Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.009 0.054 -9999.0 0.0 -0.325 30.0 30.0 epithelial cell differentiation -0.012 0.073 -9999.0 0.0 -0.444 29.0 29.0 CYFIP2 -0.011 0.067 -9999.0 0.0 -0.355 32.0 32.0 ENAH 0.057 0.059 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.295 0.383 -9999.0 0.0 -0.788 396.0 396.0 EPHA2 -0.005 0.06 -9999.0 0.0 -0.795 6.0 6.0 MYO6 -0.012 0.07 -9999.0 0.0 -0.421 30.0 30.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.006 0.039 -9999.0 0.0 -0.522 4.0 4.0 AQP5 -0.234 0.291 -9999.0 0.0 -0.587 416.0 416.0 CTNND1 -0.0 0.009 -9999.0 0.0 -0.292 1.0 1.0 mol:PI-4-5-P2 -0.011 0.068 -9999.0 0.0 -0.414 29.0 29.0 regulation of calcium-dependent cell-cell adhesion -0.034 0.113 -9999.0 0.0 -0.419 84.0 84.0 EGF -0.154 0.314 -9999.0 0.0 -0.79 206.0 206.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.038 0.142 -9999.0 0.0 -0.582 57.0 57.0 cortical microtubule organization -0.012 0.073 -9999.0 0.0 -0.444 29.0 29.0 GO:0000145 0.026 0.071 -9999.0 0.0 -0.395 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.012 0.073 -9999.0 0.0 -0.45 29.0 29.0 MLLT4 -0.005 0.06 -9999.0 0.0 -0.723 7.0 7.0 ARF6/GDP -0.012 0.062 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.003 0.036 -9999.0 0.0 -0.474 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.036 0.074 -9999.0 0.0 -0.386 29.0 29.0 PVRL2 -0.001 0.016 -9999.0 0.0 -0.292 3.0 3.0 ZYX -0.012 0.069 -9999.0 0.0 -0.421 29.0 29.0 ARF6/GTP -0.003 0.033 -9999.0 0.0 -0.435 6.0 6.0 CDH1 -0.022 0.13 -9999.0 0.0 -0.795 29.0 29.0 EGFR/EGFR/EGF/EGF -0.241 0.259 -9999.0 0.0 -0.468 544.0 544.0 RhoA/GDP -0.011 0.068 -9999.0 0.0 -0.416 29.0 29.0 actin cytoskeleton organization 0.032 0.073 -9999.0 0.0 -0.396 30.0 30.0 IGF-1R heterotetramer -0.02 0.117 -9999.0 0.0 -0.607 35.0 35.0 GIT1 -0.001 0.02 -9999.0 0.0 -0.292 5.0 5.0 IGF1R -0.02 0.117 -9999.0 0.0 -0.608 35.0 35.0 IGF1 -0.177 0.331 -9999.0 0.0 -0.795 236.0 236.0 DIAPH1 -0.002 0.044 -9999.0 0.0 -0.695 4.0 4.0 Wnt receptor signaling pathway 0.012 0.073 0.444 29.0 -9999.0 0.0 29.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.012 0.062 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.032 0.075 -9999.0 0.0 -0.406 30.0 30.0 EFNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.03 0.081 -9999.0 0.0 -0.397 37.0 37.0 Ephrin A1/EPHA2 -0.013 0.072 -9999.0 0.0 -0.402 35.0 35.0 SEC6/SEC8 -0.012 0.068 -9999.0 0.0 -0.752 1.0 1.0 MGAT3 -0.034 0.115 -9999.0 0.0 -0.427 84.0 84.0 HGF/MET -0.107 0.202 -9999.0 0.0 -0.451 250.0 250.0 HGF -0.052 0.195 -9999.0 0.0 -0.78 70.0 70.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.009 0.054 -9999.0 0.0 -0.328 30.0 30.0 actin cable formation 0.072 0.057 -9999.0 0.0 -0.324 1.0 1.0 KIAA1543 0.031 0.09 -9999.0 0.0 -0.462 30.0 30.0 KIFC3 -0.012 0.071 -9999.0 0.0 -0.421 31.0 31.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.012 0.07 -9999.0 0.0 -0.421 30.0 30.0 NCK1/GIT1 -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.012 0.073 -9999.0 0.0 -0.444 29.0 29.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.012 0.069 -9999.0 0.0 -0.421 29.0 29.0 PIP5K1C -0.012 0.069 -9999.0 0.0 -0.421 29.0 29.0 LIMA1 -0.001 0.024 -9999.0 0.0 -0.795 1.0 1.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.011 0.055 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.047 0.086 -9999.0 0.0 -0.627 7.0 7.0 IGF-1R heterotetramer/IGF1 -0.112 0.196 -9999.0 0.0 -0.435 269.0 269.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.004 0.047 -9999.0 0.0 -0.606 6.0 6.0 MET -0.135 0.298 -9999.0 0.0 -0.795 179.0 179.0 PLEKHA7 -0.013 0.079 -9999.0 0.0 -0.466 29.0 29.0 mol:GTP -0.003 0.036 -9999.0 0.0 -0.47 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.012 0.064 -9999.0 0.0 -0.707 1.0 1.0 cortical actin cytoskeleton stabilization -0.009 0.054 -9999.0 0.0 -0.325 30.0 30.0 regulation of cell-cell adhesion 0.032 0.073 -9999.0 0.0 -0.396 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.009 0.054 -9999.0 0.0 -0.328 30.0 30.0