Integrins in angiogenesis Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR2 homodimer/VEGFA homodimer 0.034 0.033 -9999.0 0.0 -0.418 4.0 4.0 alphaV beta3 Integrin -0.118 0.209 -9999.0 0.0 -0.379 389.0 389.0 PTK2 -0.056 0.154 0.324 2.0 -0.515 43.0 45.0 IGF1R 0.013 0.08 0.257 2.0 -0.57 19.0 21.0 PI4KB 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MFGE8 0.018 0.066 0.257 6.0 -0.57 12.0 18.0 SRC 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDKN1B -0.044 0.123 -9999.0 0.0 -0.533 34.0 34.0 VEGFA 0.025 0.02 0.257 7.0 -9999.0 0.0 7.0 ILK -0.042 0.116 -9999.0 0.0 -0.499 31.0 31.0 ROCK1 0.023 0.019 -9999.0 0.0 -0.57 1.0 1.0 AKT1 -0.043 0.105 -9999.0 0.0 -0.496 27.0 27.0 PTK2B -0.014 0.071 0.358 2.0 -0.336 33.0 35.0 alphaV/beta3 Integrin/JAM-A -0.076 0.176 0.299 1.0 -0.332 286.0 287.0 CBL 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV beta3 Integrin/ANGPTL3 0.031 0.075 -9999.0 0.0 -0.365 34.0 34.0 IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.043 0.193 -9999.0 0.0 -0.381 234.0 234.0 VEGF/Rho/ROCK/alphaV/beta3 Integrin 0.013 0.069 -9999.0 0.0 -0.442 10.0 10.0 alphaV/beta3 Integrin/Syndecan-1 0.042 0.083 -9999.0 0.0 -0.358 34.0 34.0 PI4KA 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/IRS1 -0.14 0.27 -9999.0 0.0 -0.458 342.0 342.0 PI4 Kinase 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Osteopontin 0.069 0.102 0.339 3.0 -0.354 34.0 37.0 RPS6KB1 -0.156 0.223 0.424 3.0 -0.548 177.0 180.0 TLN1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 -0.198 0.291 -9999.0 0.0 -0.577 337.0 337.0 GPR124 0.016 0.049 -9999.0 0.0 -0.57 7.0 7.0 MAPK1 -0.204 0.294 -9999.0 0.0 -0.579 351.0 351.0 PXN 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.018 0.055 -9999.0 0.0 -0.57 9.0 9.0 alphaV/beta3 Integrin/Tumstatin -0.033 0.166 -9999.0 0.0 -0.372 195.0 195.0 cell adhesion 0.023 0.084 0.256 1.0 -0.364 43.0 44.0 ANGPTL3 0.021 0.016 0.257 4.0 -9999.0 0.0 4.0 VEGFR2 homodimer/VEGFA homodimer/Src 0.045 0.03 -9999.0 0.0 -0.364 3.0 3.0 IGF-1R heterotetramer 0.013 0.08 0.256 2.0 -0.57 19.0 21.0 Rac1/GDP 0.018 0.003 -9999.0 0.0 -9999.0 0.0 0.0 TGFBR2 0.002 0.112 -9999.0 0.0 -0.57 38.0 38.0 ITGB3 0.005 0.107 0.257 4.0 -0.57 34.0 38.0 IGF1 -0.103 0.244 -9999.0 0.0 -0.57 222.0 222.0 RAC1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-matrix adhesion 0.024 0.08 -9999.0 0.0 -0.395 31.0 31.0 apoptosis 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CD47 0.024 0.019 -9999.0 0.0 -0.57 1.0 1.0 alphaV/beta3 Integrin/CD47 0.033 0.075 -9999.0 0.0 -0.363 34.0 34.0 VCL 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Del1 0.014 0.135 -9999.0 0.0 -0.464 68.0 68.0 CSF1 0.021 0.041 -9999.0 0.0 -0.57 5.0 5.0 PIK3C2A -0.041 0.114 -9999.0 0.0 -0.497 28.0 28.0 PI4 Kinase/Pyk2 -0.077 0.15 -9999.0 0.0 -0.517 24.0 24.0 VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.044 0.081 -9999.0 0.0 -0.366 34.0 34.0 FAK1/Vinculin -0.037 0.134 0.337 4.0 -0.412 39.0 43.0 alphaV beta3/Integrin/ppsTEM5 0.025 0.081 -9999.0 0.0 -0.397 31.0 31.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VTN 0.033 0.078 0.257 66.0 -0.57 8.0 74.0 BCAR1 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0 FGF2 -0.201 0.288 -9999.0 0.0 -0.57 393.0 393.0 F11R -0.115 0.194 -9999.0 0.0 -0.422 297.0 297.0 alphaV/beta3 Integrin/Lactadherin 0.029 0.09 0.339 1.0 -0.384 43.0 44.0 alphaV/beta3 Integrin/TGFBR2 0.021 0.118 -9999.0 0.0 -0.462 53.0 53.0 alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.05 0.037 -9999.0 0.0 -0.331 5.0 5.0 HSP90AA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Talin 0.032 0.068 -9999.0 0.0 -0.331 33.0 33.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FN1 0.116 0.114 0.257 411.0 -9999.0 0.0 411.0 alphaV/beta3 Integrin/Pyk2 0.026 0.074 -9999.0 0.0 -0.336 34.0 34.0 SDC1 0.039 0.061 0.257 68.0 -0.57 1.0 69.0 VAV3 -0.011 0.042 -9999.0 0.0 -0.316 12.0 12.0 PTPN11 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IRS1 0.001 0.114 -9999.0 0.0 -0.57 40.0 40.0 FAK1/Paxillin -0.037 0.135 0.337 4.0 -0.411 40.0 44.0 cell migration -0.036 0.123 0.304 6.0 -0.38 36.0 42.0 ITGAV 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.066 0.171 -9999.0 0.0 -0.325 249.0 249.0 SPP1 0.086 0.103 0.257 276.0 -9999.0 0.0 276.0 KDR 0.022 0.037 -9999.0 0.0 -0.57 4.0 4.0 mol:PI-4-5-P2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Caspase 8 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 COL4A3 -0.076 0.223 0.257 4.0 -0.57 175.0 179.0 angiogenesis -0.186 0.298 -9999.0 0.0 -0.581 322.0 322.0 Rac1/GTP 0.021 0.039 -9999.0 0.0 -0.292 11.0 11.0 EDIL3 -0.006 0.139 0.257 15.0 -0.57 57.0 72.0 cell proliferation 0.02 0.118 -9999.0 0.0 -0.46 53.0 53.0