Nectin adhesion pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PDGFRB 0.022 0.037 -9999.0 0.0 -0.57 4.0 4.0 alphaV beta3 Integrin 0.02 0.082 -9999.0 0.0 -0.422 34.0 34.0 PTK2 -0.041 0.155 -9999.0 0.0 -0.476 88.0 88.0 positive regulation of JNK cascade -0.021 0.124 -9999.0 0.0 -0.318 119.0 119.0 CDC42/GDP -0.018 0.172 0.433 1.0 -0.43 123.0 124.0 Rac1/GDP -0.018 0.17 -9999.0 0.0 -0.426 123.0 123.0 RAP1B 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.022 0.155 -9999.0 0.0 -0.393 117.0 117.0 nectin-3/I-afadin -0.015 0.144 -9999.0 0.0 -0.429 110.0 110.0 RAPGEF1 -0.036 0.169 0.456 1.0 -0.472 109.0 110.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK -0.05 0.185 -9999.0 0.0 -0.536 109.0 109.0 PDGFB-D/PDGFRB 0.022 0.037 -9999.0 0.0 -0.57 4.0 4.0 TLN1 -0.023 0.069 -9999.0 0.0 -0.382 13.0 13.0 Rap1/GTP -0.024 0.123 -9999.0 0.0 -0.341 106.0 106.0 IQGAP1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.04 0.027 -9999.0 0.0 -0.332 3.0 3.0 nectin-3(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin -0.015 0.144 -9999.0 0.0 -0.429 110.0 110.0 PVR 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Necl-5(dimer) 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.039 0.202 0.454 1.0 -0.526 124.0 125.0 MLLT4 0.021 0.033 0.257 1.0 -0.57 3.0 4.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.019 0.131 -9999.0 0.0 -0.342 110.0 110.0 nectin-1(dimer)/I-afadin/I-afadin/nectin-1(dimer)/I-afadin/I-afadin 0.029 0.03 -9999.0 0.0 -0.422 3.0 3.0 positive regulation of lamellipodium assembly -0.02 0.132 -9999.0 0.0 -0.336 125.0 125.0 PVRL1 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PVRL3 -0.038 0.182 -9999.0 0.0 -0.57 109.0 109.0 PVRL2 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.018 0.055 -9999.0 0.0 -0.57 9.0 9.0 CDH1 0.011 0.08 -9999.0 0.0 -0.57 19.0 19.0 CLDN1 0.007 0.118 0.257 23.0 -0.57 38.0 61.0 JAM-A/CLDN1 0.004 0.134 -9999.0 0.0 -0.363 104.0 104.0 SRC -0.056 0.206 -9999.0 0.0 -0.589 112.0 112.0 ITGB3 0.005 0.107 0.257 4.0 -0.57 34.0 38.0 nectin-1(dimer)/I-afadin/I-afadin 0.029 0.03 -9999.0 0.0 -0.422 3.0 3.0 FARP2 -0.038 0.203 0.457 1.0 -0.522 123.0 124.0 RAC1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 nectin-3(dimer)/I-afadin/I-afadin/Necl-5(dimer) 0.002 0.129 -9999.0 0.0 -0.37 109.0 109.0 nectin-1/I-afadin 0.029 0.03 -9999.0 0.0 -0.422 3.0 3.0 nectin-2/I-afadin 0.032 0.029 -9999.0 0.0 -0.422 3.0 3.0 RAC1/GTP/IQGAP1/filamentous actin 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer/I-afadin/I-afadin -0.001 0.128 -9999.0 0.0 -0.367 110.0 110.0 CDC42/GTP/IQGAP1/filamentous actin 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 F11R 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of filopodium formation -0.021 0.124 -9999.0 0.0 -0.318 119.0 119.0 alphaV/beta3 Integrin/Talin -0.007 0.105 0.258 1.0 -0.405 40.0 41.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.029 -9999.0 0.0 -0.422 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin 0.032 0.029 -9999.0 0.0 -0.422 3.0 3.0 PIP5K1C -0.019 0.077 -9999.0 0.0 -0.224 110.0 110.0 VAV2 -0.038 0.207 0.437 1.0 -0.538 123.0 124.0 RAP1/GDP -0.015 0.158 -9999.0 0.0 -0.399 116.0 116.0 ITGAV 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 nectin-3(dimer)/I-afadin/I-afadin/nectin-2(dimer)/I-afadin/I-afadin 0.002 0.129 -9999.0 0.0 -0.37 109.0 109.0 nectin-3(dimer)/I-afadin/I-afadin -0.015 0.144 -9999.0 0.0 -0.429 110.0 110.0 Rac1/GTP -0.022 0.162 -9999.0 0.0 -0.41 125.0 125.0 PTPRM -0.017 0.087 -9999.0 0.0 -0.247 112.0 112.0 E-cadherin/beta catenin/alpha catenin 0.046 0.064 -9999.0 0.0 -0.32 21.0 21.0 adherens junction assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0