ErbB4 signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations ErbB4/ErbB4/HBEGF/HBEGF 0.015 0.081 0.257 8.0 -0.278 8.0 16.0 epithelial cell differentiation 0.033 0.081 0.394 1.0 -0.367 7.0 8.0 ITCH 0.032 0.019 -9999.0 0.0 -9999.0 0.0 0.0 WWP1 0.022 0.098 0.468 8.0 -9999.0 0.0 8.0 FYN 0.022 0.027 -9999.0 0.0 -0.57 2.0 2.0 EGFR -0.191 0.285 -9999.0 0.0 -0.57 375.0 375.0 PRL 0.022 0.025 0.257 11.0 -9999.0 0.0 11.0 neuron projection morphogenesis -0.041 0.145 0.353 13.0 -0.353 39.0 52.0 PTPRZ1 -0.28 0.298 0.257 6.0 -0.57 533.0 539.0 ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC -0.053 0.14 -9999.0 0.0 -0.306 173.0 173.0 ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta -0.087 0.155 0.235 1.0 -0.325 285.0 286.0 ADAM17 0.032 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/ErbB4 -0.006 0.074 0.38 8.0 -0.298 6.0 14.0 ErbB4/ErbB4/neuregulin 3/neuregulin 3 0.0 0.109 0.258 7.0 -0.333 54.0 61.0 NCOR1 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn -0.08 0.15 -9999.0 0.0 -0.312 265.0 265.0 GRIN2B -0.098 0.157 0.241 6.0 -0.323 278.0 284.0 ErbB4/ErbB2/betacellulin 0.012 0.097 -9999.0 0.0 -0.299 46.0 46.0 STAT1 0.028 0.031 0.257 19.0 -9999.0 0.0 19.0 HBEGF 0.023 0.026 -9999.0 0.0 -0.57 2.0 2.0 PRLR 0.021 0.052 0.257 6.0 -0.57 7.0 13.0 E4ICDs/ETO2 0.007 0.088 0.273 6.0 -0.344 19.0 25.0 axon guidance 0.056 0.113 0.305 53.0 -0.325 6.0 59.0 NEDD4 0.03 0.018 -9999.0 0.0 -9999.0 0.0 0.0 Prolactin receptor/Prolactin receptor/Prolactin 0.031 0.041 -9999.0 0.0 -0.391 7.0 7.0 CBFA2T3 0.014 0.073 0.257 4.0 -0.57 15.0 19.0 ErbB4/ErbB2/HBEGF 0.03 0.072 -9999.0 0.0 -0.339 3.0 3.0 MAPK3 -0.048 0.139 0.342 4.0 -0.298 152.0 156.0 STAT1 (dimer) 0.019 0.081 0.26 10.0 -0.263 5.0 15.0 MAPK1 -0.047 0.142 0.362 5.0 -0.35 47.0 52.0 JAK2 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/ErbB2/neuregulin 1 beta -0.072 0.153 0.252 2.0 -0.314 249.0 251.0 NRG1 -0.104 0.193 0.163 2.0 -0.425 276.0 278.0 NRG3 -0.001 0.133 0.257 21.0 -0.57 51.0 72.0 NRG2 -0.262 0.297 -9999.0 0.0 -0.57 500.0 500.0 NRG4 0.027 0.028 0.257 15.0 -9999.0 0.0 15.0 heart development 0.056 0.113 0.305 53.0 -0.325 6.0 59.0 neural crest cell migration -0.071 0.152 0.251 2.0 -0.311 249.0 251.0 ERBB2 0.034 0.07 0.267 82.0 -0.415 1.0 83.0 WWOX/E4ICDs 0.011 0.076 0.259 5.0 -0.249 8.0 13.0 SHC1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/EGFR/neuregulin 4 -0.097 0.165 -9999.0 0.0 -0.314 288.0 288.0 apoptosis 0.013 0.125 0.421 54.0 -0.257 4.0 58.0 ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta -0.155 0.176 0.251 2.0 -0.326 488.0 490.0 ErbB4/ErbB2/epiregulin 0.005 0.132 0.305 21.0 -0.296 106.0 127.0 ErbB4/ErbB4/betacellulin/betacellulin -0.005 0.111 0.258 6.0 -0.324 62.0 68.0 ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 0.04 0.088 0.393 1.0 -0.377 8.0 9.0 MDM2 0.009 0.08 0.263 31.0 -0.264 5.0 36.0 ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta -0.083 0.146 -9999.0 0.0 -0.315 268.0 268.0 STAT5A 0.05 0.108 0.292 44.0 -0.324 8.0 52.0 ErbB4/EGFR/neuregulin 1 beta -0.185 0.23 -9999.0 0.0 -0.416 459.0 459.0 DLG4 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SHC 0.028 0.016 -9999.0 0.0 -9999.0 0.0 0.0 E4ICDs/TAB2/NCoR1 0.01 0.07 0.224 6.0 -0.24 6.0 12.0 STAT5A (dimer) 0.06 0.102 0.455 1.0 -0.392 7.0 8.0 MAP3K7IP2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT5B (dimer) 0.061 0.107 0.327 11.0 -0.321 7.0 18.0 LRIG1 0.022 0.032 -9999.0 0.0 -0.57 3.0 3.0 EREG -0.026 0.201 0.257 76.0 -0.57 115.0 191.0 BTC -0.008 0.135 0.257 2.0 -0.57 56.0 58.0 ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta 0.046 0.108 0.313 42.0 -0.327 6.0 48.0 ERBB4 -0.006 0.074 0.381 8.0 -0.299 6.0 14.0 STAT5B 0.022 0.027 -9999.0 0.0 -0.57 2.0 2.0 YAP1 -0.014 0.111 -9999.0 0.0 -0.389 74.0 74.0 GRB2 0.023 0.01 0.257 1.0 -9999.0 0.0 1.0 ErbB4/ErbB2/neuregulin 4 0.033 0.071 0.316 1.0 -0.413 1.0 2.0 glial cell differentiation -0.01 0.07 0.239 6.0 -0.222 6.0 12.0 WWOX 0.022 0.013 0.257 2.0 -9999.0 0.0 2.0 cell proliferation -0.039 0.171 0.349 15.0 -0.432 56.0 71.0