Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.052 0.295 -9999.0 0.0 -0.811 125.0 125.0 IHH -0.014 0.082 -9999.0 0.0 -0.418 8.0 8.0 SHH Np/Cholesterol/GAS1 -0.03 0.114 -9999.0 0.0 -0.494 59.0 59.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.03 0.114 0.491 59.0 -9999.0 0.0 59.0 SMO/beta Arrestin2 -0.075 0.23 -9999.0 0.0 -0.84 79.0 79.0 SMO -0.036 0.262 -9999.0 0.0 -0.9 79.0 79.0 AKT1 0.008 0.112 -9999.0 0.0 -0.431 19.0 19.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.059 0.209 -9999.0 0.0 -0.795 79.0 79.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.034 0.255 -9999.0 0.0 -0.874 79.0 79.0 STIL -0.039 0.209 -9999.0 0.0 -0.703 81.0 81.0 DHH N/PTCH2 -0.064 0.196 -9999.0 0.0 -0.64 106.0 106.0 DHH N/PTCH1 -0.09 0.241 -9999.0 0.0 -0.745 111.0 111.0 PIK3CA -0.0 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.023 0.132 -9999.0 0.0 -0.795 30.0 30.0 PTHLH -0.079 0.376 -9999.0 0.0 -1.057 125.0 125.0 determination of left/right symmetry -0.034 0.255 -9999.0 0.0 -0.874 79.0 79.0 PIK3R1 -0.008 0.077 -9999.0 0.0 -0.795 10.0 10.0 skeletal system development -0.077 0.367 -9999.0 0.0 -1.034 125.0 125.0 IHH N/Hhip -0.015 0.05 -9999.0 0.0 -0.412 6.0 6.0 DHH N/Hhip -0.02 0.107 -9999.0 0.0 -0.617 32.0 32.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.034 0.255 -9999.0 0.0 -0.874 79.0 79.0 pancreas development -0.004 0.043 -9999.0 0.0 -0.392 10.0 10.0 HHAT -0.001 0.024 -9999.0 0.0 -0.795 1.0 1.0 PI3K -0.006 0.059 -9999.0 0.0 -0.606 10.0 10.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.044 0.181 -9999.0 0.0 -0.795 58.0 58.0 somite specification -0.034 0.255 -9999.0 0.0 -0.874 79.0 79.0 SHH Np/Cholesterol/PTCH1 -0.071 0.204 -9999.0 0.0 -0.751 79.0 79.0 SHH Np/Cholesterol/PTCH2 -0.042 0.133 -9999.0 0.0 -0.491 84.0 84.0 SHH Np/Cholesterol/Megalin -0.135 0.215 -9999.0 0.0 -0.491 279.0 279.0 SHH 0.01 0.036 -9999.0 0.0 -0.615 1.0 1.0 catabolic process -0.046 0.257 -9999.0 0.0 -0.853 87.0 87.0 SMO/Vitamin D3 -0.074 0.223 -9999.0 0.0 -0.815 79.0 79.0 SHH Np/Cholesterol/Hhip -0.005 0.036 -9999.0 0.0 -0.368 7.0 7.0 LRP2 -0.216 0.348 -9999.0 0.0 -0.795 278.0 278.0 receptor-mediated endocytosis -0.148 0.251 -9999.0 0.0 -0.822 95.0 95.0 SHH Np/Cholesterol/BOC -0.04 0.131 -9999.0 0.0 -0.493 80.0 80.0 SHH Np/Cholesterol/CDO -0.01 0.06 -9999.0 0.0 -0.486 15.0 15.0 mesenchymal cell differentiation 0.005 0.036 0.365 7.0 -9999.0 0.0 7.0 mol:Vitamin D3 -0.029 0.22 -9999.0 0.0 -0.755 79.0 79.0 IHH N/PTCH2 -0.064 0.183 -9999.0 0.0 -0.679 83.0 83.0 CDON -0.011 0.091 -9999.0 0.0 -0.795 14.0 14.0 IHH N/PTCH1 -0.044 0.26 -9999.0 0.0 -0.86 87.0 87.0 Megalin/LRPAP1 -0.164 0.266 -9999.0 0.0 -0.606 278.0 278.0 PTCH2 -0.062 0.214 -9999.0 0.0 -0.795 83.0 83.0 SHH Np/Cholesterol -0.004 0.025 -9999.0 0.0 -0.498 1.0 1.0 PTCH1 -0.047 0.258 -9999.0 0.0 -0.858 87.0 87.0 HHIP -0.004 0.043 -9999.0 0.0 -0.393 10.0 10.0