ErbB4 signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations ErbB4/ErbB4/HBEGF/HBEGF 0.003 0.09 -9999.0 0.0 -0.419 8.0 8.0 epithelial cell differentiation 0.026 0.08 -9999.0 0.0 -9999.0 0.0 0.0 ITCH 0.025 0.02 -9999.0 0.0 -9999.0 0.0 0.0 WWP1 0.008 0.077 -9999.0 0.0 -9999.0 0.0 0.0 FYN 0.013 0.045 -9999.0 0.0 -0.722 2.0 2.0 EGFR -0.375 0.367 -9999.0 0.0 -0.722 277.0 277.0 PRL 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 neuron projection morphogenesis 0.012 0.135 -9999.0 0.0 -0.422 8.0 8.0 PTPRZ1 -0.505 0.335 -9999.0 0.0 -0.722 370.0 370.0 ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC -0.053 0.123 -9999.0 0.0 -0.46 11.0 11.0 ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta -0.04 0.163 -9999.0 0.0 -0.433 67.0 67.0 ADAM17 0.024 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/ErbB4 -0.0 0.097 -9999.0 0.0 -0.465 4.0 4.0 ErbB4/ErbB4/neuregulin 3/neuregulin 3 0.005 0.087 -9999.0 0.0 -0.413 6.0 6.0 NCOR1 0.015 0.032 -9999.0 0.0 -0.722 1.0 1.0 ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn -0.031 0.159 -9999.0 0.0 -0.412 67.0 67.0 GRIN2B -0.028 0.16 -9999.0 0.0 -0.445 26.0 26.0 ErbB4/ErbB2/betacellulin -0.0 0.114 -9999.0 0.0 -0.42 26.0 26.0 STAT1 -0.011 0.061 -9999.0 0.0 -9999.0 0.0 0.0 HBEGF 0.011 0.064 -9999.0 0.0 -0.722 4.0 4.0 PRLR -0.026 0.071 -9999.0 0.0 -9999.0 0.0 0.0 E4ICDs/ETO2 -0.054 0.191 -9999.0 0.0 -0.499 71.0 71.0 axon guidance 0.115 0.117 -9999.0 0.0 -9999.0 0.0 0.0 NEDD4 0.017 0.073 -9999.0 0.0 -0.699 5.0 5.0 Prolactin receptor/Prolactin receptor/Prolactin -0.02 0.034 -9999.0 0.0 -9999.0 0.0 0.0 CBFA2T3 -0.084 0.251 -9999.0 0.0 -0.722 70.0 70.0 ErbB4/ErbB2/HBEGF 0.017 0.075 -9999.0 0.0 -0.397 6.0 6.0 MAPK3 0.002 0.138 -9999.0 0.0 -0.434 10.0 10.0 STAT1 (dimer) 0.007 0.095 -9999.0 0.0 -0.403 4.0 4.0 MAPK1 0.002 0.138 -9999.0 0.0 -0.434 10.0 10.0 JAK2 0.015 0.033 -9999.0 0.0 -0.722 1.0 1.0 ErbB4/ErbB2/neuregulin 1 beta -0.038 0.157 -9999.0 0.0 -0.409 69.0 69.0 NRG1 -0.04 0.194 -9999.0 0.0 -0.546 67.0 67.0 NRG3 0.009 0.052 -9999.0 0.0 -0.722 2.0 2.0 NRG2 -0.48 0.347 -9999.0 0.0 -0.722 353.0 353.0 NRG4 0.015 0.014 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.115 0.117 -9999.0 0.0 -9999.0 0.0 0.0 neural crest cell migration -0.037 0.155 -9999.0 0.0 -0.404 69.0 69.0 ERBB2 0.021 0.044 -9999.0 0.0 -0.533 1.0 1.0 WWOX/E4ICDs 0.007 0.083 -9999.0 0.0 -0.405 4.0 4.0 SHC1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/EGFR/neuregulin 4 -0.232 0.185 -9999.0 0.0 -0.397 281.0 281.0 apoptosis 0.017 0.066 0.357 6.0 -9999.0 0.0 6.0 ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta -0.308 0.215 -9999.0 0.0 -0.45 354.0 354.0 ErbB4/ErbB2/epiregulin 0.019 0.076 -9999.0 0.0 -0.417 4.0 4.0 ErbB4/ErbB4/betacellulin/betacellulin -0.015 0.127 -9999.0 0.0 -0.452 28.0 28.0 ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 0.004 0.083 -9999.0 0.0 -0.423 3.0 3.0 MDM2 0.009 0.084 -9999.0 0.0 -0.405 4.0 4.0 ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta -0.061 0.137 -9999.0 0.0 -0.41 67.0 67.0 STAT5A 0.115 0.11 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/EGFR/neuregulin 1 beta -0.252 0.265 -9999.0 0.0 -0.461 290.0 290.0 DLG4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SHC -0.001 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E4ICDs/TAB2/NCoR1 -0.024 0.061 -9999.0 0.0 -0.38 6.0 6.0 STAT5A (dimer) 0.032 0.093 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP2 0.015 0.032 -9999.0 0.0 -0.722 1.0 1.0 STAT5B (dimer) 0.108 0.103 -9999.0 0.0 -9999.0 0.0 0.0 LRIG1 -0.019 0.157 -9999.0 0.0 -0.722 25.0 25.0 EREG -0.001 0.064 -9999.0 0.0 -0.722 2.0 2.0 BTC -0.019 0.155 -9999.0 0.0 -0.722 24.0 24.0 ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta 0.116 0.118 -9999.0 0.0 -9999.0 0.0 0.0 ERBB4 -0.0 0.097 -9999.0 0.0 -0.467 4.0 4.0 STAT5B 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 YAP1 -0.011 0.058 -9999.0 0.0 -0.631 4.0 4.0 GRB2 0.013 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/ErbB2/neuregulin 4 0.02 0.069 -9999.0 0.0 -0.459 2.0 2.0 glial cell differentiation 0.024 0.061 0.377 6.0 -9999.0 0.0 6.0 WWOX 0.009 0.033 -9999.0 0.0 -9999.0 0.0 0.0 cell proliferation 0.022 0.162 -9999.0 0.0 -0.481 12.0 12.0