TCR signaling in naïve CD8+ T cells Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations GRB2/SOS1/SHC -0.036 0.124 -9999.0 0.0 -0.586 41.0 41.0 FYN 0.015 0.179 -9999.0 0.0 -0.707 47.0 47.0 LAT/GRAP2/SLP76 -0.03 0.147 -9999.0 0.0 -0.645 44.0 44.0 IKBKB -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.029 0.122 -9999.0 0.0 -0.46 45.0 45.0 B2M 0.011 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IKBKG -0.008 0.027 -9999.0 0.0 -0.139 14.0 14.0 MAP3K8 -0.007 0.074 -9999.0 0.0 -0.745 10.0 10.0 mol:Ca2+ -0.024 0.047 -9999.0 0.0 -0.118 206.0 206.0 integrin-mediated signaling pathway -0.002 0.028 -9999.0 0.0 -0.528 3.0 3.0 LAT/GRAP2/SLP76/VAV1/PI3K Class IA 0.02 0.176 -9999.0 0.0 -0.683 48.0 48.0 TRPV6 -0.159 0.319 -9999.0 0.0 -0.774 219.0 219.0 CD28 -0.006 0.075 -9999.0 0.0 -0.519 18.0 18.0 SHC1 0.009 0.183 -9999.0 0.0 -0.756 44.0 44.0 receptor internalization -0.003 0.203 -9999.0 0.0 -0.641 72.0 72.0 PRF1 -0.002 0.227 -9999.0 0.0 -1.035 39.0 39.0 KRAS -0.001 0.013 -9999.0 0.0 -0.292 2.0 2.0 GRB2 -0.0 0.009 -9999.0 0.0 -0.292 1.0 1.0 COT/AKT1 0.03 0.105 -9999.0 0.0 -0.371 48.0 48.0 LAT 0.007 0.188 -9999.0 0.0 -0.74 48.0 48.0 EntrezGene:6955 0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CD3D -0.024 0.145 -9999.0 0.0 -0.491 75.0 75.0 CD3E -0.018 0.135 -9999.0 0.0 -0.805 25.0 25.0 CD3G -0.035 0.167 -9999.0 0.0 -0.561 81.0 81.0 RASGRP2 0.003 0.042 -9999.0 0.0 -0.184 45.0 45.0 RASGRP1 0.035 0.126 -9999.0 0.0 -0.466 45.0 45.0 HLA-A 0.009 0.027 -9999.0 0.0 -0.292 8.0 8.0 RASSF5 -0.003 0.043 -9999.0 0.0 -0.669 4.0 4.0 RAP1A/GTP/RAPL -0.002 0.029 -9999.0 0.0 -0.531 3.0 3.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.033 0.043 -9999.0 0.0 -0.122 39.0 39.0 PDK1/CARD11/BCL10/MALT1/TRAF6 -0.015 0.048 -9999.0 0.0 -0.23 33.0 33.0 PRKCA -0.013 0.085 -9999.0 0.0 -0.309 58.0 58.0 GRAP2 -0.015 0.107 -9999.0 0.0 -0.795 19.0 19.0 mol:IP3 0.018 0.149 0.268 176.0 -0.443 44.0 220.0 EntrezGene:6957 0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0 TCR/CD3/MHC I/CD8 -0.008 0.212 -9999.0 0.0 -0.833 46.0 46.0 ORAI1 0.078 0.151 0.382 205.0 -9999.0 0.0 205.0 CSK 0.007 0.187 -9999.0 0.0 -0.763 45.0 45.0 B7 family/CD28 -0.027 0.182 -9999.0 0.0 -0.664 59.0 59.0 CHUK 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TCR/CD3/MHC I/CD8/LCK/ZAP-70 -0.004 0.219 -9999.0 0.0 -0.747 63.0 63.0 PTPN6 0.006 0.186 -9999.0 0.0 -0.764 45.0 45.0 VAV1 0.008 0.186 -9999.0 0.0 -0.753 46.0 46.0 Monovalent TCR/CD3 -0.025 0.207 -9999.0 0.0 -0.685 68.0 68.0 CBL 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LCK 0.008 0.194 -9999.0 0.0 -0.759 48.0 48.0 PAG1 0.007 0.187 -9999.0 0.0 -0.766 45.0 45.0 RAP1A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TCR/CD3/MHC I/CD8/LCK -0.003 0.217 -9999.0 0.0 -0.762 59.0 59.0 CD80 -0.078 0.129 -9999.0 0.0 -0.291 284.0 284.0 CD86 0.001 0.023 -9999.0 0.0 -0.294 6.0 6.0 PDK1/CARD11/BCL10/MALT1 -0.018 0.058 -9999.0 0.0 -0.276 35.0 35.0 HRAS -0.002 0.027 -9999.0 0.0 -0.292 9.0 9.0 GO:0035030 -0.003 0.154 -9999.0 0.0 -0.538 59.0 59.0 CD8A -0.001 0.079 -9999.0 0.0 -0.383 35.0 35.0 CD8B -0.023 0.15 -9999.0 0.0 -0.548 66.0 66.0 PTPRC -0.002 0.076 -9999.0 0.0 -0.507 19.0 19.0 PDK1/PKC theta 0.032 0.156 -9999.0 0.0 -0.58 49.0 49.0 CSK/PAG1 0.012 0.18 -9999.0 0.0 -0.753 43.0 43.0 SOS1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 peptide-MHC class I -0.001 0.016 -9999.0 0.0 -9999.0 0.0 0.0 GRAP2/SLP76 -0.036 0.172 -9999.0 0.0 -0.739 47.0 47.0 STIM1 0.041 0.078 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP 0.04 0.055 -9999.0 0.0 -0.173 33.0 33.0 TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin -0.007 0.225 -9999.0 0.0 -0.704 72.0 72.0 mol:DAG -0.008 0.104 -9999.0 0.0 -0.403 44.0 44.0 RAP1A/GDP 0.015 0.019 -9999.0 0.0 -0.063 6.0 6.0 PLCG1 0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CD247 -0.012 0.119 -9999.0 0.0 -0.801 21.0 21.0 cytotoxic T cell degranulation 0.001 0.209 -9999.0 0.0 -0.942 40.0 40.0 RAP1A/GTP -0.003 0.013 -9999.0 0.0 -0.068 28.0 28.0 mol:PI-3-4-5-P3 0.025 0.144 -9999.0 0.0 -0.543 48.0 48.0 LAT/GRAP2/SLP76/VAV1/PLCgamma1 0.011 0.178 0.287 166.0 -0.597 44.0 210.0 NRAS -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ZAP70 -0.031 0.125 -9999.0 0.0 -0.425 76.0 76.0 GRB2/SOS1 -0.0 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LAT/GRAP2/SLP76/VAV1 -0.027 0.141 -9999.0 0.0 -0.617 44.0 44.0 MALT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRAF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CD8 heterodimer -0.033 0.136 -9999.0 0.0 -0.571 54.0 54.0 CARD11 -0.007 0.053 -9999.0 0.0 -0.338 22.0 22.0 PRKCB -0.012 0.086 -9999.0 0.0 -0.329 49.0 49.0 PRKCE -0.007 0.069 -9999.0 0.0 -0.286 37.0 37.0 PRKCQ 0.022 0.178 -9999.0 0.0 -0.675 50.0 50.0 LCP2 0.0 0.009 -9999.0 0.0 -0.292 1.0 1.0 BCL10 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of survival gene product expression 0.031 0.106 -9999.0 0.0 -0.386 45.0 45.0 IKK complex 0.041 0.045 -9999.0 0.0 -0.121 26.0 26.0 RAS family/GDP -0.002 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K14 0.035 0.082 -9999.0 0.0 -0.291 39.0 39.0 PDPK1 0.032 0.117 -9999.0 0.0 -0.431 45.0 45.0 TCR/CD3/MHC I/CD8/Fyn -0.007 0.233 -9999.0 0.0 -0.922 51.0 51.0