IL27-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB1 0.001 0.017 -9999.0 0.0 -0.292 3.0 3.0 CD4-positive alpha-beta T cell lineage commitment -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cytokine production during immune response 0.034 0.126 0.407 50.0 -9999.0 0.0 50.0 IL27/IL27R/JAK1 -0.072 0.183 -9999.0 0.0 -0.59 71.0 71.0 TBX21 -0.043 0.212 -9999.0 0.0 -0.586 87.0 87.0 IL12B -0.055 0.123 -9999.0 0.0 -0.297 92.0 92.0 IL12A -0.029 0.145 -9999.0 0.0 -0.616 59.0 59.0 IL6ST -0.089 0.265 -9999.0 0.0 -0.799 129.0 129.0 IL27RA/JAK1 -0.007 0.062 -9999.0 0.0 -1.057 3.0 3.0 IL27 -0.024 0.094 -9999.0 0.0 -0.294 115.0 115.0 TYK2 0.01 0.006 -9999.0 0.0 -9999.0 0.0 0.0 T-helper cell lineage commitment -0.125 0.178 -9999.0 0.0 -9999.0 0.0 0.0 T-helper 2 cell differentiation 0.034 0.126 0.407 50.0 -9999.0 0.0 50.0 T cell proliferation during immune response 0.034 0.126 0.407 50.0 -9999.0 0.0 50.0 MAPKKK cascade -0.034 0.126 -9999.0 0.0 -0.407 50.0 50.0 STAT3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 -0.005 0.04 -9999.0 0.0 -0.305 3.0 3.0 IL12RB1 -0.006 0.068 -9999.0 0.0 -0.318 43.0 43.0 positive regulation of tyrosine phosphorylation of STAT protein -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL12RB2 -0.059 0.228 -9999.0 0.0 -0.606 102.0 102.0 IL27/IL27R/JAK2/TYK2 -0.034 0.127 -9999.0 0.0 -0.413 49.0 49.0 positive regulation of T cell mediated cytotoxicity -0.034 0.126 -9999.0 0.0 -0.407 50.0 50.0 STAT1 (dimer) -0.092 0.223 0.463 20.0 -0.715 61.0 81.0 JAK2 0.004 0.026 -9999.0 0.0 -0.8 1.0 1.0 JAK1 -0.0 0.025 -9999.0 0.0 -0.794 1.0 1.0 STAT2 (dimer) -0.043 0.111 -9999.0 0.0 -0.446 22.0 22.0 T cell proliferation -0.185 0.248 -9999.0 0.0 -0.467 408.0 408.0 IL12/IL12R/TYK2/JAK2 0.011 0.071 -9999.0 0.0 -9999.0 0.0 0.0 IL17A -0.125 0.179 -9999.0 0.0 -9999.0 0.0 0.0 mast cell activation 0.034 0.126 0.407 50.0 -9999.0 0.0 50.0 IFNG -0.001 0.025 -9999.0 0.0 -0.084 3.0 3.0 T cell differentiation -0.004 0.006 -9999.0 0.0 -0.02 15.0 15.0 STAT3 (dimer) -0.043 0.111 -9999.0 0.0 -0.439 24.0 24.0 STAT5A (dimer) -0.046 0.119 -9999.0 0.0 -0.444 37.0 37.0 STAT4 (dimer) -0.062 0.146 -9999.0 0.0 -0.487 67.0 67.0 STAT4 -0.034 0.161 -9999.0 0.0 -0.795 45.0 45.0 T cell activation -0.009 0.008 0.125 2.0 -9999.0 0.0 2.0 IL27R/JAK2/TYK2 -0.06 0.164 -9999.0 0.0 -0.549 47.0 47.0 GATA3 -0.04 0.277 -9999.0 0.0 -1.445 39.0 39.0 IL18 0.007 0.03 -9999.0 0.0 -0.198 23.0 23.0 positive regulation of mast cell cytokine production -0.043 0.11 -9999.0 0.0 -0.428 25.0 25.0 IL27/EBI3 -0.026 0.083 -9999.0 0.0 -0.537 13.0 13.0 IL27RA -0.0 0.066 -9999.0 0.0 -1.428 2.0 2.0 IL6 -0.29 0.384 -9999.0 0.0 -0.794 388.0 388.0 STAT5A -0.006 0.069 -9999.0 0.0 -0.795 8.0 8.0 monocyte differentiation -0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 IL2 0.004 0.026 0.478 2.0 -9999.0 0.0 2.0 IL1B 0.001 0.075 -9999.0 0.0 -0.617 15.0 15.0 EBI3 -0.004 0.076 -9999.0 0.0 -0.51 19.0 19.0 TNF -0.001 0.073 -9999.0 0.0 -0.616 12.0 12.0