Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MET/RANBP9 -0.04 0.167 -9999.0 0.0 -0.415 169.0 169.0 CRKL -0.047 0.148 0.356 1.0 -0.424 74.0 75.0 mol:PIP3 0.002 0.06 0.566 1.0 -0.89 4.0 5.0 AKT1 0.01 0.075 0.368 3.0 -0.785 4.0 7.0 PTK2B 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 -0.046 0.141 0.337 1.0 -0.448 50.0 51.0 RANBP10 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET/SHIP2 -0.041 0.177 -9999.0 0.0 -0.388 204.0 204.0 MAP3K5 -0.04 0.146 0.36 1.0 -0.456 56.0 57.0 HGF/MET/CIN85/CBL/ENDOPHILINS -0.029 0.171 -9999.0 0.0 -0.356 210.0 210.0 AP1 -0.107 0.19 -9999.0 0.0 -0.396 292.0 292.0 mol:SU11274 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis -0.24 0.375 -9999.0 0.0 -0.767 338.0 338.0 STAT3 (dimer) -0.046 0.149 -9999.0 0.0 -0.346 166.0 166.0 GAB1/CRKL/SHP2/PI3K -0.018 0.152 -9999.0 0.0 -0.455 46.0 46.0 INPP5D 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CBL/CRK -0.036 0.145 0.342 1.0 -0.456 46.0 47.0 PTPN11 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GO:0007205 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLCG1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PTEN 0.023 0.019 -9999.0 0.0 -0.57 1.0 1.0 ELK1 -0.029 0.096 0.272 33.0 -0.211 132.0 165.0 mol:SU5416 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHP2/GRB2/SOS1GAB1 -0.026 0.092 -9999.0 0.0 -0.273 63.0 63.0 PAK1 0.023 0.087 0.362 7.0 -0.748 4.0 11.0 HGF/MET/RANBP10 -0.043 0.178 -9999.0 0.0 -0.385 211.0 211.0 HRAS -0.105 0.26 -9999.0 0.0 -0.639 184.0 184.0 DOCK1 -0.045 0.142 0.525 1.0 -0.409 70.0 71.0 GAB1 -0.049 0.155 -9999.0 0.0 -0.427 87.0 87.0 CRK -0.048 0.147 0.356 1.0 -0.424 74.0 75.0 mol:PHA665752 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.102 0.254 -9999.0 0.0 -0.575 219.0 219.0 JUN 0.02 0.045 -9999.0 0.0 -0.57 6.0 6.0 EntrezGene:200958 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.051 0.125 -9999.0 0.0 -0.286 213.0 213.0 PIK3R1 0.018 0.055 -9999.0 0.0 -0.57 9.0 9.0 cell morphogenesis -0.047 0.163 0.369 6.0 -0.448 82.0 88.0 GRB2/SHC -0.016 0.109 -9999.0 0.0 -0.284 118.0 118.0 FOS -0.142 0.266 -9999.0 0.0 -0.57 290.0 290.0 GLMN 0.003 0.001 -9999.0 0.0 -9999.0 0.0 0.0 cell motility -0.029 0.096 0.271 33.0 -0.211 132.0 165.0 HGF/MET/MUC20 -0.053 0.173 -9999.0 0.0 -0.384 214.0 214.0 cell migration -0.016 0.108 -9999.0 0.0 -0.28 118.0 118.0 GRB2 0.023 0.01 0.257 1.0 -9999.0 0.0 1.0 CBL 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MET/RANBP10 -0.042 0.167 -9999.0 0.0 -0.413 172.0 172.0 HGF/MET/Paxillin/FAK1/FAK12/RasGAP -0.046 0.139 -9999.0 0.0 -0.331 174.0 174.0 MET/MUC20 -0.055 0.161 -9999.0 0.0 -0.408 177.0 177.0 RAP1B -0.039 0.137 0.335 3.0 -0.438 44.0 47.0 RAP1A -0.044 0.135 0.413 2.0 -0.434 44.0 46.0 HGF/MET/RANBP9 -0.041 0.178 -9999.0 0.0 -0.388 206.0 206.0 RAF1 -0.097 0.245 -9999.0 0.0 -0.601 184.0 184.0 STAT3 -0.047 0.15 -9999.0 0.0 -0.35 166.0 166.0 cell proliferation -0.04 0.188 0.278 35.0 -0.427 152.0 187.0 RPS6KB1 -0.015 0.064 -9999.0 0.0 -0.218 40.0 40.0 MAPK3 -0.042 0.094 0.662 7.0 -9999.0 0.0 7.0 MAPK1 -0.011 0.175 0.681 52.0 -9999.0 0.0 52.0 RANBP9 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 -0.028 0.138 0.435 1.0 -0.444 46.0 47.0 SRC -0.051 0.129 0.203 1.0 -0.317 167.0 168.0 PI3K -0.026 0.128 -9999.0 0.0 -0.286 171.0 171.0 MET/Glomulin -0.047 0.145 -9999.0 0.0 -0.371 171.0 171.0 SOS1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 -0.089 0.228 0.468 1.0 -0.556 183.0 184.0 MET -0.073 0.219 -9999.0 0.0 -0.57 169.0 169.0 MAP4K1 -0.042 0.153 0.377 1.0 -0.476 58.0 59.0 PTK2 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K2 -0.089 0.228 0.468 1.0 -0.555 184.0 185.0 BAD 0.008 0.071 0.334 3.0 -0.748 4.0 7.0 MAP2K4 -0.036 0.133 0.344 1.0 -0.427 48.0 49.0 SHP2/GRB2/SOS1/GAB1 -0.039 0.174 -9999.0 0.0 -0.399 166.0 166.0 INPPL1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PXN 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 SH3KBP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 HGS -0.047 0.112 -9999.0 0.0 -0.269 197.0 197.0 PLCgamma1/PKC 0.017 0.004 -9999.0 0.0 -9999.0 0.0 0.0 HGF -0.01 0.139 0.257 2.0 -0.57 60.0 62.0 RASA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTPRJ 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK/PLCgamma1 -0.021 0.125 -9999.0 0.0 -0.266 199.0 199.0 PDPK1 0.013 0.078 0.425 1.0 -0.828 4.0 5.0 HGF/MET/SHIP -0.042 0.18 -9999.0 0.0 -0.388 212.0 212.0