Signaling events mediated by HDAC Class III Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations EP300 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HDAC4 -0.001 0.024 -9999.0 0.0 -0.795 1.0 1.0 induction of apoptosis 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of S phase of mitotic cell cycle 0.012 0.077 0.607 1.0 -9999.0 0.0 1.0 CDKN1A -0.002 0.041 -9999.0 0.0 -0.945 2.0 2.0 KAT2B -0.001 0.024 -9999.0 0.0 -0.795 1.0 1.0 BAX -0.001 0.02 -9999.0 0.0 -0.292 5.0 5.0 FOXO3 -0.001 0.018 -9999.0 0.0 -0.331 3.0 3.0 FOXO1 -0.008 0.081 -9999.0 0.0 -0.795 11.0 11.0 FOXO4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to UV 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 XRCC6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TAT -0.562 0.357 -9999.0 0.0 -0.778 764.0 764.0 mol:Lysophosphatidic acid -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYOD1 0.01 0.03 -9999.0 0.0 -0.606 1.0 1.0 PPARGC1A -0.17 0.323 -9999.0 0.0 -0.771 233.0 233.0 FHL2 -0.005 0.06 -9999.0 0.0 -0.795 6.0 6.0 response to nutrient levels -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KU70/SIRT1 0.0 0.007 -9999.0 0.0 -9999.0 0.0 0.0 HIST2H4A -0.012 0.077 -9999.0 0.0 -0.609 1.0 1.0 SIRT1/FOXO3a -0.0 0.015 -9999.0 0.0 -0.249 3.0 3.0 SIRT1 0.0 0.009 0.207 2.0 -9999.0 0.0 2.0 response to hypoxia -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SIRT1/MEF2D/HDAC4 -0.0 0.017 -9999.0 0.0 -0.523 1.0 1.0 SIRT1/Histone H1b -0.003 0.012 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis 0.0 0.012 -9999.0 0.0 -9999.0 0.0 0.0 SIRT1/PGC1A -0.113 0.216 -9999.0 0.0 -0.531 222.0 222.0 p53/SIRT1 0.001 0.019 0.43 2.0 -9999.0 0.0 2.0 SIRT1/FOXO4 0.0 0.007 -9999.0 0.0 -9999.0 0.0 0.0 FOXO1/FHL2/SIRT1 -0.007 0.061 -9999.0 0.0 -0.483 17.0 17.0 HIST1H1E -0.005 0.015 -9999.0 0.0 -9999.0 0.0 0.0 SIRT1/p300 0.0 0.007 -9999.0 0.0 -9999.0 0.0 0.0 muscle cell differentiation 0.002 0.024 0.521 1.0 -9999.0 0.0 1.0 TP53 0.0 0.009 0.207 2.0 -9999.0 0.0 2.0 KU70/SIRT1/BAX -0.0 0.012 -9999.0 0.0 -9999.0 0.0 0.0 CREBBP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MEF2D 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HIV-1 Tat/SIRT1 -0.428 0.273 -9999.0 0.0 -0.607 738.0 738.0 ACSS2 0.02 0.02 -9999.0 0.0 -0.609 1.0 1.0 SIRT1/PCAF/MYOD -0.002 0.024 -9999.0 0.0 -0.523 1.0 1.0