		Clinical Features	CN_CNMF		METHLYATION_CNMF		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
ZFPM1	26 (41%)	38	0.18055	1	0.81046	1	0.33521	1	0.81867	1	0.6795	1	0.83823	1	0.49248	1	0.9375	1
LACTB	20 (31%)	44	0.11722	1	0.68193	1	1	1	0.56014	1	0.45392	1	0.74316	1	0.31415	1	0.75608	1
CCDC102A	17 (27%)	47	0.13148	1	0.93564	1	0.91095	1	0.75835	1	0.43869	1	0.4765	1	0.68679	1	0.1451	1
ZNF517	13 (20%)	51	0.6521	1	0.96243	1	0.88407	1	1	1	0.23629	1	0.66739	1	0.79923	1	0.42747	1
TOR3A	12 (19%)	52	0.27292	1	0.02206	1	0.63759	1	0.01515	1	1	1	0.86847	1	0.82756	1	0.66184	1
USP42	16 (25%)	48	0.72527	1	0.04874	1	1	1	0.95951	1	0.56652	1	0.83933	1	0.74837	1	0.28859	1
CLDN23	10 (16%)	54	0.26303	1	0.24679	1	0.02368	1	0.18106	1	0.090519	1	0.18983	1	0.10762	1	0.32206	1
TP53	13 (20%)	51	0.02159	1	0.77532	1	0.02011	1	0.6659	1	0.01804	1	0.63752	1	0.04165	1	0.19199	1
KCNK17	9 (14%)	55	0.10297	1	0.03787	1	0.094449	1	0.0099599	1	1	1	0.52247	1	0.47398	1	0.41669	1
LZTR1	6 (9%)	58	0.22446	1	0.8062	1	0.089449	1	0.19389	1	0.41694	1	0.01375	1	0.44453	1	0.085379	1
APOE	7 (11%)	57	0.16985	1	0.62041	1	0.066919	1	0.45275	1	0.27913	1	0.82243	1	0.027	1	0.82548	1
CCDC105	7 (11%)	57	0.16857	1	0.0085899	1	0.88092	1	0.71391	1	1	1	0.050909	1	0.85899	1	0.32575	1
RINL	8 (12%)	56	0.14617	1	0.70116	1	0.50864	1	0.29372	1	0.882	1	0.16569	1	0.43791	1	0.18693	1
MAL2	12 (19%)	52	0.7821	1	0.30345	1	0.19943	1	0.51765	1	0.12302	1	0.27693	1	0.64433	1	0.32063	1
LRIG1	17 (27%)	47	0.65429	1	0.89431	1	1	1	0.78058	1	0.18568	1	0.49565	1	0.69557	1	0.87421	1
C19ORF10	8 (12%)	56	0.63261	1	0.35487	1	0.23522	1	0.10939	1	0.54989	1	0.8596	1	0.28712	1	0.76091	1
C10ORF95	7 (11%)	57	0.17163	1	0.7071	1	0.55664	1	0.81739	1	0.74993	1	0.49141	1	0.86191	1	0.50452	1
SYT8	9 (14%)	55	0.42757	1	0.40254	1	0.0346	1	0.14721	1	1	1	0.21596	1	1	1	0.64271	1
IDUA	9 (14%)	55	0.54482	1	0.89417	1	0.34512	1	0.53981	1	0.12243	1	0.45663	1	0.1963	1	0.48282	1
HHIPL1	8 (12%)	56	0.12643	1	0.28529	1	0.35778	1	0.20441	1	0.17555	1	0.78622	1	0.28944	1	0.2006	1
ASPDH	8 (12%)	56	0.3061	1	0.6441	1	0.02032	1	0.34379	1	0.47626	1	0.02772	1	0.36772	1	0.079269	1
C1ORF106	9 (14%)	55	0.77036	1	0.43376	1	0.34343	1	0.86068	1	0.47757	1	0.68902	1	0.61644	1	1	1
THEM4	6 (9%)	58	0.00358	1	0.73405	1	0.4368	1	0.88617	1	0.24464	1	0.093829	1	0.25026	1	0.11137	1
CTNNB1	7 (11%)	57	1	1	0.16718	1	0.01942	1	0.01811	1	0.00174	1	0.16881	1	0.02717	1	0.47982	1
GDF1	5 (8%)	59	0.39564	1	0.31217	1	0.3625	1	0.25407	1	0.089629	1	0.53974	1	0.01923	1	0.71349	1
TSC22D2	8 (12%)	56	0.3494	1	0.52755	1	0.81528	1	0.94214	1	0.88263	1	0.42636	1	1	1	0.33405	1
ZAR1	11 (17%)	53	0.17477	1	0.66708	1	0.60218	1	0.80229	1	0.72049	1	1	1	0.51975	1	0.71541	1
RGS9BP	8 (12%)	56	0.29493	1	0.58512	1	1	1	0.88807	1	0.33507	1	0.96156	1	0.88421	1	0.34274	1
OPRD1	12 (19%)	52	0.8238	1	0.38763	1	0.79717	1	0.96058	1	0.33972	1	0.63078	1	0.46877	1	0.46566	1
C16ORF3	6 (9%)	58	0.90367	1	0.00078999	0.784	0.7993	1	0.8305	1	0.59416	1	1	1	0.69799	1	0.71072	1
FPGS	6 (9%)	58	1	1	1	1	0.6135	1	0.61402	1	0.090529	1	0.62384	1	0.67496	1	0.78703	1
PLIN5	5 (8%)	59	0.56098	1	0.69314	1	0.79907	1	0.54247	1	0.35032	1	0.30837	1	0.12864	1	0.32098	1
IRX3	5 (8%)	59	0.33324	1	0.73314	1	0.5197	1	0.19263	1	0.24624	1	0.7785	1	0.25025	1	0.0204	1
TRIOBP	12 (19%)	52	0.82067	1	0.1765	1	1	1	0.12751	1	0.90235	1	0.9301	1	0.66509	1	0.74565	1
KRTAP4-5	5 (8%)	59	0.76911	1	0.31301	1	1	1	0.88608	1	1	1	0.84	1	1	1	0.89362	1
ATXN1	10 (16%)	54	0.40839	1	0.12883	1	0.23438	1	0.6271	1	0.32418	1	0.85185	1	0.41024	1	0.85073	1
ZNF628	7 (11%)	57	0.3054	1	0.89168	1	0.35092	1	0.12178	1	0.12453	1	0.49406	1	0.095299	1	0.72535	1
WDR34	5 (8%)	59	0.67359	1	0.77237	1	0.93077	1	0.83356	1	0.84275	1	0.52263	1	1	1	0.39627	1
BTBD11	6 (9%)	58	1	1	0.23499	1	0.47973	1	1	1	0.49269	1	0.16456	1	0.49067	1	0.21316	1
GARS	21 (33%)	43	0.23647	1	0.068529	1	0.43329	1	0.062989	1	0.23844	1	0.33937	1	0.098939	1	0.34229	1
ZNF598	13 (20%)	51	0.44589	1	0.37703	1	0.5341	1	1	1	1	1	0.21532	1	1	1	0.16226	1
BHLHE22	5 (8%)	59	0.39142	1	0.064129	1	0.10362	1	0.83003	1	0.59521	1	0.88135	1	0.69764	1	0.78544	1
PTPLA	4 (6%)	60	0.44113	1	0.2921	1	0.33154	1	0.47435	1	0.79017	1	1	1	0.20952	1	0.58339	1
CD320	4 (6%)	60	0.93529	1	0.89655	1	0.73707	1	0.68418	1	0.41607	1	0.22088	1	0.17516	1	0.17296	1
KIAA1984	4 (6%)	60	0.25183	1	0.73468	1	0.12576	1	0.04635	1	0.0364	1	0.58018	1	0.061699	1	0.66933	1
TPO	12 (19%)	52	0.53219	1	0.30476	1	0.21362	1	0.15858	1	0.13985	1	0.31852	1	0.27979	1	0.12247	1
AATK	6 (9%)	58	0.11512	1	0.31609	1	0.35973	1	0.25122	1	1	1	0.50562	1	1	1	0.4554	1
PANK2	5 (8%)	59	0.73506	1	0.4283	1	0.11353	1	0.10781	1	0.4412	1	0.34219	1	0.59406	1	0.32284	1
SNED1	6 (9%)	58	0.39386	1	0.59433	1	0.21235	1	0.45542	1	0.04417	1	0.64906	1	0.04589	1	0.32061	1
CCDC150	4 (6%)	60	0.44086	1	0.80766	1	0.26488	1	0.19676	1	0.41741	1	0.18159	1	0.44169	1	0.14295	1
ERCC2	10 (16%)	54	0.75612	1	0.19618	1	0.50999	1	0.14944	1	0.67106	1	0.23917	1	0.2896	1	0.088439	1
RREB1	5 (8%)	59	0.73605	1	0.80672	1	0.61243	1	1	1	0.6749	1	0.5036	1	0.67546	1	0.55363	1
RNF39	5 (8%)	59	0.42685	1	0.31113	1	0.18447	1	0.26744	1	0.16739	1	0.6951	1	0.35136	1	0.55262	1
SEMA5B	8 (12%)	56	0.38973	1	0.35048	1	0.39906	1	0.27377	1	0.85282	1	0.33691	1	0.6367	1	0.66562	1
TAF5	4 (6%)	60	0.93668	1	0.73292	1	1	1	0.88371	1	0.02122	1	0.12113	1	0.01946	1	0.19726	1
SARM1	7 (11%)	57	0.03013	1	0.43528	1	0.27521	1	0.02852	1	0.11292	1	0.75418	1	0.04596	1	0.91705	1
PRSS27	3 (5%)	61	0.79659	1	0.90882	1	0.60941	1	0.1085	1	0.14053	1	1	1	0.20649	1	1	1
TMEM189	4 (6%)	60	0.16191	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
NOXA1	5 (8%)	59	0.14971	1	0.42644	1	0.21945	1	0.47551	1	0.30178	1	0.34113	1	0.31362	1	0.32778	1
LRP11	7 (11%)	57	0.04064	1	0.072719	1	0.79851	1	0.54098	1	0.59265	1	0.93604	1	0.69506	1	0.94988	1
RNF149	4 (6%)	60	0.37564	1	0.0356	1	0.35995	1	0.61618	1	0.32863	1	0.35255	1	0.34287	1	0.44358	1
DMKN	3 (5%)	61	0.80071	1	0.29152	1	0.61112	1	0.47394	1	0.0083099	1	0.5601	1	0.01009	1	0.82309	1
FANK1	4 (6%)	60	0.93616	1	0.34953	1	0.85465	1	0.32792	1	0.7897	1	0.2267	1	1	1	0.17158	1
MUC5B	22 (34%)	42	1	1	0.57224	1	0.67625	1	0.73062	1	0.81659	1	0.6309	1	0.59053	1	0.84633	1
PABPC1	4 (6%)	60	0.41488	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
GLTPD2	6 (9%)	58	0.071439	1	0.84394	1	0.88299	1	0.45342	1	0.55283	1	0.51017	1	0.85754	1	0.5965	1
MEN1	5 (8%)	59	0.095519	1	0.04326	1	0.01267	1	0.0061299	1	0.21546	1	0.0387	1	0.35144	1	0.0088899	1
SRPX	3 (5%)	61	0.89373	1	0.12546	1	0.46813	1	1	1	0.78949	1	0.78856	1	1	1	0.82242	1
MAP1S	5 (8%)	59	0.27558	1	0.38386	1	0.34911	1	1	1	1	1	0.88159	1	0.84164	1	1	1
SCRT1	3 (5%)	61	0.79861	1	0.42484	1	0.60894	1	0.63901	1	0.44056	1	0.70975	1	0.59239	1	0.87509	1
OBSCN	20 (31%)	44	0.65718	1	0.26103	1	0.45769	1	0.62428	1	0.094529	1	0.7802	1	0.1956	1	0.73022	1
IER5	3 (5%)	61	0.36916	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
TNIP2	5 (8%)	59	0.67281	1	0.62526	1	0.73473	1	0.8865	1	1	1	0.40158	1	1	1	0.23453	1
NOTCH2	7 (11%)	57	0.30407	1	0.79783	1	0.35037	1	0.03381	1	0.0083499	1	0.41721	1	0.0089299	1	0.3251	1
RASIP1	7 (11%)	57	0.62976	1	0.67612	1	0.03912	1	0.15934	1	0.02197	1	0.68638	1	0.03768	1	0.74793	1
NMU	5 (8%)	59	0.82142	1	1	1	0.04848	1	0.6393	1	1	1	0.50642	1	1	1	0.45531	1
VARS	6 (9%)	58	0.44486	1	0.43726	1	0.18523	1	0.081819	1	0.85447	1	0.86074	1	0.34017	1	0.7617	1
SHOX2	3 (5%)	61	0.33425	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
HSD17B1	4 (6%)	60	1	1	0.10804	1	1	1	0.01275	1	1	1	0.83984	1	1	1	0.76189	1
COQ2	5 (8%)	59	0.2959	1	0.76505	1	0.36106	1	0.61626	1	1	1	0.66905	1	1	1	0.76161	1
KNDC1	10 (16%)	54	0.78477	1	0.12943	1	0.14061	1	0.37179	1	0.28835	1	0.35721	1	0.22846	1	0.74873	1
AR	4 (6%)	60	0.31961	1	0.42628	1	0.61023	1	0.47192	1	0.44463	1	1	1	0.59577	1	1	1
KCTD3	4 (6%)	60	0.41358	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
FZD1	3 (5%)	61	0.4066	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
ZC3H12D	3 (5%)	61	0.0033	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
KRTAP5-5	5 (8%)	59	0.36199	1	1	1	0.21875	1	0.21558	1	0.44371	1	0.17993	1	0.5933	1	0.055969	1
AKAP2	4 (6%)	60	0.074529	1	0.47489	1	0.73825	1	0.31557	1	0.67308	1	0.46833	1	0.34089	1	0.64663	1
KBTBD13	9 (14%)	55	0.58425	1	0.10709	1	0.7341	1	0.13518	1	1	1	0.35795	1	1	1	0.78026	1
SPIRE2	3 (5%)	61	0.30162	1	0.02675	1	1	1	0.82439	1	1	1	0.70773	1	1	1	0.87463	1
NPTX1	3 (5%)	61	0.33661	1	1	1	1	1	0.82507	1	0.58677	1	0.70816	1	0.43003	1	0.65669	1
ADAD2	4 (6%)	60	0.25126	1	0.57383	1	0.73819	1	0.31749	1	0.02058	1	0.5399	1	0.01958	1	0.83675	1
SEZ6L2	8 (12%)	56	0.35475	1	0.59835	1	0.882	1	1	1	0.45913	1	0.58435	1	0.4558	1	0.80766	1
NEFH	7 (11%)	57	0.03617	1	0.15719	1	0.02364	1	0.0082499	1	0.16761	1	0.52123	1	0.34961	1	0.15789	1
DLEU7	3 (5%)	61	0.56802	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
AMDHD1	11 (17%)	53	0.02665	1	0.72113	1	0.56926	1	0.18475	1	0.23603	1	0.88811	1	0.062549	1	0.95415	1
GLTSCR2	5 (8%)	59	0.21973	1	0.80584	1	0.26412	1	0.19682	1	1	1	0.62317	1	0.25072	1	0.5891	1
PLEC	13 (20%)	51	0.61249	1	0.71264	1	0.19417	1	0.68085	1	0.67273	1	0.60395	1	0.39595	1	0.47141	1
MAP7	3 (5%)	61	1	1	0.69664	1	1	1	0.82529	1	0.58797	1	0.70841	1	0.42907	1	0.65491	1
DSPP	10 (16%)	54	0.92834	1	0.063989	1	1	1	0.51567	1	0.51474	1	0.57392	1	0.31267	1	0.32966	1
CRIPAK	10 (16%)	54	0.20062	1	0.92806	1	0.47354	1	0.83613	1	0.80664	1	0.35859	1	0.71864	1	0.28701	1
PRKAR1A	6 (9%)	58	0.48718	1	1	1	0.27675	1	0.45697	1	0.086499	1	0.564	1	0.17361	1	0.15055	1
CYP4A22	4 (6%)	60	0.11348	1	0.62155	1	0.1627	1	0.50734	1	0.24569	1	0.20715	1	0.24918	1	0.83682	1
NOM1	6 (9%)	58	1	1	0.2328	1	0.93021	1	1	1	1	1	0.74204	1	0.8399	1	0.27569	1
RNF135	3 (5%)	61	0.89448	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C12ORF65	3 (5%)	61	0.37142	1	0.03538	1	0.11298	1	0.062299	1	0.44495	1	0.56347	1	0.59267	1	0.73537	1
HLA-B	6 (9%)	58	0.29302	1	0.77461	1	0.88291	1	1	1	0.65349	1	0.27381	1	0.53529	1	0.3192	1
CSGALNACT2	3 (5%)	61	0.89466	1	0.02558	1	0.69111	1	0.82337	1	0.58427	1	0.87607	1	0.42958	1	0.93325	1
UQCRFS1	5 (8%)	59	0.50825	1	0.50185	1	1	1	0.8849	1	0.48961	1	0.18738	1	0.49365	1	0.050789	1
PDCD6	3 (5%)	61	0.30169	1	0.69939	1	NA	NA	NA	NA	1	1	0.63181	1	1	1	0.69614	1
PTX4	3 (5%)	61	0.56751	1	1	1	0.61215	1	0.21699	1	0.44354	1	1	1	0.59514	1	0.39209	1
SGK223	3 (5%)	61	0.89549	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
POLRMT	4 (6%)	60	0.50821	1	0.03631	1	0.32719	1	0.073749	1	0.18898	1	0.3534	1	0.12538	1	0.44339	1
CACNA1D	3 (5%)	61	0.5657	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
NF1	7 (11%)	57	0.15156	1	0.90395	1	0.4105	1	0.26839	1	0.34214	1	0.85268	1	0.099859	1	0.5271	1
RGMB	6 (9%)	58	0.58126	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
ADAMTS7	4 (6%)	60	0.13955	1	0.57498	1	0.073199	1	0.46532	1	0.060999	1	0.35139	1	0.038	1	0.28841	1
CLIC6	6 (9%)	58	0.96218	1	1	1	0.66525	1	0.19282	1	0.2457	1	0.57929	1	0.24793	1	0.75949	1
EMR2	4 (6%)	60	0.37495	1	0.31374	1	0.47341	1	0.61423	1	0.67446	1	0.20684	1	0.6758	1	0.83861	1
PCDHB13	5 (8%)	59	0.51296	1	0.13865	1	0.1074	1	0.25597	1	0.54227	1	0.056569	1	0.80135	1	0.01259	1
MTFMT	3 (5%)	61	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
SPTAN1	3 (5%)	61	0.24435	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
HLA-A	3 (5%)	61	1	1	1	1	0.85411	1	0.21867	1	1	1	0.44475	1	1	1	0.21533	1
ASB16	6 (9%)	58	0.74346	1	0.94537	1	0.61418	1	0.88529	1	0.54311	1	0.77811	1	0.80198	1	0.95925	1
GPRIN2	9 (14%)	55	0.59114	1	0.37047	1	0.64955	1	0.42754	1	0.58162	1	0.80077	1	0.381	1	0.64671	1
HNRNPCL1	3 (5%)	61	0.33568	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
BTNL9	4 (6%)	60	0.41581	1	0.096209	1	0.14139	1	0.061799	1	0.14222	1	1	1	0.20851	1	1	1
KCNJ11	4 (6%)	60	0.0135	1	0.62438	1	0.43373	1	0.14002	1	0.13209	1	0.04984	1	0.17415	1	0.21103	1
JMJD4	3 (5%)	61	0.8003	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
LRRC4B	6 (9%)	58	0.18804	1	0.18901	1	0.0133	1	0.070819	1	0.17356	1	0.0299	1	0.17172	1	0.0097399	1
OPLAH	3 (5%)	61	0.56625	1	0.8536	1	0.60805	1	0.47224	1	0.4435	1	0.34205	1	0.59389	1	0.39449	1
BAGE2	3 (5%)	61	0.89508	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
MADCAM1	3 (5%)	61	0.48054	1	0.69606	1	NA	NA	NA	NA	1	1	0.1994	1	1	1	0.13571	1
CTBP2	3 (5%)	61	0.89455	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
MSH3	4 (6%)	60	0.01762	1	0.70014	1	0.33472	1	1	1	0.3001	1	0.4425	1	0.3141	1	0.49462	1
ATN1	4 (6%)	60	0.13022	1	0.85314	1	0.85539	1	1	1	0.79082	1	0.79018	1	1	1	0.82251	1
FAM46A	3 (5%)	61	0.89679	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
UTS2R	3 (5%)	61	0.16223	1	0.69864	1	0.68975	1	0.82399	1	0.58611	1	0.7908	1	0.42823	1	0.82306	1
SMG1	3 (5%)	61	0.16446	1	0.12517	1	0.1435	1	0.062079	1	0.30478	1	0.02561	1	0.31573	1	0.18792	1
FUCA1	3 (5%)	61	0.40436	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
FEZ2	3 (5%)	61	0.47655	1	0.34752	1	0.17902	1	0.82481	1	0.20914	1	0.70909	1	0.13261	1	0.6576	1
GLI3	5 (8%)	59	0.73674	1	0.40683	1	1	1	0.88541	1	0.13374	1	0.39937	1	0.17551	1	0.091939	1
NOL9	4 (6%)	60	0.00202	1	1	1	1	1	1	1	0.78882	1	0.55872	1	1	1	0.73293	1
