Regulation of Telomerase Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Telomerase catalytic core complex -0.054 0.117 -9999.0 0.0 -0.593 5.0 5.0 RAD9A -0.0 0.009 -9999.0 0.0 -0.292 1.0 1.0 AP1 -0.183 0.284 -9999.0 0.0 -0.616 314.0 314.0 IFNAR2 0.011 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.037 0.109 -9999.0 0.0 -0.285 162.0 162.0 ER alpha/Oestrogen -0.117 0.221 -9999.0 0.0 -0.444 274.0 274.0 NFX1/SIN3/HDAC complex 0.013 0.023 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.151 0.315 -9999.0 0.0 -0.79 206.0 206.0 SMG5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMG6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SP3/HDAC2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TERT/c-Abl -0.066 0.089 -9999.0 0.0 -0.582 4.0 4.0 SAP18 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MRN complex 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WT1 -0.144 0.151 -9999.0 0.0 -0.291 538.0 538.0 WRN 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SP1 0.011 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SP3 0.009 0.005 -9999.0 0.0 -9999.0 0.0 0.0 TERF2IP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Telomerase/Nucleolin -0.052 0.078 -9999.0 0.0 -0.589 2.0 2.0 Mad/Max -0.0 0.006 -9999.0 0.0 -9999.0 0.0 0.0 TERT -0.055 0.119 -9999.0 0.0 -0.64 4.0 4.0 CCND1 -0.048 0.135 -9999.0 0.0 -1.262 5.0 5.0 MAX 0.009 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RBBP7 -0.002 0.025 -9999.0 0.0 -0.293 8.0 8.0 RBBP4 -0.001 0.024 -9999.0 0.0 -0.795 1.0 1.0 TERF2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTGES3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SIN3A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Telomerase/911 0.011 0.024 -9999.0 0.0 -9999.0 0.0 0.0 CDKN1B 0.009 0.075 -9999.0 0.0 -0.871 3.0 3.0 RAD1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 XRCC5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 XRCC6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SAP30 -0.001 0.018 -9999.0 0.0 -0.292 4.0 4.0 TRF2/PARP2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 UBE3A 0.009 0.005 -9999.0 0.0 -9999.0 0.0 0.0 JUN 0.001 0.065 -9999.0 0.0 -0.795 7.0 7.0 E6 0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 HPV-16 E6/E6AP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FOS -0.229 0.367 -9999.0 0.0 -0.795 313.0 313.0 IFN-gamma/IRF1 -0.025 0.063 -9999.0 0.0 -0.363 3.0 3.0 PARP2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BLM -0.031 0.09 -9999.0 0.0 -0.292 112.0 112.0 Telomerase -0.005 0.028 -9999.0 0.0 -9999.0 0.0 0.0 IRF1 0.011 0.021 -9999.0 0.0 -0.285 2.0 2.0 ESR1 -0.156 0.287 -9999.0 0.0 -0.577 286.0 286.0 KU/TER 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ATM/TRF2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ubiquitin-dependent protein catabolic process -0.0 0.007 -9999.0 0.0 -9999.0 0.0 0.0 HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex -0.0 0.007 -9999.0 0.0 -9999.0 0.0 0.0 HDAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HDAC2 0.011 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ATM 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMAD3 0.021 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ABL1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MXD1 0.008 0.011 -9999.0 0.0 -0.291 1.0 1.0 MRE11A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HUS1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RPS6KB1 -0.001 0.016 -9999.0 0.0 -0.292 3.0 3.0 TERT/NF kappa B1/14-3-3 -0.066 0.102 -9999.0 0.0 -0.671 3.0 3.0 NR2F2 0.001 0.043 -9999.0 0.0 -0.795 3.0 3.0 MAPK3 0.014 0.019 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.014 0.019 -9999.0 0.0 -9999.0 0.0 0.0 TGFB1/TGF beta receptor Type II 0.0 0.016 -9999.0 0.0 -0.291 3.0 3.0 NFKB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HNRNPC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DNA damage response signal transduction by p53 class mediator resulting in induction of apoptosis 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NBN 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.292 0.385 -9999.0 0.0 -0.788 396.0 396.0 mol:Oestrogen 0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 EGF/EGFR -0.335 0.35 -9999.0 0.0 -0.664 533.0 533.0 MYC -0.008 0.117 -9999.0 0.0 -0.794 23.0 23.0 IL2 0.004 0.027 -9999.0 0.0 -0.289 8.0 8.0 KU 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAD50 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HSP90AA1 -0.0 0.009 -9999.0 0.0 -0.292 1.0 1.0 TGFB1 0.0 0.016 -9999.0 0.0 -0.291 3.0 3.0 TRF2/BLM -0.018 0.051 -9999.0 0.0 -9999.0 0.0 0.0 FRAP1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KU/TERT -0.063 0.087 -9999.0 0.0 -0.576 4.0 4.0 SP1/HDAC2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PINX1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Telomerase/EST1A -0.052 0.078 -9999.0 0.0 -0.589 2.0 2.0 Smad3/Myc -0.012 0.077 -9999.0 0.0 -0.523 23.0 23.0 911 complex -0.0 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IFNG -0.03 0.102 -9999.0 0.0 -9999.0 0.0 0.0 Telomerase/PinX1 -0.052 0.078 -9999.0 0.0 -0.589 2.0 2.0 Telomerase/AKT1/mTOR/p70S6K 0.002 0.055 -9999.0 0.0 -9999.0 0.0 0.0 SIN3B 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 YWHAE 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Telomerase/EST1B -0.052 0.078 -9999.0 0.0 -0.589 2.0 2.0 response to DNA damage stimulus 0.003 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MRN complex/TRF2/Rap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRF2/WRN 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Telomerase/hnRNP C1/C2 -0.052 0.078 -9999.0 0.0 -0.589 2.0 2.0 E2F1 -0.085 0.142 -9999.0 0.0 -0.299 97.0 97.0 ZNFX1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIF1 -0.059 0.117 -9999.0 0.0 -0.292 213.0 213.0 NCL 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DKC1 -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 telomeric DNA binding 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0