E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.017 0.096 -9999.0 0.0 -0.581 29.0 29.0 KLHL20 -0.008 0.033 -9999.0 0.0 -0.242 4.0 4.0 CYFIP2 -0.011 0.067 -9999.0 0.0 -0.355 32.0 32.0 Rac1/GDP 0.049 0.067 -9999.0 0.0 -0.344 29.0 29.0 ENAH -0.016 0.095 -9999.0 0.0 -0.576 29.0 29.0 AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.008 0.047 -9999.0 0.0 -0.495 1.0 1.0 ABI1/Sra1/Nap1 -0.006 0.024 -9999.0 0.0 -0.209 2.0 2.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.017 0.082 -9999.0 0.0 -0.474 31.0 31.0 RAPGEF1 0.039 0.088 -9999.0 0.0 -0.481 29.0 29.0 CTNND1 -0.0 0.009 -9999.0 0.0 -0.292 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.017 0.099 -9999.0 0.0 -0.6 29.0 29.0 CRK 0.03 0.096 -9999.0 0.0 -0.532 29.0 29.0 E-cadherin/gamma catenin/alpha catenin -0.015 0.087 -9999.0 0.0 -0.522 30.0 30.0 alphaE/beta7 Integrin -0.006 0.04 -9999.0 0.0 -0.606 2.0 2.0 IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin -0.003 0.036 -9999.0 0.0 -0.482 6.0 6.0 DLG1 -0.016 0.095 -9999.0 0.0 -0.576 29.0 29.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.008 0.039 -9999.0 0.0 -0.313 2.0 2.0 MLLT4 -0.005 0.06 -9999.0 0.0 -0.723 7.0 7.0 ARF6/GTP/NME1/Tiam1 -0.007 0.029 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.01 0.05 -9999.0 0.0 -0.424 2.0 2.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.017 0.101 -9999.0 0.0 -0.606 30.0 30.0 TIAM1 -0.001 0.018 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ -0.012 0.073 -9999.0 0.0 -0.45 29.0 29.0 AKT1 -0.006 0.028 -9999.0 0.0 -0.221 2.0 2.0 PIK3R1 -0.008 0.077 -9999.0 0.0 -0.795 10.0 10.0 CDH1 -0.022 0.13 -9999.0 0.0 -0.795 29.0 29.0 RhoA/GDP 0.049 0.067 -9999.0 0.0 -0.344 29.0 29.0 actin cytoskeleton organization -0.006 0.024 -9999.0 0.0 -0.179 3.0 3.0 CDC42/GDP 0.049 0.067 -9999.0 0.0 -0.344 29.0 29.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.01 0.056 -9999.0 0.0 -0.335 30.0 30.0 ITGB7 -0.009 0.058 -9999.0 0.0 -0.326 30.0 30.0 RAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.013 0.077 -9999.0 0.0 -0.474 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.013 0.075 -9999.0 0.0 -0.457 29.0 29.0 mol:GDP 0.046 0.078 -9999.0 0.0 -0.411 29.0 29.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.001 0.026 -9999.0 0.0 -0.544 2.0 2.0 p120 catenin/RhoA/GDP -0.01 0.058 -9999.0 0.0 -0.35 29.0 29.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.007 0.03 -9999.0 0.0 -0.222 8.0 8.0 NME1 -0.015 0.064 -9999.0 0.0 -0.292 54.0 54.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.017 0.095 -9999.0 0.0 -0.571 30.0 30.0 regulation of cell-cell adhesion -0.007 0.042 -9999.0 0.0 -0.419 1.0 1.0 WASF2 -0.003 0.013 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.01 0.055 -9999.0 0.0 -0.588 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.016 0.077 -9999.0 0.0 -0.442 32.0 32.0 CCND1 -0.009 0.037 -9999.0 0.0 -0.32 6.0 6.0 VAV2 0.035 0.092 -9999.0 0.0 -0.509 29.0 29.0 RAP1/GDP -0.009 0.055 -9999.0 0.0 -0.566 1.0 1.0 adherens junction assembly -0.016 0.092 -9999.0 0.0 -0.549 30.0 30.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.015 0.073 -9999.0 0.0 -0.418 32.0 32.0 E-cadherin/beta catenin -0.013 0.08 -9999.0 0.0 -0.49 29.0 29.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.016 0.095 -9999.0 0.0 -0.576 29.0 29.0 PIK3CA -0.0 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.011 0.054 -9999.0 0.0 -0.403 4.0 4.0 E-cadherin/beta catenin/alpha catenin -0.014 0.085 -9999.0 0.0 -0.522 29.0 29.0 ITGAE 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.017 0.101 -9999.0 0.0 -0.617 29.0 29.0