Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.062 0.242 -9999.0 0.0 -0.634 33.0 33.0 IHH -0.063 0.183 -9999.0 0.0 -0.498 38.0 38.0 SHH Np/Cholesterol/GAS1 -0.171 0.198 -9999.0 0.0 -0.345 141.0 141.0 LRPAP1 0.013 0.03 -9999.0 0.0 -0.483 1.0 1.0 dorsoventral neural tube patterning 0.17 0.196 0.343 141.0 -9999.0 0.0 141.0 SMO/beta Arrestin2 -0.046 0.167 -9999.0 0.0 -0.499 19.0 19.0 SMO -0.057 0.175 -9999.0 0.0 -0.495 25.0 25.0 AKT1 -0.002 0.081 -9999.0 0.0 -0.303 1.0 1.0 ARRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.033 0.16 -9999.0 0.0 -0.566 22.0 22.0 ADRBK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.056 0.173 -9999.0 0.0 -0.487 25.0 25.0 STIL -0.15 0.211 -9999.0 0.0 -0.459 59.0 59.0 DHH N/PTCH2 -0.015 0.12 -9999.0 0.0 -0.408 23.0 23.0 DHH N/PTCH1 -0.035 0.152 -9999.0 0.0 -0.463 17.0 17.0 PIK3CA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.008 0.11 -9999.0 0.0 -0.566 10.0 10.0 PTHLH -0.114 0.369 -9999.0 0.0 -1.036 33.0 33.0 determination of left/right symmetry -0.056 0.173 -9999.0 0.0 -0.487 25.0 25.0 PIK3R1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.111 0.363 -9999.0 0.0 -1.018 33.0 33.0 IHH N/Hhip -0.142 0.231 -9999.0 0.0 -0.435 95.0 95.0 DHH N/Hhip -0.105 0.199 -9999.0 0.0 -0.414 77.0 77.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.056 0.173 -9999.0 0.0 -0.487 25.0 25.0 pancreas development -0.136 0.252 -9999.0 0.0 -0.563 69.0 69.0 HHAT 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.12 0.245 -9999.0 0.0 -0.565 62.0 62.0 somite specification -0.056 0.173 -9999.0 0.0 -0.487 25.0 25.0 SHH Np/Cholesterol/PTCH1 -0.122 0.193 -9999.0 0.0 -0.437 45.0 45.0 SHH Np/Cholesterol/PTCH2 -0.111 0.173 -9999.0 0.0 -0.321 105.0 105.0 SHH Np/Cholesterol/Megalin -0.149 0.196 -9999.0 0.0 -0.343 125.0 125.0 SHH -0.135 0.205 -9999.0 0.0 -0.406 97.0 97.0 catabolic process -0.034 0.156 -9999.0 0.0 -0.523 13.0 13.0 SMO/Vitamin D3 -0.114 0.204 -9999.0 0.0 -0.466 39.0 39.0 SHH Np/Cholesterol/Hhip -0.181 0.214 -9999.0 0.0 -0.37 138.0 138.0 LRP2 -0.083 0.197 -9999.0 0.0 -0.483 52.0 52.0 receptor-mediated endocytosis -0.149 0.207 -9999.0 0.0 -0.471 50.0 50.0 SHH Np/Cholesterol/BOC -0.122 0.185 -9999.0 0.0 -0.334 109.0 109.0 SHH Np/Cholesterol/CDO -0.145 0.186 -9999.0 0.0 -0.33 127.0 127.0 mesenchymal cell differentiation 0.179 0.212 0.367 138.0 -9999.0 0.0 138.0 mol:Vitamin D3 -0.12 0.194 -9999.0 0.0 -0.438 45.0 45.0 IHH N/PTCH2 -0.046 0.143 -9999.0 0.0 -0.396 29.0 29.0 CDON -0.072 0.207 -9999.0 0.0 -0.566 40.0 40.0 IHH N/PTCH1 -0.034 0.157 -9999.0 0.0 -0.529 13.0 13.0 Megalin/LRPAP1 -0.05 0.143 -9999.0 0.0 -0.336 53.0 53.0 PTCH2 -0.013 0.125 -9999.0 0.0 -0.566 13.0 13.0 SHH Np/Cholesterol -0.112 0.153 -9999.0 0.0 -0.315 97.0 97.0 PTCH1 -0.034 0.156 -9999.0 0.0 -0.525 13.0 13.0 HHIP -0.136 0.252 -9999.0 0.0 -0.564 69.0 69.0