Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.015 0.14 0.424 81.0 -0.245 2.0 83.0 KIRREL -0.023 0.163 -9999.0 0.0 -0.575 83.0 83.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.015 0.14 0.245 2.0 -0.424 81.0 83.0 PLCG1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.034 0.118 0.286 4.0 -0.322 80.0 84.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.008 0.088 0.237 1.0 -0.281 68.0 69.0 FYN 0.014 0.129 0.28 98.0 -0.309 79.0 177.0 mol:Ca2+ 0.031 0.113 0.28 3.0 -0.32 75.0 78.0 mol:DAG 0.033 0.114 0.284 3.0 -0.321 75.0 78.0 NPHS2 0.014 0.031 0.265 4.0 -9999.0 0.0 4.0 mol:IP3 0.033 0.114 0.284 3.0 -0.321 75.0 78.0 regulation of endocytosis 0.024 0.105 0.245 4.0 -0.292 79.0 83.0 Nephrin/NEPH1/podocin/Cholesterol 0.024 0.113 0.251 9.0 -0.32 80.0 89.0 establishment of cell polarity 0.015 0.14 0.245 2.0 -0.424 81.0 83.0 Nephrin/NEPH1/podocin/NCK1-2 0.044 0.114 0.319 1.0 -0.298 78.0 79.0 Nephrin/NEPH1/beta Arrestin2 0.027 0.107 0.254 4.0 -0.296 79.0 83.0 NPHS1 0.06 0.091 0.259 164.0 -9999.0 0.0 164.0 Nephrin/NEPH1/podocin 0.025 0.111 0.304 4.0 -0.31 79.0 83.0 TJP1 0.023 0.019 -9999.0 0.0 -0.57 1.0 1.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.034 0.115 0.289 3.0 -0.323 75.0 78.0 CD2AP 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.032 0.116 0.295 5.0 -0.322 77.0 82.0 GRB2 0.023 0.01 0.257 1.0 -9999.0 0.0 1.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.013 0.134 0.287 97.0 -0.31 85.0 182.0 cytoskeleton organization 0.004 0.108 0.27 17.0 -0.333 64.0 81.0 Nephrin/NEPH1 0.016 0.104 0.2 2.0 -0.301 81.0 83.0 Nephrin/NEPH1/ZO-1 0.026 0.121 -9999.0 0.0 -0.347 81.0 81.0