E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.019 0.111 -9999.0 0.0 -0.411 42.0 42.0 KLHL20 0.015 0.065 0.227 11.0 -0.223 13.0 24.0 CYFIP2 0.028 0.049 0.257 27.0 -0.57 3.0 30.0 Rac1/GDP 0.001 0.085 0.26 8.0 -0.308 19.0 27.0 ENAH -0.015 0.104 -9999.0 0.0 -0.401 41.0 41.0 AP1M1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.009 0.048 -9999.0 0.0 -0.407 1.0 1.0 ABI1/Sra1/Nap1 -0.012 0.032 -9999.0 0.0 -0.165 8.0 8.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.047 0.067 -9999.0 0.0 -0.334 21.0 21.0 RAPGEF1 -0.018 0.106 0.258 2.0 -0.397 30.0 32.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.021 0.123 -9999.0 0.0 -0.41 53.0 53.0 CRK -0.016 0.101 -9999.0 0.0 -0.411 35.0 35.0 E-cadherin/gamma catenin/alpha catenin 0.032 0.06 -9999.0 0.0 -0.364 19.0 19.0 alphaE/beta7 Integrin 0.036 0.034 -9999.0 0.0 -0.422 2.0 2.0 IQGAP1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.04 0.027 -9999.0 0.0 -0.332 3.0 3.0 DLG1 -0.023 0.117 -9999.0 0.0 -0.405 49.0 49.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.017 0.031 -9999.0 0.0 -0.222 3.0 3.0 MLLT4 0.021 0.033 0.257 1.0 -0.571 3.0 4.0 ARF6/GTP/NME1/Tiam1 0.044 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.003 0.045 -9999.0 0.0 -0.29 3.0 3.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.021 0.065 -9999.0 0.0 -0.337 29.0 29.0 TIAM1 0.025 0.015 0.257 4.0 -9999.0 0.0 4.0 E-cadherin(dimer)/Ca2+ 0.041 0.056 -9999.0 0.0 -0.315 19.0 19.0 AKT1 -0.007 0.035 -9999.0 0.0 -0.211 1.0 1.0 PIK3R1 0.018 0.055 -9999.0 0.0 -0.57 9.0 9.0 CDH1 0.011 0.08 -9999.0 0.0 -0.57 19.0 19.0 RhoA/GDP 0.001 0.085 0.259 8.0 -0.311 18.0 26.0 actin cytoskeleton organization 0.014 0.053 0.186 20.0 -0.164 12.0 32.0 CDC42/GDP 0.001 0.083 0.259 8.0 -0.311 18.0 26.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.008 0.043 -9999.0 0.0 -0.266 20.0 20.0 ITGB7 0.029 0.046 0.257 28.0 -0.57 2.0 30.0 RAC1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.044 0.06 -9999.0 0.0 -0.334 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.03 0.052 -9999.0 0.0 -0.313 19.0 19.0 mol:GDP -0.013 0.091 0.267 8.0 -0.353 20.0 28.0 CDC42/GTP/IQGAP1 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.006 0.087 0.262 7.0 -0.318 18.0 25.0 RAC1/GTP/IQGAP1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.013 0.047 0.176 37.0 -0.231 5.0 42.0 NME1 0.026 0.031 0.257 17.0 -9999.0 0.0 17.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.021 0.115 -9999.0 0.0 -0.411 46.0 46.0 regulation of cell-cell adhesion 0.003 0.04 -9999.0 0.0 -0.284 2.0 2.0 WASF2 0.007 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.013 0.058 0.239 2.0 -0.279 17.0 19.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.053 0.067 -9999.0 0.0 -0.318 21.0 21.0 CCND1 0.014 0.055 0.202 34.0 -0.29 5.0 39.0 VAV2 -0.019 0.149 -9999.0 0.0 -0.541 39.0 39.0 RAP1/GDP 0.007 0.07 0.264 3.0 -0.286 17.0 20.0 adherens junction assembly -0.021 0.112 -9999.0 0.0 -0.398 46.0 46.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.041 0.063 -9999.0 0.0 -0.308 21.0 21.0 E-cadherin/beta catenin 0.001 0.06 -9999.0 0.0 -0.344 29.0 29.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.022 0.117 -9999.0 0.0 -0.4 51.0 51.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.005 0.089 0.256 31.0 -0.338 25.0 56.0 E-cadherin/beta catenin/alpha catenin 0.034 0.06 -9999.0 0.0 -0.364 19.0 19.0 ITGAE 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.021 0.125 -9999.0 0.0 -0.418 53.0 53.0