Endothelins Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations AKT1 -0.11 0.244 -9999.0 0.0 -0.455 172.0 172.0 PTK2B 0.016 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.143 0.302 -9999.0 0.0 -0.746 76.0 76.0 EDN1 -0.208 0.354 -9999.0 0.0 -0.72 169.0 169.0 EDN3 -0.598 0.276 -9999.0 0.0 -0.722 437.0 437.0 EDN2 -0.061 0.09 -9999.0 0.0 -0.722 2.0 2.0 HRAS/GDP -0.244 0.25 -9999.0 0.0 -0.501 202.0 202.0 ETA receptor/Endothelin-1/Gq/GTP/PLC beta -0.114 0.194 -9999.0 0.0 -0.359 156.0 156.0 ADCY4 -0.096 0.21 -9999.0 0.0 -0.385 174.0 174.0 ADCY5 -0.094 0.205 -9999.0 0.0 -0.38 173.0 173.0 ADCY6 -0.092 0.204 -9999.0 0.0 -0.378 172.0 172.0 ADCY7 -0.092 0.205 -9999.0 0.0 -0.379 172.0 172.0 ADCY1 -0.093 0.204 -9999.0 0.0 -0.378 172.0 172.0 ADCY2 -0.098 0.212 -9999.0 0.0 -0.386 176.0 176.0 ADCY3 -0.092 0.204 -9999.0 0.0 -0.378 172.0 172.0 ADCY8 -0.092 0.205 -9999.0 0.0 -0.379 172.0 172.0 ADCY9 -0.092 0.205 -9999.0 0.0 -0.379 172.0 172.0 arachidonic acid secretion -0.531 0.372 -9999.0 0.0 -0.698 401.0 401.0 ETB receptor/Endothelin-1/Gq/GTP -0.258 0.25 -9999.0 0.0 -0.421 329.0 329.0 GNAO1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HRAS 0.009 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ETA receptor/Endothelin-1/G12/GTP -0.095 0.236 -9999.0 0.0 -0.425 171.0 171.0 ETA receptor/Endothelin-1/Gs/GTP -0.093 0.226 -9999.0 0.0 -0.407 172.0 172.0 mol:GTP -0.007 0.009 -9999.0 0.0 -9999.0 0.0 0.0 COL3A1 -0.109 0.244 -9999.0 0.0 -0.453 171.0 171.0 EDNRB -0.351 0.37 -9999.0 0.0 -0.725 260.0 260.0 response to oxidative stress -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYSLTR2 -0.108 0.242 -9999.0 0.0 -0.45 171.0 171.0 CYSLTR1 -0.113 0.251 -9999.0 0.0 -0.46 173.0 173.0 SLC9A1 -0.063 0.136 -9999.0 0.0 -0.266 112.0 112.0 mol:GDP -0.268 0.271 -9999.0 0.0 -0.516 228.0 228.0 SLC9A3 -0.401 0.409 -9999.0 0.0 -0.665 331.0 331.0 RAF1 -0.36 0.292 -9999.0 0.0 -0.559 309.0 309.0 JUN -0.239 0.466 -9999.0 0.0 -1.108 109.0 109.0 JAK2 -0.11 0.246 -9999.0 0.0 -0.457 171.0 171.0 mol:IP3 -0.227 0.245 -9999.0 0.0 -0.459 218.0 218.0 ETA receptor/Endothelin-1 -0.124 0.293 -9999.0 0.0 -0.536 173.0 173.0 PLCB1 -0.101 0.254 -9999.0 0.0 -0.726 74.0 74.0 PLCB2 0.005 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ETA receptor/Endothelin-3 -0.445 0.213 -9999.0 0.0 -0.54 437.0 437.0 FOS -0.708 0.472 -9999.0 0.0 -0.997 378.0 378.0 Gai/GDP -0.103 0.164 -9999.0 0.0 -0.791 2.0 2.0 CRK 0.014 0.032 -9999.0 0.0 -0.724 1.0 1.0 mol:Ca ++ -0.304 0.33 -9999.0 0.0 -0.638 219.0 219.0 BCAR1 0.017 0.001 -9999.0 0.0 -9999.0 0.0 0.0 PRKCB1 -0.223 0.236 -9999.0 0.0 -0.454 210.0 210.0 GNAQ -0.008 0.01 -9999.0 0.0 -9999.0 0.0 0.0 GNAZ 0.008 0.078 -9999.0 0.0 -0.722 6.0 6.0 GNAL 0.012 0.056 -9999.0 0.0 -0.722 3.0 3.0 Gs family/GDP -0.253 0.219 -9999.0 0.0 -0.48 207.0 207.0 ETA receptor/Endothelin-1/Gq/GTP -0.085 0.168 -9999.0 0.0 -0.308 169.0 169.0 MAPK14 -0.244 0.254 -9999.0 0.0 -0.444 268.0 268.0 TRPC6 -0.153 0.325 -9999.0 0.0 -0.803 76.0 76.0 GNAI2 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GNAI3 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAI1 -0.249 0.354 -9999.0 0.0 -0.722 189.0 189.0 ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.267 0.269 -9999.0 0.0 -0.453 302.0 302.0 ETB receptor/Endothelin-2 -0.293 0.288 -9999.0 0.0 -0.579 262.0 262.0 ETB receptor/Endothelin-3 -0.673 0.338 -9999.0 0.0 -0.778 455.0 455.0 ETB receptor/Endothelin-1 -0.412 0.379 -9999.0 0.0 -0.675 329.0 329.0 MAPK3 -0.616 0.425 -9999.0 0.0 -0.865 380.0 380.0 MAPK1 -0.616 0.425 -9999.0 0.0 -0.865 380.0 380.0 Rac1/GDP -0.241 0.25 -9999.0 0.0 -0.498 203.0 203.0 cAMP biosynthetic process -0.039 0.19 -9999.0 0.0 -0.356 63.0 63.0 MAPK8 -0.158 0.287 -9999.0 0.0 -0.618 118.0 118.0 SRC 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ETB receptor/Endothelin-1/Gi/GTP -0.304 0.323 -9999.0 0.0 -0.511 309.0 309.0 p130Cas/CRK/Src/PYK2 -0.24 0.291 -9999.0 0.0 -0.565 189.0 189.0 mol:K + 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 G12/GDP -0.241 0.25 -9999.0 0.0 -0.498 203.0 203.0 COL1A2 -0.318 0.347 -9999.0 0.0 -0.689 193.0 193.0 EntrezGene:2778 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ETA receptor/Endothelin-2 0.03 0.077 -9999.0 0.0 -0.531 4.0 4.0 mol:DAG -0.229 0.245 -9999.0 0.0 -0.458 220.0 220.0 MAP2K2 -0.47 0.342 -9999.0 0.0 -0.657 382.0 382.0 MAP2K1 -0.47 0.342 -9999.0 0.0 -0.657 382.0 382.0 EDNRA 0.024 0.053 -9999.0 0.0 -0.708 2.0 2.0 positive regulation of muscle contraction -0.089 0.214 -9999.0 0.0 -0.391 172.0 172.0 Gq family/GDP -0.22 0.21 -9999.0 0.0 -0.473 165.0 165.0 HRAS/GTP -0.275 0.257 -9999.0 0.0 -0.443 311.0 311.0 PRKCH -0.222 0.243 -9999.0 0.0 -0.473 195.0 195.0 RAC1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCA -0.22 0.237 -9999.0 0.0 -0.452 210.0 210.0 PRKCB -0.232 0.238 -9999.0 0.0 -0.437 240.0 240.0 PRKCE -0.219 0.236 -9999.0 0.0 -0.468 193.0 193.0 PRKCD -0.224 0.239 -9999.0 0.0 -0.457 211.0 211.0 PRKCG -0.223 0.239 -9999.0 0.0 -0.474 193.0 193.0 regulation of vascular smooth muscle contraction -0.827 0.548 -9999.0 0.0 -1.164 377.0 377.0 PRKCQ -0.226 0.239 -9999.0 0.0 -0.458 212.0 212.0 PLA2G4A -0.605 0.436 -9999.0 0.0 -0.795 401.0 401.0 GNA14 -0.018 0.09 -9999.0 0.0 -0.728 6.0 6.0 GNA15 0.006 0.021 -9999.0 0.0 -9999.0 0.0 0.0 GNA12 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNA11 0.009 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.094 0.235 -9999.0 0.0 -0.423 171.0 171.0 MMP1 0.026 0.135 -9999.0 0.0 -9999.0 0.0 0.0