Endothelins Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations AKT1 -0.073 0.133 -9999.0 0.0 -0.428 94.0 94.0 PTK2B 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.052 0.192 -9999.0 0.0 -0.784 47.0 47.0 EDN1 -0.074 0.166 -9999.0 0.0 -0.545 94.0 94.0 EDN3 -0.225 0.291 0.257 2.0 -0.57 430.0 432.0 EDN2 0.074 0.107 0.257 236.0 -0.57 5.0 241.0 HRAS/GDP -0.093 0.194 0.277 1.0 -0.465 157.0 158.0 ETA receptor/Endothelin-1/Gq/GTP/PLC beta -0.061 0.142 -9999.0 0.0 -0.393 108.0 108.0 ADCY4 -0.13 0.199 0.282 2.0 -0.424 271.0 273.0 ADCY5 -0.212 0.243 -9999.0 0.0 -0.449 456.0 456.0 ADCY6 -0.121 0.185 0.282 2.0 -0.404 262.0 264.0 ADCY7 -0.118 0.184 0.282 2.0 -0.399 262.0 264.0 ADCY1 -0.12 0.197 0.265 1.0 -0.414 262.0 263.0 ADCY2 -0.136 0.218 0.288 7.0 -0.449 278.0 285.0 ADCY3 -0.121 0.184 0.265 1.0 -0.404 261.0 262.0 ADCY8 -0.103 0.172 0.273 2.0 -0.408 199.0 201.0 ADCY9 -0.115 0.18 0.265 1.0 -0.399 250.0 251.0 arachidonic acid secretion -0.162 0.272 0.306 2.0 -0.501 341.0 343.0 ETB receptor/Endothelin-1/Gq/GTP -0.05 0.149 -9999.0 0.0 -0.346 165.0 165.0 GNAO1 0.018 0.09 0.257 32.0 -0.57 19.0 51.0 HRAS 0.025 0.021 0.256 8.0 -9999.0 0.0 8.0 ETA receptor/Endothelin-1/G12/GTP -0.059 0.133 -9999.0 0.0 -0.402 91.0 91.0 ETA receptor/Endothelin-1/Gs/GTP -0.123 0.197 -9999.0 0.0 -0.421 263.0 263.0 mol:GTP -0.002 0.005 -9999.0 0.0 -9999.0 0.0 0.0 COL3A1 -0.064 0.153 0.37 10.0 -0.436 92.0 102.0 EDNRB -0.027 0.171 -9999.0 0.0 -0.569 93.0 93.0 response to oxidative stress -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYSLTR2 -0.077 0.159 -9999.0 0.0 -0.491 100.0 100.0 CYSLTR1 -0.08 0.156 -9999.0 0.0 -0.488 97.0 97.0 SLC9A1 -0.045 0.093 -9999.0 0.0 -0.292 90.0 90.0 mol:GDP -0.104 0.205 0.333 2.0 -0.488 165.0 167.0 SLC9A3 -0.109 0.279 -9999.0 0.0 -0.64 183.0 183.0 RAF1 -0.138 0.234 0.326 1.0 -0.454 292.0 293.0 JUN -0.05 0.183 -9999.0 0.0 -0.777 40.0 40.0 JAK2 -0.071 0.134 -9999.0 0.0 -0.424 97.0 97.0 mol:IP3 -0.074 0.166 -9999.0 0.0 -0.435 127.0 127.0 ETA receptor/Endothelin-1 -0.083 0.16 -9999.0 0.0 -0.485 101.0 101.0 PLCB1 -0.017 0.147 -9999.0 0.0 -0.573 68.0 68.0 PLCB2 0.014 0.026 0.257 1.0 -0.572 1.0 2.0 ETA receptor/Endothelin-3 -0.19 0.213 -9999.0 0.0 -0.433 440.0 440.0 FOS -0.286 0.44 -9999.0 0.0 -0.93 321.0 321.0 Gai/GDP -0.098 0.294 -9999.0 0.0 -0.746 159.0 159.0 CRK 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca ++ -0.108 0.202 0.275 1.0 -0.536 137.0 138.0 BCAR1 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PRKCB1 -0.077 0.163 -9999.0 0.0 -0.413 141.0 141.0 GNAQ 0.014 0.032 -9999.0 0.0 -0.579 2.0 2.0 GNAZ 0.018 0.055 -9999.0 0.0 -0.57 9.0 9.0 GNAL -0.108 0.246 -9999.0 0.0 -0.57 229.0 229.0 Gs family/GDP -0.149 0.235 -9999.0 0.0 -0.487 267.0 267.0 ETA receptor/Endothelin-1/Gq/GTP -0.047 0.12 -9999.0 0.0 -0.359 88.0 88.0 MAPK14 -0.066 0.158 -9999.0 0.0 -0.403 138.0 138.0 TRPC6 -0.056 0.207 -9999.0 0.0 -0.873 44.0 44.0 GNAI2 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GNAI3 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GNAI1 -0.005 0.13 -9999.0 0.0 -0.57 52.0 52.0 ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.066 0.167 -9999.0 0.0 -0.39 165.0 165.0 ETB receptor/Endothelin-2 0.024 0.154 0.242 16.0 -0.388 103.0 119.0 ETB receptor/Endothelin-3 -0.191 0.245 -9999.0 0.0 -0.439 493.0 493.0 ETB receptor/Endothelin-1 -0.078 0.182 -9999.0 0.0 -0.462 166.0 166.0 MAPK3 -0.246 0.382 -9999.0 0.0 -0.789 325.0 325.0 MAPK1 -0.254 0.393 -9999.0 0.0 -0.803 329.0 329.0 Rac1/GDP -0.094 0.193 0.277 1.0 -0.463 158.0 159.0 cAMP biosynthetic process -0.156 0.218 0.527 1.0 -0.487 242.0 243.0 MAPK8 -0.059 0.209 -9999.0 0.0 -0.724 63.0 63.0 SRC 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ETB receptor/Endothelin-1/Gi/GTP -0.067 0.167 -9999.0 0.0 -0.373 185.0 185.0 p130Cas/CRK/Src/PYK2 -0.097 0.214 0.491 1.0 -0.562 126.0 127.0 mol:K + 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 G12/GDP -0.093 0.192 0.277 1.0 -0.475 147.0 148.0 COL1A2 -0.088 0.194 0.376 9.0 -0.478 148.0 157.0 EntrezGene:2778 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ETA receptor/Endothelin-2 0.022 0.095 0.255 13.0 -0.349 10.0 23.0 mol:DAG -0.074 0.166 -9999.0 0.0 -0.435 127.0 127.0 MAP2K2 -0.188 0.296 0.344 2.0 -0.591 330.0 332.0 MAP2K1 -0.187 0.293 0.324 2.0 -0.584 332.0 334.0 EDNRA -0.034 0.064 0.285 1.0 -0.28 20.0 21.0 positive regulation of muscle contraction -0.063 0.116 -9999.0 0.0 -0.382 89.0 89.0 Gq family/GDP -0.058 0.191 -9999.0 0.0 -0.467 115.0 115.0 HRAS/GTP -0.101 0.2 0.34 1.0 -0.466 169.0 170.0 PRKCH -0.076 0.163 -9999.0 0.0 -0.427 126.0 126.0 RAC1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PRKCA -0.072 0.178 0.284 3.0 -0.452 131.0 134.0 PRKCB -0.074 0.175 0.24 1.0 -0.443 129.0 130.0 PRKCE -0.079 0.163 -9999.0 0.0 -0.429 130.0 130.0 PRKCD -0.076 0.161 -9999.0 0.0 -0.424 127.0 127.0 PRKCG -0.077 0.166 0.273 1.0 -0.434 128.0 129.0 regulation of vascular smooth muscle contraction -0.337 0.512 -9999.0 0.0 -1.084 322.0 322.0 PRKCQ -0.085 0.183 -9999.0 0.0 -0.459 146.0 146.0 PLA2G4A -0.179 0.304 0.329 1.0 -0.551 341.0 342.0 GNA14 0.014 0.069 0.254 19.0 -0.577 10.0 29.0 GNA15 0.022 0.027 0.255 6.0 -0.571 1.0 7.0 GNA12 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GNA11 0.02 0.028 -9999.0 0.0 -0.571 2.0 2.0 Rac1/GTP -0.059 0.133 -9999.0 0.0 -0.395 95.0 95.0 MMP1 0.171 0.128 0.41 70.0 -9999.0 0.0 70.0