BMP receptor signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BMP7/BMPR2/BMPR1A-1B/FS 0.059 0.164 0.315 8.0 -0.347 111.0 119.0 SMAD6-7/SMURF1 0.046 0.015 -9999.0 0.0 -9999.0 0.0 0.0 NOG 0.012 0.097 0.257 19.0 -0.57 25.0 44.0 SMAD9 -0.087 0.253 -9999.0 0.0 -0.6 177.0 177.0 SMAD4 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SMAD5 -0.02 0.142 -9999.0 0.0 -0.432 65.0 65.0 BMP7/USAG1 -0.196 0.25 -9999.0 0.0 -0.428 520.0 520.0 SMAD5/SKI -0.015 0.151 -9999.0 0.0 -0.442 64.0 64.0 SMAD1 0.013 0.063 -9999.0 0.0 -0.414 8.0 8.0 BMP2 -0.075 0.222 0.257 2.0 -0.57 173.0 175.0 SMAD1/SMAD1/SMAD4 0.018 0.069 -9999.0 0.0 -0.387 11.0 11.0 BMPR1A 0.023 0.026 -9999.0 0.0 -0.57 2.0 2.0 BMPR1B 0.104 0.151 0.257 413.0 -0.57 22.0 435.0 BMPR1A-1B/BAMBI 0.083 0.123 0.339 10.0 -0.33 53.0 63.0 AHSG 0.022 0.03 0.257 16.0 -9999.0 0.0 16.0 CER1 0.019 0.014 0.257 3.0 -9999.0 0.0 3.0 BMP2-4/CER1 -0.047 0.179 -9999.0 0.0 -0.392 208.0 208.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA -0.038 0.157 -9999.0 0.0 -0.382 124.0 124.0 BMP2-4 (homodimer) -0.067 0.201 -9999.0 0.0 -0.449 215.0 215.0 RGMB 0.023 0.019 -9999.0 0.0 -0.57 1.0 1.0 BMP6/BMPR2/BMPR1A-1B 0.071 0.139 -9999.0 0.0 -0.313 92.0 92.0 RGMA -0.051 0.197 -9999.0 0.0 -0.57 131.0 131.0 SMURF1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP -0.035 0.162 0.234 1.0 -0.41 118.0 119.0 BMP2-4/USAG1 -0.223 0.265 -9999.0 0.0 -0.444 561.0 561.0 SMAD6/SMURF1/SMAD5 -0.016 0.152 -9999.0 0.0 -0.441 66.0 66.0 SOSTDC1 -0.258 0.297 0.257 3.0 -0.57 493.0 496.0 BMP7/BMPR2/BMPR1A-1B 0.067 0.143 0.302 4.0 -0.323 91.0 95.0 SKI 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BMP6 (homodimer) -0.015 0.148 0.256 2.0 -0.57 69.0 71.0 HFE2 0.018 0.024 0.257 9.0 -9999.0 0.0 9.0 ZFYVE16 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/CHRD -0.045 0.198 -9999.0 0.0 -0.408 214.0 214.0 SMAD5/SMAD5/SMAD4 -0.016 0.151 -9999.0 0.0 -0.44 66.0 66.0 MAPK1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 TAK1/TAB family -0.021 0.149 -9999.0 0.0 -0.374 106.0 106.0 BMP7 (homodimer) -0.014 0.16 0.256 29.0 -0.57 75.0 104.0 NUP214 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BMP6/FETUA 0.002 0.116 0.195 16.0 -0.405 74.0 90.0 SMAD1/SKI 0.02 0.077 -9999.0 0.0 -0.423 12.0 12.0 SMAD6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTDSP2 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/FETUA -0.046 0.182 0.339 1.0 -0.393 210.0 211.0 MAP3K7IP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GREM1 0.037 0.098 0.257 94.0 -0.57 14.0 108.0 BMPR2 (homodimer) 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GADD34/PP1CA 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 BMPR1A-1B (homodimer) 0.086 0.11 -9999.0 0.0 -0.416 24.0 24.0 CHRDL1 -0.378 0.278 -9999.0 0.0 -0.57 703.0 703.0 ENDOFIN/SMAD1 0.019 0.079 -9999.0 0.0 -0.436 12.0 12.0 SMAD6-7/SMURF1/SMAD1 0.036 0.082 -9999.0 0.0 -0.417 12.0 12.0 SMAD6/SMURF1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BAMBI 0.015 0.112 0.257 38.0 -0.57 31.0 69.0 SMURF2 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/CHRDL1 -0.298 0.267 -9999.0 0.0 -0.459 703.0 703.0 BMP2-4/GREM1 -0.037 0.2 -9999.0 0.0 -0.4 218.0 218.0 SMAD7 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SMAD8A/SMAD8A/SMAD4 -0.08 0.25 -9999.0 0.0 -0.58 181.0 181.0 SMAD1/SMAD6 0.019 0.079 -9999.0 0.0 -0.431 13.0 13.0 TAK1/SMAD6 0.034 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BMP7 -0.014 0.16 0.257 29.0 -0.57 75.0 104.0 BMP6 -0.015 0.148 0.257 2.0 -0.57 69.0 71.0 MAP3K7IP2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 -0.033 0.165 -9999.0 0.0 -0.42 118.0 118.0 PPM1A 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SMAD1/SMURF2 0.018 0.076 -9999.0 0.0 -0.416 13.0 13.0 SMAD7/SMURF1 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTDSPL 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PPP1CA 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 XIAP 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CTDSP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PPP1R15A 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/FS -0.045 0.196 0.234 1.0 -0.472 127.0 128.0 CHRD 0.025 0.096 0.257 54.0 -0.57 19.0 73.0 BMPR2 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM -0.049 0.182 -9999.0 0.0 -0.478 117.0 117.0 BMP4 -0.011 0.14 0.257 1.0 -0.57 61.0 62.0 FST 0.002 0.114 0.257 4.0 -0.57 39.0 43.0 BMP2-4/NOG -0.049 0.189 0.339 1.0 -0.407 205.0 206.0 BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 0.071 0.14 0.298 4.0 -0.306 91.0 95.0