Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	93.0	4747.0	51.0	-0.81	0.015	1000.0	-1000.0	-0.135	-1000.0
Glypican 2 network	71.0	287.0	4.0	-0.142	-0.111	1000.0	-1000.0	-0.012	-1000.0
Aurora B signaling	64.0	4349.0	67.0	-0.504	0.015	1000.0	-1000.0	-0.055	-1000.0
Signaling events regulated by Ret tyrosine kinase	58.0	4759.0	82.0	-0.279	0.015	1000.0	-1000.0	-0.069	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	52.0	3553.0	68.0	-0.693	0.346	1000.0	-1000.0	-0.086	-1000.0
Signaling mediated by p38-alpha and p38-beta	47.0	2070.0	44.0	-0.235	0.015	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by the Hedgehog family	46.0	2409.0	52.0	-0.181	0.179	1000.0	-1000.0	-0.044	-1000.0
Nongenotropic Androgen signaling	44.0	2292.0	52.0	-0.241	0.134	1000.0	-1000.0	-0.046	-1000.0
IL4-mediated signaling events	43.0	3984.0	91.0	-0.786	0.545	1000.0	-1000.0	-0.113	-1000.0
Endothelins	43.0	4163.0	96.0	-0.318	0.053	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	42.0	3353.0	78.0	-0.283	0.1	1000.0	-1000.0	-0.044	-1000.0
IGF1 pathway	40.0	2287.0	57.0	-0.254	0.049	1000.0	-1000.0	-0.078	-1000.0
Reelin signaling pathway	37.0	2112.0	56.0	-0.218	0.039	1000.0	-1000.0	-0.072	-1000.0
p75(NTR)-mediated signaling	36.0	4503.0	125.0	-0.165	0.045	1000.0	-1000.0	-0.079	-1000.0
Aurora C signaling	36.0	255.0	7.0	-0.209	0.0	1000.0	-1000.0	-0.024	-1000.0
TCGA08_retinoblastoma	36.0	294.0	8.0	-0.23	0.063	1000.0	-1000.0	-0.014	-1000.0
Thromboxane A2 receptor signaling	35.0	3714.0	105.0	-0.187	0.036	1000.0	-1000.0	-0.054	-1000.0
HIF-1-alpha transcription factor network	33.0	2540.0	76.0	-0.331	0.033	1000.0	-1000.0	-0.054	-1000.0
PLK1 signaling events	33.0	2814.0	85.0	-0.351	0.049	1000.0	-1000.0	-0.041	-1000.0
Plasma membrane estrogen receptor signaling	33.0	2859.0	86.0	-0.248	0.126	1000.0	-1000.0	-0.066	-1000.0
Ephrin A  reverse signaling	31.0	219.0	7.0	-0.071	-0.0	1000.0	-1000.0	-0.014	-1000.0
Fc-epsilon receptor I signaling in mast cells	31.0	3099.0	97.0	-0.184	0.04	1000.0	-1000.0	-0.069	-1000.0
IL23-mediated signaling events	31.0	1891.0	60.0	-0.611	0.015	1000.0	-1000.0	-0.12	-1000.0
Ras signaling in the CD4+ TCR pathway	31.0	527.0	17.0	-0.151	0.021	1000.0	-1000.0	-0.027	-1000.0
Syndecan-1-mediated signaling events	30.0	1044.0	34.0	-0.272	0.015	1000.0	-1000.0	-0.029	-1000.0
Rapid glucocorticoid signaling	30.0	601.0	20.0	-0.229	0.035	1000.0	-1000.0	-0.018	-1000.0
Integrins in angiogenesis	29.0	2489.0	84.0	-0.269	0.031	1000.0	-1000.0	-0.075	-1000.0
Glypican 1 network	28.0	1356.0	48.0	-0.255	0.035	1000.0	-1000.0	-0.03	-1000.0
PDGFR-alpha signaling pathway	28.0	1242.0	44.0	-0.325	0.032	1000.0	-1000.0	-0.045	-1000.0
amb2 Integrin signaling	28.0	2328.0	82.0	-0.334	0.021	1000.0	-1000.0	-0.061	-1000.0
BMP receptor signaling	27.0	2218.0	81.0	-0.314	0.051	1000.0	-1000.0	-0.069	-1000.0
Glucocorticoid receptor regulatory network	27.0	3162.0	114.0	-0.596	0.263	1000.0	-1000.0	-0.066	-1000.0
TCR signaling in naïve CD8+ T cells	27.0	2590.0	93.0	-0.138	0.065	1000.0	-1000.0	-0.065	-1000.0
Calcium signaling in the CD4+ TCR pathway	27.0	838.0	31.0	-0.281	0.015	1000.0	-1000.0	-0.075	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	26.0	1371.0	52.0	-0.305	0.03	1000.0	-1000.0	-0.035	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	26.0	3155.0	120.0	-0.329	0.189	1000.0	-1000.0	-0.059	-1000.0
S1P1 pathway	25.0	912.0	36.0	-0.293	0.016	1000.0	-1000.0	-0.047	-1000.0
LPA receptor mediated events	25.0	2606.0	102.0	-0.228	0.033	1000.0	-1000.0	-0.067	-1000.0
IL6-mediated signaling events	25.0	1911.0	75.0	-0.245	0.068	1000.0	-1000.0	-0.058	-1000.0
S1P5 pathway	24.0	413.0	17.0	-0.159	0.112	1000.0	-1000.0	-0.02	-1000.0
Visual signal transduction: Cones	22.0	858.0	38.0	-0.118	0.018	1000.0	-1000.0	-0.052	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	22.0	1189.0	54.0	-0.188	0.03	1000.0	-1000.0	-0.081	-1000.0
LPA4-mediated signaling events	21.0	252.0	12.0	-0.166	0.022	1000.0	-1000.0	-0.018	-1000.0
IL12-mediated signaling events	21.0	1828.0	87.0	-0.404	0.029	1000.0	-1000.0	-0.092	-1000.0
BCR signaling pathway	21.0	2086.0	99.0	-0.19	0.035	1000.0	-1000.0	-0.074	-1000.0
S1P4 pathway	21.0	543.0	25.0	-0.159	0.029	1000.0	-1000.0	-0.028	-1000.0
Wnt signaling	20.0	144.0	7.0	-0.057	0.015	1000.0	-1000.0	-0.015	-1000.0
S1P3 pathway	20.0	857.0	42.0	-0.158	0.03	1000.0	-1000.0	-0.021	-1000.0
Coregulation of Androgen receptor activity	19.0	1484.0	76.0	-0.219	0.034	1000.0	-1000.0	-0.035	-1000.0
Osteopontin-mediated events	19.0	727.0	38.0	-0.18	0.016	1000.0	-1000.0	-0.082	-1000.0
JNK signaling in the CD4+ TCR pathway	19.0	336.0	17.0	-0.154	0.017	1000.0	-1000.0	-0.029	-1000.0
TCGA08_p53	19.0	139.0	7.0	-0.16	0.073	1000.0	-1000.0	-0.009	-1000.0
Arf6 signaling events	18.0	1139.0	62.0	-0.238	0.029	1000.0	-1000.0	-0.048	-1000.0
Aurora A signaling	18.0	1121.0	60.0	-0.353	0.029	1000.0	-1000.0	-0.042	-1000.0
Class IB PI3K non-lipid kinase events	18.0	54.0	3.0	-0.024	-1000.0	1000.0	-1000.0	-0.012	-1000.0
Syndecan-2-mediated signaling events	17.0	1198.0	69.0	-0.086	0.034	1000.0	-1000.0	-0.027	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	16.0	549.0	34.0	-0.047	0.015	1000.0	-1000.0	-0.046	-1000.0
FAS signaling pathway (CD95)	16.0	789.0	47.0	-0.567	0.019	1000.0	-1000.0	-0.034	-1000.0
Angiopoietin receptor Tie2-mediated signaling	16.0	1467.0	88.0	-0.236	0.057	1000.0	-1000.0	-0.082	-1000.0
Presenilin action in Notch and Wnt signaling	15.0	947.0	61.0	-0.181	0.043	1000.0	-1000.0	-0.056	-1000.0
Syndecan-4-mediated signaling events	15.0	1048.0	67.0	-0.185	0.022	1000.0	-1000.0	-0.07	-1000.0
Noncanonical Wnt signaling pathway	14.0	373.0	26.0	-0.092	0.015	1000.0	-1000.0	-0.036	-1000.0
Canonical Wnt signaling pathway	14.0	763.0	51.0	-0.181	0.081	1000.0	-1000.0	-0.04	-1000.0
Visual signal transduction: Rods	14.0	741.0	52.0	-0.2	0.015	1000.0	-1000.0	-0.074	-1000.0
Sphingosine 1-phosphate (S1P) pathway	13.0	388.0	28.0	-0.159	0.03	1000.0	-1000.0	-0.023	-1000.0
ErbB4 signaling events	12.0	880.0	69.0	-0.232	0.036	1000.0	-1000.0	-0.072	-1000.0
Effects of Botulinum toxin	12.0	334.0	26.0	-0.074	0.015	1000.0	-1000.0	-0.05	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	12.0	416.0	33.0	-0.277	0.044	1000.0	-1000.0	-0.037	-1000.0
ErbB2/ErbB3 signaling events	11.0	779.0	65.0	-0.232	0.026	1000.0	-1000.0	-0.055	-1000.0
Caspase cascade in apoptosis	11.0	820.0	74.0	-0.049	0.044	1000.0	-1000.0	-0.026	-1000.0
Regulation of Androgen receptor activity	11.0	770.0	70.0	-0.224	0.03	1000.0	-1000.0	-0.058	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	10.0	876.0	85.0	-0.212	0.022	1000.0	-1000.0	-0.065	-1000.0
IL27-mediated signaling events	10.0	517.0	51.0	-0.245	0.025	1000.0	-1000.0	-0.062	-1000.0
IL2 signaling events mediated by STAT5	10.0	230.0	22.0	-0.119	0.062	1000.0	-1000.0	-0.02	-1000.0
Hedgehog signaling events mediated by Gli proteins	9.0	609.0	65.0	-0.159	0.064	1000.0	-1000.0	-0.049	-1000.0
FOXA2 and FOXA3 transcription factor networks	9.0	452.0	46.0	-0.185	0.095	1000.0	-1000.0	-0.039	-1000.0
Nectin adhesion pathway	9.0	601.0	63.0	-0.048	0.03	1000.0	-1000.0	-0.055	-1000.0
EGFR-dependent Endothelin signaling events	9.0	202.0	21.0	-0.061	0.022	1000.0	-1000.0	-0.06	-1000.0
Regulation of nuclear SMAD2/3 signaling	8.0	1115.0	136.0	-0.182	0.067	1000.0	-1000.0	-0.053	-1000.0
Cellular roles of Anthrax toxin	8.0	318.0	39.0	-0.095	0.018	1000.0	-1000.0	-0.019	-1000.0
IL1-mediated signaling events	8.0	502.0	62.0	-0.095	0.073	1000.0	-1000.0	-0.081	-1000.0
IL2 signaling events mediated by PI3K	8.0	500.0	58.0	-0.183	0.049	1000.0	-1000.0	-0.063	-1000.0
a4b1 and a4b7 Integrin signaling	7.0	38.0	5.0	-0.006	0.007	1000.0	-1000.0	-0.013	-1000.0
Signaling events mediated by PTP1B	7.0	600.0	76.0	-0.135	0.036	1000.0	-1000.0	-0.065	-1000.0
Ephrin B reverse signaling	7.0	351.0	48.0	-0.051	0.02	1000.0	-1000.0	-0.051	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	7.0	586.0	83.0	-0.268	0.042	1000.0	-1000.0	-0.061	-1000.0
Syndecan-3-mediated signaling events	7.0	274.0	35.0	-0.136	0.045	1000.0	-1000.0	-0.035	-1000.0
Regulation of p38-alpha and p38-beta	7.0	392.0	54.0	-0.15	0.039	1000.0	-1000.0	-0.045	-1000.0
Class I PI3K signaling events mediated by Akt	6.0	431.0	68.0	-0.208	0.059	1000.0	-1000.0	-0.042	-1000.0
Ceramide signaling pathway	6.0	501.0	76.0	-0.248	0.044	1000.0	-1000.0	-0.033	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	6.0	238.0	37.0	-0.033	0.035	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class III	6.0	278.0	40.0	-0.219	0.025	1000.0	-1000.0	-0.033	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	461.0	74.0	-0.248	0.075	1000.0	-1000.0	-0.076	-1000.0
Regulation of Telomerase	6.0	657.0	102.0	-0.161	0.04	1000.0	-1000.0	-0.083	-1000.0
Insulin Pathway	6.0	455.0	74.0	-0.257	0.041	1000.0	-1000.0	-0.075	-1000.0
BARD1 signaling events	5.0	318.0	57.0	-0.149	0.045	1000.0	-1000.0	-0.055	-1000.0
IFN-gamma pathway	5.0	358.0	68.0	-0.174	0.055	1000.0	-1000.0	-0.078	-1000.0
EPHB forward signaling	5.0	431.0	85.0	-0.041	0.04	1000.0	-1000.0	-0.076	-1000.0
Signaling events mediated by PRL	5.0	199.0	34.0	-0.094	0.026	1000.0	-1000.0	-0.029	-1000.0
E-cadherin signaling events	5.0	28.0	5.0	-0.004	0.017	1000.0	-1000.0	-0.015	-1000.0
EPO signaling pathway	4.0	266.0	55.0	-0.046	0.052	1000.0	-1000.0	-0.078	-1000.0
TRAIL signaling pathway	4.0	232.0	48.0	-0.01	0.048	1000.0	-1000.0	-0.054	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	67.0	15.0	-0.0	0.032	1000.0	-1000.0	-0.025	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	193.0	45.0	-0.031	0.068	1000.0	-1000.0	-0.076	-1000.0
Arf6 trafficking events	4.0	339.0	71.0	-0.409	0.049	1000.0	-1000.0	-0.059	-1000.0
PDGFR-beta signaling pathway	4.0	454.0	97.0	-0.056	0.058	1000.0	-1000.0	-0.072	-1000.0
PLK2 and PLK4 events	3.0	10.0	3.0	0.006	0.019	1000.0	-1000.0	-0.009	-1000.0
Retinoic acid receptors-mediated signaling	3.0	230.0	58.0	-0.086	0.035	1000.0	-1000.0	-0.061	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	120.0	36.0	-0.033	0.034	1000.0	-1000.0	-0.058	-1000.0
TCGA08_rtk_signaling	3.0	102.0	26.0	-0.072	0.045	1000.0	-1000.0	-0.016	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	260.0	76.0	-0.019	0.056	1000.0	-1000.0	-0.07	-1000.0
Signaling events mediated by HDAC Class II	2.0	205.0	75.0	-0.087	0.038	1000.0	-1000.0	-0.036	-1000.0
Class I PI3K signaling events	2.0	201.0	73.0	-0.056	0.039	1000.0	-1000.0	-0.055	-1000.0
E-cadherin signaling in keratinocytes	2.0	97.0	43.0	-0.045	0.047	1000.0	-1000.0	-0.052	-1000.0
p38 MAPK signaling pathway	2.0	115.0	44.0	-0.038	0.046	1000.0	-1000.0	-0.048	-1000.0
Canonical NF-kappaB pathway	1.0	75.0	39.0	-0.026	0.089	1000.0	-1000.0	-0.063	-1000.0
Circadian rhythm pathway	1.0	28.0	22.0	-0.015	0.052	1000.0	-1000.0	-0.021	-1000.0
Insulin-mediated glucose transport	1.0	48.0	32.0	-0.14	0.04	1000.0	-1000.0	-0.042	-1000.0
mTOR signaling pathway	1.0	60.0	53.0	-0.006	0.04	1000.0	-1000.0	-0.053	-1000.0
ceramide signaling pathway	1.0	77.0	49.0	-0.019	0.05	1000.0	-1000.0	-0.032	-1000.0
HIF-2-alpha transcription factor network	1.0	55.0	43.0	-0.156	0.16	1000.0	-1000.0	-0.057	-1000.0
FoxO family signaling	1.0	112.0	64.0	-0.068	0.096	1000.0	-1000.0	-0.053	-1000.0
Atypical NF-kappaB pathway	1.0	34.0	31.0	0.0	0.053	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	160.0	125.0	-0.048	0.1	1000.0	-1000.0	-0.082	-1000.0
VEGFR1 specific signals	1.0	60.0	56.0	-0.046	0.071	1000.0	-1000.0	-0.039	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	10.0	23.0	0.006	0.053	1000.0	-1000.0	-0.039	-1000.0
Arf6 downstream pathway	0.0	13.0	43.0	-0.038	0.039	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class I	0.0	69.0	104.0	-0.03	0.064	1000.0	-1000.0	-0.056	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	16.0	27.0	-0.0	0.037	1000.0	-1000.0	-0.041	-1000.0
Arf1 pathway	0.0	4.0	54.0	-0.0	0.038	1000.0	-1000.0	-0.031	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.045	1000.0	-1000.0	-0.023	-1000.0
Total	2259	132565	7203	-23.7818837818	-993.322730112	131000	-131000	-6.57980648065	-131000