Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.075 0.227 -9999.0 0.0 -0.576 12.0 12.0 IHH -0.028 0.134 -9999.0 0.0 -0.559 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.076 0.161 -9999.0 0.0 -0.334 20.0 20.0 LRPAP1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.076 0.16 0.332 20.0 -9999.0 0.0 20.0 SMO/beta Arrestin2 -0.094 0.16 -9999.0 0.0 -0.449 5.0 5.0 SMO -0.103 0.167 -9999.0 0.0 -0.435 7.0 7.0 AKT1 -0.049 0.103 -9999.0 0.0 -0.342 3.0 3.0 ARRB2 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.008 0.084 -9999.0 0.0 -0.512 2.0 2.0 ADRBK1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.102 0.165 -9999.0 0.0 -0.429 7.0 7.0 STIL -0.089 0.156 -9999.0 0.0 -0.378 10.0 10.0 DHH N/PTCH2 -0.009 0.065 -9999.0 0.0 -0.365 2.0 2.0 DHH N/PTCH1 -0.04 0.138 -9999.0 0.0 -0.326 10.0 10.0 PIK3CA 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.021 0.09 -9999.0 0.0 -0.512 2.0 2.0 PTHLH -0.126 0.347 -9999.0 0.0 -0.906 12.0 12.0 determination of left/right symmetry -0.102 0.165 -9999.0 0.0 -0.429 7.0 7.0 PIK3R1 -0.014 0.101 -9999.0 0.0 -0.512 3.0 3.0 skeletal system development -0.124 0.342 -9999.0 0.0 -0.894 12.0 12.0 IHH N/Hhip -0.083 0.173 -9999.0 0.0 -0.402 17.0 17.0 DHH N/Hhip -0.077 0.152 -9999.0 0.0 -0.382 15.0 15.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.102 0.165 -9999.0 0.0 -0.429 7.0 7.0 pancreas development -0.091 0.19 -9999.0 0.0 -0.511 13.0 13.0 HHAT -0.017 0.114 -9999.0 0.0 -0.512 4.0 4.0 PI3K -0.003 0.073 -9999.0 0.0 -0.365 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.026 0.127 -9999.0 0.0 -0.512 5.0 5.0 somite specification -0.102 0.165 -9999.0 0.0 -0.429 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.09 0.153 -9999.0 0.0 -0.366 9.0 9.0 SHH Np/Cholesterol/PTCH2 -0.058 0.139 -9999.0 0.0 -0.31 17.0 17.0 SHH Np/Cholesterol/Megalin -0.061 0.139 -9999.0 0.0 -0.315 17.0 17.0 SHH -0.081 0.177 -9999.0 0.0 -0.405 17.0 17.0 catabolic process -0.042 0.139 -9999.0 0.0 -0.321 15.0 15.0 SMO/Vitamin D3 -0.113 0.165 -9999.0 0.0 -0.455 7.0 7.0 SHH Np/Cholesterol/Hhip -0.105 0.192 -9999.0 0.0 -0.359 25.0 25.0 LRP2 0.003 0.015 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.107 0.164 -9999.0 0.0 -0.477 6.0 6.0 SHH Np/Cholesterol/BOC -0.065 0.144 -9999.0 0.0 -0.309 19.0 19.0 SHH Np/Cholesterol/CDO -0.069 0.148 -9999.0 0.0 -0.31 20.0 20.0 mesenchymal cell differentiation 0.104 0.19 0.357 25.0 -9999.0 0.0 25.0 mol:Vitamin D3 -0.088 0.155 -9999.0 0.0 -0.366 9.0 9.0 IHH N/PTCH2 -0.008 0.082 -9999.0 0.0 -0.332 4.0 4.0 CDON -0.016 0.102 -9999.0 0.0 -0.512 3.0 3.0 IHH N/PTCH1 -0.034 0.145 -9999.0 0.0 -0.324 15.0 15.0 Megalin/LRPAP1 0.009 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.006 0.021 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.063 0.138 -9999.0 0.0 -0.315 17.0 17.0 PTCH1 -0.042 0.14 -9999.0 0.0 -0.322 15.0 15.0 HHIP -0.091 0.191 -9999.0 0.0 -0.512 13.0 13.0