IL23-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CCL2 -0.024 0.488 0.804 47.0 -1.07 75.0 122.0 IL23A -0.035 0.488 0.849 33.0 -1.103 72.0 105.0 NF kappa B1 p50/RelA/I kappa B alpha -0.063 0.449 0.748 9.0 -0.88 151.0 160.0 positive regulation of T cell mediated cytotoxicity -0.026 0.543 0.85 72.0 -0.959 157.0 229.0 ITGA3 -0.02 0.479 0.795 44.0 -1.051 76.0 120.0 IL17F -0.008 0.36 0.589 76.0 -0.672 82.0 158.0 IL12B 0.085 0.152 0.353 211.0 -9999.0 0.0 211.0 STAT1 (dimer) -0.041 0.503 0.747 49.0 -0.926 157.0 206.0 CD4 -0.019 0.484 0.821 45.0 -1.028 75.0 120.0 IL23 -0.02 0.487 0.819 49.0 -1.068 71.0 120.0 IL23R 0.048 0.203 0.604 17.0 -0.941 16.0 33.0 IL1B -0.037 0.503 0.825 42.0 -1.135 78.0 120.0 T-helper cell lineage commitment 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL24 0.015 0.487 0.833 64.0 -1.014 72.0 136.0 TYK2 0.026 0.059 0.201 10.0 -9999.0 0.0 10.0 STAT4 -0.001 0.12 0.257 1.0 -0.57 44.0 45.0 STAT3 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IL18RAP 0.007 0.11 0.27 5.0 -0.568 36.0 41.0 IL12RB1 0.035 0.093 0.367 44.0 -0.589 2.0 46.0 PIK3CA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IL12Rbeta1/TYK2 0.039 0.089 0.308 46.0 -0.434 2.0 48.0 IL23R/JAK2 0.061 0.219 0.551 30.0 -0.866 15.0 45.0 positive regulation of chronic inflammatory response -0.026 0.543 0.85 72.0 -0.959 157.0 229.0 natural killer cell activation -0.004 0.015 -9999.0 0.0 -0.051 35.0 35.0 JAK2 0.038 0.083 0.258 38.0 -9999.0 0.0 38.0 PIK3R1 0.019 0.055 -9999.0 0.0 -0.564 9.0 9.0 NFKB1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of dendritic cell antigen processing and presentation -0.014 0.473 0.801 54.0 -1.005 72.0 126.0 ALOX12B -0.02 0.481 0.811 49.0 -1.023 75.0 124.0 CXCL1 -0.187 0.698 0.843 46.0 -1.242 271.0 317.0 T cell proliferation -0.026 0.543 0.85 72.0 -0.959 157.0 229.0 NFKBIA 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IL17A 0.02 0.314 0.553 90.0 -0.533 71.0 161.0 PI3K -0.059 0.469 0.687 24.0 -0.911 144.0 168.0 IFNG 0.026 0.068 0.172 134.0 -0.116 14.0 148.0 STAT3 (dimer) -0.059 0.448 0.711 14.0 -0.93 111.0 125.0 IL18R1 0.017 0.076 -9999.0 0.0 -0.568 17.0 17.0 IL23/IL23R/JAK2/TYK2/SOCS3 0.035 0.346 0.644 85.0 -0.621 58.0 143.0 IL18/IL18R 0.04 0.103 0.286 10.0 -0.365 51.0 61.0 macrophage activation -0.0 0.029 0.056 102.0 -0.044 54.0 156.0 TNF -0.034 0.499 0.831 43.0 -1.113 77.0 120.0 STAT3/STAT4 -0.06 0.486 0.682 24.0 -0.929 156.0 180.0 STAT4 (dimer) -0.054 0.514 0.739 43.0 -0.962 159.0 202.0 IL18 0.029 0.036 0.262 22.0 -9999.0 0.0 22.0 IL19 0.019 0.487 0.816 67.0 -1.015 71.0 138.0 STAT5A (dimer) -0.044 0.5 0.733 44.0 -0.926 158.0 202.0 STAT1 0.028 0.031 0.257 19.0 -9999.0 0.0 19.0 SOCS3 0.02 0.041 -9999.0 0.0 -0.57 5.0 5.0 CXCL9 0.005 0.512 0.833 80.0 -1.047 77.0 157.0 MPO -0.051 0.547 0.82 43.0 -1.181 111.0 154.0 positive regulation of humoral immune response -0.026 0.543 0.85 72.0 -0.959 157.0 229.0 IL23/IL23R/JAK2/TYK2 -0.034 0.562 0.878 63.0 -1.013 151.0 214.0 IL6 -0.3 0.743 0.789 38.0 -1.205 384.0 422.0 STAT5A 0.02 0.045 -9999.0 0.0 -0.57 6.0 6.0 IL2 0.022 0.038 0.3 8.0 -9999.0 0.0 8.0 positive regulation of tyrosine phosphorylation of STAT protein -0.004 0.015 -9999.0 0.0 -0.051 35.0 35.0 CD3E -0.03 0.509 0.821 58.0 -1.132 82.0 140.0 keratinocyte proliferation -0.026 0.543 0.85 72.0 -0.959 157.0 229.0 NOS2 -0.02 0.484 0.804 47.0 -1.053 74.0 121.0