Thromboxane A2 receptor signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGM2 0.027 0.028 0.258 15.0 -9999.0 0.0 15.0 GNB1/GNG2 -0.016 0.048 -9999.0 0.0 -0.193 62.0 62.0 AKT1 0.024 0.093 0.324 15.0 -0.325 13.0 28.0 EGF -0.082 0.228 0.257 2.0 -0.57 186.0 188.0 mol:TXA2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FGR 0.014 0.058 0.25 2.0 -0.295 5.0 7.0 mol:Ca2+ 0.022 0.114 0.383 14.0 -0.304 70.0 84.0 LYN 0.012 0.054 0.25 2.0 -0.324 2.0 4.0 RhoA/GTP 0.009 0.045 0.133 4.0 -0.139 22.0 26.0 mol:PGI2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SYK 0.02 0.121 0.393 15.0 -0.348 61.0 76.0 GNG2 0.018 0.058 -9999.0 0.0 -0.571 10.0 10.0 ARRB2 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 TP alpha/Gq family/GDP/G beta5/gamma2 -0.007 0.123 -9999.0 0.0 -0.589 36.0 36.0 G beta5/gamma2 -0.012 0.067 -9999.0 0.0 -0.258 62.0 62.0 PRKCH 0.018 0.123 0.382 15.0 -0.357 63.0 78.0 DNM1 0.02 0.049 0.257 1.0 -0.57 7.0 8.0 TXA2/TP beta/beta Arrestin3 0.008 0.032 -9999.0 0.0 -0.53 1.0 1.0 mol:GTP 0.001 0.001 -9999.0 0.0 -9999.0 0.0 0.0 PTGDR 0.008 0.102 0.257 7.0 -0.571 30.0 37.0 G12 family/GTP 0.0 0.089 -9999.0 0.0 -0.308 58.0 58.0 ADRBK1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK2 0.021 0.037 -9999.0 0.0 -0.571 4.0 4.0 RhoA/GTP/ROCK1 0.031 0.015 -9999.0 0.0 -0.361 1.0 1.0 mol:GDP -0.012 0.099 0.358 33.0 -0.328 9.0 42.0 mol:NADP 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAB11A 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PRKG1 -0.013 0.144 -9999.0 0.0 -0.571 65.0 65.0 mol:IP3 0.02 0.135 0.454 10.0 -0.382 70.0 80.0 cell morphogenesis 0.031 0.015 -9999.0 0.0 -0.36 1.0 1.0 PLCB2 0.012 0.172 0.543 7.0 -0.521 70.0 77.0 mol:cGMP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BLK 0.025 0.07 0.254 7.0 -0.287 5.0 12.0 mol:PDG2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HCK 0.015 0.059 0.243 4.0 -0.296 4.0 8.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PTGIR 0.026 0.022 0.257 9.0 -9999.0 0.0 9.0 PRKCB1 0.019 0.129 0.442 10.0 -0.378 64.0 74.0 GNAQ 0.023 0.026 -9999.0 0.0 -0.57 2.0 2.0 mol:L-citrulline 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 TXA2/TXA2-R family 0.015 0.168 0.531 8.0 -0.533 63.0 71.0 LCK 0.016 0.073 0.25 2.0 -0.362 13.0 15.0 TXA2/TP beta/beta Arrestin3/RAB11/GDP 0.023 0.054 -9999.0 0.0 -0.248 25.0 25.0 TXA2-R family/G12 family/GDP/G beta/gamma 0.007 0.103 -9999.0 0.0 -0.422 48.0 48.0 TXA2/TP beta/beta Arrestin2/RAB11/GDP 0.023 0.051 -9999.0 0.0 -0.246 21.0 21.0 MAPK14 0.019 0.089 0.322 18.0 -0.232 59.0 77.0 TGM2/GTP 0.015 0.148 0.492 10.0 -0.429 67.0 77.0 MAPK11 0.017 0.09 0.331 17.0 -0.239 58.0 75.0 ARHGEF1 0.012 0.066 0.269 11.0 -0.185 48.0 59.0 GNAI2 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 JNK cascade 0.021 0.133 0.416 14.0 -0.39 63.0 77.0 RAB11/GDP 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ICAM1 0.023 0.103 0.378 14.0 -0.283 59.0 73.0 cAMP biosynthetic process 0.017 0.127 0.429 10.0 -0.358 69.0 79.0 Gq family/GTP/EBP50 0.015 0.042 0.218 4.0 -0.279 5.0 9.0 actin cytoskeleton reorganization 0.031 0.015 -9999.0 0.0 -0.36 1.0 1.0 SRC 0.013 0.057 0.25 2.0 -0.283 5.0 7.0 GNB5 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GNB1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EGF/EGFR -0.047 0.105 0.22 5.0 -0.286 74.0 79.0 VCAM1 0.021 0.109 0.374 14.0 -0.313 60.0 74.0 TP beta/Gq family/GDP/G beta5/gamma2 -0.007 0.123 -9999.0 0.0 -0.589 36.0 36.0 platelet activation 0.024 0.115 0.394 17.0 -0.308 60.0 77.0 PGI2/IP 0.02 0.015 0.176 9.0 -9999.0 0.0 9.0 PRKACA 0.008 0.052 -9999.0 0.0 -0.283 30.0 30.0 Gq family/GDP/G beta5/gamma2 -0.0 0.1 -9999.0 0.0 -0.495 29.0 29.0 TXA2/TP beta/beta Arrestin2 -0.006 0.067 -9999.0 0.0 -0.441 16.0 16.0 positive regulation of NF-kappaB transcription factor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TBXA2R 0.002 0.047 -9999.0 0.0 -0.267 28.0 28.0 mol:DAG 0.019 0.144 0.464 10.0 -0.425 66.0 76.0 EGFR -0.191 0.285 -9999.0 0.0 -0.57 375.0 375.0 TXA2/TP alpha 0.015 0.165 0.521 8.0 -0.49 69.0 77.0 Gq family/GTP 0.002 0.048 0.253 1.0 -0.215 42.0 43.0 YES1 0.014 0.059 0.25 2.0 -0.297 4.0 6.0 GNAI2/GTP 0.014 0.05 -9999.0 0.0 -0.261 18.0 18.0 PGD2/DP 0.006 0.075 0.176 7.0 -0.397 33.0 40.0 SLC9A3R1 0.036 0.054 0.257 57.0 -9999.0 0.0 57.0 FYN 0.012 0.058 0.257 1.0 -0.326 6.0 7.0 mol:NO 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GNA15 0.025 0.026 0.257 6.0 -0.57 1.0 7.0 PGK/cGMP 0.008 0.095 -9999.0 0.0 -0.361 65.0 65.0 RhoA/GDP 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 TP alpha/TGM2/GDP/G beta/gamma 0.036 0.069 -9999.0 0.0 -0.397 11.0 11.0 NOS3 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PRKCA 0.022 0.133 0.417 12.0 -0.382 58.0 70.0 PRKCB 0.021 0.129 0.408 13.0 -0.371 61.0 74.0 PRKCE 0.019 0.122 0.444 10.0 -0.361 59.0 69.0 PRKCD 0.018 0.127 0.425 11.0 -0.386 60.0 71.0 PRKCG 0.02 0.132 0.45 10.0 -0.389 62.0 72.0 muscle contraction 0.016 0.16 0.507 9.0 -0.492 65.0 74.0 PRKCZ 0.018 0.119 0.389 14.0 -0.346 62.0 76.0 ARR3 0.021 0.021 0.257 8.0 -9999.0 0.0 8.0 TXA2/TP beta 0.025 0.058 -9999.0 0.0 -0.264 30.0 30.0 PRKCQ 0.015 0.136 0.388 17.0 -0.396 64.0 81.0 MAPKKK cascade 0.015 0.154 0.478 9.0 -0.463 68.0 77.0 SELE 0.017 0.123 0.377 14.0 -0.393 58.0 72.0 TP beta/GNAI2/GDP/G beta/gamma 0.035 0.068 -9999.0 0.0 -0.411 11.0 11.0 ROCK1 0.023 0.019 -9999.0 0.0 -0.57 1.0 1.0 GNA14 0.023 0.066 0.257 19.0 -0.57 10.0 29.0 chemotaxis 0.014 0.183 0.584 7.0 -0.611 60.0 67.0 GNA12 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GNA13 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GNA11 0.023 0.026 -9999.0 0.0 -0.57 2.0 2.0 Rac1/GTP 0.018 0.003 -9999.0 0.0 -9999.0 0.0 0.0