), ZAP70(10)	7530408	133	64	130	59	47	43	2	25	16	0	0.795	1.000	1.000
355	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(16), CD3E(2), CD4(5), CREBBP(26), CSK(5), GNAS(20), GNGT1(3), HLA-DRA(6), LCK(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PTPRC(15), ZAP70(10)	7530408	133	64	130	59	47	43	2	25	16	0	0.795	1.000	1.000
356	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(11), ELK1(3), GNAS(20), GNGT1(3), GRB2(4), IGF1R(15), ITGB1(6), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MKNK1(3), MKNK2(1), MYC(3), NGFR(4), PDGFRA(11), PPP2CA(3), PTPRR(7), RAF1(7), RPS6KA1(6), RPS6KA5(2), SHC1(3), SOS1(6), SRC(2), STAT3(6)	10848402	136	64	130	62	48	40	0	39	9	0	0.887	1.000	1.000
357	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(4), ATM(30), ATR(12), CCNA1(7), CCND1(1), CCNE1(3), CDC25A(3), CDK2(3), CDK6(4), CDKN1A(1), CDKN2A(6), E2F1(2), GSK3B(4), HDAC1(3), RB1(6), SKP2(5), TFDP1(3), TGFB1(3), TGFB2(6), TGFB3(5)	9658459	111	64	109	37	29	31	4	30	15	2	0.443	1.000	1.000
358	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(4), ALDH4A1(4), ALDH5A1(5), CAD(12), CPS1(18), EPRS(7), GAD1(6), GAD2(7), GCLC(1), GCLM(2), GFPT1(3), GLS(8), GLS2(6), GLUD1(3), GLUL(5), GMPS(4), GOT1(2), GOT2(2), GPT(1), GPT2(2), GSS(3), NADSYN1(4), PPAT(3), QARS(3)	10898744	115	64	114	47	37	39	3	29	7	0	0.695	1.000	1.000
359	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(5), AKR1D1(2), ARSD(4), ARSE(4), CARM1(2), CYP11B1(7), CYP11B2(4), CYP19A1(9), HEMK1(1), HSD11B1(2), HSD11B2(2), HSD17B1(4), HSD17B12(2), HSD17B2(2), HSD17B3(1), HSD17B7(2), HSD3B1(1), HSD3B2(3), LCMT1(1), LCMT2(7), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), SRD5A1(3), SRD5A2(3), STS(4), SULT1E1(2), SULT2A1(3), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(8), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3), WBSCR22(4)	16443905	150	64	149	56	39	55	6	33	17	0	0.288	1.000	1.000
360	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(3), ALOX12B(8), ALOX15(3), ALOX15B(3), ALOX5(6), CBR1(1), CBR3(3), CYP2B6(6), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2E1(4), CYP2J2(4), CYP2U1(5), CYP4A11(2), CYP4A22(2), CYP4F2(8), CYP4F3(7), EPHX2(3), GGT1(4), GPX1(1), GPX2(1), GPX3(1), GPX5(1), GPX6(3), GPX7(3), LTA4H(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PTGDS(1), PTGES2(3), PTGIS(5), PTGS1(7), PTGS2(5), TBXAS1(2)	12750712	151	64	149	43	49	40	5	41	16	0	0.0299	1.000	1.000
361	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(3), DLG4(3), GRIN1(4), GRIN2A(11), GRIN2B(18), GRIN2C(4), GRIN2D(4), NOS1(22), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), SYT1(3)	8368958	112	64	112	52	44	28	3	23	14	0	0.751	1.000	1.000
362	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(1), AKT1(3), AKT2(6), AKT3(6), BAD(3), BTK(2), CDKN2A(6), DAPP1(1), GRB2(4), GSK3A(2), GSK3B(4), IARS(9), IGFBP1(5), INPP5D(1), PDK1(2), PPP1R13B(6), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), SHC1(3), SOS1(6), SOS2(11), TEC(4), YWHAB(1), YWHAE(1), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(2)	10846322	116	64	116	41	37	30	2	28	19	0	0.520	1.000	1.000
363	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(2), ELK1(3), FOS(1), IKBKB(7), IRAK1(5), JUN(3), LY96(1), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K1(9), MAP3K14(3), MAP3K7(8), MAPK14(1), MAPK8(5), MYD88(1), NFKB1(7), NFKBIA(1), PPARA(3), RELA(3), TIRAP(1), TLR10(6), TLR2(1), TLR3(5), TLR4(18), TLR6(1), TLR7(5), TLR9(13), TOLLIP(2), TRAF6(5)	11960756	135	64	129	52	39	34	8	32	22	0	0.497	1.000	1.000
364	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(3), AGTR1(1), ATF2(1), CALM1(1), CALM2(3), EGFR(11), ELK1(3), GNAQ(3), GRB2(4), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K4(7), MAP3K1(9), MAPK1(2), MAPK3(1), MAPK8(5), MEF2B(4), MEF2C(3), MEF2D(6), PAK1(5), PRKCA(3), PTK2(10), PTK2B(10), RAF1(7), SHC1(3), SOS1(6), SRC(2), SYT1(3)	10994905	126	63	121	44	46	30	7	26	17	0	0.272	1.000	1.000
365	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(11), DIAPH1(7), FYN(8), GSN(9), ITGA1(7), ITGB1(6), MAP2K1(5), MAPK1(2), MAPK3(1), MYL2(6), MYLK(15), PIK3R1(8), PTK2(10), PXN(3), RAF1(7), ROCK1(9), SHC1(3), SRC(2), TLN1(14)	11546890	133	63	129	36	35	36	9	33	18	2	0.0580	1.000	1.000
366	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(3), AVP(3), CABIN1(13), CALM1(1), CALM2(3), CAMK1(2), CAMK1G(3), HDAC5(6), IGF1(4), IGF1R(15), INSR(12), MAP2K6(1), MAPK14(1), MAPK7(7), MEF2B(4), MEF2C(3), MEF2D(6), MYOD1(4), NFATC1(11), NFATC2(14), PIK3R1(8), PPP3CA(5), PPP3CB(6), PPP3CC(3), SYT1(3), YWHAH(3)	10667257	144	63	143	49	55	40	4	25	20	0	0.0961	1.000	1.000
367	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(5), ALG10(6), ALG10B(3), ALG12(3), ALG13(7), ALG14(1), ALG3(2), ALG5(2), ALG6(2), ALG8(1), ALG9(1), B4GALT1(2), B4GALT2(5), B4GALT3(2), DHDDS(3), DOLPP1(2), DPAGT1(1), DPM1(1), FUT8(3), GANAB(4), MAN1A1(2), MAN1A2(3), MAN1B1(5), MAN1C1(2), MAN2A1(3), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(2), MGAT5(8), MGAT5B(4), RFT1(3), RPN1(2), RPN2(3), STT3B(3)	13892080	107	63	106	57	34	30	7	18	17	1	0.963	1.000	1.000
368	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(30), ATR(12), BRCA1(14), BRCA2(27), CHEK1(4), CHEK2(7), FANCA(5), FANCC(4), FANCD2(10), FANCE(2), FANCG(3), HUS1(2), MRE11A(2), RAD1(2), RAD17(4), RAD50(9), RAD51(1), RAD9A(2)	14236642	140	62	139	32	30	42	6	42	18	2	0.0346	1.000	1.000
369	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(5), ARSB(2), FUCA1(1), FUCA2(1), GALNS(1), GBA(6), GLB1(2), GNS(3), GUSB(8), HEXA(2), HEXB(2), HGSNAT(3), HPSE(6), HPSE2(2), HYAL1(4), HYAL2(4), IDS(3), IDUA(2), LCT(15), MAN2B1(10), MAN2B2(12), MAN2C1(7), MANBA(5), NAGLU(3), NEU1(1), NEU2(3), NEU3(4), NEU4(1), SPAM1(8)	11267026	126	62	124	44	45	43	7	20	11	0	0.201	1.000	1.000
370	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2B(2), GTF2E1(4), GTF2E2(2), GTF2F1(5), GTF2F2(1), GTF2H1(1), GTF2H3(2), GTF2H4(3), GTF2I(6), GTF2IRD1(11), TAF1(13), TAF10(1), TAF13(1), TAF1L(19), TAF2(8), TAF4(10), TAF4B(3), TAF5(2), TAF5L(3), TAF6(8), TAF6L(4), TAF7(5), TAF7L(3), TAF9B(3), TBPL1(2), TBPL2(5)	11829191	129	62	126	34	37	37	9	27	19	0	0.0330	1.000	1.000
371	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ADRBK2(5), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CLCA1(8), CLCA2(5), CLCA4(7), CNGA3(7), CNGA4(17), CNGB1(10), GNAL(2), GUCA1A(2), GUCA1B(2), GUCA1C(3), PDC(1), PDE1C(5), PRKACA(3), PRKACB(2), PRKACG(5), PRKG1(8), PRKG2(10), PRKX(4)	10020003	128	62	123	47	49	30	4	33	12	0	0.292	1.000	1.000
372	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(4), CALM1(1), CALM2(3), CRKL(1), GNAQ(3), GRB2(4), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP3K1(9), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(5), PAK1(5), PLCG1(16), PRKCA(3), PTK2B(10), RAF1(7), SHC1(3), SOS1(6), SRC(2), SYT1(3)	9329121	113	62	107	32	40	30	4	25	14	0	0.0750	1.000	1.000
373	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(3), EGR2(6), EGR3(5), GNAQ(3), MAP3K1(9), MYC(3), NFATC1(11), NFATC2(14), NFKB1(7), NFKBIA(1), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RELA(3), SYT1(3), VIP(3), VIPR2(3)	9170775	127	62	123	39	49	34	2	25	17	0	0.0574	1.000	1.000
374	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(16), EXT2(5), EXTL1(4), EXTL2(2), EXTL3(10), GLCE(3), HS2ST1(2), HS3ST1(2), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(3), HS3ST5(6), HS6ST1(2), HS6ST2(4), HS6ST3(6), NDST1(10), NDST2(6), NDST3(10), NDST4(13)	6771461	114	61	111	34	37	33	4	31	9	0	0.153	1.000	1.000
375	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(5), BAIAP2(4), CASP1(2), CASP3(2), CASP7(2), CASP8(8), GAPDH(1), INSR(12), ITCH(4), MAGI1(14), MAGI2(23), RERE(17), WWP1(9), WWP2(10)	7867633	113	61	107	36	30	29	7	23	24	0	0.271	1.000	1.000
376	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(7), ADCY3(5), ADCY9(8), AK1(1), ARF1(4), ARF4(1), ARL4D(1), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), ERO1L(1), GNAS(20), PDIA4(1), PLCG1(16), PLCG2(11), PRKCA(3), SEC61A1(3), SEC61B(1), SEC61G(1), TRIM23(3)	12143535	135	61	131	56	54	32	5	33	11	0	0.672	1.000	1.000
377	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(11), ATP4B(1), ATP6AP1(5), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), ATP7A(8), ATP7B(11), COX10(1), COX4I1(3), COX6B1(2), COX7A2(1), COX7C(1), NDUFA1(1), NDUFA10(1), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(6), NDUFS2(2), NDUFV1(2), PPA2(3), SDHA(6), SDHB(4), SHMT1(1), UQCRB(1), UQCRC1(2), UQCRFS1(1)	12526073	140	61	138	56	46	43	6	31	14	0	0.600	1.000	1.000
378	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(3), BRAF(9), CREB1(3), CREB3(4), CREB5(4), DUSP6(3), DUSP9(3), EEF2K(7), EIF4E(2), GRB2(4), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MKNK1(3), MKNK2(1), MOS(9), NFKB1(7), RAP1A(2), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), SHC1(3), SOS1(6), SOS2(11), TRAF3(3)	9672183	114	61	110	46	35	31	2	30	16	0	0.655	1.000	1.000
379	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(5), BAK1(3), BAX(1), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CASP2(3), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), FAS(3), FASLG(2), GZMB(2), JUN(3), MAP2K4(7), MAP3K1(9), MAP3K14(3), MAPK10(5), MCL1(1), MDM2(3), MYC(3), NFKB1(7), NFKBIA(1), PARP1(7), PRF1(1), RELA(3), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TNFSF10(3), TRADD(2), TRAF1(3), TRAF2(2)	11983207	113	60	110	41	34	28	3	30	18	0	0.381	1.000	1.000
380	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(2), ACP5(1), ACPP(2), ACPT(4), ALPI(6), ALPL(4), ALPP(7), ALPPL2(6), CYP19A1(9), CYP1A1(4), CYP1A2(4), CYP2A13(7), CYP2A6(5), CYP2A7(5), CYP2B6(6), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2D6(4), CYP2E1(4), CYP2F1(5), CYP2J2(4), CYP3A4(2), CYP3A7(4), CYP4B1(7), CYP4F8(2), CYP51A1(6), PON1(2)	9619453	123	60	121	43	51	30	4	27	11	0	0.246	1.000	1.000
381	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(4), ACAA2(4), ACADM(4), ACADS(3), ACAT1(3), ACAT2(3), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH6A1(4), ALDH9A1(3), AOX1(7), AUH(7), BCAT1(3), BCAT2(5), BCKDHA(5), BCKDHB(1), DBT(2), DLD(3), EHHADH(6), HADH(3), HADHA(4), HADHB(4), HIBADH(3), HMGCS1(1), HMGCS2(3), HSD17B4(4), IVD(4), MCCC1(3), MCCC2(3), MCEE(2), MUT(3), OXCT1(6), OXCT2(1), PCCA(8), PCCB(4)	14129026	148	60	143	53	38	50	3	31	25	1	0.401	1.000	1.000
382	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(9), ACY3(1), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), AOC2(4), AOC3(4), ASPA(1), CARM1(2), CNDP1(1), DDC(5), FTCD(2), HAL(1), HARS(5), HARS2(2), HDC(7), HEMK1(1), HNMT(2), LCMT1(1), LCMT2(7), MAOA(1), MAOB(3), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), PRPS1(2), PRPS2(2), UROC1(8), WBSCR22(4)	12993177	131	60	131	42	40	37	6	34	14	0	0.144	1.000	1.000
383	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(3), ARSD(4), ARSE(4), ASAH1(2), B4GALT6(2), CERK(5), DEGS1(2), DEGS2(1), ENPP7(5), GAL3ST1(6), GALC(5), GBA(6), GLB1(2), LCT(15), NEU1(1), NEU2(3), NEU3(4), NEU4(1), PPAP2A(1), PPAP2C(4), SGMS1(2), SGMS2(2), SGPP1(1), SGPP2(1), SMPD1(5), SMPD2(1), SMPD3(9), SMPD4(7), SPHK1(4), SPHK2(2), SPTLC1(1), SPTLC2(3), UGCG(3), UGT8(4)	11697205	121	60	120	46	50	38	5	16	12	0	0.275	1.000	1.000
384	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(3), AKT2(6), AKT3(6), BAD(3), BCL2(2), GRB2(4), GSK3A(2), GSK3B(4), IL4R(1), IRS1(15), IRS2(4), JAK1(6), JAK3(9), MAP4K1(3), MAPK1(2), MAPK3(1), PDK1(2), PIK3CD(10), PIK3R1(8), PPP1R13B(6), RAF1(7), SHC1(3), SOCS1(1), SOS1(6), SOS2(11), STAT6(1)	11253385	126	60	122	40	50	31	2	26	17	0	0.185	1.000	1.000
385	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), DAG1(8), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), NFAT5(9), PDE6A(4), PDE6B(8), PDE6C(3), PDE6G(1), SLC6A13(5), TF(6)	11741959	135	60	134	58	57	33	8	27	9	1	0.543	1.000	1.000
386	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(6), ACTN2(22), ACTN3(2), BCAR1(4), CSK(5), CTNNA1(11), CTNNA2(16), CTNNB1(16), PTK2(10), PXN(3), SRC(2), VCL(1)	6259481	98	59	96	42	32	23	7	26	10	0	0.731	1.000	1.000
387	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(1), GHR(6), GRB2(4), INSR(12), IRS1(15), JAK2(10), MAP2K1(5), MAPK1(2), MAPK3(1), PIK3R1(8), PLCG1(16), PRKCA(3), PTPN6(3), RAF1(7), RPS6KA1(6), SHC1(3), SLC2A4(4), SOCS1(1), SOS1(6), SRF(1), STAT5A(4), STAT5B(6)	10135840	124	59	120	37	40	42	2	22	18	0	0.0814	1.000	1.000
388	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(3), ALDOC(3), DLAT(3), DLD(3), ENO1(2), ENO2(3), ENO3(4), FBP1(2), FBP2(4), GAPDH(1), GAPDHS(3), GCK(4), GOT1(2), GOT2(2), GPI(5), HK1(11), HK2(8), HK3(5), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), MDH1(3), PC(7), PCK1(6), PDHA1(1), PDHA2(4), PDHB(3), PDHX(2), PFKL(4), PFKM(3), PFKP(8), PGAM2(4), PGK1(4), PGK2(2), PKLR(5), PKM2(5), TNFAIP1(4), TPI1(1)	13937519	146	59	144	68	57	45	3	33	8	0	0.782	1.000	1.000
389	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(6), AKR1B10(2), B4GALT1(2), B4GALT2(5), G6PC2(1), GAA(2), GALE(1), GALK1(2), GALK2(2), GALT(1), GANC(7), GCK(4), GLB1(2), HK1(11), HK2(8), HK3(5), HSD3B7(4), LALBA(1), LCT(15), MGAM(9), PFKL(4), PFKM(3), PFKP(8), PGM1(2), PGM3(10), RDH11(1), RDH12(1), RDH13(3), UGP2(3)	12646519	125	59	124	61	51	39	2	24	9	0	0.849	1.000	1.000
390	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(5), AASDH(5), AASS(6), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), BBOX1(3), DLST(4), DOT1L(8), EHHADH(6), EHMT1(10), EHMT2(6), GCDH(5), HADHA(4), PLOD1(7), PLOD2(6), PLOD3(8), SDS(2), SHMT1(1), SHMT2(5), TMLHE(5)	12112794	138	59	136	51	44	47	2	24	21	0	0.253	1.000	1.000
391	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(1), CREB1(3), DAXX(9), DDIT3(3), ELK1(3), GRB2(4), MAP2K4(7), MAP2K6(1), MAP3K1(9), MAP3K5(4), MAP3K7(8), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MAX(3), MEF2B(4), MEF2C(3), MEF2D(6), MKNK1(3), MYC(3), PLA2G4A(4), RIPK1(1), RPS6KA5(2), SHC1(3), STAT1(7), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TRADD(2), TRAF2(2)	12026493	121	59	118	41	36	35	5	21	24	0	0.278	1.000	1.000
392	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(7), GTF2A1(2), GTF2B(2), GTF2E1(4), GTF2F1(5), HDAC3(4), NCOA1(12), NCOA2(21), NCOA3(11), NCOR2(21), POLR2A(15), RARA(2), RXRA(3), TBP(2)	8158428	111	59	110	41	31	42	3	24	11	0	0.379	1.000	1.000
393	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(7), DYRK1B(7), GLI2(11), GLI3(33), GSK3B(4), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), SHH(4), SMO(10), SUFU(5)	5437712	103	59	103	42	42	22	4	28	7	0	0.405	1.000	1.000
394	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(3), AKT2(6), AKT3(6), CISH(1), GRB2(4), IARS(9), IL13RA1(3), IL2RG(5), IL4(1), IL4R(1), INPP5D(1), JAK1(6), JAK2(10), JAK3(9), NR0B2(2), PI3(1), PPP1R13B(6), RPS6KB1(4), SERPINA4(2), SHC1(3), SOS1(6), SOS2(11), SRC(2), STAT6(1), TYK2(4)	11389156	107	59	105	38	32	29	2	29	15	0	0.561	1.000	1.000
395	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(6), CFL1(1), GNAQ(3), GNAS(20), GNGT1(3), LIMK1(3), MAP2K1(5), MAPK1(2), MAPK3(1), MYL2(6), NOX1(4), PIK3C2G(7), PLCB1(13), PPP1R12B(12), PRKCA(3), PTK2(10), RAF1(7), ROCK2(7)	8273506	114	58	110	32	42	23	4	29	16	0	0.201	1.000	1.000
396	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(4), ALAS1(2), ALAS2(9), BLVRA(3), COX10(1), COX15(5), CP(9), CPOX(2), EARS2(3), EPRS(7), FECH(6), FTH1(3), FTMT(3), GUSB(8), HCCS(1), HMBS(2), HMOX1(5), HMOX2(1), MMAB(2), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(8), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3), UROD(1), UROS(3)	13808126	130	58	130	55	30	44	6	38	12	0	0.766	1.000	1.000
397	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(2), CAPN1(2), CAPN2(3), CAPNS1(2), CAPNS2(2), EGF(8), EGFR(11), ITGA1(7), ITGB1(6), MAPK1(2), MAPK3(1), MYL2(6), MYLK(15), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PTK2(10), PXN(3), TLN1(14)	10719086	116	58	114	53	44	31	7	24	10	0	0.711	1.000	1.000
398	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(26), DUSP1(2), EP300(19), IKBKB(7), IL1B(2), IL8(1), MAP2K3(7), MAP2K6(1), MAP3K14(3), MAP3K7(8), MAPK11(1), MAPK14(1), MYD88(1), NFKB1(7), NFKBIA(1), NR3C1(5), RELA(3), TGFBR1(5), TGFBR2(11), TLR2(1), TNF(1)	9714449	113	58	112	37	31	34	8	21	19	0	0.249	1.000	1.000
399	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(19), ACAT1(3), ACAT2(3), ACYP1(1), ACYP2(3), ADH5(3), AKR1B1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), DLAT(3), DLD(3), GLO1(1), GRHPR(2), HAGH(2), LDHA(3), LDHB(4), LDHC(1), LDHD(3), MDH1(3), ME1(1), ME2(4), ME3(4), PC(7), PCK1(6), PDHA1(1), PDHA2(4), PDHB(3), PKLR(5), PKM2(5)	12121292	139	58	137	53	43	48	3	29	16	0	0.479	1.000	1.000
400	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(4), ABP1(9), ACADL(2), ACADM(4), ACADSB(5), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AOC2(4), AOC3(4), CNDP1(1), DPYD(12), DPYS(7), EHHADH(6), GAD1(6), GAD2(7), HADHA(4), MLYCD(5), SDS(2), SMS(3), UPB1(2)	9540105	123	57	119	40	35	41	4	32	11	0	0.130	1.000	1.000
401	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(9), ABAT(4), ACADS(3), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH5A1(5), ALDH9A1(3), EHHADH(6), GAD1(6), GAD2(7), HADHA(4), L2HGDH(1), OXCT1(6), PDHA1(1), PDHA2(4), PDHB(3), SDHB(4), SDS(2)	8462762	107	57	105	45	36	32	0	26	13	0	0.681	1.000	1.000
402	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(4), ACAD8(3), ACAD9(5), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), AKR1B10(2), AKR1C4(5), AKR1D1(2), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), BAAT(1), CEL(7), CYP27A1(4), CYP7A1(4), HADHB(4), HSD3B7(4), LIPA(1), RDH11(1), RDH12(1), RDH13(3), SLC27A5(4), SOAT1(6), SOAT2(2), SRD5A1(3), SRD5A2(3)	10386794	124	57	122	39	31	43	5	30	15	0	0.109	1.000	1.000
403	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(5), C1GALT1(3), C1GALT1C1(4), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(1), GALNT13(7), GALNT14(6), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(7), GALNT6(2), GALNT8(5), GALNT9(2), GALNTL1(7), GALNTL2(7), GALNTL4(7), GALNTL5(3), GCNT3(2), GCNT4(2), OGT(2), ST3GAL1(4), ST3GAL2(4), ST6GALNAC1(2)	10206868	101	57	100	47	36	26	4	28	7	0	0.916	1.000	1.000
404	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(4), ACACA(19), ACACB(22), ACADM(4), ACAT1(3), ACAT2(3), ACSS1(9), ACSS2(6), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH6A1(4), ALDH9A1(3), EHHADH(6), HADHA(4), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), MCEE(2), MLYCD(5), MUT(3), PCCA(8), PCCB(4), SUCLA2(4), SUCLG1(2), SUCLG2(2)	13039588	154	57	149	43	41	46	4	38	25	0	0.0526	1.000	1.000
405	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(3), CDK5(2), CDK5R1(1), CFL1(1), CHN1(3), LIMK1(3), MAP3K1(9), MYL2(6), MYLK(15), NCF2(2), PAK1(5), PDGFRA(11), PIK3R1(8), PLD1(13), PPP1R12B(12), RALBP1(5), RPS6KB1(4), TRIO(26), VAV1(6), WASF1(3)	10749995	138	57	136	50	43	44	2	29	20	0	0.430	1.000	1.000
406	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(7), GTF2B(2), GTF2E1(4), GTF2E2(2), GTF2F2(1), GTF2H1(1), GTF2H4(3), ILK(3), MNAT1(2), POLR1A(12), POLR1B(4), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLR3B(7), POLR3D(4), POLR3E(3), POLR3K(1), TAF13(1), TAF5(2), TAF6(8), TAF7(5), TBP(2)	11501047	108	57	107	38	40	34	2	20	12	0	0.348	1.000	1.000
407	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(16), AKT1(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CREB1(3), GNAS(20), GRB2(4), MAPK1(2), MAPK14(1), MAPK3(1), PIK3R1(8), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), RPS6KA1(6), RPS6KA5(2), SOS1(6)	8828321	109	56	108	44	42	35	0	19	13	0	0.642	1.000	1.000
408	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(6), AKR1B10(2), ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), FPGT(3), FUK(3), GMDS(2), GMPPA(6), GMPPB(2), HK1(11), HK2(8), HK3(5), HSD3B7(4), KHK(2), LHPP(3), MPI(3), MTMR1(4), MTMR2(3), MTMR6(5), PFKFB1(2), PFKFB2(5), PFKFB3(3), PFKFB4(3), PFKL(4), PFKM(3), PFKP(8), PGM2(1), PHPT1(2), PMM1(2), PMM2(2), RDH11(1), RDH12(1), RDH13(3), SORD(2), TPI1(1), TSTA3(6)	12181843	133	56	133	46	52	43	2	26	10	0	0.133	1.000	1.000
409	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(3), BAD(3), BCL2(2), CBL(2), CRKL(1), E2F1(2), FOS(1), GRB2(4), IL2RA(2), IL2RB(2), IL2RG(5), IRS1(15), JAK1(6), JAK3(9), MAPK1(2), MAPK3(1), MYC(3), NMI(2), PIK3R1(8), PTPN6(3), RAF1(7), RPS6KB1(4), SHC1(3), SOCS1(1), SOCS3(3), SOS1(6), STAT5A(4), STAT5B(6), SYK(6)	11122696	116	56	113	41	31	41	1	25	18	0	0.393	1.000	1.000
410	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(2), DLG4(3), EPHB2(8), F2(5), F2RL1(2), F2RL2(2), F2RL3(1), JUN(3), MAP2K5(1), MAPK1(2), MAPK7(7), MAPK8(5), MYEF2(9), PLD1(13), PLD2(13), PLD3(4), PTK2(10), RAF1(7), RASAL1(4), SRC(2), TEC(4), VAV1(6)	8978757	113	56	112	30	38	34	6	20	15	0	0.0291	1.000	1.000
411	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(28), MAP2(23), PPP1CA(2), PPP2CA(3), PRKACB(2), PRKACG(5), PRKAG1(3), PRKAR2A(2), PRKAR2B(7), PRKCE(8)	5961212	83	55	82	29	14	29	2	27	11	0	0.526	1.000	1.000
412	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(5), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CASP10(5), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), GAS2(2), LMNA(3), MAP3K14(3), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), SPTAN1(18), TNFRSF10A(1), TNFRSF10B(2), TNFRSF25(4), TNFSF10(3), TRADD(2), TRAF2(2)	10941157	94	55	92	31	26	24	2	28	14	0	0.459	1.000	1.000
413	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNA1(1), IFNB1(2), IKBKB(7), IL1A(2), IL1B(2), IL1R1(4), IL1RAP(5), IL1RN(1), IRAK1(5), IRAK2(8), IRAK3(4), JUN(3), MAP2K3(7), MAP2K6(1), MAP3K1(9), MAP3K14(3), MAP3K7(8), MAPK14(1), MAPK8(5), MYD88(1), NFKB1(7), NFKBIA(1), RELA(3), TGFB1(3), TGFB2(6), TGFB3(5), TNF(1), TOLLIP(2), TRAF6(5)	9724136	112	55	109	37	34	29	6	26	17	0	0.305	1.000	1.000
414	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(16), AKT1(3), BAD(3), BAX(1), BCL2(2), CSF2RB(7), IGF1(4), IGF1R(15), IL3(1), IL3RA(5), KIT(12), KITLG(2), PIK3R1(8), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), YWHAH(3)	6478074	104	54	103	42	34	37	2	21	10	0	0.369	1.000	1.000
415	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(6), B4GALT1(2), B4GALT2(5), FBP2(4), GAA(2), GALE(1), GALK1(2), GALK2(2), GALT(1), GANAB(4), GCK(4), GLB1(2), HK1(11), HK2(8), HK3(5), LALBA(1), LCT(15), MGAM(9), PFKM(3), PFKP(8), PGM1(2), PGM3(10)	10668999	107	54	106	53	45	30	2	19	11	0	0.866	1.000	1.000
416	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(4), ACO1(8), ACO2(5), CLYBL(1), CS(2), DLD(3), DLST(4), FH(2), IDH1(1), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(3), MDH1(3), OGDH(7), OGDHL(10), PC(7), PCK1(6), PCK2(7), SDHA(6), SDHB(4), SDHC(1), SUCLA2(4), SUCLG1(2), SUCLG2(2)	9815813	96	54	92	37	44	23	5	11	13	0	0.406	1.000	1.000
417	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(4), ABP1(9), ACADM(4), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AOC2(4), AOC3(4), CNDP1(1), DPYD(12), DPYS(7), EHHADH(6), GAD1(6), GAD2(7), HADHA(4), MLYCD(5), SMS(3), SRM(1), UPB1(2)	8861538	107	54	103	33	31	34	4	28	10	0	0.0968	1.000	1.000
418	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(5), POLA2(3), POLB(2), POLD1(10), POLD2(1), POLD3(3), POLE(17), POLE2(3), POLE3(1), POLG(5), POLG2(4), POLH(5), POLI(1), POLK(6), POLL(2), POLM(3), POLQ(22), PRIM1(2), PRIM2(6), REV1(7), REV3L(23), RFC5(1)	13329313	132	54	132	52	38	36	5	30	23	0	0.733	1.000	1.000
419	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), CDC42(1), CREB1(3), CREB3(4), CREB5(4), DUSP1(2), DUSP10(6), EEF2K(7), EIF4E(2), ELK1(3), IL1R1(4), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K10(8), MAP3K4(15), MAP3K5(4), MAP3K7(8), MAPK1(2), MAPK11(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MKNK1(3), MKNK2(1), MYEF2(9), NFKB1(7), NR2C2(2), SRF(1), TRAF6(5)	10922282	124	54	123	42	35	42	10	20	17	0	0.141	1.000	1.000
420	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(1), CSNK1D(2), DRD1(3), DRD2(7), GRM1(26), PLCB1(13), PPP1CA(2), PPP1R1B(1), PPP2CA(3), PPP3CA(5), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7)	5251638	87	53	85	33	30	25	1	20	11	0	0.444	1.000	1.000
421	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(3), ASNS(3), ASRGL1(2), CA13(3), CA14(3), CA2(1), CA3(3), CA4(3), CA5B(1), CA6(3), CA7(3), CA8(3), CA9(4), CPS1(18), CTH(2), GLS(8), GLS2(6), GLUD1(3), GLUD2(10), GLUL(5), HAL(1)	6974059	88	53	88	35	21	31	3	26	7	0	0.647	1.000	1.000
422	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	BCL2(2), CREBBP(26), EP300(19), FYN(8), IL2RG(5), IL7(1), IL7R(5), JAK1(6), JAK3(9), LCK(3), NMI(2), PIK3R1(8), PTK2B(10), STAT5A(4), STAT5B(6)	8446462	114	53	111	32	32	36	1	26	19	0	0.0864	1.000	1.000
423	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(2), EGF(8), EGFR(11), GRB2(4), MAP2K1(5), MAPK1(2), MAPK3(1), PTPRB(17), RAF1(7), RASA1(11), SHC1(3), SOS1(6), SPRY1(2), SPRY3(6), SPRY4(4), SRC(2)	8197714	91	53	88	33	26	22	2	32	9	0	0.615	1.000	1.000
424	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(16), AKT1(3), ASAH1(2), GNAI1(1), GNGT1(3), ITGAV(5), ITGB3(3), MAPK1(2), MAPK3(1), PDGFA(2), PDGFRA(11), PIK3R1(8), PLCB1(13), PRKCA(3), PTK2(10), SMPD1(5), SMPD2(1), SPHK1(4), SRC(2)	8291921	95	52	94	42	31	33	4	13	14	0	0.639	1.000	1.000
425	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(2), ADCY1(16), CAP1(3), CCNB1(3), CDC25C(7), GNAI1(1), GNAS(20), GNGT1(3), MAPK1(2), MAPK3(1), MYT1(14), PIN1(1), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RPS6KA1(6), SRC(2)	6741430	103	52	101	44	40	26	1	26	10	0	0.722	1.000	1.000
426	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(11), ARHGEF1(9), GNA12(1), GNA13(3), GNAQ(3), GNGT1(3), MYL2(6), MYLK(15), PLCB1(13), PPP1R12B(12), PRKCA(3), ROCK1(9)	6794253	88	52	86	29	24	23	2	23	14	2	0.471	1.000	1.000
427	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(7), IL1A(2), IL1R1(4), IRAK1(5), MAP3K1(9), MAP3K14(3), MAP3K7(8), MYD88(1), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), TLR4(18), TNF(1), TNFAIP3(5), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF6(5)	7959028	86	52	82	30	24	20	5	24	13	0	0.438	1.000	1.000
428	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(16), ARHGEF1(9), F2(5), F2R(2), F2RL3(1), GNA12(1), GNA13(3), GNAI1(1), GNAQ(3), GNGT1(3), MAP3K7(8), PIK3R1(8), PLCB1(13), PPP1R12B(12), PRKCA(3), PTK2B(10), ROCK1(9)	7761854	107	52	106	43	34	32	2	21	17	1	0.659	1.000	1.000
429	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(4), ACACA(19), ACADL(2), ACADM(4), ACADSB(5), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH6A1(4), ALDH9A1(3), EHHADH(6), HADHA(4), LDHA(3), LDHB(4), LDHC(1), MCEE(2), MLYCD(5), MUT(3), PCCA(8), PCCB(4), SDS(2), SUCLA2(4), SUCLG1(2), SUCLG2(2)	10874139	130	52	125	38	34	46	1	29	20	0	0.130	1.000	1.000
430	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(2), GORASP1(3), MAP2K4(7), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), MAPKAPK5(1), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PIK3CD(10), PIK3R1(8), SYT1(3), TRAF2(2), TRAF3(3), TRAF6(5)	10037206	103	52	102	31	42	26	3	15	17	0	0.0780	1.000	1.000
431	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(5), F2R(2), F2RL3(1), GNAI1(1), GNGT1(3), ITGA1(7), ITGB1(6), MAP2K1(5), MAPK1(2), MAPK3(1), PLA2G4A(4), PLCB1(13), PRKCA(3), PTGS1(7), PTK2(10), RAF1(7), SRC(2), SYK(6), TBXAS1(2)	7991998	87	52	83	36	28	21	6	21	11	0	0.653	1.000	1.000
432	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(6), ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), FPGT(3), GCK(4), GMDS(2), GMPPA(6), GMPPB(2), HK1(11), HK2(8), HK3(5), KHK(2), MPI(3), PFKFB1(2), PFKFB3(3), PFKFB4(3), PFKM(3), PFKP(8), PMM1(2), PMM2(2), SORD(2), TPI1(1)	7856467	90	51	90	31	41	24	1	18	6	0	0.157	1.000	1.000
433	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(2), CHIA(4), CHIT1(3), CMAS(4), CTBS(2), CYB5R1(1), CYB5R3(1), GFPT1(3), GFPT2(4), GNE(5), GNPDA1(3), GNPDA2(2), GNPNAT1(2), HEXA(2), HEXB(2), HK1(11), HK2(8), HK3(5), LHPP(3), MTMR1(4), MTMR2(3), MTMR6(5), NANS(1), NPL(2), PGM3(10), PHPT1(2), RENBP(2), UAP1(3)	9415778	99	51	99	32	27	35	4	25	8	0	0.179	1.000	1.000
434	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(8), ANAPC10(1), ANAPC11(1), ANAPC2(4), ANAPC5(2), ANAPC7(3), BTRC(4), CDC16(4), CDC20(4), CDC23(4), CDC26(1), CDC27(2), CUL1(14), CUL2(5), CUL3(5), FBXW11(10), FZR1(3), ITCH(4), RBX1(1), SKP2(5), SMURF1(3), SMURF2(3), TCEB1(1), UBA1(2), UBE2D3(2), UBE2E3(3), WWP1(9), WWP2(10)	12652439	118	51	115	35	43	40	1	21	13	0	0.112	1.000	1.000
435	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(21), C5(11), C6(10), C7(2), ICAM1(1), IL1A(2), IL8(1), ITGA4(9), ITGAL(11), ITGB1(6), ITGB2(5), SELP(6), SELPLG(6), TNF(1), VCAM1(8)	8155883	100	51	98	35	35	24	3	29	9	0	0.260	1.000	1.000
436	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(3), EIF4A1(3), EIF4A2(4), EIF4B(4), EIF4E(2), EIF4EBP1(2), EIF4G1(19), EIF4G2(5), EIF4G3(7), FKBP1A(2), MKNK1(3), PDPK1(2), PIK3R1(8), PPP2CA(3), RPS6(1), RPS6KB1(4), TSC1(3), TSC2(7)	8077172	82	51	82	26	26	26	3	16	11	0	0.318	1.000	1.000
437	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(18), COL4A2(10), COL4A3(8), COL4A4(10), COL4A5(9), COL4A6(6), P4HB(2), SLC23A1(4), SLC23A2(9), SLC2A1(6), SLC2A3(5)	8239432	87	51	87	43	32	29	2	19	5	0	0.695	1.000	1.000
438	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(2), EPHA4(14), EPHB1(18), FYN(8), ITGA1(7), ITGB1(6), L1CAM(12), LYN(4), RAP1B(5), SELP(6)	5190737	82	50	80	33	32	15	8	21	5	1	0.487	1.000	1.000
439	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(2), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT4(4), CHST1(13), CHST2(10), CHST4(4), CHST6(6), FUT8(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(1), ST3GAL4(4)	4083927	70	50	68	28	39	16	1	11	3	0	0.429	1.000	1.000
440	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(4), ACADL(2), ACADM(4), ACADS(3), ACADSB(5), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH6A1(4), ALDH9A1(3), AOX1(7), BCAT1(3), BCKDHA(5), BCKDHB(1), EHHADH(6), HADHA(4), HADHB(4), HIBADH(3), IVD(4), MCCC1(3), MCCC2(3), MCEE(2), MUT(3), OXCT1(6), PCCA(8), PCCB(4), SDS(2)	11820864	132	50	128	51	29	52	2	27	21	1	0.575	1.000	1.000
441	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(6), AGT(3), AGTR1(1), AGTR2(2), COL4A1(18), COL4A2(10), COL4A3(8), COL4A4(10), COL4A5(9), COL4A6(6), REN(2)	8301669	75	49	75	31	25	24	3	20	3	0	0.401	1.000	1.000
442	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(4), ADSL(3), ADSS(4), AGXT(1), AGXT2(7), ASL(5), ASNS(3), ASPA(1), CAD(12), CRAT(1), DARS(2), DDO(4), GAD1(6), GAD2(7), GOT1(2), GOT2(2), GPT(1), GPT2(2), NARS(4), PC(7)	8542230	82	49	80	43	34	26	0	19	3	0	0.902	1.000	1.000
443	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(4), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), CYP2C19(7), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), EHHADH(6), ESCO1(4), ESCO2(4), HADHA(4), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), SH3GLB1(1), YOD1(2)	10139122	110	49	109	31	30	37	2	26	15	0	0.0805	1.000	1.000
444	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(4), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), AKR1C4(5), AKR1D1(2), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), BAAT(1), CEL(7), CYP27A1(4), CYP7A1(4), HADHB(4), SOAT2(2), SRD5A1(3), SRD5A2(3)	7624006	99	48	98	36	25	33	2	25	14	0	0.355	1.000	1.000
445	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(9), CHAT(4), COMT(4), DBH(5), DDC(5), GAD1(6), GAD2(7), HDC(7), MAOA(1), PAH(4), PNMT(8), SLC18A3(7), TH(2), TPH1(3)	4707288	73	48	72	37	30	17	2	20	4	0	0.827	1.000	1.000
446	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(3), CREBBP(26), EP300(19), NCOA3(11), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RARA(2), RXRA(3)	6778303	88	48	87	33	30	30	1	13	14	0	0.357	1.000	1.000
447	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(6), CD2(2), CD33(7), CD5(4), CD7(3), IFNA1(1), IFNB1(2), IFNG(2), IL10(2), IL12A(2), IL12B(1), IL13(1), IL3(1), IL4(1), ITGAX(8), TLR2(1), TLR4(18), TLR7(5), TLR9(13)	6104533	80	48	75	41	23	17	5	28	7	0	0.941	1.000	1.000
448	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(5), CS(2), DLAT(3), DLD(3), DLST(4), FH(2), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(3), MDH1(3), OGDH(7), PC(7), PDHA1(1), PDHA2(4), PDHB(3), PDHX(2), PDK1(2), PDK3(4), PDK4(2), PDP2(4), SDHA(6), SDHB(4), SDHC(1), SUCLA2(4), SUCLG1(2), SUCLG2(2)	9315063	84	48	82	42	28	25	2	16	13	0	0.933	1.000	1.000
449	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(3), BIRC3(3), CASP3(2), CASP8(8), JUN(3), MAP2K4(7), MAP3K3(4), MAP3K7(8), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), NR2C2(2), RALBP1(5), RIPK1(1), TNF(1), TNFAIP3(5), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF2(2)	8913854	85	48	85	32	29	19	6	19	12	0	0.469	1.000	1.000
450	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(3), BCL2(2), EGFR(11), IGF1R(15), MYC(3), POLR2A(15), PPP2CA(3), PRKCA(3), RB1(6), TEP1(21), TERF1(3), TERT(3), TNKS(13), XRCC5(4)	8986276	105	48	103	45	31	42	4	20	8	0	0.543	1.000	1.000
451	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX15(3), ALOX5(6), CYP1A2(4), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2E1(4), CYP2J2(4), CYP3A4(2), CYP3A43(4), CYP3A7(4), HSD3B7(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), RDH11(1), RDH12(1), RDH13(3)	7853020	82	47	82	26	24	26	3	23	6	0	0.209	1.000	1.000
452	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), CARS(4), DARS(2), EPRS(7), FARS2(6), GARS(1), HARS(5), IARS(9), KARS(5), LARS(4), LARS2(7), MARS(4), MARS2(1), NARS(4), QARS(3), RARS(4), SARS(4), TARS(6), WARS(3), WARS2(7), YARS(3)	10538377	93	46	92	29	29	30	3	22	9	0	0.237	1.000	1.000
453	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(16), GNAS(20), GNGT1(3), PPP2CA(3), PRKAA1(4), PRKAA2(5), PRKAB1(2), PRKAB2(2), PRKACB(2), PRKACG(5), PRKAG1(3), PRKAG2(3), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7)	5032008	83	46	82	34	32	24	1	17	9	0	0.694	1.000	1.000
454	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(6), DCXR(1), GUSB(8), RPE(4), UGDH(5), UGP2(3), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(8), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3), XYLB(5)	8903723	80	46	80	24	18	29	3	23	7	0	0.147	1.000	1.000
455	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(4), CARM1(2), CBS(5), CTH(2), GGT1(4), HEMK1(1), LCMT1(1), LCMT2(7), MARS(4), MARS2(1), MAT1A(2), MAT2B(2), METTL6(2), PAPSS1(4), PAPSS2(4), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), SCLY(1), SEPHS1(4), SEPHS2(2), WBSCR22(4)	8183586	72	46	71	40	24	19	4	13	12	0	0.928	1.000	1.000
456	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(7), ELK1(3), FOS(1), GRB2(4), IL6R(1), IL6ST(4), JAK1(6), JAK2(10), JAK3(9), JUN(3), MAP2K1(5), MAPK3(1), PTPN11(5), RAF1(7), SHC1(3), SOS1(6), SRF(1), STAT3(6)	7830204	82	46	79	34	19	28	1	31	3	0	0.722	1.000	1.000
457	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(3), ASNS(3), CA14(3), CA2(1), CA3(3), CA4(3), CA5B(1), CA6(3), CA7(3), CA8(3), CA9(4), CPS1(18), CTH(2), GLS(8), GLS2(6), GLUD1(3), GLUL(5), HAL(1)	6241441	73	46	73	33	16	28	3	19	7	0	0.833	1.000	1.000
458	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(13), APOA1(5), APOA4(5), APOC2(1), APOE(1), CETP(3), CYP7A1(4), DGAT1(1), HMGCR(6), LCAT(4), LDLR(7), LIPC(2), LPL(4), LRP1(25), SCARB1(4), SOAT1(6)	8995945	91	46	88	40	40	18	7	19	7	0	0.705	1.000	1.000
459	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(4), GPLD1(8), PGAP1(8), PIGA(2), PIGB(5), PIGC(3), PIGG(8), PIGK(3), PIGL(2), PIGM(5), PIGN(5), PIGO(4), PIGP(1), PIGQ(2), PIGS(3), PIGT(2), PIGU(1), PIGV(4), PIGW(1), PIGX(2), PIGZ(2)	7810694	75	45	73	32	22	24	2	18	8	1	0.654	1.000	1.000
460	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(16), ADRB2(7), GNAS(20), PLCE1(11), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7)	4845460	76	45	75	40	31	24	0	14	7	0	0.932	1.000	1.000
461	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(26), EP300(19), HDAC3(4), IKBKB(7), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF6(5)	7319376	80	45	79	30	27	23	2	14	14	0	0.476	1.000	1.000
462	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(3), CRADD(1), IKBKB(7), JUN(3), LTA(3), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K1(9), MAP3K14(3), MAP4K2(4), MAPK14(1), MAPK8(5), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), TANK(3), TNF(1), TNFRSF1A(3), TRADD(2), TRAF2(2)	7876599	77	45	75	29	23	21	5	11	17	0	0.497	1.000	1.000
463	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(7), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNH(2), CDC25A(3), CDK2(3), CDK6(4), CDKN1A(1), CDKN2A(6), CDKN2D(3), E2F1(2), RB1(6), RBL1(7), TFDP1(3)	5270869	59	44	57	23	14	22	2	15	6	0	0.584	1.000	1.000
464	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(3), ARSB(2), ARSD(4), ARSE(4), ASAH1(2), GAL3ST1(6), GALC(5), GBA(6), GLB1(2), LCT(15), NEU1(1), NEU2(3), NEU3(4), NEU4(1), PPAP2A(1), PPAP2C(4), SMPD1(5), SMPD2(1), SPTLC1(1), SPTLC2(3), UGCG(3)	7922149	76	44	75	31	33	27	3	7	6	0	0.436	1.000	1.000
465	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(2), GNS(3), GUSB(8), HEXA(2), HEXB(2), HGSNAT(3), HPSE(6), HPSE2(2), HYAL1(4), HYAL2(4), IDS(3), IDUA(2), LCT(15), NAGLU(3), SPAM1(8)	6697252	70	44	69	28	21	28	3	13	5	0	0.500	1.000	1.000
466	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(9), AMT(3), ATIC(6), FTCD(2), GART(8), MTFMT(1), MTHFD1(3), MTHFD1L(6), MTHFD2(1), MTHFR(6), MTHFS(1), MTR(12), SHMT1(1), SHMT2(5), TYMS(1)	6208573	65	44	63	26	19	16	4	13	13	0	0.531	1.000	1.000
467	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(12), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLR3A(15), POLR3B(7), POLR3G(2), POLR3K(1)	7710349	76	44	75	24	28	23	1	20	4	0	0.238	1.000	1.000
468	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(7), DDX20(4), E2F1(2), E2F4(1), ETS1(5), ETS2(3), ETV3(1), FOS(1), HDAC2(2), HDAC5(6), JUN(3), NCOR2(21), RBL1(7), RBL2(4), SIN3A(8), SIN3B(10)	8479106	86	43	86	33	29	21	4	23	9	0	0.537	1.000	1.000
469	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(6), F2(5), F2R(2), F3(1), F5(13), F7(9), FGA(7), FGB(2), FGG(2), PROC(2), PROS1(8), SERPINC1(4), TFPI(3)	5388988	64	43	64	24	19	18	4	20	3	0	0.530	1.000	1.000
470	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), G6PD(2), GPI(5), H6PD(4), PFKL(4), PFKM(3), PFKP(8), PGD(6), PGLS(2), PGM1(2), PGM3(10), PRPS1(2), PRPS1L1(2), PRPS2(2), RBKS(1), RPE(4), RPIA(1), TALDO1(4), TKT(3), TKTL1(8), TKTL2(7)	7958475	92	43	92	32	29	32	5	20	6	0	0.162	1.000	1.000
471	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(7), BST1(2), C9orf95(1), CD38(3), ENPP1(5), ENPP3(4), NADK(6), NADSYN1(4), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(1), NNT(11), NT5C(1), NT5C1A(4), NT5C1B(5), NT5C2(7), NT5C3(1), NUDT12(3)	7052766	68	43	66	38	22	23	3	10	9	1	0.939	1.000	1.000
472	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), CSF1R(7), EGF(8), EGFR(11), GRB2(4), MET(7), PDGFRA(11), PRKCA(3), SH3GLB1(1), SH3GLB2(5), SH3KBP1(10), SRC(2)	6383057	71	42	69	39	26	19	2	13	11	0	0.942	1.000	1.000
473	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(16), ADRB2(7), CFTR(8), GNAS(20), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7)	4283034	73	42	72	34	30	21	0	15	7	0	0.859	1.000	1.000
474	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(8), ACO2(5), CS(2), DLD(3), DLST(4), FH(2), IDH1(1), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(3), MDH1(3), PC(7), PCK1(6), SDHA(6), SDHB(4), SUCLA2(4), SUCLG1(2), SUCLG2(2)	6765651	66	42	63	28	32	15	1	10	8	0	0.561	1.000	1.000
475	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(8), EGFR(11), MAP2K1(5), MAP3K1(9), MAPK14(1), NCOR2(21), RARA(2), RXRA(3), THRA(4), THRB(7)	5644405	71	42	68	34	30	18	1	14	8	0	0.826	1.000	1.000
476	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(4), AMD1(3), BHMT(4), CBS(5), CTH(2), DNMT1(12), DNMT3A(5), DNMT3B(9), MARS(4), MARS2(1), MAT1A(2), MAT2B(2), MTAP(1), MTFMT(1), MTR(12), SRM(1), TAT(4)	6799749	72	42	70	40	23	26	2	13	8	0	0.926	1.000	1.000
477	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(5), FUCA1(1), FUCA2(1), GLB1(2), HEXA(2), HEXB(2), LCT(15), MAN2B1(10), MAN2B2(12), MAN2C1(7), MANBA(5), NEU1(1), NEU2(3), NEU3(4), NEU4(1)	6663517	71	42	70	27	29	20	3	11	8	0	0.460	1.000	1.000
478	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(4), B4GALNT1(3), GLB1(2), HEXA(2), HEXB(2), LCT(15), SLC33A1(4), ST3GAL1(4), ST3GAL2(4), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC5(1), ST6GALNAC6(2), ST8SIA1(4), ST8SIA5(4)	5403872	58	42	58	34	25	15	1	13	4	0	0.955	1.000	1.000
479	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	26	ANXA1(2), ANXA2(1), ANXA4(3), ANXA5(1), ANXA6(2), CYP11A1(4), EDN1(2), EDNRA(3), HSD11B1(2), HSD11B2(2), PLA2G4A(4), PRL(1), PTGDR(6), PTGDS(1), PTGER2(4), PTGER4(4), PTGFR(3), PTGIS(5), PTGS1(7), PTGS2(5), S100A6(1), TBXAS1(2)	6476015	65	42	65	36	16	18	5	20	6	0	0.973	1.000	1.000
480	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(4), ARFGAP1(2), ARFGAP3(4), ARFGEF2(19), CLTA(2), CLTB(1), COPA(6), GBF1(14), GPLD1(8), KDELR1(2), KDELR2(2)	5335434	64	41	64	23	22	29	1	10	2	0	0.244	1.000	1.000
481	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(5), ARHGDIB(1), BIRC2(3), BIRC3(3), CASP1(2), CASP10(5), CASP2(3), CASP3(2), CASP4(4), CASP6(1), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), GZMB(2), LMNA(3), LMNB1(1), LMNB2(4), PRF1(1)	6328543	59	41	58	22	18	15	5	15	6	0	0.582	1.000	1.000
482	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1R(3), C1S(5), C2(2), C3(21), C5(11), C6(10), C7(2), C8A(5), C9(6), MASP1(3), MASP2(4), MBL2(1)	7007514	74	41	72	26	24	19	4	16	10	1	0.519	1.000	1.000
483	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(3), BCAT2(5), IARS(9), IARS2(7), ILVBL(3), LARS(4), LARS2(7), PDHA1(1), PDHA2(4), PDHB(3), VARS(10), VARS2(9)	6103991	65	41	65	25	21	18	2	16	8	0	0.679	1.000	1.000
484	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), GOT1(2), GOT2(2), GPT(1), GPT2(2), MDH1(3), ME1(1), ME3(4), PGK1(4), PGK2(2), PKLR(5), PKM2(5), RPE(4), RPIA(1), TKT(3), TKTL1(8), TKTL2(7), TPI1(1)	6615512	67	41	67	34	23	21	4	16	3	0	0.856	1.000	1.000
485	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(4), IL22RA1(1), IL22RA2(1), JAK1(6), JAK2(10), JAK3(9), SOCS3(3), STAT1(7), STAT3(6), STAT5A(4), STAT5B(6), TYK2(4)	6019507	61	41	60	23	16	18	2	20	5	0	0.560	1.000	1.000
486	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(9), AMT(3), ATIC(6), GART(8), MTHFD1(3), MTHFD1L(6), MTHFD2(1), MTHFR(6), MTHFS(1), MTR(12), SHMT1(1), SHMT2(5), TYMS(1)	5872118	62	41	60	22	18	16	4	12	12	0	0.323	1.000	1.000
487	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(5), AKR1D1(2), ARSB(2), ARSD(4), ARSE(4), CYP11B1(7), CYP11B2(4), HSD11B1(2), HSD11B2(2), HSD17B2(2), HSD17B3(1), HSD3B1(1), HSD3B2(3), SRD5A1(3), SRD5A2(3), STS(4), SULT1E1(2), SULT2A1(3), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(2), UGT2B4(3)	8941815	78	40	78	29	22	32	2	13	9	0	0.320	1.000	1.000
488	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(5), GABRA1(12), GABRA2(5), GABRA3(7), GABRA4(7), GABRA5(5), GABRA6(8), GPHN(9), NSF(1), SRC(2), UBQLN1(4)	3926090	65	40	65	25	12	14	9	27	3	0	0.673	1.000	1.000
489	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(6), G6PD(2), GCLC(1), GCLM(2), GGT1(4), GPX1(1), GPX2(1), GPX3(1), GPX5(1), GPX6(3), GPX7(3), GSR(4), GSS(3), GSTA1(2), GSTA2(1), GSTA4(2), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(2), GSTM5(1), GSTO2(3), GSTZ1(3), IDH1(1), IDH2(1), MGST1(2), MGST3(2), OPLAH(5), TXNDC12(1)	7178462	64	40	64	29	22	18	1	17	6	0	0.707	1.000	1.000
490	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT1(3), B3GNT2(2), B3GNT3(5), B3GNT4(4), B3GNT5(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT4(4), FUT1(2), FUT3(1), FUT4(1), FUT5(2), FUT6(2), FUT7(2), FUT9(5), GCNT2(1), ST3GAL6(3), ST8SIA1(4)	5278238	54	40	53	22	21	16	2	12	3	0	0.539	1.000	1.000
491	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), G6PD(2), GPI(5), H6PD(4), PFKM(3), PFKP(8), PGD(6), PGLS(2), PGM1(2), PGM3(10), PRPS1(2), PRPS1L1(2), PRPS2(2), RBKS(1), RPE(4), RPIA(1), TAL1(1), TALDO1(4), TKT(3)	6701187	74	40	74	27	24	24	4	17	5	0	0.237	1.000	1.000
492	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(5), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), FDXR(3), SHMT1(1)	5259322	65	40	63	23	17	21	3	15	9	0	0.410	1.000	1.000
493	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(4), BLVRA(3), CP(9), CPOX(2), EPRS(7), FECH(6), GUSB(8), HCCS(1), HMBS(2), HMOX1(5), HMOX2(1), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(2), UGT2B4(3), UROD(1), UROS(3)	8975452	78	40	78	32	20	29	1	19	9	0	0.665	1.000	1.000
494	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(5), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), SHMT1(1)	4945363	62	39	60	22	15	21	3	15	8	0	0.437	1.000	1.000
495	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), GOT1(2), GOT2(2), GPT(1), GPT2(2), MDH1(3), ME1(1), ME2(4), ME3(4), PGK1(4), PKLR(5), PKM2(5), RPE(4), RPIA(1), TKT(3), TPI1(1)	5914458	54	39	54	27	18	18	3	12	3	0	0.805	1.000	1.000
496	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(8), EGFR(11), ERBB3(29), NRG1(11)	3381148	59	39	53	22	23	15	2	17	2	0	0.560	1.000	1.000
497	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(5), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), SHMT1(1)	4945363	62	39	60	22	15	21	3	15	8	0	0.437	1.000	1.000
498	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(9), ABCC2(11), ABCG2(3), BCHE(11), CES1(8), CES2(5), CYP3A4(2), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2)	7512643	68	39	68	29	18	22	2	18	8	0	0.704	1.000	1.000
499	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(2), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT5(5), DPAGT1(1), DPM1(1), FUT8(3), MAN1A1(2), MAN1B1(5), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(2), MGAT5(8), RPN1(2), RPN2(3)	6520781	56	39	55	32	21	13	5	10	7	0	0.954	1.000	1.000
500	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(3), AKT2(6), AKT3(6), CDKN1A(1), ELK1(3), GRB2(4), MAP2K1(5), MAP2K2(2), NGFR(4), NTRK1(6), PIK3CD(10), SHC1(3), SOS1(6)	4562751	59	39	56	23	25	16	1	17	0	0	0.508	1.000	1.000
501	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(5), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), SHMT1(1)	4945363	62	39	60	22	15	21	3	15	8	0	0.437	1.000	1.000
502	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(3), BAD(3), CHRNB1(1), CHRNG(4), MUSK(7), PIK3R1(8), PTK2(10), PTK2B(10), RAPSN(2), SRC(2), TERT(3), YWHAH(3)	4633640	56	38	56	21	18	13	5	11	9	0	0.502	1.000	1.000
503	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(6), AGT(3), AGTR2(2), EDN1(2), EDNRA(3), EGF(8), EGFR(11), FOS(1), JUN(3), MYC(3), NFKB1(7), PLCG1(16), PRKCA(3), RELA(3)	6452386	71	38	69	27	24	17	5	21	4	0	0.467	1.000	1.000
504	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1R(3), C1S(5), C2(2), C3(21), C5(11), C6(10), C7(2), C8A(5), C9(6)	5756517	66	38	64	24	21	16	4	16	8	1	0.630	1.000	1.000
505	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(10), POLD2(1), POLE(17), POLG(5), POLL(2), POLQ(22)	5484674	59	38	59	31	18	13	3	15	10	0	0.947	1.000	1.000
506	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), MRPS7(1), RPL10A(1), RPL10L(9), RPL12(1), RPL13A(2), RPL14(1), RPL18(1), RPL19(2), RPL22L1(1), RPL23A(1), RPL24(1), RPL26(1), RPL28(1), RPL3(2), RPL31(1), RPL34(2), RPL36A(1), RPL38(1), RPL3L(2), RPL6(1), RPL7(1), RPL8(2), RPL9(3), RPS10(1), RPS11(1), RPS13(2), RPS23(1), RPS24(1), RPS27(1), RPS3(1), RPS3A(2), RPS4Y1(1), RPS5(3), RPS6(1), RPS9(1), RPSA(6)	7417354	62	38	62	27	19	22	1	12	8	0	0.858	1.000	1.000
507	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(6), ACE2(6), AGT(3), AGTR1(1), AGTR2(2), ANPEP(6), CPA3(1), CTSA(1), CTSG(3), ENPEP(9), LNPEP(8), MAS1(1), MME(5), NLN(6), REN(2), THOP1(4)	6936406	64	38	64	27	24	22	3	13	2	0	0.525	1.000	1.000
508	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(5), CLOCK(3), CRY1(3), CRY2(4), CSNK1D(2), CSNK1E(7), NPAS2(9), NR1D1(4), PER1(5), PER2(9), PER3(8)	5582542	59	38	59	21	16	13	3	17	10	0	0.525	1.000	1.000
509	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), CAT(4), EPX(6), LPO(7), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(1), SHMT1(1), SHMT2(5), TPO(15)	3855470	52	38	52	18	17	10	4	12	9	0	0.423	1.000	1.000
510	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(4), BHMT(4), CBS(5), CTH(2), DNMT1(12), DNMT3A(5), DNMT3B(9), MARS(4), MARS2(1), MAT1A(2), MAT2B(2), MTR(12)	5701888	62	38	60	35	22	20	2	10	8	0	0.921	1.000	1.000
511	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(4), ICAM1(1), ITGA4(9), ITGAL(11), ITGAM(6), ITGB1(6), ITGB2(5), SELE(4), SELL(4), SELP(6)	5240905	56	38	55	31	22	10	1	15	8	0	0.937	1.000	1.000
512	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(2), CCR2(5), CCR3(6), CCR5(3), CCR7(2), CD4(5), CXCR4(1), IFNG(2), IFNGR1(5), IFNGR2(1), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL18R1(2), IL4(1), IL4R(1), TGFB1(3), TGFB2(6), TGFB3(5)	6573665	65	38	65	30	17	17	2	23	6	0	0.833	1.000	1.000
513	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(7), ESR2(8), ITPKA(1), PDE1A(6), PDE1B(3), PLCB1(13), PLCB2(4), PRL(1), TRH(3), VIP(3)	3641575	49	38	48	22	16	12	4	14	3	0	0.764	1.000	1.000
514	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(7), DNMT1(12), MTNR1A(4), MTNR1B(6), PTAFR(5), PTGDR(6), PTGER2(4), PTGER4(4), PTGFR(3), TBXA2R(8)	3644520	59	38	59	32	24	17	3	13	2	0	0.808	1.000	1.000
515	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(2), HSPA1A(1), IFNG(2), IFNGR1(5), IFNGR2(1), IKBKB(7), JAK2(10), LIN7A(7), NFKB1(7), NFKBIA(1), RB1(6), RELA(3), TNF(1), TNFRSF1A(3), TNFRSF1B(1), USH1C(2), WT1(3)	5686226	62	38	60	25	14	19	1	21	7	0	0.695	1.000	1.000
516	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(6), GBA3(1), LPO(7), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(1), TPO(15), TYR(6)	3150845	46	37	46	21	13	11	4	14	4	0	0.806	1.000	1.000
517	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(20), GNGT1(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3)	3149049	51	36	50	17	24	11	2	9	5	0	0.423	1.000	1.000
518	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(4), CDKN2A(6), E2F1(2), MDM2(3), MYC(3), PIK3R1(8), POLR1A(12), POLR1B(4), POLR1C(2), POLR1D(1), RB1(6), TBX2(3), TWIST1(1)	5657242	55	36	54	28	18	17	1	8	11	0	0.872	1.000	1.000
519	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(6), G6PD(2), GCLC(1), GCLM(2), GGT1(4), GPX1(1), GPX2(1), GPX3(1), GPX5(1), GSS(3), GSTA1(2), GSTA2(1), GSTA4(2), GSTM2(1), GSTM3(2), GSTM4(2), GSTM5(1), GSTO2(3), GSTZ1(3), IDH1(1), IDH2(1), MGST1(2), MGST3(2), PGD(6)	5906218	51	36	51	18	18	14	0	14	5	0	0.335	1.000	1.000
520	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP2(2), ACP5(1), ACP6(2), ACPP(2), ACPT(4), ALPI(6), ALPL(4), ALPP(7), ALPPL2(6), CYP3A4(2), CYP3A43(4), CYP3A7(4), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), PON1(2), PON2(3), PON3(1)	5910298	62	36	61	28	25	18	1	11	7	0	0.632	1.000	1.000
521	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(3), AKT2(6), AKT3(6), BPNT1(1), GRB2(4), ILK(3), MAPK1(2), MAPK3(1), PDK1(2), PIK3CD(10), PTK2B(10), RBL2(4), SHC1(3), SOS1(6)	5713748	61	36	60	18	29	14	0	14	4	0	0.303	1.000	1.000
522	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(6), ARG1(2), ASL(5), CKB(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(18), GATM(3), GLUD1(3), NAGS(1), ODC1(3), OTC(2), PYCR1(3), SMS(3)	5735231	62	36	62	21	23	17	3	17	2	0	0.291	1.000	1.000
523	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(6), DHCR24(2), DHCR7(3), EBP(1), FDPS(6), GGCX(2), GGPS1(1), HMGCR(6), HSD17B7(2), LSS(4), MVD(2), MVK(8), NQO1(2), NSDHL(3), SC4MOL(4), SC5DL(4), SQLE(4), TM7SF2(1)	6316156	64	35	62	24	19	16	3	17	9	0	0.613	1.000	1.000
524	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(4), HK1(11), HK2(8), HK3(5), IMPA1(3), IMPA2(1), ISYNA1(2), PGM1(2), PGM3(10), TGDS(3)	3826449	49	35	49	20	15	17	2	12	3	0	0.465	1.000	1.000
525	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(6), GBA(6), GBA3(1), LPO(7), MPO(6), PRDX6(1), TPO(15)	2737617	42	35	42	17	16	11	2	10	3	0	0.608	1.000	1.000
526	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(7), FOS(1), GRB2(4), IL3(1), IL3RA(5), JAK2(10), MAP2K1(5), MAPK3(1), PTPN6(3), RAF1(7), SHC1(3), SOS1(6), STAT5A(4), STAT5B(6)	5806936	63	35	60	24	20	22	0	18	3	0	0.552	1.000	1.000
527	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(4), ESR1(7), GREB1(20), MTA1(6), MTA3(2), PDZK1(2), TUBA8(4)	3576892	45	35	45	21	18	15	3	5	4	0	0.574	1.000	1.000
528	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(5), FUCA1(1), FUCA2(1), GLB1(2), HEXA(2), HEXB(2), LCT(15), MAN2C1(7), MANBA(5), NEU1(1), NEU2(3), NEU3(4), NEU4(1)	5403449	49	35	49	22	17	15	2	8	7	0	0.783	1.000	1.000
529	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(2), IKBKAP(6), IKBKB(7), LTA(3), MAP3K1(9), MAP3K14(3), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), TANK(3), TNFAIP3(5), TNFRSF1B(1), TRAF1(3), TRAF2(2), TRAF3(3)	7365885	59	35	57	25	22	13	2	10	12	0	0.747	1.000	1.000
530	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(2), GNS(3), GUSB(8), HEXA(2), HEXB(2), IDS(3), IDUA(2), LCT(15), NAGLU(3)	4691627	43	34	43	23	13	17	0	9	4	0	0.843	1.000	1.000
531	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(2), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(1), ARPC4(2), NCK1(6), NCKAP1(8), NTRK1(6), PIR(1), PSMA7(4), WASF1(3), WASF2(6), WASF3(6), WASL(1)	5011433	53	33	52	28	24	15	2	6	6	0	0.858	1.000	1.000
532	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(2), IKBKAP(6), IKBKB(7), MAP3K1(9), MAP3K14(3), NFKB1(7), NFKBIA(1), RELA(3), TNFAIP3(5), TRAF3(3), TRAF6(5)	5950050	51	33	49	17	19	11	2	9	10	0	0.483	1.000	1.000
533	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(26), DFFA(4), DFFB(3), GZMA(1), GZMB(2), HMGB2(2), PRF1(1), SET(3)	3465016	44	33	44	17	13	15	2	8	6	0	0.477	1.000	1.000
534	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD4(5), FYN(8), HLA-DRA(6), LCK(3), PTPRC(15), ZAP70(10)	2967631	49	33	47	23	13	18	1	15	2	0	0.834	1.000	1.000
535	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(2), ACP5(1), ACP6(2), ACPP(2), ACPT(4), ENPP1(5), ENPP3(4), FLAD1(3), LHPP(3), MTMR1(4), MTMR2(3), MTMR6(5), PHPT1(2), RFK(1), TYR(6)	4937950	47	32	47	17	10	17	3	12	5	0	0.432	1.000	1.000
536	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(4), ACOX3(8), ELOVL2(4), ELOVL5(2), ELOVL6(1), FADS1(2), FADS2(4), FASN(14), HADHA(4), HSD17B12(2), SCD(1)	4650230	46	32	42	22	22	8	2	7	7	0	0.734	1.000	1.000
537	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(3), CD3E(2), ETV5(3), IFNG(2), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL18(1), IL18R1(2), JAK2(10), JUN(3), MAP2K6(1), MAPK14(1), MAPK8(5), STAT4(3), TYK2(4)	6120380	55	32	55	23	8	22	4	15	6	0	0.740	1.000	1.000
538	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(6), CD44(4), CSF1(1), FCGR3A(3), IL1B(2), IL6R(1), SELL(4), SPN(3), TGFB1(3), TGFB2(6), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TNFRSF8(2), TNFSF8(3)	4313736	43	32	43	27	15	11	0	11	6	0	0.951	1.000	1.000
539	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6R(1), JAK1(6), JAK2(10), JAK3(9), PIAS3(2), PTPRU(16), REG1A(3), SRC(2), STAT3(6)	4997029	56	32	55	26	17	19	0	17	3	0	0.805	1.000	1.000
540	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(3), HMOX1(5), IL10(2), IL10RA(4), IL10RB(2), IL1A(2), JAK1(6), STAT1(7), STAT3(6), STAT5A(4), TNF(1)	4009679	42	31	42	16	10	11	1	16	4	0	0.613	1.000	1.000
541	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(2), CD8A(4), ICAM1(1), ITGAL(11), ITGB2(5), PTPRC(15), THY1(1)	3533188	41	31	39	19	11	12	2	13	3	0	0.783	1.000	1.000
542	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(4), FUT1(2), FUT9(5), GBGT1(1), HEXA(2), HEXB(2), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST8SIA1(4)	3327035	36	30	36	15	18	5	0	11	2	0	0.646	1.000	1.000
543	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT5(5), FUT8(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(1), ST3GAL4(4)	2580773	33	30	32	11	16	9	1	6	1	0	0.399	1.000	1.000
544	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(2), GALNT10(5), GALNT2(4), GALNT3(2), GALNT4(2), GALNT6(2), GALNT8(5), GALNT9(2), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4)	4344528	36	30	36	15	17	5	2	9	3	0	0.711	1.000	1.000
545	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA2(1), PSMA3(2), PSMA4(4), PSMA6(4), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(1), PSMC3(6), RPN1(2), RPN2(3), UBE2A(1), UBE3A(5)	4248563	45	30	44	18	14	16	5	6	4	0	0.569	1.000	1.000
546	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(6), JAK2(10), JAK3(9), PIAS1(6), PIAS3(2), PTPRU(16), REG1A(3), SOAT1(6)	4497587	59	30	57	23	17	19	2	14	7	0	0.677	1.000	1.000
547	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(2), CD4(5), ICAM1(1), ITGAL(11), ITGB2(5), PTPRC(15), THY1(1)	3706941	42	30	40	22	11	12	1	15	3	0	0.917	1.000	1.000
548	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	6	ADCY1(16), CREM(3), FHL5(1), FSHB(1), GNAS(20), XPO1(5)	2678065	46	29	44	22	20	11	0	11	4	0	0.950	1.000	1.000
549	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(16), GNAS(20), GNGT1(3), PRKACA(3), PRKAR1A(3)	2169317	45	29	44	19	20	10	0	9	6	0	0.802	1.000	1.000
550	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(4), B3GALNT1(2), B3GALT5(1), FUT1(2), FUT9(5), GBGT1(1), HEXA(2), HEXB(2), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST8SIA1(4)	3531535	35	29	35	17	17	4	1	11	2	0	0.816	1.000	1.000
551	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(4), IL2RG(5), IL4(1), IL4R(1), IRS1(15), JAK1(6), JAK3(9), RPS6KB1(4), SHC1(3), STAT6(1)	4845760	52	29	50	22	16	17	0	9	10	0	0.776	1.000	1.000
552	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), EHHADH(6), HADHA(4), SDS(2)	3988987	48	29	47	20	13	15	0	11	9	0	0.642	1.000	1.000
553	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(4), ICAM1(1), ITGA4(9), ITGAL(11), ITGB1(6), ITGB2(5), SELE(4), SELL(4)	3986353	44	29	43	23	17	10	1	10	6	0	0.822	1.000	1.000
554	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(7), CD38(3), ENPP1(5), ENPP3(4), NADSYN1(4), NMNAT1(1), NMNAT2(1), NNMT(1), NNT(11), NT5C(1)	4764617	38	29	37	24	7	11	3	10	6	1	0.974	1.000	1.000
555	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(3), CD2(2), CD3E(2), CD4(5), IFNG(2), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), JAK2(10), STAT4(3), TYK2(4)	4821447	46	29	46	23	6	18	3	15	4	0	0.920	1.000	1.000
556	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(7), CCNA2(1), CCND1(1), CCNE1(3), CCNE2(2), CDK2(3), CDKN2A(6), E2F1(2), E2F2(3), E2F4(1), PRB1(2)	2933001	31	29	31	18	5	14	1	6	5	0	0.933	1.000	1.000
557	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(6), JAK2(10), JAK3(9), MAPK1(2), MAPK3(1), STAT3(6), TYK2(4)	3831596	38	29	37	17	9	15	0	12	2	0	0.761	1.000	1.000
558	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(8), ACO2(5), CS(2), GRHPR(2), HAO1(3), HAO2(3), HYI(2), MDH1(3), MTHFD1(3), MTHFD1L(6), MTHFD2(1)	4204956	38	28	37	18	14	15	1	4	4	0	0.707	1.000	1.000
559	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), HEMK1(1), LCMT1(1), LCMT2(7), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), WBSCR22(4)	4932363	45	28	45	17	14	15	1	9	6	0	0.411	1.000	1.000
560	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(8), ACO2(5), AFMID(1), CS(2), GRHPR(2), HAO1(3), HAO2(3), HYI(2), MDH1(3), MTHFD1(3), MTHFD1L(6), MTHFD2(1)	4403536	39	28	38	18	15	15	1	4	4	0	0.665	1.000	1.000
561	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(3), CAMK1(2), CAMK1G(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), CAMKK1(5), CAMKK2(1), CREB1(3), SYT1(3)	3782577	39	27	39	18	12	17	2	6	2	0	0.638	1.000	1.000
562	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(5), DLL1(10), FURIN(4), NOTCH1(19), PSEN1(2)	3009188	40	27	40	24	17	6	4	8	5	0	0.902	1.000	1.000
563	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(4), CBS(5), CTH(2), GGT1(4), MARS(4), MARS2(1), MAT1A(2), MAT2B(2), PAPSS1(4), PAPSS2(4), SCLY(1), SEPHS1(4)	4058004	37	27	36	24	13	9	2	6	7	0	0.954	1.000	1.000
564	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(2), HLA-DRA(6), IFNG(2), IFNGR1(5), IFNGR2(1), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL18(1), IL18R1(2), IL2RA(2), IL4(1), IL4R(1)	4164756	38	27	38	19	11	11	2	11	3	0	0.804	1.000	1.000
565	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(9), CHAT(4), CHKA(1), PCYT1A(6), PDHA1(1), PDHA2(4), PEMT(1), SLC18A3(7)	2278795	33	26	33	22	12	8	0	10	3	0	0.965	1.000	1.000
566	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(5), CS(2), FH(2), IDH2(1), MDH1(3), OGDH(7), SDHA(6), SUCLA2(4)	3094516	30	26	29	12	11	8	2	4	5	0	0.587	1.000	1.000
567	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(4), ICAM1(1), ITGAL(11), ITGAM(6), ITGB2(5), SELE(4), SELL(4)	3412762	35	26	35	22	15	7	1	8	4	0	0.964	1.000	1.000
568	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3)	2620083	36	25	36	16	9	11	0	10	6	0	0.761	1.000	1.000
569	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3)	2620083	36	25	36	16	9	11	0	10	6	0	0.761	1.000	1.000
570	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(5), GAD1(6), HDC(7), PNMT(8), TH(2), TPH1(3)	1973649	31	25	30	17	14	7	2	6	2	0	0.858	1.000	1.000
571	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(3), ADSS(4), IMPDH1(5), MTHFD2(1), POLB(2), POLD1(10), POLG(5), PRPS2(2), RRM1(5), SRM(1)	4085683	38	25	38	16	10	15	2	8	3	0	0.628	1.000	1.000
572	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(6), CAPN1(2), CAPNS1(2), CAPNS2(2), CDK5(2), CDK5R1(1), CSNK1A1(3), CSNK1D(2), GSK3B(4), MAPT(4), PPP2CA(3)	3022973	31	25	30	20	11	10	0	6	4	0	0.952	1.000	1.000
573	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(4), CCND1(1), CDK2(3), CDKN1A(1), CDKN2A(6), CFL1(1), E2F1(2), E2F2(3), MDM2(3), NXT1(2), PRB1(2)	2488524	28	25	28	11	10	10	1	1	6	0	0.611	1.000	1.000
574	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(3), IL13RA2(6), IL4R(1), JAK1(6), JAK2(10), TYK2(4)	3442081	31	25	31	17	7	12	2	7	3	0	0.903	1.000	1.000
575	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(3), IL13RA2(6), IL4R(1), JAK1(6), JAK2(10), TYK2(4)	3442081	31	25	31	17	7	12	2	7	3	0	0.903	1.000	1.000
576	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(6), AGT(3), AGTR1(1), AGTR2(2), BDKRB2(3), KNG1(8), NOS3(5), REN(2)	3220717	30	24	30	15	11	7	2	6	4	0	0.759	1.000	1.000
577	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(2), CYP11A1(4), CYP11B1(7), CYP11B2(4), CYP17A1(3), CYP21A2(4), HSD11B1(2), HSD11B2(2), HSD3B1(1), HSD3B2(3)	3038945	37	24	37	15	13	12	2	9	1	0	0.527	1.000	1.000
578	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	9	CD3E(2), GZMB(2), HLA-A(6), ICAM1(1), ITGAL(11), ITGB2(5), PRF1(1)	2784927	28	24	28	12	10	7	2	6	3	0	0.628	1.000	1.000
579	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(9), EGF(8), EGFR(11), HGS(1), RAB5A(2), TF(6), TFRC(1)	4217844	38	24	38	23	11	9	1	13	3	1	0.968	1.000	1.000
580	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(2), CYP11A1(4), CYP11B1(7), CYP11B2(4), CYP17A1(3), CYP21A2(4), HSD11B1(2), HSD11B2(2), HSD3B1(1), HSD3B2(3)	3038945	37	24	37	15	13	12	2	9	1	0	0.527	1.000	1.000
581	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(3), HDAC9(6), MEF2B(4), MEF2C(3), MEF2D(6), MYOD1(4), YWHAH(3)	2537458	31	24	30	15	14	5	3	6	3	0	0.755	1.000	1.000
582	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(3), IARS(9), LARS(4), LARS2(7), PDHA1(1), PDHA2(4), PDHB(3)	3295346	31	24	31	15	4	10	1	9	7	0	0.922	1.000	1.000
583	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(1), ARPC4(2), CDC42(1), PAK1(5), PDGFRA(11), PIK3R1(8), WASL(1)	3682867	36	23	36	19	5	17	1	5	8	0	0.904	1.000	1.000
584	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(2), APAF1(5), BCL2(2), CASP3(2), CASP9(2), DAXX(9), FAS(3), FASLG(2), IL1A(2), MAPKAPK2(1), MAPKAPK3(4), TNF(1)	3718456	35	23	35	19	14	8	0	10	3	0	0.888	1.000	1.000
585	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), ANKRD1(3), CYR61(1), DUSP14(2), EIF4E(2), EIF4EBP1(2), HBEGF(2), IFNG(2), IFRD1(3), IL18(1), IL1A(2), IL1R1(4), JUND(1), MYOG(1), NR4A3(4)	3499349	32	23	32	14	13	4	4	9	2	0	0.655	1.000	1.000
586	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP1(1), RANBP2(27), RANGAP1(5)	2768597	34	23	34	16	4	14	2	11	3	0	0.799	1.000	1.000
587	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(3), GNGT1(3), HTR2C(5), PLCB1(13), TUB(5)	2350041	31	23	30	12	9	7	0	9	6	0	0.666	1.000	1.000
588	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(2), IFNG(2), IL10(2), IL12A(2), IL12B(1), IL13(1), IL16(5), IL18(1), IL1A(2), IL3(1), IL4(1), IL8(1), LTA(3), TNF(1)	3263335	26	22	26	17	5	9	2	9	1	0	0.950	1.000	1.000
589	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(4), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(1), ST8SIA1(4)	1855029	23	22	23	11	12	4	0	7	0	0	0.677	1.000	1.000
590	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(2), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), HSD3B7(4), PON1(2), PON2(3), PON3(1), RDH11(1), RDH12(1), RDH13(3)	2954173	29	22	29	15	10	9	1	8	1	0	0.816	1.000	1.000
591	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CDO1(1), CSAD(7), GAD1(6), GAD2(7), GGT1(4)	1885172	26	22	26	13	14	4	0	7	1	0	0.707	1.000	1.000
592	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(5), TAX1BP3(2), UBE2A(1), UBE2D3(2), UBE2E3(3), UBE2G2(1), UBE2H(1), UBE2I(1), UBE2J1(1), UBE2J2(3), UBE2L3(1), UBE2L6(1), UBE2N(2), UBE3A(5)	3450536	31	22	31	16	14	9	0	4	4	0	0.770	1.000	1.000
593	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), CDK5R1(1), EGR1(4), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), NGFR(4), RAF1(7)	2674709	28	21	25	17	10	9	0	9	0	0	0.880	1.000	1.000
594	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(6), FARSA(1), FARSB(1), GOT1(2), GOT2(2), PAH(4), TAT(4), YARS(3), YARS2(3)	2858620	26	21	26	11	9	10	0	7	0	0	0.692	1.000	1.000
595	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(5), IFNGR2(1), JAK1(6), JAK2(10), STAT1(7)	2699309	31	21	31	13	5	12	2	8	4	0	0.699	1.000	1.000
596	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), LTB4R(1), P2RY1(3), P2RY2(5), P2RY6(6)	1954313	25	21	25	10	15	3	0	5	2	0	0.429	1.000	1.000
597	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP2(3), MMP9(13), RECK(5), TIMP2(2), TIMP3(3)	2468477	26	21	26	14	13	6	0	3	4	0	0.706	1.000	1.000
598	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(2), ACP5(1), ACPP(2), ACPT(4), ENPP1(5), ENPP3(4), FLAD1(3), RFK(1), TYR(6)	3183031	28	21	28	11	5	9	2	8	4	0	0.574	1.000	1.000
599	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(6), EIF4E(2), FBL(4), GPT(1), LDHA(3), LDHB(4), LDHC(1), MAPK14(1), NCL(6)	2939806	28	21	28	11	6	8	0	10	4	0	0.739	1.000	1.000
600	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(3), CASP8(8), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF2(2)	2731630	22	21	22	11	6	3	1	8	4	0	0.834	1.000	1.000
601	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(5), CLOCK(3), CRY1(3), CRY2(4), CSNK1E(7), PER1(5)	2776707	27	20	27	12	8	6	1	7	5	0	0.854	1.000	1.000
602	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT1(3), B3GALT2(6), B3GALT5(1), B3GNT5(3), FUT1(2), FUT3(1), ST3GAL3(1), ST3GAL4(4)	2365956	22	20	22	12	12	4	0	4	2	0	0.846	1.000	1.000
603	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(6), HADH(3), HADHA(4), HSD17B4(4), NTAN1(3), SIRT1(4), SIRT2(1), SIRT5(3), SIRT7(3), VNN2(2)	3894410	34	20	33	12	8	7	4	5	10	0	0.496	1.000	1.000
604	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(6), BMPR1A(3), BMPR1B(4), BMPR2(11)	2056897	24	20	24	10	8	6	1	2	5	2	0.694	1.000	1.000
605	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(3), MAX(3), MYC(3), SP1(6), SP3(3), WT1(3)	2043527	21	19	21	10	6	8	0	4	3	0	0.688	1.000	1.000
606	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(4), CYP11A1(4), CYP11B2(4), CYP17A1(3), HSD11B1(2), HSD11B2(2), HSD3B1(1), HSD3B2(3)	2272066	23	17	23	11	7	4	3	8	1	0	0.736	1.000	1.000
607	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), CS(2), MDH1(3), ME1(1), PC(7), PDHA1(1), SLC25A1(1), SLC25A11(1)	3040165	20	15	19	13	9	5	2	2	2	0	0.922	1.000	1.000
608	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(4), PLCD1(4), PRKCA(3), TGM2(5)	1632404	16	15	16	9	12	2	0	2	0	0	0.754	1.000	1.000
609	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(3), HSD3B7(4), RDH11(1), RDH12(1), RDH13(3)	1574645	14	14	14	9	4	6	0	4	0	0	0.868	1.000	1.000
610	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(2), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(1), ARPC4(2), CDC42(1), WASF1(3), WASL(1)	2671379	17	13	17	20	5	6	1	3	2	0	1.000	1.000	1.000
611	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(4), COQ6(2), COQ7(2), NDUFA13(3)	1309381	12	11	12	6	4	5	1	2	0	0	0.772	1.000	1.000
612	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(3), ALDH1A2(5), BCMO1(1), RDH5(2)	1281198	11	10	11	14	4	2	0	4	1	0	0.999	1.000	1.000
613	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(2), RAB11A(4), RAB27A(4), RAB4A(1), RAB5A(2), RAB6A(1)	1396343	14	9	14	12	5	6	0	2	1	0	0.947	1.000	1.000
614	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT1(2), FUT3(1), FUT5(2), FUT6(2), ST3GAL3(1)	1666837	9	8	9	7	6	2	0	1	0	0	0.879	1.000	1.000
615	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(7)	665732	7	5	7	4	2	2	0	3	0	0	0.888	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		167479	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
