Arf6 signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CENTA1/KIF3B 0.027 0.029 -9999.0 0.0 -0.394 3.0 3.0 ARNO/beta Arrestin1-2 -0.064 0.163 -9999.0 0.0 -0.549 44.0 44.0 EGFR -0.191 0.285 -9999.0 0.0 -0.571 375.0 375.0 EPHA2 0.021 0.041 -9999.0 0.0 -0.57 5.0 5.0 USP6 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IQSEC1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.207 0.256 -9999.0 0.0 -0.457 506.0 506.0 ARRB2 -0.043 0.13 -9999.0 0.0 -0.361 146.0 146.0 mol:GTP 0.011 0.049 0.139 31.0 -0.196 21.0 52.0 ARRB1 0.021 0.027 -9999.0 0.0 -0.57 2.0 2.0 FBXO8 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 TSHR 0.001 0.115 0.256 4.0 -0.571 40.0 44.0 EGF -0.082 0.228 0.257 2.0 -0.571 186.0 188.0 somatostatin receptor activity -0.0 0.0 0.001 1.0 -0.001 281.0 282.0 ARAP2 0.021 0.041 -9999.0 0.0 -0.571 5.0 5.0 mol:GDP -0.117 0.16 -9999.0 0.0 -0.318 300.0 300.0 mol:PI-3-4-5-P3 -0.0 0.0 -9999.0 0.0 -0.001 174.0 174.0 ITGA2B 0.033 0.061 0.257 52.0 -0.571 3.0 55.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.045 0.039 -9999.0 0.0 -0.331 5.0 5.0 ADAP1 0.025 0.028 0.257 8.0 -0.571 1.0 9.0 KIF13B 0.019 0.028 -9999.0 0.0 -0.57 2.0 2.0 HGF/MET -0.064 0.2 -9999.0 0.0 -0.447 214.0 214.0 PXN 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.115 0.131 0.186 1.0 -0.279 312.0 313.0 EGFR/EGFR/EGF/EGF/ARFGEP100 -0.17 0.231 -9999.0 0.0 -0.4 495.0 495.0 ADRB2 -0.102 0.243 -9999.0 0.0 -0.571 220.0 220.0 receptor agonist activity -0.0 0.0 0.0 1.0 -0.0 280.0 281.0 actin filament binding -0.0 0.0 0.0 2.0 -0.001 285.0 287.0 SRC 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ITGB3 0.005 0.107 0.257 4.0 -0.571 34.0 38.0 GNAQ 0.023 0.026 -9999.0 0.0 -0.571 2.0 2.0 EFA6/PI-4-5-P2 -0.0 0.0 0.001 1.0 -0.001 166.0 167.0 ARF6/GDP -0.038 0.149 0.253 2.0 -0.435 89.0 91.0 ARF6/GDP/GULP/ACAP1 -0.109 0.185 -9999.0 0.0 -0.401 214.0 214.0 alphaIIb/beta3 Integrin/paxillin/GIT1 0.05 0.081 -9999.0 0.0 -0.329 37.0 37.0 ACAP1 0.028 0.065 0.257 42.0 -0.571 6.0 48.0 ACAP2 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LHCGR/beta Arrestin2 -0.058 0.174 -9999.0 0.0 -0.486 146.0 146.0 EFNA1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 HGF -0.01 0.139 0.257 2.0 -0.571 60.0 62.0 CYTH3 0.004 0.013 -9999.0 0.0 -0.421 1.0 1.0 CYTH2 0.007 0.096 -9999.0 0.0 -1.015 9.0 9.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 fibronectin binding -0.0 0.0 0.0 1.0 -0.0 228.0 229.0 endosomal lumen acidification -0.0 0.0 0.001 5.0 -0.0 261.0 266.0 microtubule-based process 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GULP1 -0.013 0.144 -9999.0 0.0 -0.57 65.0 65.0 GNAQ/ARNO 0.019 0.092 -9999.0 0.0 -0.95 9.0 9.0 mol:Phosphatidic acid -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP3-E -0.0 0.0 -9999.0 0.0 -0.0 223.0 223.0 MET -0.073 0.219 -9999.0 0.0 -0.571 169.0 169.0 GNA14 0.022 0.066 0.257 19.0 -0.571 10.0 29.0 GNA15 0.025 0.026 0.257 6.0 -0.571 1.0 7.0 GIT1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.0 0.0 0.001 1.0 -0.001 228.0 229.0 GNA11 0.023 0.026 -9999.0 0.0 -0.571 2.0 2.0 LHCGR -0.069 0.203 -9999.0 0.0 -0.571 146.0 146.0 AGTR1 -0.095 0.26 0.257 62.0 -0.571 231.0 293.0 desensitization of G-protein coupled receptor protein signaling pathway -0.058 0.173 -9999.0 0.0 -0.484 146.0 146.0 IPCEF1/ARNO -0.131 0.192 -9999.0 0.0 -0.588 64.0 64.0 alphaIIb/beta3 Integrin 0.026 0.092 -9999.0 0.0 -0.416 37.0 37.0