S1P1 pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR2 homodimer/VEGFA homodimer 0.018 0.043 -9999.0 0.0 -0.384 5.0 5.0 PDGFRB 0.018 0.038 -9999.0 0.0 -0.577 4.0 4.0 SPHK1 -0.018 0.098 -9999.0 0.0 -0.751 14.0 14.0 mol:S1P -0.021 0.096 0.387 1.0 -0.665 14.0 15.0 S1P1/S1P/Gi -0.131 0.233 0.311 2.0 -0.441 322.0 324.0 GNAO1 0.006 0.092 0.245 32.0 -0.579 19.0 51.0 PDGFB-D/PDGFRB/PLCgamma1 -0.112 0.213 0.373 3.0 -0.406 300.0 303.0 PLCG1 -0.125 0.216 0.355 2.0 -0.424 305.0 307.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PDGFB-D/PDGFRB 0.018 0.038 -9999.0 0.0 -0.576 4.0 4.0 GNAI2 0.009 0.023 -9999.0 0.0 -9999.0 0.0 0.0 GNAI3 0.009 0.023 -9999.0 0.0 -9999.0 0.0 0.0 GNAI1 -0.019 0.131 -9999.0 0.0 -0.583 52.0 52.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EDG1 -0.014 0.03 0.203 1.0 -0.377 4.0 5.0 S1P1/S1P -0.034 0.098 0.275 2.0 -0.466 18.0 20.0 negative regulation of cAMP metabolic process -0.128 0.226 0.31 2.0 -0.429 322.0 324.0 MAPK3 -0.183 0.299 0.3 12.0 -0.584 343.0 355.0 calcium-dependent phospholipase C activity -0.003 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.018 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.018 0.003 -9999.0 0.0 -9999.0 0.0 0.0 KDR 0.012 0.041 -9999.0 0.0 -0.581 4.0 4.0 PLCB2 -0.025 0.097 0.298 6.0 -0.413 19.0 25.0 RAC1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.032 0.082 -9999.0 0.0 -0.394 18.0 18.0 receptor internalization -0.035 0.088 -9999.0 0.0 -0.432 18.0 18.0 PTGS2 -0.333 0.5 0.382 2.0 -1.019 354.0 356.0 Rac1/GTP -0.032 0.082 -9999.0 0.0 -0.394 18.0 18.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VEGFA 0.015 0.027 0.255 7.0 -9999.0 0.0 7.0 negative regulation of T cell proliferation -0.128 0.226 0.31 2.0 -0.429 322.0 324.0 GO:0007205 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAZ 0.004 0.059 -9999.0 0.0 -0.577 9.0 9.0 MAPK1 -0.201 0.326 0.342 2.0 -0.624 358.0 360.0 S1P1/S1P/PDGFB-D/PDGFRB -0.033 0.116 0.31 4.0 -0.476 17.0 21.0 ABCC1 0.012 0.019 -9999.0 0.0 -9999.0 0.0 0.0