Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q TP53 64 (49%) 66 0.10927 1 0.14827 1 0.04003 1 0.0066299 1 0.24398 1 0.29881 1 0.45258 1 0.31472 1 0.46007 1 0.31559 1 KDM6A 31 (24%) 99 0.15424 1 0.82359 1 0.33988 1 0.13638 1 0.60788 1 0.6675 1 0.12063 1 0.50056 1 0.65808 1 0.32625 1 RB1 17 (13%) 113 0.00472 1 0.74329 1 0.59186 1 0.31587 1 0.60484 1 0.53965 1 1 1 0.34617 1 0.21685 1 0.43173 1 ARID1A 32 (25%) 98 0.68044 1 0.8283 1 0.58904 1 0.080319 1 0.37826 1 0.56417 1 0.12546 1 0.092619 1 0.37599 1 0.28205 1 CDKN1A 18 (14%) 112 0.89994 1 0.078459 1 0.83063 1 0.8235 1 0.73034 1 0.49783 1 0.38152 1 0.91043 1 0.8415 1 0.53 1 MLL2 36 (28%) 94 0.42486 1 0.81442 1 0.36646 1 0.32796 1 0.19901 1 0.30803 1 0.32638 1 0.29164 1 0.70967 1 0.5891 1 ELF3 11 (8%) 119 0.78378 1 0.20772 1 0.75912 1 0.38339 1 0.66908 1 0.22218 1 0.5693 1 0.84725 1 0.91622 1 0.45615 1 FGFR3 16 (12%) 114 0.01864 1 0.23208 1 0.092439 1 0.0098599 1 0.18572 1 0.04732 1 0.19657 1 0.0092899 1 0.01105 1 0.04137 1 CDKN2A 7 (5%) 123 0.14063 1 0.56295 1 0.38876 1 0.18316 1 0.79913 1 0.86606 1 0.33139 1 0.28257 1 0.30105 1 1 1 STAG2 14 (11%) 116 0.31839 1 0.18313 1 0.30116 1 0.55326 1 0.32157 1 0.14356 1 0.18984 1 0.25978 1 0.24856 1 0.01766 1 NFE2L2 11 (8%) 119 0.11699 1 0.6545 1 0.30657 1 0.72545 1 0.095689 1 0.0416 1 1 1 0.0163 1 0.84328 1 0.7504 1 ERCC2 16 (12%) 114 0.61773 1 0.44824 1 0.086709 1 0.01781 1 0.17404 1 0.12253 1 0.39507 1 0.10529 1 0.78003 1 0.93347 1 FBXW7 13 (10%) 117 0.28762 1 0.04155 1 0.26235 1 0.53168 1 0.10379 1 0.090379 1 0.21371 1 0.02837 1 0.02642 1 0.18685 1 RHOB 7 (5%) 123 1 1 0.70467 1 0.56449 1 0.31747 1 0.79622 1 0.3455 1 0.70423 1 0.54427 1 0.29946 1 0.49762 1 TSC1 11 (8%) 119 0.16725 1 0.69913 1 0.41557 1 0.56901 1 0.24383 1 0.14081 1 0.6212 1 0.49615 1 0.41313 1 0.085459 1 FOXQ1 7 (5%) 123 0.42335 1 0.37808 1 0.46695 1 0.36619 1 0.88359 1 1 1 0.15193 1 0.29357 1 0.29881 1 0.42202 1 PIK3CA 26 (20%) 104 0.40723 1 0.96095 1 0.22414 1 0.64231 1 0.43209 1 0.16624 1 0.78892 1 0.53743 1 0.41872 1 0.60027 1 RXRA 12 (9%) 118 0.1191 1 0.19291 1 0.16751 1 0.92296 1 0.59068 1 0.32082 1 0.54904 1 0.33571 1 0.67381 1 0.31542 1 CREBBP 17 (13%) 113 0.29906 1 0.8491 1 0.92133 1 0.5462 1 0.21338 1 0.28799 1 0.19286 1 0.91088 1 0.65132 1 0.2474 1 ERBB3 14 (11%) 116 0.936 1 0.59312 1 0.69308 1 0.4934 1 0.67486 1 0.84234 1 0.82055 1 0.73055 1 0.57286 1 1 1 FAT1 15 (12%) 115 0.20516 1 0.3653 1 0.21954 1 0.43557 1 0.3701 1 1 1 0.45349 1 0.28813 1 0.088429 1 0.073749 1 MLL 18 (14%) 112 0.84504 1 0.98392 1 0.02828 1 0.00499 1 0.32463 1 0.53222 1 0.81283 1 0.70533 1 0.89068 1 0.88122 1 HRAS 6 (5%) 124 0.57041 1 0.79912 1 0.01684 1 0.33917 1 0.87966 1 0.43942 1 0.57 1 0.64765 1 0.19709 1 0.25796 1 ACRC 4 (3%) 126 0.28079 1 0.10993 1 0.85451 1 0.75961 1 1 1 0.9117 1 1 1 0.87021 1 1 1 0.81228 1 TXNIP 9 (7%) 121 0.58757 1 0.27437 1 0.87154 1 0.70317 1 1 1 0.080079 1 0.90869 1 0.98288 1 0.73174 1 0.89727 1 ECM1 5 (4%) 125 0.079439 1 0.26779 1 0.94683 1 0.18101 1 0.73273 1 0.54997 1 0.51998 1 0.18605 1 0.41582 1 0.69843 1 KLF5 10 (8%) 120 0.091679 1 0.77816 1 0.30271 1 0.3097 1 0.91525 1 0.67875 1 0.70562 1 0.23 1 0.19234 1 0.02342 1 RBM26 9 (7%) 121 0.61892 1 0.96444 1 0.255 1 0.72508 1 0.38185 1 0.56608 1 0.093769 1 0.28817 1 0.38901 1 0.24616 1 RAD51C 4 (3%) 126 1 1 0.16472 1 0.18172 1 1 1 0.03724 1 0.21044 1 0.13362 1 0.44857 1 0.13432 1 0.37499 1 CEP192 5 (4%) 125 0.84995 1 0.72499 1 0.89517 1 0.69638 1 0.73287 1 0.58705 1 0.73363 1 0.061499 1 0.59057 1 0.69902 1 ASXL2 9 (7%) 121 0.04755 1 0.50806 1 0.34793 1 0.36507 1 0.25037 1 0.81732 1 0.90963 1 0.39865 1 0.48417 1 0.45384 1 PSIP1 7 (5%) 123 0.37061 1 0.6253 1 0.13804 1 0.3849 1 0.88442 1 0.50932 1 0.48295 1 0.84677 1 0.53584 1 0.1913 1 ZNF513 7 (5%) 123 0.15975 1 0.70415 1 0.2061 1 0.41409 1 0.48027 1 0.33541 1 0.88999 1 0.76095 1 1 1 1 1 FOXA1 7 (5%) 123 0.6108 1 0.90983 1 0.53918 1 0.69393 1 0.25727 1 0.90806 1 0.88773 1 0.64685 1 0.67536 1 0.66147 1 TRIP11 5 (4%) 125 0.82231 1 0.53064 1 0.80413 1 0.28793 1 0.7313 1 0.86939 1 0.31592 1 0.093269 1 0.33987 1 0.36767 1