Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.012 0.043 -9999.0 0.0 -0.26 20.0 20.0 epithelial cell differentiation 0.036 0.054 -9999.0 0.0 -0.312 19.0 19.0 CYFIP2 0.028 0.049 0.257 27.0 -0.57 3.0 30.0 ENAH -0.004 0.06 0.294 11.0 -9999.0 0.0 11.0 EGFR -0.191 0.285 -9999.0 0.0 -0.57 375.0 375.0 EPHA2 0.021 0.041 -9999.0 0.0 -0.57 5.0 5.0 MYO6 -0.012 0.052 0.361 1.0 -0.302 20.0 21.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.035 -9999.0 0.0 -0.364 3.0 3.0 AQP5 -0.184 0.258 0.33 1.0 -0.498 407.0 408.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.012 0.05 0.358 1.0 -0.298 19.0 20.0 regulation of calcium-dependent cell-cell adhesion -0.023 0.075 0.358 1.0 -0.297 61.0 62.0 EGF -0.082 0.228 0.257 2.0 -0.57 186.0 188.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.016 0.118 0.288 1.0 -0.468 53.0 54.0 cortical microtubule organization 0.036 0.054 -9999.0 0.0 -0.312 19.0 19.0 GO:0000145 -0.012 0.048 0.351 1.0 -0.285 19.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.041 0.056 -9999.0 0.0 -0.315 19.0 19.0 MLLT4 0.021 0.033 0.257 1.0 -0.57 3.0 4.0 ARF6/GDP -0.02 0.039 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.045 0.039 -9999.0 0.0 -0.331 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.001 0.049 -9999.0 0.0 -0.284 19.0 19.0 PVRL2 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.012 0.05 0.361 1.0 -0.301 19.0 20.0 ARF6/GTP 0.049 0.04 -9999.0 0.0 -0.311 5.0 5.0 CDH1 0.011 0.08 -9999.0 0.0 -0.57 19.0 19.0 EGFR/EGFR/EGF/EGF -0.142 0.196 -9999.0 0.0 -0.332 501.0 501.0 RhoA/GDP 0.037 0.053 -9999.0 0.0 -0.299 19.0 19.0 actin cytoskeleton organization -0.013 0.049 0.343 1.0 -0.294 20.0 21.0 IGF-1R heterotetramer 0.013 0.08 0.256 2.0 -0.57 19.0 21.0 GIT1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.08 0.257 2.0 -0.57 19.0 21.0 IGF1 -0.103 0.244 -9999.0 0.0 -0.57 222.0 222.0 DIAPH1 0.026 0.101 -9999.0 0.0 -0.587 9.0 9.0 Wnt receptor signaling pathway -0.036 0.054 0.312 19.0 -9999.0 0.0 19.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.02 0.039 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.014 0.05 0.346 1.0 -0.301 20.0 21.0 EFNA1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.015 0.053 -9999.0 0.0 -0.292 26.0 26.0 Ephrin A1/EPHA2 0.025 0.053 -9999.0 0.0 -0.294 21.0 21.0 SEC6/SEC8 -0.022 0.042 -9999.0 0.0 -0.297 20.0 20.0 MGAT3 -0.023 0.076 0.361 1.0 -0.302 61.0 62.0 HGF/MET -0.038 0.153 -9999.0 0.0 -0.319 222.0 222.0 HGF -0.01 0.139 0.257 2.0 -0.57 60.0 62.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.012 0.043 -9999.0 0.0 -0.262 20.0 20.0 actin cable formation 0.041 0.095 0.302 40.0 -0.292 1.0 41.0 KIAA1543 -0.013 0.054 0.273 2.0 -0.331 19.0 21.0 KIFC3 -0.013 0.049 0.361 1.0 -0.302 19.0 20.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.012 0.049 -9999.0 0.0 -0.302 19.0 19.0 NCK1/GIT1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.036 0.054 -9999.0 0.0 -0.312 19.0 19.0 EXOC4 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.012 0.049 0.361 1.0 -0.302 18.0 19.0 PIP5K1C -0.012 0.051 0.361 1.0 -0.302 19.0 20.0 LIMA1 0.024 0.019 -9999.0 0.0 -0.57 1.0 1.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.016 0.088 0.305 25.0 -9999.0 0.0 25.0 adherens junction assembly -0.022 0.103 0.298 3.0 -0.63 16.0 19.0 IGF-1R heterotetramer/IGF1 -0.042 0.149 -9999.0 0.0 -0.311 226.0 226.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.029 -9999.0 0.0 -0.422 3.0 3.0 MET -0.073 0.219 -9999.0 0.0 -0.57 169.0 169.0 PLEKHA7 -0.013 0.057 0.361 1.0 -0.346 19.0 20.0 mol:GTP 0.043 0.038 -9999.0 0.0 -0.329 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.008 0.067 0.367 7.0 -0.517 1.0 8.0 cortical actin cytoskeleton stabilization 0.012 0.043 -9999.0 0.0 -0.26 20.0 20.0 regulation of cell-cell adhesion -0.013 0.049 0.343 1.0 -0.294 20.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.012 0.043 -9999.0 0.0 -0.262 20.0 20.0