BCR signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations JUN 0.023 0.128 0.321 11.0 -0.386 38.0 49.0 IKBKB 0.024 0.089 0.294 10.0 -0.315 12.0 22.0 AKT1 0.039 0.106 0.257 90.0 -0.241 19.0 109.0 IKBKG 0.027 0.073 0.304 6.0 -0.308 5.0 11.0 CALM1 0.001 0.096 0.255 1.0 -0.443 17.0 18.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K1 0.023 0.159 0.372 11.0 -0.518 44.0 55.0 MAP3K7 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.002 0.101 -9999.0 0.0 -0.359 41.0 41.0 DOK1 0.025 0.015 0.257 4.0 -9999.0 0.0 4.0 AP-1 -0.021 0.098 0.27 5.0 -0.248 50.0 55.0 LYN 0.021 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BLNK 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BCR complex 0.005 0.156 0.365 19.0 -0.443 92.0 111.0 CD22 -0.012 0.132 0.278 20.0 -0.438 63.0 83.0 CAMK2G 0.003 0.095 0.296 1.0 -0.416 17.0 18.0 CSNK2A1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 INPP5D 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SHC/GRB2/SOS1 0.002 0.086 -9999.0 0.0 -0.327 52.0 52.0 GO:0007205 0.002 0.103 -9999.0 0.0 -0.365 41.0 41.0 SYK 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ELK1 0.002 0.1 0.256 1.0 -0.435 19.0 20.0 NFATC1 0.03 0.133 0.3 24.0 -0.442 34.0 58.0 B-cell antigen/BCR complex 0.005 0.156 0.365 19.0 -0.443 92.0 111.0 PAG1/CSK 0.03 0.016 -9999.0 0.0 -9999.0 0.0 0.0 NFKBIB 0.023 0.049 0.156 14.0 -0.126 29.0 43.0 HRAS 0.011 0.107 0.264 13.0 -0.353 37.0 50.0 NFKBIA 0.023 0.048 0.154 15.0 -0.121 29.0 44.0 NF-kappa-B/RelA/I kappa B beta 0.027 0.043 0.166 11.0 -9999.0 0.0 11.0 RasGAP/Csk 0.032 0.123 0.326 20.0 -0.36 66.0 86.0 mol:GDP 0.004 0.099 -9999.0 0.0 -0.421 20.0 20.0 PTEN 0.023 0.019 -9999.0 0.0 -0.57 1.0 1.0 CD79B 0.012 0.099 0.257 19.0 -0.57 26.0 45.0 NF-kappa-B/RelA/I kappa B alpha 0.027 0.042 0.166 11.0 -9999.0 0.0 11.0 GRB2 0.023 0.01 0.257 1.0 -9999.0 0.0 1.0 PI3K/BCAP/CD19 0.023 0.163 0.351 11.0 -0.493 49.0 60.0 PIK3R1 0.018 0.055 -9999.0 0.0 -0.57 9.0 9.0 mol:IP3 0.002 0.102 -9999.0 0.0 -0.362 44.0 44.0 CSK 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 FOS -0.077 0.155 -9999.0 0.0 -0.433 79.0 79.0 CHUK 0.024 0.081 0.306 6.0 -0.312 16.0 22.0 IBTK 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CARD11/BCL10/MALT1/TAK1 0.019 0.096 -9999.0 0.0 -0.408 17.0 17.0 PTPN6 -0.014 0.125 0.291 8.0 -0.563 31.0 39.0 RELA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BCL2A1 0.024 0.036 0.168 9.0 -9999.0 0.0 9.0 VAV2 0.014 0.142 0.292 8.0 -0.57 30.0 38.0 ubiquitin-dependent protein catabolic process 0.025 0.048 0.157 14.0 -0.121 38.0 52.0 BTK 0.015 0.062 -9999.0 0.0 -0.967 4.0 4.0 CD19 0.005 0.135 0.271 31.0 -0.426 61.0 92.0 MAP4K1 0.032 0.054 0.257 43.0 -0.57 2.0 45.0 CD72 0.03 0.042 0.257 28.0 -0.57 1.0 29.0 PAG1 0.021 0.014 0.257 2.0 -9999.0 0.0 2.0 MAPK14 0.025 0.141 0.353 14.0 -0.442 42.0 56.0 SH3BP5 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIK3AP1 0.003 0.107 -9999.0 0.0 -0.441 27.0 27.0 B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 0.003 0.134 0.265 3.0 -0.421 71.0 74.0 RAF1 0.01 0.102 0.278 7.0 -0.415 18.0 25.0 RasGAP/p62DOK/SHIP 0.032 0.119 0.298 19.0 -0.351 66.0 85.0 CD79A -0.003 0.173 0.257 78.0 -0.57 78.0 156.0 re-entry into mitotic cell cycle -0.021 0.097 0.265 5.0 -0.248 48.0 53.0 RASA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 0.018 0.097 0.272 25.0 -0.368 13.0 38.0 MAPK1 0.01 0.09 0.267 7.0 -0.36 16.0 23.0 CD72/SHP1 0.029 0.145 0.355 26.0 -0.543 30.0 56.0 NFKB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 0.023 0.144 0.348 16.0 -0.443 44.0 60.0 actin cytoskeleton organization 0.031 0.138 0.312 26.0 -0.496 29.0 55.0 NF-kappa-B/RelA 0.055 0.082 0.285 13.0 -0.213 1.0 14.0 Calcineurin 0.019 0.092 -9999.0 0.0 -0.394 15.0 15.0 PI3K -0.013 0.095 -9999.0 0.0 -0.44 27.0 27.0 B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 0.006 0.111 -9999.0 0.0 -0.393 47.0 47.0 SOS1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Bam32/HPK1 0.012 0.199 0.441 5.0 -0.704 49.0 54.0 DAPP1 -0.017 0.203 -9999.0 0.0 -0.784 51.0 51.0 cytokine secretion 0.031 0.126 0.284 30.0 -0.41 34.0 64.0 mol:DAG 0.002 0.102 -9999.0 0.0 -0.362 44.0 44.0 PLCG2 0.02 0.028 0.257 1.0 -0.57 2.0 3.0 MAP2K1 0.01 0.097 0.276 8.0 -0.4 16.0 24.0 B-cell antigen/BCR complex/FcgammaRIIB 0.016 0.132 0.339 19.0 -0.412 67.0 86.0 mol:PI-3-4-5-P3 0.005 0.09 0.219 18.0 -0.326 23.0 41.0 ETS1 0.001 0.089 0.283 1.0 -0.399 18.0 19.0 B-cell antigen/BCR complex/LYN/SYK/BLNK 0.034 0.126 0.328 20.0 -0.357 71.0 91.0 B-cell antigen/BCR complex/LYN -0.011 0.134 0.296 5.0 -0.445 66.0 71.0 MALT1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 TRAF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.024 0.141 0.305 23.0 -0.533 29.0 52.0 B-cell antigen/BCR complex/LYN/SYK 0.014 0.141 0.349 21.0 -0.438 57.0 78.0 CARD11 0.004 0.104 0.279 3.0 -0.459 19.0 22.0 FCGR2B 0.018 0.038 0.257 1.0 -0.57 4.0 5.0 PPP3CA 0.024 0.011 0.257 2.0 -9999.0 0.0 2.0 BCL10 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IKK complex 0.027 0.051 0.156 51.0 -0.136 4.0 55.0 PTPRC 0.021 0.041 0.257 11.0 -0.57 3.0 14.0 PDPK1 0.019 0.082 0.213 52.0 -0.228 19.0 71.0 PPP3CB 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PPP3CC 0.02 0.01 -9999.0 0.0 -9999.0 0.0 0.0 POU2F2 0.021 0.034 0.175 10.0 -9999.0 0.0 10.0