Endothelins Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations AKT1 -0.01 0.197 -9999.0 0.0 -0.595 87.0 87.0 PTK2B 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.022 0.198 -9999.0 0.0 -0.964 31.0 31.0 EDN1 -0.037 0.242 -9999.0 0.0 -0.819 85.0 85.0 EDN3 -0.372 0.396 -9999.0 0.0 -0.793 496.0 496.0 EDN2 -0.075 0.139 -9999.0 0.0 -0.308 259.0 259.0 HRAS/GDP -0.028 0.205 -9999.0 0.0 -0.525 101.0 101.0 ETA receptor/Endothelin-1/Gq/GTP/PLC beta -0.002 0.142 -9999.0 0.0 -0.476 43.0 43.0 ADCY4 -0.148 0.291 -9999.0 0.0 -0.558 305.0 305.0 ADCY5 -0.278 0.362 -9999.0 0.0 -0.604 502.0 502.0 ADCY6 -0.131 0.269 -9999.0 0.0 -0.532 287.0 287.0 ADCY7 -0.131 0.269 -9999.0 0.0 -0.532 287.0 287.0 ADCY1 -0.149 0.29 -9999.0 0.0 -0.562 302.0 302.0 ADCY2 -0.169 0.319 -9999.0 0.0 -0.602 314.0 314.0 ADCY3 -0.132 0.269 -9999.0 0.0 -0.532 287.0 287.0 ADCY8 -0.138 0.271 -9999.0 0.0 -0.54 287.0 287.0 ADCY9 -0.131 0.269 -9999.0 0.0 -0.532 287.0 287.0 arachidonic acid secretion -0.102 0.293 -9999.0 0.0 -0.578 204.0 204.0 ETB receptor/Endothelin-1/Gq/GTP -0.033 0.174 -9999.0 0.0 -0.391 156.0 156.0 GNAO1 -0.03 0.132 -9999.0 0.0 -0.795 25.0 25.0 HRAS -0.002 0.027 -9999.0 0.0 -0.293 9.0 9.0 ETA receptor/Endothelin-1/G12/GTP 0.039 0.208 -9999.0 0.0 -0.556 87.0 87.0 ETA receptor/Endothelin-1/Gs/GTP -0.09 0.321 -9999.0 0.0 -0.568 287.0 287.0 mol:GTP -0.001 0.006 -9999.0 0.0 -9999.0 0.0 0.0 COL3A1 -0.019 0.208 -9999.0 0.0 -0.601 87.0 87.0 EDNRB -0.072 0.242 -9999.0 0.0 -0.793 107.0 107.0 response to oxidative stress -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYSLTR2 -0.023 0.24 -9999.0 0.0 -0.68 102.0 102.0 CYSLTR1 -0.02 0.233 -9999.0 0.0 -0.671 99.0 99.0 SLC9A1 0.002 0.102 -9999.0 0.0 -0.304 86.0 86.0 mol:GDP -0.036 0.22 -9999.0 0.0 -0.557 106.0 106.0 SLC9A3 -0.052 0.283 -9999.0 0.0 -0.627 178.0 178.0 RAF1 -0.082 0.249 -9999.0 0.0 -0.543 157.0 157.0 JUN 0.028 0.178 -9999.0 0.0 -0.853 28.0 28.0 JAK2 -0.01 0.199 -9999.0 0.0 -0.6 87.0 87.0 mol:IP3 -0.028 0.174 -9999.0 0.0 -0.516 71.0 71.0 ETA receptor/Endothelin-1 0.036 0.252 -9999.0 0.0 -0.679 89.0 89.0 PLCB1 -0.051 0.209 -9999.0 0.0 -0.797 77.0 77.0 PLCB2 0.007 0.027 -9999.0 0.0 -0.543 2.0 2.0 ETA receptor/Endothelin-3 -0.273 0.316 -9999.0 0.0 -0.607 495.0 495.0 FOS -0.248 0.493 -9999.0 0.0 -0.985 320.0 320.0 Gai/GDP -0.016 0.157 -9999.0 0.0 -0.827 25.0 25.0 CRK 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca ++ -0.049 0.249 -9999.0 0.0 -0.669 111.0 111.0 BCAR1 0.004 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PRKCB1 -0.031 0.169 -9999.0 0.0 -0.463 87.0 87.0 GNAQ 0.008 0.036 -9999.0 0.0 -0.801 2.0 2.0 GNAZ -0.007 0.073 -9999.0 0.0 -0.795 9.0 9.0 GNAL -0.19 0.339 -9999.0 0.0 -0.795 253.0 253.0 Gs family/GDP -0.172 0.257 -9999.0 0.0 -0.536 299.0 299.0 ETA receptor/Endothelin-1/Gq/GTP 0.018 0.129 -9999.0 0.0 -0.425 45.0 45.0 MAPK14 -0.031 0.172 -9999.0 0.0 -0.467 92.0 92.0 TRPC6 0.02 0.215 -9999.0 0.0 -1.059 31.0 31.0 GNAI2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAI3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAI1 -0.043 0.179 -9999.0 0.0 -0.795 57.0 57.0 ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.04 0.182 -9999.0 0.0 -0.446 122.0 122.0 ETB receptor/Endothelin-2 -0.108 0.205 -9999.0 0.0 -0.655 114.0 114.0 ETB receptor/Endothelin-3 -0.339 0.341 -9999.0 0.0 -0.652 550.0 550.0 ETB receptor/Endothelin-1 -0.082 0.272 -9999.0 0.0 -0.661 178.0 178.0 MAPK3 -0.192 0.411 -9999.0 0.0 -0.79 324.0 324.0 MAPK1 -0.192 0.411 -9999.0 0.0 -0.79 324.0 324.0 Rac1/GDP -0.027 0.202 -9999.0 0.0 -0.523 98.0 98.0 cAMP biosynthetic process -0.178 0.301 -9999.0 0.0 -0.6 301.0 301.0 MAPK8 0.019 0.189 -9999.0 0.0 -0.772 37.0 37.0 SRC -0.0 0.009 -9999.0 0.0 -0.292 1.0 1.0 ETB receptor/Endothelin-1/Gi/GTP -0.049 0.187 -9999.0 0.0 -0.543 84.0 84.0 p130Cas/CRK/Src/PYK2 -0.014 0.214 -9999.0 0.0 -0.617 73.0 73.0 mol:K + 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 G12/GDP -0.027 0.202 -9999.0 0.0 -0.522 99.0 99.0 COL1A2 -0.055 0.254 -9999.0 0.0 -0.686 101.0 101.0 EntrezGene:2778 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ETA receptor/Endothelin-2 -0.029 0.115 -9999.0 0.0 -0.436 21.0 21.0 mol:DAG -0.028 0.175 -9999.0 0.0 -0.517 71.0 71.0 MAP2K2 -0.128 0.314 -9999.0 0.0 -0.565 330.0 330.0 MAP2K1 -0.128 0.314 -9999.0 0.0 -0.565 330.0 330.0 EDNRA 0.027 0.07 -9999.0 0.0 -0.41 6.0 6.0 positive regulation of muscle contraction -0.011 0.172 -9999.0 0.0 -0.52 87.0 87.0 Gq family/GDP -0.073 0.161 -9999.0 0.0 -0.594 58.0 58.0 HRAS/GTP -0.051 0.208 -9999.0 0.0 -0.484 131.0 131.0 PRKCH -0.022 0.172 -9999.0 0.0 -0.52 64.0 64.0 RAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCA -0.034 0.197 -9999.0 0.0 -0.57 83.0 83.0 PRKCB -0.034 0.193 -9999.0 0.0 -0.599 66.0 66.0 PRKCE -0.022 0.168 -9999.0 0.0 -0.561 51.0 51.0 PRKCD -0.023 0.17 -9999.0 0.0 -0.518 64.0 64.0 PRKCG -0.032 0.174 -9999.0 0.0 -0.513 71.0 71.0 regulation of vascular smooth muscle contraction -0.292 0.565 -9999.0 0.0 -1.137 320.0 320.0 PRKCQ -0.045 0.214 -9999.0 0.0 -0.624 88.0 88.0 PLA2G4A -0.117 0.327 -9999.0 0.0 -0.646 204.0 204.0 GNA14 -0.004 0.089 -9999.0 0.0 -0.457 31.0 31.0 GNA15 0.007 0.035 -9999.0 0.0 -0.355 8.0 8.0 GNA12 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNA11 0.008 0.035 -9999.0 0.0 -0.795 2.0 2.0 Rac1/GTP 0.039 0.208 -9999.0 0.0 -0.555 87.0 87.0 MMP1 -0.125 0.127 -9999.0 0.0 -9999.0 0.0 0.0